JP2014518630A5 - - Google Patents
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- Publication number
- JP2014518630A5 JP2014518630A5 JP2014513202A JP2014513202A JP2014518630A5 JP 2014518630 A5 JP2014518630 A5 JP 2014518630A5 JP 2014513202 A JP2014513202 A JP 2014513202A JP 2014513202 A JP2014513202 A JP 2014513202A JP 2014518630 A5 JP2014518630 A5 JP 2014518630A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- human
- sequence
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004965 antibodies Human genes 0.000 claims 16
- 108090001123 antibodies Proteins 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920000023 polynucleotide Polymers 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 206010003816 Autoimmune disease Diseases 0.000 claims 3
- 206010008943 Chronic leukaemia Diseases 0.000 claims 3
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims 3
- 206010018651 Graft versus host disease Diseases 0.000 claims 3
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 3
- 206010024324 Leukaemias Diseases 0.000 claims 3
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 3
- 206010052779 Transplant rejections Diseases 0.000 claims 3
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 210000004027 cells Anatomy 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 201000002481 myositis Diseases 0.000 claims 3
- 210000000056 organs Anatomy 0.000 claims 3
- 102000013135 CD52 Antigen Human genes 0.000 claims 2
- 108010065524 CD52 Antigen Proteins 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- 101000451425 CD52 Proteins 0.000 claims 1
- 102100002977 CDR1 Human genes 0.000 claims 1
- 230000035693 Fab Effects 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 210000003283 T-Lymphocytes, Helper-Inducer Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000002443 helper T lymphocyte Anatomy 0.000 claims 1
- 102000029818 human CD52 protein Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000004962 mammalian cells Anatomy 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492005P | 2011-06-01 | 2011-06-01 | |
| GB1109238.4 | 2011-06-01 | ||
| GBGB1109238.4A GB201109238D0 (en) | 2011-06-01 | 2011-06-01 | Antibodies |
| US61/492,005 | 2011-06-01 | ||
| PCT/EP2012/060345 WO2012164063A1 (en) | 2011-06-01 | 2012-06-01 | Humanised anti-cd52 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518630A JP2014518630A (ja) | 2014-08-07 |
| JP2014518630A5 true JP2014518630A5 (ru) | 2015-07-16 |
| JP6254522B2 JP6254522B2 (ja) | 2017-12-27 |
Family
ID=44310746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513202A Active JP6254522B2 (ja) | 2011-06-01 | 2012-06-01 | ヒト化抗ｃｄ５２抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9321841B2 (ru) |
| EP (1) | EP2714739A1 (ru) |
| JP (1) | JP6254522B2 (ru) |
| KR (1) | KR20140036274A (ru) |
| CN (1) | CN103649122B (ru) |
| AU (1) | AU2012264643B2 (ru) |
| BR (1) | BR112013030875A2 (ru) |
| CA (1) | CA2837965A1 (ru) |
| GB (1) | GB201109238D0 (ru) |
| IL (1) | IL229713A (ru) |
| MX (1) | MX342676B (ru) |
| MY (1) | MY163257A (ru) |
| RU (1) | RU2605307C2 (ru) |
| SG (1) | SG195042A1 (ru) |
| WO (1) | WO2012164063A1 (ru) |
| ZA (1) | ZA201308900B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY160126A (en) | 2009-05-13 | 2017-02-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
| CA3022765A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| EP3452508A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CN109415432B (zh) | 2016-05-02 | 2022-07-08 | 普罗塞纳生物科学有限公司 | Tau免疫疗法 |
| CN106018814B (zh) * | 2016-08-07 | 2017-11-14 | 深圳市南海生物科技有限公司 | 一种用于白血病和自身免疫病检测用试剂盒 |
| JP7219721B2 (ja) * | 2017-04-21 | 2023-02-08 | ジェンザイム・コーポレーション | 抗ｃｄ５２抗体を用いて多発性硬化症を処置するための経路およびスケジュール |
| KR20200030029A (ko) | 2017-05-02 | 2020-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| MX2020011552A (es) | 2018-05-03 | 2020-11-24 | Genmab Bv | Combinaciones de variantes de anticuerpos y usos de las mismas. |
| PE20212324A1 (es) * | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| JP3121823B2 (ja) * | 1988-02-12 | 2001-01-09 | ビーティージー・インターナショナル・リミテッド | 抗体におけるまたは抗体に関する改良 |
| GB9022547D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
| GB9603507D0 (en) * | 1996-02-20 | 1996-04-17 | Isis Innovation | Antibody variants |
| GB9712892D0 (en) | 1997-06-20 | 1997-08-20 | Eclagen Ltd | Identification of mhc binding peptides |
| AU9399501A (en) * | 2000-10-09 | 2002-04-22 | Isis Innovation | Therapeutic antibodies |
| EP1553975B8 (en) * | 2002-09-27 | 2023-04-12 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| CN1225480C (zh) * | 2002-12-18 | 2005-11-02 | 马菁 | 抗cd52单克隆抗体、其编码序列及应用 |
| BRPI0416141B8 (pt) | 2003-11-01 | 2021-05-25 | Biovation Ltd | anticorpo anti-cd52 modificado, composição farmacêutica, vetores de expressão, e método para preparar uma imunoglobulina |
| JP2007515492A (ja) * | 2003-12-22 | 2007-06-14 | ジェンザイム コーポレイション | 糖尿病の抗ｃｄ５２抗体治療法 |
| US20080206239A1 (en) | 2005-02-03 | 2008-08-28 | Antitope Limited | Human Antibodies And Proteins |
| CN101238150A (zh) * | 2005-05-24 | 2008-08-06 | 阿维斯塔金格兰技术有限公司 | 用于治疗慢性淋巴细胞性白血病的抗cd52单克隆抗体的重组生产方法 |
| MY160126A (en) | 2009-05-13 | 2017-02-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| CN102079787A (zh) * | 2010-12-09 | 2011-06-01 | 协和干细胞基因工程有限公司 | 抗人cd52的工程抗体、载体、试剂盒及其用途 |
-
2011
- 2011-06-01 GB GBGB1109238.4A patent/GB201109238D0/en not_active Ceased
-
2012
- 2012-06-01 AU AU2012264643A patent/AU2012264643B2/en active Active
- 2012-06-01 SG SG2013085477A patent/SG195042A1/en unknown
- 2012-06-01 BR BR112013030875A patent/BR112013030875A2/pt not_active IP Right Cessation
- 2012-06-01 CA CA2837965A patent/CA2837965A1/en not_active Abandoned
- 2012-06-01 KR KR1020137034842A patent/KR20140036274A/ko active IP Right Grant
- 2012-06-01 MX MX2013014083A patent/MX342676B/es active IP Right Grant
- 2012-06-01 RU RU2013158454/10A patent/RU2605307C2/ru active
- 2012-06-01 CN CN201280033384.6A patent/CN103649122B/zh active Active
- 2012-06-01 EP EP12727814.1A patent/EP2714739A1/en active Pending
- 2012-06-01 JP JP2014513202A patent/JP6254522B2/ja active Active
- 2012-06-01 US US14/123,349 patent/US9321841B2/en active Active
- 2012-06-01 WO PCT/EP2012/060345 patent/WO2012164063A1/en active Application Filing
- 2012-06-01 MY MYPI2013004327A patent/MY163257A/en unknown
-
2013
- 2013-11-26 ZA ZA2013/08900A patent/ZA201308900B/en unknown
- 2013-11-28 IL IL229713A patent/IL229713A/en not_active IP Right Cessation
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