JP2014518882A5 - - Google Patents
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- Publication number
- JP2014518882A5 JP2014518882A5 JP2014512183A JP2014512183A JP2014518882A5 JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5 JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014512183 A JP2014512183 A JP 2014512183A JP 2014518882 A5 JP2014518882 A5 JP 2014518882A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- compound
- alkoxy
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 22
- 239000011780 sodium chloride Substances 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 13
- -1 C 1 -C 4 alkenyl ester Chemical class 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- 125000005842 heteroatoms Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004429 atoms Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 235000013877 carbamide Nutrition 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 239000005977 Ethylene Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 239000004202 carbamide Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 230000001264 neutralization Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490881P | 2011-05-27 | 2011-05-27 | |
| US61/490,881 | 2011-05-27 | ||
| US201161504905P | 2011-07-06 | 2011-07-06 | |
| US61/504,905 | 2011-07-06 | ||
| US201161567216P | 2011-12-06 | 2011-12-06 | |
| US61/567,216 | 2011-12-06 | ||
| PCT/US2012/039835 WO2012166716A2 (en) | 2011-05-27 | 2012-05-29 | Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Division JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518882A JP2014518882A (ja) | 2014-08-07 |
| JP2014518882A5 true JP2014518882A5 (is) | 2015-07-09 |
| JP6198721B2 JP6198721B2 (ja) | 2017-09-20 |
Family
ID=47219638
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512183A Expired - Fee Related JP6198721B2 (ja) | 2011-05-27 | 2012-05-29 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044853A Pending JP2017101086A (ja) | 2011-05-27 | 2017-03-09 | Ｈｃｖ感染症を治療するのに有用な置換されたアリファン、シクロファン、ヘテラファン、ヘテロファン、ヘテロ−ヘテラファンおよびメタロセン |
Country Status (25)
| Country | Link |
|---|---|
| US (8) | US8809313B2 (is) |
| EP (2) | EP3059241B1 (is) |
| JP (2) | JP6198721B2 (is) |
| KR (1) | KR101931311B1 (is) |
| CN (2) | CN105801467A (is) |
| AP (1) | AP2013007263A0 (is) |
| AU (2) | AU2012262338B2 (is) |
| BR (1) | BR112013030045A2 (is) |
| CA (1) | CA2837481A1 (is) |
| CY (1) | CY1118111T1 (is) |
| EA (2) | EA029099B1 (is) |
| ES (1) | ES2584418T3 (is) |
| HK (1) | HK1196559A1 (is) |
| HR (1) | HRP20160863T1 (is) |
| HU (1) | HUE029326T2 (is) |
| IL (3) | IL229165A (is) |
| LT (1) | LT2714036T (is) |
| MX (2) | MX357867B (is) |
| PL (1) | PL2714036T3 (is) |
| PT (1) | PT2714036T (is) |
| RS (1) | RS55123B1 (is) |
| SG (1) | SG194681A1 (is) |
| SI (1) | SI2714036T1 (is) |
| SM (1) | SMT201600325B (is) |
| WO (1) | WO2012166716A2 (is) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2454254A2 (en) | 2009-07-16 | 2012-05-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
| WO2011119853A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| US8859595B2 (en) | 2010-08-26 | 2014-10-14 | Rfs Pharma, Llc | Potent and selective inhibitors of hepatitis C virus |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8809313B2 (en) | 2011-05-27 | 2014-08-19 | Achillion Pharmaceuticals, Inc. | Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating HCV infections |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2016522172A (ja) | 2013-04-12 | 2016-07-28 | アキリオン ファーマシューティカルズ，インコーポレーテッド | Ｈｃｖを治療するのに有用な重水素化されたヌクレオシドプロドラッグ |
| WO2015026454A1 (en) * | 2013-07-17 | 2015-02-26 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis c virus |
| US9717712B2 (en) * | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| WO2015005901A1 (en) * | 2013-07-09 | 2015-01-15 | Bristol-Myers Squibb Company | Combinations of hepatitis c virus inhibitors |
| CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
| WO2016020295A1 (en) | 2014-08-04 | 2016-02-11 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| WO2016054240A1 (en) | 2014-09-30 | 2016-04-07 | Sean Dalziel | Fixed dose combinations for the treatment of viral diseases |
| WO2017023631A1 (en) | 2015-08-06 | 2017-02-09 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| WO2017035409A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) * | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| WO2017076194A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏豪森药业集团有限公司 | 具有抑制hcv活性的化合物及其制备方法和应用 |
| WO2017076187A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏豪森药业集团有限公司 | 1,4(1,4)-二苯杂环六蕃-12,43-二基衍生物及其制备方法与应用 |
| CN106083829B (zh) * | 2016-01-12 | 2019-01-22 | 深圳市塔吉瑞生物医药有限公司 | 一种丙型肝炎病毒抑制剂、药物组合物及其应用 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EP3454856A4 (en) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP3454862A4 (en) | 2016-05-10 | 2020-02-12 | C4 Therapeutics, Inc. | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2018064585A1 (en) * | 2016-09-29 | 2018-04-05 | Janssen Pharmaceuticals, Inc. | Odalasvir polymorphs and methods of manufacture thereof |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| WO2018160892A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| KR102632860B1 (ko) | 2017-03-01 | 2024-02-02 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물 |
| CN112839945A (zh) | 2018-09-06 | 2021-05-25 | 艾其林医药公司 | 补体因子d抑制剂的形态形式 |
| WO2020051532A2 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| EP3856164A4 (en) | 2018-09-25 | 2022-07-13 | Achillion Pharmaceuticals, Inc. | MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS |
| TW202106677A (zh) * | 2019-04-25 | 2021-02-16 | 美商貝達醫藥公司 | 用於治療c型肝炎病毒感染之ns5a的二胺甲酸酯抑制劑 |
| WO2021124277A1 (en) | 2019-12-20 | 2021-06-24 | Nuevolution A/S | Compounds active towards nuclear receptors |
| US11780843B2 (en) | 2020-03-31 | 2023-10-10 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4126875A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CN115181117B (zh) * | 2022-08-08 | 2024-05-17 | 中国医学科学院医学生物学研究所 | 一种s构型手性分子化合物及其制备方法和作为疫苗佐剂的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448392B1 (en) | 1985-03-06 | 2002-09-10 | Chimerix, Inc. | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use |
| US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
| DE4010531A1 (de) * | 1990-04-02 | 1991-10-10 | Thomae Gmbh Dr K | Cyclophane, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| WO2002060926A2 (en) * | 2000-11-20 | 2002-08-08 | Bristol-Myers Squibb Company | Hepatitis c tripeptide inhibitors |
| MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| AU2006244203B2 (en) | 2005-05-09 | 2012-05-03 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
| EP2012799B1 (en) | 2006-05-03 | 2016-08-24 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
| UA101468C2 (ru) * | 2006-07-13 | 2013-04-10 | Ачілліон Фармасьютікалз, Інк. | 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации |
| EP2041156B1 (en) | 2006-07-13 | 2013-11-20 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
| US20100158862A1 (en) | 2006-08-11 | 2010-06-24 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2687817A1 (en) | 2007-05-22 | 2008-12-04 | Achillion Pharmaceuticals, Inc. | Heteroaryl substituted thiazoles |
| EP2190858A4 (en) | 2007-09-24 | 2013-02-13 | Achillion Pharmaceuticals Inc | PEPTIDES CONTAINING UREA AS INHIBITORS OF VIRAL REPLICATION |
| NZ592110A (en) | 2008-11-20 | 2012-06-29 | Achillion Pharmaceuticals Inc | Cyclic carboxamide compounds and analogues thereof as of hepatitis c virus |
| SI2364309T1 (sl) | 2008-12-10 | 2015-03-31 | Achillion Pharmaceuticals, Inc. | Novi 4-amino-4-oksobutanoil peptidi kot inhibitorji virusne replikacije |
| NZ592705A (en) | 2008-12-10 | 2013-02-22 | Achillion Pharmaceuticals Inc | 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication |
| EP2393359A4 (en) * | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| MX2011010084A (es) | 2009-03-27 | 2011-10-14 | Merck Sharp & Dohme | Inhibidores de la replicacion del virus de la hepatitis c. |
| TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| KR20140122705A (ko) | 2009-05-13 | 2014-10-20 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 |
| WO2011031904A1 (en) | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| WO2011050146A1 (en) * | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Chemical compounds |
| WO2011091532A1 (en) | 2010-01-28 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| US8809313B2 (en) | 2011-05-27 | 2014-08-19 | Achillion Pharmaceuticals, Inc. | Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating HCV infections |
-
2012
- 2012-05-29 US US13/482,558 patent/US8809313B2/en active Active
- 2012-05-29 AU AU2012262338A patent/AU2012262338B2/en not_active Ceased
- 2012-05-29 HU HUE12793566A patent/HUE029326T2/hu unknown
- 2012-05-29 PT PT127935666T patent/PT2714036T/pt unknown
- 2012-05-29 EA EA201301335A patent/EA029099B1/ru not_active IP Right Cessation
- 2012-05-29 RS RS20160570A patent/RS55123B1/sr unknown
- 2012-05-29 KR KR1020137031871A patent/KR101931311B1/ko active IP Right Grant
- 2012-05-29 AP AP2013007263A patent/AP2013007263A0/xx unknown
- 2012-05-29 MX MX2017001464A patent/MX357867B/es unknown
- 2012-05-29 WO PCT/US2012/039835 patent/WO2012166716A2/en active Application Filing
- 2012-05-29 PL PL12793566T patent/PL2714036T3/pl unknown
- 2012-05-29 CN CN201610206020.3A patent/CN105801467A/zh active Pending
- 2012-05-29 CN CN201280025427.6A patent/CN103561739B/zh not_active Expired - Fee Related
- 2012-05-29 ES ES12793566.6T patent/ES2584418T3/es active Active
- 2012-05-29 EP EP16157270.6A patent/EP3059241B1/en not_active Not-in-force
- 2012-05-29 SI SI201230643A patent/SI2714036T1/sl unknown
- 2012-05-29 BR BR112013030045A patent/BR112013030045A2/pt not_active Application Discontinuation
- 2012-05-29 SG SG2013080155A patent/SG194681A1/en unknown
- 2012-05-29 JP JP2014512183A patent/JP6198721B2/ja not_active Expired - Fee Related
- 2012-05-29 CA CA2837481A patent/CA2837481A1/en not_active Abandoned
- 2012-05-29 EP EP12793566.6A patent/EP2714036B1/en active Active
- 2012-05-29 LT LTEP12793566.6T patent/LT2714036T/lt unknown
- 2012-05-29 EA EA201791776A patent/EA201791776A1/ru unknown
- 2012-05-29 MX MX2013013670A patent/MX349079B/es active IP Right Grant
-
2013
- 2013-10-31 IL IL229165A patent/IL229165A/en active IP Right Grant
-
2014
- 2014-07-10 US US14/328,312 patent/US9273082B2/en not_active Expired - Fee Related
- 2014-10-09 HK HK14110090.2A patent/HK1196559A1/zh not_active IP Right Cessation
-
2015
- 2015-12-17 US US14/972,827 patent/US9468629B2/en not_active Expired - Fee Related
- 2015-12-17 US US14/972,913 patent/US9474742B2/en not_active Expired - Fee Related
-
2016
- 2016-07-14 HR HRP20160863TT patent/HRP20160863T1/hr unknown
- 2016-08-22 CY CY20161100824T patent/CY1118111T1/el unknown
- 2016-09-19 SM SM201600325T patent/SMT201600325B/it unknown
- 2016-09-20 US US15/271,066 patent/US9592222B2/en active Active
-
2017
- 2017-02-01 IL IL250389A patent/IL250389A/en not_active IP Right Cessation
- 2017-02-20 US US15/437,117 patent/US9833440B2/en active Active
- 2017-03-07 AU AU2017201535A patent/AU2017201535B2/en not_active Ceased
- 2017-03-09 JP JP2017044853A patent/JP2017101086A/ja active Pending
- 2017-09-11 IL IL254422A patent/IL254422A0/en unknown
- 2017-11-06 US US15/804,842 patent/US10092547B2/en active Active
-
2018
- 2018-06-29 US US16/024,021 patent/US20180303800A1/en not_active Abandoned
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