JP2014526541A5 - - Google Patents
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- Publication number
- JP2014526541A5 JP2014526541A5 JP2014531244A JP2014531244A JP2014526541A5 JP 2014526541 A5 JP2014526541 A5 JP 2014526541A5 JP 2014531244 A JP2014531244 A JP 2014531244A JP 2014531244 A JP2014531244 A JP 2014531244A JP 2014526541 A5 JP2014526541 A5 JP 2014526541A5
- Authority
- JP
- Japan
- Prior art keywords
- inh
- immunoglobulin
- combination
- administered
- ivig
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 24
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 24
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims 24
- 108060003951 Immunoglobulin Proteins 0.000 claims 23
- 102000018358 immunoglobulin Human genes 0.000 claims 23
- 229940123965 Immunoglobulin inhibitor Drugs 0.000 claims 12
- 201000006474 Brain Ischemia Diseases 0.000 claims 6
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 6
- 206010008118 cerebral infarction Diseases 0.000 claims 6
- 206010061216 Infarction Diseases 0.000 claims 5
- 230000007574 infarction Effects 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000035602 clotting Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008227 sterile water for injection Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- -1 antibiotic Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 1
- 229960003009 clopidogrel Drugs 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 229960002768 dipyridamole Drugs 0.000 claims 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940027941 immunoglobulin g Drugs 0.000 claims 1
- 230000006749 inflammatory damage Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161538832P | 2011-09-24 | 2011-09-24 | |
| US61/538,832 | 2011-09-24 | ||
| PCT/EP2012/068643 WO2013041677A1 (en) | 2011-09-24 | 2012-09-21 | Combination therapy using immunoglobulin and c1-inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526541A JP2014526541A (ja) | 2014-10-06 |
| JP2014526541A5 true JP2014526541A5 (enExample) | 2015-11-05 |
| JP6190368B2 JP6190368B2 (ja) | 2017-08-30 |
Family
ID=46881067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531244A Active JP6190368B2 (ja) | 2011-09-24 | 2012-09-21 | 免疫グロブリンおよびｃ１−阻害剤を用いる組合せ療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10471142B2 (enExample) |
| EP (1) | EP2758076B1 (enExample) |
| JP (1) | JP6190368B2 (enExample) |
| KR (1) | KR101956585B1 (enExample) |
| CN (1) | CN104010656B (enExample) |
| AU (1) | AU2012311483B2 (enExample) |
| DK (1) | DK2758076T3 (enExample) |
| ES (1) | ES2714999T3 (enExample) |
| WO (1) | WO2013041677A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2683397T3 (en) | 2011-03-09 | 2017-09-18 | Csl Behring Gmbh | FACTOR XII INHIBITORS FOR ADMINISTRATION OF MEDICAL PROCEDURES COMPREHENSIVE CONTACT WITH ARTIFICIAL SURFACES |
| WO2014131865A1 (en) * | 2013-02-28 | 2014-09-04 | Csl Behring Gmbh | Therapeutic agent for amniotic fluid embolism |
| KR102403299B1 (ko) | 2013-03-08 | 2022-06-03 | 체에스엘 베링 게엠베하 | 원격 허혈-재관류 손상의 치료 및 예방 |
| ME03326B (me) | 2013-03-15 | 2019-10-20 | Shire Viropharma Inc | C1-inh kompozicije i postupci za prevenciju i liječenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze |
| LT2994160T (lt) * | 2013-05-06 | 2019-08-26 | Baxalta Incorporated | Alzheimerio ligos pogrupių gydymas su iš kelių donorų sumaišytu imunoglobulinu g |
| ES2708655T3 (es) * | 2013-11-22 | 2019-04-10 | Shire Viropharma Inc | Métodos para tratar el rechazo mediado por anticuerpos en pacientes con trasplante de órganos con el inhibidor de la c1-esterasa |
| CN106456778A (zh) | 2014-06-18 | 2017-02-22 | 德国杰特贝林生物制品有限公司 | 在神经创伤性病患中使用因子xii抑制剂进行治疗 |
| JP6516855B2 (ja) * | 2015-02-20 | 2019-05-22 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | Ｃ１エステラーゼ阻害剤の医薬製剤 |
| US10532087B2 (en) | 2015-06-03 | 2020-01-14 | Children's Hospital Medical Center | Compositions and methods for treating neonatal biliary atresia |
| US20190175683A1 (en) | 2016-08-05 | 2019-06-13 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| WO2022251654A1 (en) * | 2021-05-28 | 2022-12-01 | West Virginia University Board of Governors on behalf of West Virginia University | Mitoneet ligands for use in protection from tissue ischemic reperfusion injury |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2009158A (en) * | 1934-08-01 | 1935-07-23 | Ophthalmological Foundation In | Ophthalmic ergograph |
| DE3228502A1 (de) | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
| DE4222534A1 (de) | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
| DE4244735A1 (de) | 1992-08-24 | 1994-03-31 | Behringwerke Ag | Verwendung von C1-Inaktivator zur Bekämpfung von Komplikationen bei der Anwendung von Zytokinen, endogenen Mediatoren, gentechnisch produzierten Mediator-Hybriden oder Wachstumsfaktoren im Rahmen der therapeutischen Anwendung dieser Substanzen |
| US5827832A (en) * | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
| AU6083899A (en) | 1999-09-16 | 2001-04-17 | Aventis Behring Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| EP1601377A4 (en) * | 2003-02-21 | 2009-07-15 | Genentech Inc | METHOD FOR THE PREVENTION AND TREATMENT OF TISSUE DAMAGE IN CONNECTION WITH ISCHEMIC REPERFUSION DAMAGE |
| US8053569B2 (en) * | 2005-10-07 | 2011-11-08 | Armagen Technologies, Inc. | Nucleic acids encoding and methods of producing fusion proteins |
| SI2380587T1 (en) | 2005-12-21 | 2018-03-30 | Pharming Intellectual Property B.V. | Use of a C1 inhibitor to prevent ischemic reperfusion injury |
| US20100143325A1 (en) | 2008-12-09 | 2010-06-10 | Vascular Laboratory, Inc. | Composition And Methods Involving Thrombolytic Agents |
| EP2233499A1 (en) * | 2009-03-26 | 2010-09-29 | CSL Behring AG | Antibody composition with altered Fab sialylation |
| MY157239A (en) | 2009-05-27 | 2016-05-13 | Baxalta Inc | A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use |
-
2012
- 2012-09-21 AU AU2012311483A patent/AU2012311483B2/en active Active
- 2012-09-21 WO PCT/EP2012/068643 patent/WO2013041677A1/en not_active Ceased
- 2012-09-21 ES ES12761739T patent/ES2714999T3/es active Active
- 2012-09-21 JP JP2014531244A patent/JP6190368B2/ja active Active
- 2012-09-21 US US14/346,478 patent/US10471142B2/en active Active
- 2012-09-21 KR KR1020147010605A patent/KR101956585B1/ko active Active
- 2012-09-21 DK DK12761739.7T patent/DK2758076T3/en active
- 2012-09-21 CN CN201280046349.8A patent/CN104010656B/zh active Active
- 2012-09-21 EP EP12761739.7A patent/EP2758076B1/en active Active
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