JP2014529395A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014529395A5 JP2014529395A5 JP2014523291A JP2014523291A JP2014529395A5 JP 2014529395 A5 JP2014529395 A5 JP 2014529395A5 JP 2014523291 A JP2014523291 A JP 2014523291A JP 2014523291 A JP2014523291 A JP 2014523291A JP 2014529395 A5 JP2014529395 A5 JP 2014529395A5
- Authority
- JP
- Japan
- Prior art keywords
- dystonia
- syndrome
- disease
- polynucleotide
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000010118 dystonia Diseases 0.000 claims description 69
- 208000014094 Dystonic disease Diseases 0.000 claims description 68
- 102000040430 polynucleotide Human genes 0.000 claims description 30
- 108091033319 polynucleotide Proteins 0.000 claims description 30
- 239000002157 polynucleotide Substances 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 208000004350 Strabismus Diseases 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 238000001356 surgical procedure Methods 0.000 claims description 13
- 108030001720 Bontoxilysin Proteins 0.000 claims description 12
- 108010032088 Calpain Proteins 0.000 claims description 12
- 238000003776 cleavage reaction Methods 0.000 claims description 12
- 230000007017 scission Effects 0.000 claims description 12
- 208000005392 Spasm Diseases 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 208000012661 Dyskinesia Diseases 0.000 claims description 9
- 208000007101 Muscle Cramp Diseases 0.000 claims description 9
- 208000002033 Myoclonus Diseases 0.000 claims description 9
- 101710138657 Neurotoxin Proteins 0.000 claims description 9
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 239000002581 neurotoxin Substances 0.000 claims description 9
- 231100000618 neurotoxin Toxicity 0.000 claims description 9
- 206010044074 Torticollis Diseases 0.000 claims description 8
- 230000002920 convulsive effect Effects 0.000 claims description 8
- 230000004064 dysfunction Effects 0.000 claims description 8
- 210000005070 sphincter Anatomy 0.000 claims description 8
- 206010010904 Convulsion Diseases 0.000 claims description 7
- 206010013952 Dysphonia Diseases 0.000 claims description 7
- 206010033799 Paralysis Diseases 0.000 claims description 7
- 230000006378 damage Effects 0.000 claims description 7
- 208000014674 injury Diseases 0.000 claims description 7
- 210000003127 knee Anatomy 0.000 claims description 7
- 102000007590 Calpain Human genes 0.000 claims description 6
- 208000000289 Esophageal Achalasia Diseases 0.000 claims description 6
- 208000008454 Hyperhidrosis Diseases 0.000 claims description 6
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 6
- 206010030136 Oesophageal achalasia Diseases 0.000 claims description 6
- 208000018737 Parkinson disease Diseases 0.000 claims description 6
- 206010044565 Tremor Diseases 0.000 claims description 6
- 208000027418 Wounds and injury Diseases 0.000 claims description 6
- 201000003426 X-linked dystonia-parkinsonism Diseases 0.000 claims description 6
- 201000000621 achalasia Diseases 0.000 claims description 6
- 210000003423 ankle Anatomy 0.000 claims description 6
- 230000036461 convulsion Effects 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 230000001681 protective effect Effects 0.000 claims description 6
- 210000002027 skeletal muscle Anatomy 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
- 210000000689 upper leg Anatomy 0.000 claims description 6
- 210000001260 vocal cord Anatomy 0.000 claims description 6
- 206010028311 Muscle hypertrophy Diseases 0.000 claims description 5
- 206010067672 Spasmodic dysphonia Diseases 0.000 claims description 5
- 210000000744 eyelid Anatomy 0.000 claims description 5
- 230000001969 hypertrophic effect Effects 0.000 claims description 5
- 208000018197 inherited torticollis Diseases 0.000 claims description 5
- 210000002414 leg Anatomy 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 230000012042 muscle hypertrophy Effects 0.000 claims description 5
- 201000002849 spasmodic dystonia Diseases 0.000 claims description 5
- 208000003926 Myelitis Diseases 0.000 claims description 4
- 206010005159 blepharospasm Diseases 0.000 claims description 4
- 230000000744 blepharospasm Effects 0.000 claims description 4
- 210000004720 cerebrum Anatomy 0.000 claims description 4
- 210000003205 muscle Anatomy 0.000 claims description 4
- 230000002980 postoperative effect Effects 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 241000567030 Ampulloclitocybe clavipes Species 0.000 claims description 3
- 206010003062 Apraxia Diseases 0.000 claims description 3
- 102000014461 Ataxins Human genes 0.000 claims description 3
- 108010078286 Ataxins Proteins 0.000 claims description 3
- 206010059237 Auriculotemporal syndrome Diseases 0.000 claims description 3
- 208000035143 Bacterial infection Diseases 0.000 claims description 3
- 206010069632 Bladder dysfunction Diseases 0.000 claims description 3
- 208000019352 Blepharospasm-oromandibular dystonia syndrome Diseases 0.000 claims description 3
- 208000006274 Brain Stem Neoplasms Diseases 0.000 claims description 3
- 206010072043 Central nervous system haemorrhage Diseases 0.000 claims description 3
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 3
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims description 3
- 206010061842 Entropion Diseases 0.000 claims description 3
- 208000001692 Esotropia Diseases 0.000 claims description 3
- 201000005538 Exotropia Diseases 0.000 claims description 3
- 206010068737 Facial asymmetry Diseases 0.000 claims description 3
- 206010017533 Fungal infection Diseases 0.000 claims description 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 3
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims description 3
- 206010018691 Granuloma Diseases 0.000 claims description 3
- 208000004041 Gustatory Sweating Diseases 0.000 claims description 3
- 208000004095 Hemifacial Spasm Diseases 0.000 claims description 3
- 208000032843 Hemorrhage Diseases 0.000 claims description 3
- 208000023105 Huntington disease Diseases 0.000 claims description 3
- 201000005190 Meige syndrome Diseases 0.000 claims description 3
- 208000008238 Muscle Spasticity Diseases 0.000 claims description 3
- 208000031888 Mycoses Diseases 0.000 claims description 3
- 201000002481 Myositis Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 208000030852 Parasitic disease Diseases 0.000 claims description 3
- 208000037158 Partial Epilepsies Diseases 0.000 claims description 3
- 206010061334 Partial seizures Diseases 0.000 claims description 3
- 206010035628 Pleurothotonus Diseases 0.000 claims description 3
- 208000036071 Rhinorrhea Diseases 0.000 claims description 3
- 206010039101 Rhinorrhoea Diseases 0.000 claims description 3
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 3
- 206010072148 Stiff-Person syndrome Diseases 0.000 claims description 3
- 208000006011 Stroke Diseases 0.000 claims description 3
- 208000003028 Stuttering Diseases 0.000 claims description 3
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 3
- 208000002667 Subdural Hematoma Diseases 0.000 claims description 3
- 206010042364 Subdural haemorrhage Diseases 0.000 claims description 3
- 206010043101 Talipes Diseases 0.000 claims description 3
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 3
- 208000016620 Tourette disease Diseases 0.000 claims description 3
- 208000036142 Viral infection Diseases 0.000 claims description 3
- 208000013142 Writer cramp Diseases 0.000 claims description 3
- 210000001015 abdomen Anatomy 0.000 claims description 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 3
- 230000001363 autoimmune Effects 0.000 claims description 3
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 3
- 210000004227 basal ganglia Anatomy 0.000 claims description 3
- 230000004071 biological effect Effects 0.000 claims description 3
- 210000000133 brain stem Anatomy 0.000 claims description 3
- 206010006514 bruxism Diseases 0.000 claims description 3
- 210000003169 central nervous system Anatomy 0.000 claims description 3
- 206010008129 cerebral palsy Diseases 0.000 claims description 3
- 201000002866 cervical dystonia Diseases 0.000 claims description 3
- 201000011228 clubfoot Diseases 0.000 claims description 3
- 210000000959 ear middle Anatomy 0.000 claims description 3
- 206010014599 encephalitis Diseases 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 201000007186 focal epilepsy Diseases 0.000 claims description 3
- 201000002865 focal hand dystonia Diseases 0.000 claims description 3
- 208000008675 hereditary spastic paraplegia Diseases 0.000 claims description 3
- 230000037315 hyperhidrosis Effects 0.000 claims description 3
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims description 3
- 238000007913 intrathecal administration Methods 0.000 claims description 3
- 208000011977 language disease Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 208000018389 neoplasm of cerebral hemisphere Diseases 0.000 claims description 3
- 210000005036 nerve Anatomy 0.000 claims description 3
- 208000008795 neuromyelitis optica Diseases 0.000 claims description 3
- 206010029864 nystagmus Diseases 0.000 claims description 3
- 201000002851 oromandibular dystonia Diseases 0.000 claims description 3
- 208000021090 palsy Diseases 0.000 claims description 3
- 230000002085 persistent effect Effects 0.000 claims description 3
- 230000036563 plantar hyperhidrosis Effects 0.000 claims description 3
- 230000008929 regeneration Effects 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 3
- 201000002899 segmental dystonia Diseases 0.000 claims description 3
- 230000001148 spastic effect Effects 0.000 claims description 3
- 208000018198 spasticity Diseases 0.000 claims description 3
- 208000020431 spinal cord injury Diseases 0.000 claims description 3
- 206010062261 spinal cord neoplasm Diseases 0.000 claims description 3
- 208000023516 stroke disease Diseases 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- 210000001942 upper esophageal sphincter Anatomy 0.000 claims description 3
- 206010046947 vaginismus Diseases 0.000 claims description 3
- 230000009385 viral infection Effects 0.000 claims description 3
- 206010003591 Ataxia Diseases 0.000 claims description 2
- 206010015995 Eyelid ptosis Diseases 0.000 claims description 2
- 206010056696 Gaze palsy Diseases 0.000 claims description 2
- 206010020880 Hypertrophy Diseases 0.000 claims description 2
- 206010061216 Infarction Diseases 0.000 claims description 2
- 208000016285 Movement disease Diseases 0.000 claims description 2
- 206010052904 Musculoskeletal stiffness Diseases 0.000 claims description 2
- 208000001738 Nervous System Trauma Diseases 0.000 claims description 2
- 206010058571 Spinal cord infarction Diseases 0.000 claims description 2
- 201000007293 brain stem infarction Diseases 0.000 claims description 2
- 230000001054 cortical effect Effects 0.000 claims description 2
- 230000007850 degeneration Effects 0.000 claims description 2
- 230000007574 infarction Effects 0.000 claims description 2
- 210000001352 masseter muscle Anatomy 0.000 claims description 2
- 210000003784 masticatory muscle Anatomy 0.000 claims description 2
- 230000009826 neoplastic cell growth Effects 0.000 claims description 2
- 201000003004 ptosis Diseases 0.000 claims description 2
- 210000003813 thumb Anatomy 0.000 claims description 2
- 206010002153 Anal fissure Diseases 0.000 claims 1
- 208000016583 Anus disease Diseases 0.000 claims 1
- 206010065562 Crocodile tears syndrome Diseases 0.000 claims 1
- 208000009531 Fissure in Ano Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000006199 Parasomnias Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010051482 Prostatomegaly Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 210000003811 finger Anatomy 0.000 claims 1
- 210000002683 foot Anatomy 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 230000004264 retinal detachment Effects 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 3
- 201000004240 prostatic hypertrophy Diseases 0.000 description 3
- 206010008748 Chorea Diseases 0.000 description 2
- 241000270722 Crocodylidae Species 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000012075 Paroxysmal dystonia Diseases 0.000 description 2
- 206010036346 Posterior capsule opacification Diseases 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 description 2
- 208000031477 focal task-specific dystonia Diseases 0.000 description 2
- 208000013667 paroxysmal dyskinesia Diseases 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 208000009174 transverse myelitis Diseases 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 208000030644 Esophageal Motility disease Diseases 0.000 description 1
- 206010063006 Facial spasm Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000014934 Oesophageal motility disease Diseases 0.000 description 1
- 241001227561 Valgus Species 0.000 description 1
- 241000469816 Varus Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 201000011191 dyskinesia of esophagus Diseases 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000010879 hemorrhoidectomy Methods 0.000 description 1
- 238000011540 hip replacement Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 230000018984 mastication Effects 0.000 description 1
- 238000010077 mastication Methods 0.000 description 1
- 201000003102 mental depression Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161574596P | 2011-08-04 | 2011-08-04 | |
| EP11176531.9 | 2011-08-04 | ||
| US61/574,596 | 2011-08-04 | ||
| EP11176531 | 2011-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014529395A JP2014529395A (ja) | 2014-11-13 |
| JP2014529395A5 true JP2014529395A5 (enExample) | 2016-07-28 |
Family
ID=47628649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014523291A Pending JP2014529395A (ja) | 2011-08-04 | 2012-07-26 | ボツリヌス神経毒のタンパク質分解的切断の改変 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140170133A1 (enExample) |
| EP (1) | EP2739297A1 (enExample) |
| JP (1) | JP2014529395A (enExample) |
| AU (1) | AU2012292163A1 (enExample) |
| CA (1) | CA2841933A1 (enExample) |
| WO (1) | WO2013017522A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3290437A1 (en) | 2016-08-31 | 2018-03-07 | Merz Pharma GmbH & Co. KGaA | Novel recombinant clostridial neurotoxins with decreased duration of effect |
| EP3312193A1 (en) | 2016-10-19 | 2018-04-25 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with accelerated onset of effect |
| WO2018081282A1 (en) * | 2016-10-25 | 2018-05-03 | Cellsnap Llc | Neurotoxins and uses thereof |
| EP3335719A1 (en) * | 2016-12-14 | 2018-06-20 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with a stabilized light chain |
| CN118126143B (zh) * | 2024-03-14 | 2025-06-24 | 河北平朴生物科技合伙企业(有限合伙) | 一种a型肉毒毒素的突变体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
| US20030219462A1 (en) * | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
| US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
| US6943555B2 (en) * | 2002-05-23 | 2005-09-13 | Lockheed Martin Corporation | Redundant safety circuit for squib testing |
| JP5746624B2 (ja) * | 2008-08-29 | 2015-07-08 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | 変化した持続性を有するクロストリジウム性神経毒 |
| GB0903006D0 (en) * | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
-
2012
- 2012-07-26 EP EP12742873.8A patent/EP2739297A1/en not_active Withdrawn
- 2012-07-26 AU AU2012292163A patent/AU2012292163A1/en not_active Abandoned
- 2012-07-26 JP JP2014523291A patent/JP2014529395A/ja active Pending
- 2012-07-26 WO PCT/EP2012/064690 patent/WO2013017522A1/en not_active Ceased
- 2012-07-26 US US14/236,454 patent/US20140170133A1/en not_active Abandoned
- 2012-07-26 CA CA2841933A patent/CA2841933A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009541396A5 (enExample) | ||
| JP2015536644A5 (enExample) | ||
| RU2015124069A (ru) | Способы производства протеолитически процессированных полипептидов | |
| JP5897784B2 (ja) | ボツリヌス毒素の神経毒成分の高頻度適用 | |
| JP2014529395A5 (enExample) | ||
| Hackett | Prolotherapy in whiplash and low back pain | |
| RU2012103376A (ru) | Биологическая активность | |
| EP3600384A1 (en) | Improved use of botulinum neurotoxin in the treatment of sialorrhea | |
| JP2015504304A (ja) | ポリ−グリシンを伴う修飾神経毒及びその使用 | |
| WO2022109304A1 (en) | Systems, devices, and methods for gamma entrainment using haptic stimuli | |
| WO2011160826A1 (en) | Botulinum toxin therapy | |
| US20120251574A1 (en) | Endopeptidase and Neurotoxin Combination Treatment of Multiple Medical Conditions | |
| US20120251575A1 (en) | Endopeptidase Treatment of Involuntary Movement Disorders | |
| RU2344805C2 (ru) | Способ лечения заболеваний, травм периферической нервной системы, их последствий и последствий нарушения спинального мозгового кровообращения и спинальных травм | |
| TAYLOR | Fracture-dislocation of the neck: a method of treatment | |
| Har-Shai et al. | Lengthening temporalis myoplasty for facial palsy reanimation | |
| Abdelghany et al. | Effect of Instrument Assisted Soft Tissue Mobilization on Range of Motion in Children with Diplegic Cerebral Palsy: A Review Article | |
| Guidubaldi et al. | Clinical use of botulinum neurotoxin: neuromuscular disorders | |
| RU2745475C1 (ru) | Способ корректирующего массажа шейно-воротниковой зоны и плечевого пояса | |
| Kay et al. | Mobilization/Manipulation of the Cervical and Thoracic Spine (Techniques) | |
| Strashko et al. | Efficacy of the rehabilitation plan based on the theory of muscular spirals in patients with scapulohumeral pain syndrome according to shear wave elastography data | |
| Olaru | Introductory Chapter: Introduction to Rehabilitation | |
| Elfiah et al. | A COMBINATION OF CHEEK FLAP, CARTILAGE INSERTION, AND FAT TRANSFER ON POST-TRAUMA LOWER EYELID ECTROPION RECONSTRUCTION. | |
| Sancheti et al. | Efficacy of early community integration rehabilitation for cervical laminectomy: A case report | |
| Farrell et al. | Focal treatments, including botulinum toxin |