JP2014528770A5 - - Google Patents
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- JP2014528770A5 JP2014528770A5 JP2014526178A JP2014526178A JP2014528770A5 JP 2014528770 A5 JP2014528770 A5 JP 2014528770A5 JP 2014526178 A JP2014526178 A JP 2014526178A JP 2014526178 A JP2014526178 A JP 2014526178A JP 2014528770 A5 JP2014528770 A5 JP 2014528770A5
- Authority
- JP
- Japan
- Prior art keywords
- conduit
- pump
- blood
- pumped
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004369 Blood Anatomy 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- 210000001367 Arteries Anatomy 0.000 claims description 9
- 230000017531 blood circulation Effects 0.000 claims description 4
- 229920004934 Dacron® Polymers 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims 2
- 206010003226 Arteriovenous fistula Diseases 0.000 claims 1
- 210000002048 Axillary Vein Anatomy 0.000 claims 1
- 210000002302 Brachial Artery Anatomy 0.000 claims 1
- 210000003129 Brachiocephalic Veins Anatomy 0.000 claims 1
- 210000001105 Femoral Artery Anatomy 0.000 claims 1
- 210000003191 Femoral Vein Anatomy 0.000 claims 1
- 210000002837 Heart Atria Anatomy 0.000 claims 1
- 210000003111 Iliac Vein Anatomy 0.000 claims 1
- 210000004731 Jugular Veins Anatomy 0.000 claims 1
- 210000002321 Radial Artery Anatomy 0.000 claims 1
- 210000001321 Subclavian Vein Anatomy 0.000 claims 1
- 210000002559 Ulnar Artery Anatomy 0.000 claims 1
- 210000001631 Vena Cava, Inferior Anatomy 0.000 claims 1
- 210000002620 Vena Cava, Superior Anatomy 0.000 claims 1
- 230000000845 anti-microbial Effects 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000003874 surgical anastomosis Effects 0.000 claims 1
- 230000005641 tunneling Effects 0.000 claims 1
- 210000004204 Blood Vessels Anatomy 0.000 description 4
- 210000003462 Veins Anatomy 0.000 description 1
- 230000002459 sustained Effects 0.000 description 1
Description
壁剪断応力が、上昇した血流に対応して静脈と動脈の全体直径と内腔直径の持続的増大を生じさせるための鍵となる因子であることが分かっている。血管内の血流がハーゲンーポアズイユの法則に従う（すなわち、完全な放物線状の速度分布を有する層流である）とすると、ＷＳＳは次式で与えられる。
ＷＳＳ（Ｐａ）＝４Ｑμ／πＲ３
ここで、
Ｑ＝流速（ｍ３／ｓ）
μ＝血液の粘度（Ｐａ＊ｓ）
Ｒ＝血管半径（ｍ）
である。
ＷＳＳ（Ｐａ）＝４Ｑμ／πＲ３
ここで、
Ｑ＝流速（ｍ３／ｓ）
μ＝血液の粘度（Ｐａ＊ｓ）
Ｒ＝血管半径（ｍ）
である。
血管内の血流がハーゲンーポアズイユの法則に従う（すなわち、完全な放物線状の速度分布を有する層流である）とすると、ＷＳＳは次式で与えられる。
ＷＳＳ（Ｐａ）＝４Ｑμ／ππＲ３
ここで、
Ｑ＝流速（ｍ３／ｓ）
μ＝血液の粘度（Ｐａ＊ｓ）
Ｒ＝血管半径（ｍ）
である。
ＷＳＳ（Ｐａ）＝４Ｑμ／ππＲ３
ここで、
Ｑ＝流速（ｍ３／ｓ）
μ＝血液の粘度（Ｐａ＊ｓ）
Ｒ＝血管半径（ｍ）
である。
Claims (28)
- 患者に動静脈フィステル又は動静脈グラフトを形成するより前の使用のためのシステムであって、
入口と出口を有するポンプと、
供与動脈へ流体接続する第１の入口と前記ポンプの前記入口へ流体接続される第１の出口とを有すると共に、酸素化された血液を前記ポンプに案内するための第１導管と、
受容位置へ流体接続する第２の出口と前記ポンプの前記出口へ流体接続される第２の入口とを有すると共に、前記血液を前記受容位置へ移動させるための第２導管と、
ルーチン作動の間、前記供与動脈内の壁剪断応力が１．５Ｐａ以上となるように、前記ポンプを制御するように構成された制御ユニットと、
を含み、
前記制御ユニットは、ポンプ輸送の停止後、前記供与動脈の前記血液の流れが前記供与動脈の全体直径の持続的増大を引き起こすときまで、前記システムを作動するように構成されている、
システム。 - 前記血液を５０ｍＬ／ｍｉｎ〜２５００ｍＬ／ｍｉｎの間の速度でポンプ輸送することができる、請求項１に記載のシステム。
- 前記血液を１００ｍＬ／ｍｉｎ〜１０００ｍＬ／ｍｉｎの間の速度でポンプ輸送することができる、請求項１に記載のシステム。
- 前記供与動脈内の平均壁剪断応力が１．５Ｐａ〜２３Ｐａの間に維持されるための速度で前記血液をポンプ輸送することができる、請求項１に記載のシステム。
- 前記供与動脈内の平均壁剪断応力が２．５Ｐａ〜１０Ｐａの間に維持されるための速度で前記血液をポンプ輸送することができる、請求項１に記載のシステム。
- 前記供与動脈内の前記血液の平均速度が１５ｃｍ／ｓ〜１００ｃｍ／ｓの間に維持されるための速度で前記血液をポンプ輸送することができる、請求項１に記載のシステム。
- 前記供与動脈内の血液の平均速度が２５ｃｍ／ｓ〜１００ｃｍ／ｓの間に維持されるための速度で前記血液をポンプ輸送することができる、請求項１に記載のシステム。
- 前記システムを通して前記血液を７日〜８４日の間ポンプ輸送することができる、請求項１に記載のシステム。
- 前記システムを通して前記血液を７日〜４２日の間ポンプ輸送することができる、請求項１に記載のシステム。
- 前記システムの前記ポンプは、前記患者の体内に移植されるように構成されている、請求項１に記載のシステム。
- 前記システムの前記ポンプは、前記患者の体外に配置されるように構成されている、請求項１に記載のシステム。
- 前記システムの前記ポンプは、遠心ポンプである、請求項１に記載のシステム。
- 前記システムの前記ポンプは、少なくとも１つの接触軸受で構成されている、請求項１に記載のシステム。
- 前記システムの前記ポンプは、電気モータで駆動される、請求項１に記載のシステム。
- 前記第１導管と前記第２導管を合わせた長さは、２ｃｍ〜２００ｃｍの間である、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、所望の長さに切って前記ポンプに取り付けることができる、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、ポリウレタン及び／又はシリコーンから選択される少なくとも１つの部材で構成される、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、ｅＰＴＦＥ又はダクロンである、請求項１に記載のシステム。
- 前記ｅＰＴＦＥ又は前記ダクロンの部分は、長さが５ｃｍ未満である、請求項１８に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、ニチノールで強化されている、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、抗菌コーティングを備える、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の内腔の少なくとも一部は、抗血栓コーティングを備える、請求項１に記載のシステム。
- 前記第１導管又は前記第２導管の少なくとも一部は、皮下トンネリング用に構成されている、請求項１に記載のシステム。
- 前記システムの前記ポンプの速度は、前記制御ユニットを利用して手動調節される、請求項１に記載のシステム。
- 前記制御ユニットは、前記システムのポンプ速度又は流速を監視するソフトウェアによって、自動調節される、請求項１に記載のシステム。
- 前記制御ユニットは、前記システムの前記ポンプに電力を供給するための再充電可能な電源ユニットを含んでいる、請求項１に記載のシステム。
- 前記第１導管は、外科的吻合を介した橈骨動脈、尺骨動脈、上腕動脈、又は大腿動脈への液体接続を可能にするように構成されている、請求項１に記載のシステム。
- 前記第２導管は、腋窩静脈、鎖骨下静脈、腕頭静脈、頸静脈、上大静脈、大腿静脈、腸骨静脈、下大静脈、又は右心房への液体接続を生成するように構成されている、請求項１に記載のシステム。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524759P | 2011-08-17 | 2011-08-17 | |
| US61/524,759 | 2011-08-17 | ||
| US201161561859P | 2011-11-19 | 2011-11-19 | |
| US61/561,859 | 2011-11-19 | ||
| PCT/US2012/050978 WO2013025821A2 (en) | 2011-08-17 | 2012-08-15 | System and method to increase the overall diameter of veins and arteries |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017041461A Division JP6334764B2 (ja) | 2011-08-17 | 2017-03-06 | 静脈と動脈の全体直径を増大させるシステムと方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528770A JP2014528770A (ja) | 2014-10-30 |
| JP2014528770A5 true JP2014528770A5 (ja) | 2015-10-29 |
| JP6106673B2 JP6106673B2 (ja) | 2017-04-05 |
Family
ID=47715686
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526178A Expired - Fee Related JP6106673B2 (ja) | 2011-08-17 | 2012-08-15 | 静脈と動脈の全体直径を増大させるシステムと方法 |
| JP2017041461A Active JP6334764B2 (ja) | 2011-08-17 | 2017-03-06 | 静脈と動脈の全体直径を増大させるシステムと方法 |
| JP2018084942A Active JP6643391B2 (ja) | 2011-08-17 | 2018-04-26 | 静脈と動脈の全体直径を増大させるシステムと方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017041461A Active JP6334764B2 (ja) | 2011-08-17 | 2017-03-06 | 静脈と動脈の全体直径を増大させるシステムと方法 |
| JP2018084942A Active JP6643391B2 (ja) | 2011-08-17 | 2018-04-26 | 静脈と動脈の全体直径を増大させるシステムと方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9539380B2 (ja) |
| EP (1) | EP2744539B1 (ja) |
| JP (3) | JP6106673B2 (ja) |
| KR (2) | KR102260851B1 (ja) |
| CN (2) | CN107242890B (ja) |
| AU (4) | AU2012296563B2 (ja) |
| BR (1) | BR112014003592A2 (ja) |
| CA (1) | CA2845253C (ja) |
| HK (2) | HK1243304A1 (ja) |
| IL (2) | IL230991B (ja) |
| RU (2) | RU2664156C2 (ja) |
| WO (1) | WO2013025821A2 (ja) |
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- 2012-08-15 EP EP12823591.8A patent/EP2744539B1/en active Active
- 2012-08-15 CN CN201710413256.9A patent/CN107242890B/zh active Active
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