JP2014524916A - 高耐塩性のイオン交換材料 - Google Patents
高耐塩性のイオン交換材料 Download PDFInfo
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Abstract
【選択図】 なし
Description
(i)スルホン化芳香族単位を含む架橋されたスルホン化ポリマーを用いて、生物源由来の溶液から高分子を分離する方法であって、
スルホン化芳香族単位が、置換されていないか又は脂肪族基によって置換され、スルホン化ポリマーの基本骨格に結合している。
(ii)実施形態(i)の方法であって、基本骨格が架橋されたポリビニル骨格である。
(iii)実施形態(i)又は(ii)の方法であって、芳香族単位がフェニルスルホン酸基である。
(iV)実施形態(i)〜(iii)のいずれかの方法であって、架橋されたスルホン化ポリマーがスルホン化ポリスチレン/ジビニルベンゼン共重合体(コポリマー)である。
(v)実施形態(i)〜(iv)のいずれかの方法であって、架橋されたスルホン化ポリマー架橋度が、0.5〜50%である。
(vi)実施形態(i)〜(v)のいずれかの方法であって、重合に用いられスルホン化されるすべてのモノマー単位に対する、スルホン酸基のモル数を基にした、スルホン化度が、1〜80%である。
(vii)実施形態(i)〜(vi)のいずれかの方法であって、架橋されたスルホン化ポリマーが、樹脂粒子の形状で存在する。
(viii)実施形態(vii)の方法であって、樹脂粒子が、1〜1,000μmの平均粒子径を有する。
(ix)実施形態(vii)又は(viii)の方法であって、樹脂粒子が、10〜400nmの範囲の平均孔径を有する孔を含む。
(x)実施形態(i)〜(ix)のいずれかの方法であって、高分子がペプチドである。
(xi)実施形態(x)の方法であって、ペプチドがインスリンである。
(xii)実施形態(i)〜(ix)のいずれかの方法であって、架橋されたスルホン化ポリマーが、アミノ基を含む架橋ポリマーで被覆されている。
(xiii)実施形態(xii)の方法であって、アミノ基を含むポリマーの架橋度が、5〜80%である。
(xiv)実施形態(xii)又は(xiii)の方法であって、アミノ基を含む架橋ポリマーが、架橋されたポリビニルアミンである。
(xv)実施形態(xii)〜(xiv)のいずれかの方法であって、架橋に利用されるアミノ基の全てが、架橋後にアミンの状態で存在している。
(xvi)実施形態(xii)〜(xv)のいずれかの方法であって、アミノ基を含む架橋ポリマーに対する、架橋されたスルホン化ポリマーの重量比が、3〜20の範囲である。
(xvii)実施形態(xii)〜(xvi)のいずれかの方法であって、高分子が、エンドトキシン、DNA、又は、RNAである。
このために、実施例2で製造されたアニオン交換体を、21.2ml容積の270×10mmカラムへ充填した。発酵液を0.45μmのフィルターで濾過し、沈殿物をなくした。300mlの発酵液を、外部ポンプを用いてカラムに導入した。
Claims (16)
- 生物源由来の溶液から高分子を分離するための、架橋されたスルホン化ポリマーの使用であって、
前記架橋されたスルホン化ポリマーが、スルホン化芳香族単位を含み、前記スルホン化芳香族単位が、置換されていないか又は脂肪族基によって置換され、前記スルホン化ポリマーの基本骨格に結合した状態で存在する使用。 - 請求項1に記載の使用であって、前記基本骨格が架橋されたポリビニル骨格である使用。
- 請求項1又は2に記載の使用であって、前記芳香族単位がフェニルスルホン酸基である使用。
- 請求項1〜3のいずれか1項に記載の使用であって、前記架橋されたスルホン化ポリマーが、スルホン化ポリスチレン/ジビニルベンゼン共重合体である使用。
- 請求項1〜4のいずれか1項に記載の使用であって、前記架橋されたスルホン化ポリマー架橋度が、0.5〜50%である使用。
- 請求項1〜5のいずれか1項に記載の使用であって、重合に用いられスルホン化されるすべてのモノマー単位に対する、スルホン酸基のモル数を基にした、スルホン化度が、1〜80%である使用。
- 請求項1〜6のいずれか1項に記載の使用であって、前記架橋されたスルホン化ポリマーが、樹脂粒子の形状で存在する使用。
- 請求項7に記載の使用であって、前記樹脂粒子が、1〜1,000μmの平均粒子径を有する使用。
- 請求項7又は8に記載の使用であって、前記樹脂粒子が、10〜400nmの範囲の平均孔径を有する孔を含む使用。
- 請求項1〜9のいずれか1項に記載の使用であって、前記高分子がペプチドである使用。
- 請求項10に記載の使用であって、前記ペプチドがインスリンである使用。
- 請求項1〜9のいずれか1項に記載の使用であって、前記架橋されたスルホン化ポリマーが、アミノ基を含む架橋ポリマーで被覆されている使用。
- 請求項12に記載の使用であって、前記アミノ基を含むポリマーの架橋度が、5〜80%である使用。
- 請求項12又は13に記載の使用であって、前記アミノ基を含む架橋ポリマーが、架橋されたポリビニルアミンである使用。
- 請求項12〜14のいずれか1項に記載の使用であって、架橋に利用されるアミノ基の全てが、架橋後にアミンの状態で存在している使用。
- 請求項12〜15のいずれか1項に記載の使用であって、前記高分子が、エンドトキシン、DNA、又は、RNAである使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011107197A DE102011107197A1 (de) | 2011-07-13 | 2011-07-13 | Ionenaustauschermaterial mit hoher Salztoleranz |
DE102011107197.4 | 2011-07-13 | ||
DE102011111044.9 | 2011-08-19 | ||
DE102011111044 | 2011-08-19 | ||
PCT/EP2012/063729 WO2013007799A1 (de) | 2011-07-13 | 2012-07-12 | Ionenaustauschermaterial mit hoher salztoleranz |
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JP2014524916A true JP2014524916A (ja) | 2014-09-25 |
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JP2014519566A Ceased JP2014524916A (ja) | 2011-07-13 | 2012-07-12 | 高耐塩性のイオン交換材料 |
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US (1) | US20140336355A1 (ja) |
EP (1) | EP2731958A1 (ja) |
JP (1) | JP2014524916A (ja) |
KR (1) | KR20140116051A (ja) |
CN (1) | CN103827135B (ja) |
AR (1) | AR087173A1 (ja) |
CA (1) | CA2841346A1 (ja) |
WO (1) | WO2013007799A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2014522089A (ja) * | 2011-08-09 | 2014-08-28 | エルジー・ケム・リミテッド | 二次電池パック |
JP2017125796A (ja) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | 分離材及びカラム |
WO2018147393A1 (ja) * | 2017-02-10 | 2018-08-16 | 三菱ケミカル株式会社 | ヒトインスリン精製用分離剤及びヒトインスリンの精製方法 |
JP2019533012A (ja) * | 2016-09-15 | 2019-11-14 | クラヴェゴ ゲーエムベーハー アンド コー カーゲー | 巨大分子の精製のための高分子メッシュの利用 |
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US10475544B2 (en) * | 2017-09-18 | 2019-11-12 | Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C. | Method for oxidative degradation of ion exchange resin |
US10737259B2 (en) * | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
JP6564539B1 (ja) * | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
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JPS63237794A (ja) * | 1987-02-27 | 1988-10-04 | イーライ・リリー・アンド・カンパニー | 糖ペプチド回収方法 |
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- 2012-07-12 WO PCT/EP2012/063729 patent/WO2013007799A1/de active Application Filing
- 2012-07-12 KR KR1020147003487A patent/KR20140116051A/ko not_active Application Discontinuation
- 2012-07-12 CN CN201280034371.0A patent/CN103827135B/zh not_active Expired - Fee Related
- 2012-07-12 JP JP2014519566A patent/JP2014524916A/ja not_active Ceased
- 2012-07-12 CA CA2841346A patent/CA2841346A1/en not_active Abandoned
- 2012-07-12 US US14/131,954 patent/US20140336355A1/en not_active Abandoned
- 2012-07-12 EP EP12737260.5A patent/EP2731958A1/de not_active Withdrawn
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2014522089A (ja) * | 2011-08-09 | 2014-08-28 | エルジー・ケム・リミテッド | 二次電池パック |
JP2017125796A (ja) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | 分離材及びカラム |
JP2019533012A (ja) * | 2016-09-15 | 2019-11-14 | クラヴェゴ ゲーエムベーハー アンド コー カーゲー | 巨大分子の精製のための高分子メッシュの利用 |
JP7068316B2 (ja) | 2016-09-15 | 2022-05-16 | クラヴェゴ ゲーエムベーハー アンド コー カーゲー | 巨大分子の精製のための高分子メッシュの利用 |
WO2018147393A1 (ja) * | 2017-02-10 | 2018-08-16 | 三菱ケミカル株式会社 | ヒトインスリン精製用分離剤及びヒトインスリンの精製方法 |
JPWO2018147393A1 (ja) * | 2017-02-10 | 2019-11-21 | 三菱ケミカル株式会社 | ヒトインスリン精製用分離剤及びヒトインスリンの精製方法 |
Also Published As
Publication number | Publication date |
---|---|
KR20140116051A (ko) | 2014-10-01 |
US20140336355A1 (en) | 2014-11-13 |
EP2731958A1 (de) | 2014-05-21 |
WO2013007799A1 (de) | 2013-01-17 |
CN103827135A (zh) | 2014-05-28 |
CN103827135B (zh) | 2016-04-06 |
CA2841346A1 (en) | 2013-01-17 |
AR087173A1 (es) | 2014-02-26 |
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