CA2841933A1 - Alteration of proteolytic cleavage of botulinum neurotoxins - Google Patents
Alteration of proteolytic cleavage of botulinum neurotoxins Download PDFInfo
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- CA2841933A1 CA2841933A1 CA2841933A CA2841933A CA2841933A1 CA 2841933 A1 CA2841933 A1 CA 2841933A1 CA 2841933 A CA2841933 A CA 2841933A CA 2841933 A CA2841933 A CA 2841933A CA 2841933 A1 CA2841933 A1 CA 2841933A1
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- light chain
- dystonia
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- calpain
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161574596P | 2011-08-04 | 2011-08-04 | |
| EP11176531.9 | 2011-08-04 | ||
| US61/574,596 | 2011-08-04 | ||
| EP11176531 | 2011-08-04 | ||
| PCT/EP2012/064690 WO2013017522A1 (en) | 2011-08-04 | 2012-07-26 | Alteration of proteolytic cleavage of botulinum neurotoxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2841933A1 true CA2841933A1 (en) | 2013-02-07 |
Family
ID=47628649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2841933A Abandoned CA2841933A1 (en) | 2011-08-04 | 2012-07-26 | Alteration of proteolytic cleavage of botulinum neurotoxins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140170133A1 (enExample) |
| EP (1) | EP2739297A1 (enExample) |
| JP (1) | JP2014529395A (enExample) |
| AU (1) | AU2012292163A1 (enExample) |
| CA (1) | CA2841933A1 (enExample) |
| WO (1) | WO2013017522A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3290437A1 (en) | 2016-08-31 | 2018-03-07 | Merz Pharma GmbH & Co. KGaA | Novel recombinant clostridial neurotoxins with decreased duration of effect |
| EP3312193A1 (en) | 2016-10-19 | 2018-04-25 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with accelerated onset of effect |
| WO2018081282A1 (en) * | 2016-10-25 | 2018-05-03 | Cellsnap Llc | Neurotoxins and uses thereof |
| EP3335719A1 (en) * | 2016-12-14 | 2018-06-20 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with a stabilized light chain |
| CN118126143B (zh) * | 2024-03-14 | 2025-06-24 | 河北平朴生物科技合伙企业(有限合伙) | 一种a型肉毒毒素的突变体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
| US20030219462A1 (en) * | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
| US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
| US6943555B2 (en) * | 2002-05-23 | 2005-09-13 | Lockheed Martin Corporation | Redundant safety circuit for squib testing |
| JP5746624B2 (ja) * | 2008-08-29 | 2015-07-08 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | 変化した持続性を有するクロストリジウム性神経毒 |
| GB0903006D0 (en) * | 2009-02-23 | 2009-04-08 | Syntaxin Ltd | Modified non-cytotoxic proteases |
-
2012
- 2012-07-26 EP EP12742873.8A patent/EP2739297A1/en not_active Withdrawn
- 2012-07-26 AU AU2012292163A patent/AU2012292163A1/en not_active Abandoned
- 2012-07-26 JP JP2014523291A patent/JP2014529395A/ja active Pending
- 2012-07-26 WO PCT/EP2012/064690 patent/WO2013017522A1/en not_active Ceased
- 2012-07-26 US US14/236,454 patent/US20140170133A1/en not_active Abandoned
- 2012-07-26 CA CA2841933A patent/CA2841933A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2739297A1 (en) | 2014-06-11 |
| US20140170133A1 (en) | 2014-06-19 |
| JP2014529395A (ja) | 2014-11-13 |
| WO2013017522A1 (en) | 2013-02-07 |
| AU2012292163A1 (en) | 2014-02-27 |
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