JP2014523420A5 - - Google Patents

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Publication number
JP2014523420A5
JP2014523420A5 JP2014516016A JP2014516016A JP2014523420A5 JP 2014523420 A5 JP2014523420 A5 JP 2014523420A5 JP 2014516016 A JP2014516016 A JP 2014516016A JP 2014516016 A JP2014516016 A JP 2014516016A JP 2014523420 A5 JP2014523420 A5 JP 2014523420A5
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JP
Japan
Prior art keywords
methyl
oxo
azaspiro
oxa
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014516016A
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English (en)
Japanese (ja)
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JP5969016B2 (ja
JP2014523420A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/042607 external-priority patent/WO2012174342A1/en
Publication of JP2014523420A publication Critical patent/JP2014523420A/ja
Publication of JP2014523420A5 publication Critical patent/JP2014523420A5/ja
Application granted granted Critical
Publication of JP5969016B2 publication Critical patent/JP5969016B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014516016A 2011-06-17 2012-06-15 Ｔｒｐｖ４拮抗薬 Expired - Fee Related JP5969016B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498104P 2011-06-17 2011-06-17
US61/498,104 2011-06-17
PCT/US2012/042607 WO2012174342A1 (en) 2011-06-17 2012-06-15 Trpv4 antagonists

Publications (3)

Publication Number Publication Date
JP2014523420A JP2014523420A (ja) 2014-09-11
JP2014523420A5 true JP2014523420A5 (https=) 2015-07-16
JP5969016B2 JP5969016B2 (ja) 2016-08-10

Family

ID=47357483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516016A Expired - Fee Related JP5969016B2 (ja) 2011-06-17 2012-06-15 Ｔｒｐｖ４拮抗薬

Country Status (5)

Country Link
US (1) US9487507B2 (https=)
EP (1) EP2720546B1 (https=)
JP (1) JP5969016B2 (https=)
ES (1) ES2571409T3 (https=)
WO (1) WO2012174342A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3154B1 (ar) * 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
ES2595606T3 (es) 2011-06-17 2017-01-02 Glaxosmithkline Intellectual Property (No. 2) Limited Antagonistas TRPV4
EP2832731A4 (en) 2012-03-27 2015-08-19 Shionogi & Co AROMATIC HETEROCYCLIC CHAIN 5-CORE DERIVED DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY
WO2015046193A1 (ja) 2013-09-25 2015-04-02 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体
JP6643545B2 (ja) 2014-03-14 2020-02-12 ラクオリア創薬株式会社 Ｔｒｐｍ８拮抗剤としてのアザスピロ誘導体
WO2017199199A1 (en) * 2016-05-19 2017-11-23 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonist
US10968209B2 (en) 2016-05-19 2021-04-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonist
WO2018185701A1 (en) * 2017-04-06 2018-10-11 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonists as antitussive agents
WO2021221169A1 (en) 2020-04-30 2021-11-04 Raqualia Pharma Inc. Pyrimidin-4(3h)-one derivatives as trpv4 antagonists
CN111704613B (zh) * 2020-06-23 2021-07-06 中国人民解放军军事科学院军事医学研究院 咪唑类衍生物及其作为trpv4抑制剂的用途
KR20230041680A (ko) 2020-07-16 2023-03-24 라퀄리아 파마 인코포레이티드 안구 질환 치료제로서의 trpv4 억제제
CA3261160A1 (en) 2022-07-08 2024-01-11 Actio Biosciences, Inc. COMPOUNDS AND THERAPEUTIC METHODS
WO2024217452A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
WO2024217429A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE482945T1 (de) * 1998-05-26 2010-10-15 Chugai Pharmaceutical Co Ltd Heterozyklische indolderivate und mono- oder diazaindol-derivate
CA2531619A1 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
EP2121673A1 (en) * 2007-02-01 2009-11-25 Glaxo Group Limited I-oxa-3-azaspiro (4.5) decan-2-one and 1-oxa-3, 8-diazaspiro (4.5) decan-2-one derivatives for the treatment of eating disorders
JP2010517967A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド 摂食障害の治療のための１−オキサ−３−アザスピロ［４，５］デカン−２−オン誘導体
GB0707934D0 (en) * 2007-04-24 2007-05-30 Glaxo Group Ltd Chemical compounds
US7998982B2 (en) * 2007-08-09 2011-08-16 Abbott Laboratories Amide derivatives as TRPV1 antagonists
TW200944520A (en) * 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
JP5607046B2 (ja) * 2008-07-25 2014-10-15 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｔｒｐｖ４拮抗薬
JP2012006837A (ja) * 2008-09-30 2012-01-12 Mochida Pharmaceut Co Ltd ２−インドールアクリルアミド類縁体
JO3154B1 (ar) 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
ES2595606T3 (es) 2011-06-17 2017-01-02 Glaxosmithkline Intellectual Property (No. 2) Limited Antagonistas TRPV4

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