JP2014523236A5 - - Google Patents

Download PDF

Info

Publication number
JP2014523236A5
JP2014523236A5 JP2014513035A JP2014513035A JP2014523236A5 JP 2014523236 A5 JP2014523236 A5 JP 2014523236A5 JP 2014513035 A JP2014513035 A JP 2014513035A JP 2014513035 A JP2014513035 A JP 2014513035A JP 2014523236 A5 JP2014523236 A5 JP 2014523236A5
Authority
JP
Japan
Prior art keywords
sequence
gfp
tumor
expression cassette
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014513035A
Other languages
English (en)
Japanese (ja)
Other versions
JP5943996B2 (ja
JP2014523236A (ja
Filing date
Publication date
Priority claimed from CN2011101433853A external-priority patent/CN102260712B/zh
Application filed filed Critical
Publication of JP2014523236A publication Critical patent/JP2014523236A/ja
Publication of JP2014523236A5 publication Critical patent/JP2014523236A5/ja
Application granted granted Critical
Publication of JP5943996B2 publication Critical patent/JP5943996B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014513035A 2011-05-31 2012-02-29 腫瘍溶解性強化B型ヒトアデノウイルスAd11突然変異体の構築とその応用 Active JP5943996B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2011101433853A CN102260712B (zh) 2011-05-31 2011-05-31 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用
CN201110143385.3 2011-05-31
PCT/CN2012/071757 WO2012163119A1 (zh) 2011-05-31 2012-02-29 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用

Publications (3)

Publication Number Publication Date
JP2014523236A JP2014523236A (ja) 2014-09-11
JP2014523236A5 true JP2014523236A5 (https=) 2015-08-20
JP5943996B2 JP5943996B2 (ja) 2016-07-05

Family

ID=45007547

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014513035A Active JP5943996B2 (ja) 2011-05-31 2012-02-29 腫瘍溶解性強化B型ヒトアデノウイルスAd11突然変異体の構築とその応用

Country Status (5)

Country Link
US (3) US9315827B2 (https=)
EP (1) EP2716764B1 (https=)
JP (1) JP5943996B2 (https=)
CN (1) CN102260712B (https=)
WO (1) WO2012163119A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260712B (zh) * 2011-05-31 2013-10-02 北京锤特生物科技有限公司 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
WO2017147269A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CN106591368A (zh) * 2016-10-12 2017-04-26 郑州大学 携带il‑15r/il‑15融合基因的b亚群腺病毒11载体及其构建和用途
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
CN110093323B (zh) * 2018-01-31 2024-01-30 上海元宋生物技术有限公司 重组溶瘤腺病毒OncoAd-P28GANK-E1A-△E1B及其构建方法和应用
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2372823T3 (es) * 1999-05-17 2012-01-26 Crucell Holland B.V. Adenovirus recombinante del serotipo ad11.
AP2351A (en) * 2004-10-13 2012-01-25 Crucell Holland Bv Improved adenoviral vectors and uses thereof.
CN102220357B (zh) * 2004-11-16 2013-12-25 克鲁塞尔荷兰公司 包含重组病毒载体的多价疫苗
PL2137210T3 (pl) * 2007-03-02 2017-06-30 Glaxosmithkline Biologicals Sa Nowy sposób i kompozycje
CN102260712B (zh) * 2011-05-31 2013-10-02 北京锤特生物科技有限公司 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用

Similar Documents

Publication Publication Date Title
JP5943996B2 (ja) 腫瘍溶解性強化B型ヒトアデノウイルスAd11突然変異体の構築とその応用
JP2014523236A5 (https=)
JP6817979B2 (ja) 腫瘍選択的e1aおよびe1b変異体
EP2137301B1 (en) Adenovirus with mutations in the endoplasmic reticulum retention domain of the e3-19k protein and their use in cancer treatment.
CN103614416B (zh) 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途
US11866724B2 (en) Adenoviral vectors
Yan et al. Developing novel oncolytic adenoviruses through bioselection
AU2002346084B2 (en) Viral mutants that selectively replicate in targeted human cancer cells
Gao et al. A systematic comparison of the anti-tumoural activity and toxicity of the three Adv-TKs
Wang et al. Adenovirus vector-mediated single chain variable fragments target the nucleocapsid protein of porcine epidemic diarrhea virus and protect against viral infection in piglets
WO2022192278A2 (en) Muc16 promoter containing virus
AU2024297471A1 (en) Adenoviruses
AU2024287471A1 (en) Mutated adenoviruses with improved replication and their use for treating cancer
AU2024403953A1 (en) Adenoviruses
Stepanenko et al. Potency-enhancing mutations in E3-19K and i-Leader increase the cytolytic activity of the PH20/SPAM1-armed oncolytic adenovirus Ad5-Δ24-RGD
WO2024251286A1 (zh) 溶瘤性hsv-1临床分离株、定向进化株、感染性克隆及应用
Kong Determining the oncogenic activity of different Epstein-Barr virus proteins on the development of nasopharyngeal cancer
Sapre Nanoparticle Cloaking of Viral Vectors for Enhanced Gene Delivery
Young A Development of an immunocompetent model of oncolytic adenoviral gene therapy for ovarian cancer.
Hammer Engineering of oncolytic adenoviruses for delivery by mesenchymal stem cells to pancreatic cancer
Strauss ANALYSIS OF RESISTANCE OF PRIMARY OVARIAN CANCER CELLS TO VIRAL ONCOLYSIS DISSER TAT ION zur Erlangung des akademischen Grades doctor rerum naturalium