JP2014515742A5 - - Google Patents

Download PDF

Info

Publication number
JP2014515742A5
JP2014515742A5 JP2014502868A JP2014502868A JP2014515742A5 JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5 JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5
Authority
JP
Japan
Prior art keywords
seq
antibody
polypeptide
nos
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014502868A
Other languages
English (en)
Japanese (ja)
Other versions
JP6018622B2 (ja
JP2014515742A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/031648 external-priority patent/WO2012135740A2/en
Publication of JP2014515742A publication Critical patent/JP2014515742A/ja
Publication of JP2014515742A5 publication Critical patent/JP2014515742A5/ja
Application granted granted Critical
Publication of JP6018622B2 publication Critical patent/JP6018622B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014502868A 2011-04-01 2012-03-30 Cd37結合性分子及びその免疫複合体 Expired - Fee Related JP6018622B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161470863P 2011-04-01 2011-04-01
US61/470,863 2011-04-01
PCT/US2012/031648 WO2012135740A2 (en) 2011-04-01 2012-03-30 Cd37-binding molecules and immunoconjugates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016095431A Division JP2016145254A (ja) 2011-04-01 2016-05-11 Cd37結合性分子及びその免疫複合体

Publications (3)

Publication Number Publication Date
JP2014515742A JP2014515742A (ja) 2014-07-03
JP2014515742A5 true JP2014515742A5 (OSRAM) 2015-05-14
JP6018622B2 JP6018622B2 (ja) 2016-11-02

Family

ID=46932414

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014502868A Expired - Fee Related JP6018622B2 (ja) 2011-04-01 2012-03-30 Cd37結合性分子及びその免疫複合体
JP2016095431A Pending JP2016145254A (ja) 2011-04-01 2016-05-11 Cd37結合性分子及びその免疫複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016095431A Pending JP2016145254A (ja) 2011-04-01 2016-05-11 Cd37結合性分子及びその免疫複合体

Country Status (14)

Country Link
US (3) US9447189B2 (OSRAM)
EP (1) EP2694105A4 (OSRAM)
JP (2) JP6018622B2 (OSRAM)
KR (1) KR20140031883A (OSRAM)
CN (2) CN105999293B (OSRAM)
AU (2) AU2012236210B2 (OSRAM)
BR (1) BR112013025208A2 (OSRAM)
CA (1) CA2831111A1 (OSRAM)
EA (1) EA201391342A1 (OSRAM)
IL (1) IL228537A0 (OSRAM)
MX (1) MX2013011385A (OSRAM)
SG (1) SG193447A1 (OSRAM)
WO (1) WO2012135740A2 (OSRAM)
ZA (1) ZA201307302B (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106046159B (zh) 2010-03-12 2020-06-16 德彪发姆国际有限公司 Cd37结合分子及其免疫缀合物
EP2694105A4 (en) 2011-04-01 2015-04-29 Immunogen Inc CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
US20160058884A1 (en) 2014-09-02 2016-03-03 Immunogen, Inc. Methods for formulating antibody drug conjugate compositions
CA2986437A1 (en) 2015-06-08 2016-12-15 Debiopharm International, S.A. Anti-cd37 immunoconjugate and anti-cd20 antibody combinations
WO2017040247A1 (en) 2015-08-28 2017-03-09 Immunogen, Inc. Antibodies and assays for detection of cd37
WO2017122203A1 (en) * 2016-01-11 2017-07-20 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018083633A1 (en) 2016-11-02 2018-05-11 Debiopharm International, S.A. Methods for improving anti-cd37 immunoconjugate therapy
KR102020706B1 (ko) 2017-01-20 2019-09-11 주식회사 엘지화학 이차전지 분리막 내 수분함량 측정방법
KR102706161B1 (ko) 2017-03-31 2024-09-19 젠맵 홀딩 비.브이. 이중특이적 항-cd37 항체, 모노클로날 항-cd37 항체 및 그의 사용 방법
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CN110075315B (zh) * 2018-01-26 2023-08-11 上海复旦张江生物医药股份有限公司 一种抗体偶联物及其制备方法和应用
MX2020012755A (es) 2018-05-30 2021-02-26 Debiopharm Int Sa Regimenes de dosificacion del inmunoconjugado anti antigeno leucocitario (cd37).
JP7513530B2 (ja) 2018-06-22 2024-07-09 ジェンマブ ホールディング ビー.ブイ. 抗cd37抗体および抗cd20抗体、組成物、ならびにそれらの使用方法
EP3860715A1 (en) 2018-10-04 2021-08-11 Genmab Holding B.V. Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
US20210388106A1 (en) * 2018-10-26 2021-12-16 Teneobio, Inc. Heavy chain antibodies binding to cd38
CN111320690B (zh) * 2018-12-17 2022-04-05 程联胜 一种抗人Tim3单克隆抗体及其应用
US20220226334A1 (en) * 2019-05-21 2022-07-21 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody conjugate and application of pharmaceutical composition thereof
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
EP4077391A1 (en) * 2019-12-18 2022-10-26 Teneofour, Inc. Heavy chain antibodies binding to cd38
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
CN118339188A (zh) 2021-09-21 2024-07-12 齐鲁普吉湾生物治疗公司 用于制备融合蛋白和双特异性抗体的异二聚体Fc
CA3235358A1 (en) 2021-10-18 2023-04-27 Daiichi Sankyo Company, Limited Anti-cd37 antibody-drug conjugate
AU2023253796A1 (en) 2022-04-14 2024-10-17 Debiopharm Research & Manufacturing S.A. Ligand-drug-conjugates with improved pharmacokinetic and drug release properties
CN120209126B (zh) * 2025-05-28 2025-09-16 中国医学科学院医学生物学研究所 人偏肺病毒单克隆抗体及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89220A (en) * 1988-02-11 1994-02-27 Bristol Myers Squibb Co Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them
US5977316A (en) * 1995-01-17 1999-11-02 The Board Of Trustees Of The University Of Kentucky Monoclonal antibody 1A7 and related polypeptides
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7303749B1 (en) 1999-10-01 2007-12-04 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
AU2002243718B2 (en) 2001-01-31 2007-12-06 Biogen Idec Inc. Use of immunoregulatory antibodies in the treatment of neoplastic disorders
US20030103971A1 (en) 2001-11-09 2003-06-05 Kandasamy Hariharan Immunoregulatory antibodies and uses thereof
AU2002314495A1 (en) 2001-06-20 2003-01-02 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
JP2005524386A (ja) 2001-11-08 2005-08-18 ▲養▼生堂有限公司 抗e型肝炎ウイルスモノクローナル抗体、又は結合性を有するそのフラグメント、及びそれらの使用
US7585491B2 (en) 2002-12-13 2009-09-08 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
WO2004045642A1 (en) 2002-11-15 2004-06-03 Immunomedics, Inc. Use of multi-specific, non-covalent complexes for targeted delivery of therapeutics
KR101412271B1 (ko) 2003-05-09 2014-06-25 듀크 유니버시티 Cd20-특이적 항체 및 이를 이용한 방법
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
SI1631313T1 (sl) * 2003-06-05 2015-06-30 Genentech, Inc. Kombinirana terapija za B-celične motnje
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
US7241598B2 (en) 2004-06-29 2007-07-10 The Chinese University Of Hong Kong Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
WO2006085961A2 (en) 2004-06-30 2006-08-17 Centocor, Inc. Anti-mcp-1 antibodies, compositions, methods and uses
KR20070100346A (ko) 2005-01-05 2007-10-10 바이오겐 아이덱 엠에이 인코포레이티드 크립토 결합 분자
FR2880696B1 (fr) * 2005-01-07 2007-08-24 Ioltechnologie Production Sarl Lentille intraoculaire photochromique
KR101363120B1 (ko) 2005-02-10 2014-02-13 베일러 리서치 인스티튜트 항-인터페론 알파 모노클로날 항체 및 사용 방법
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
US7601335B2 (en) * 2005-05-20 2009-10-13 Genentech, Inc. Pretreatment of a biological sample from an autoimmune disease subject
EP1904101A4 (en) 2005-06-08 2011-06-15 Univ Duke ANTI-CD19 ANTIBODY THERAPY FOR TRANSPLANTATION
SI1912675T1 (sl) 2005-07-25 2014-07-31 Emergent Product Development Seattle, Llc zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
US20080279850A1 (en) 2005-07-25 2008-11-13 Trubion Pharmaceuticals, Inc. B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
HRP20140172T1 (hr) * 2006-05-30 2014-03-28 Genentech, Inc. Protutijela i imunokonjugati kao i njihove uporabe
EP2418223A3 (en) 2006-06-12 2013-01-16 Emergent Product Development Seattle, LLC Single-chain multivalent binding proteins with effector function
KR101479537B1 (ko) * 2006-08-03 2015-01-07 백시넥스 인코포레이티드 항-il-6 모노클로날 항체 및 이의 용도
CN101646688A (zh) 2006-10-24 2010-02-10 特鲁比昂药品公司 利用栗精胺提高抗体依赖性细胞毒性的方法
US7846434B2 (en) 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
FI2155783T4 (fi) 2007-04-03 2022-12-15 Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni
EP2167130A2 (en) 2007-07-06 2010-03-31 Trubion Pharmaceuticals, Inc. Binding peptides having a c-terminally disposed specific binding domain
PE20140196A1 (es) 2007-08-09 2014-03-19 Boehringer Ingelheim Int Anticuerpos anti-cd37
GB2454915B (en) 2007-11-23 2012-02-15 Schlumberger Holdings Spooling apparatus for well intervention system
WO2009085576A2 (en) 2007-12-28 2009-07-09 Spring Bioscience Corporation Positive control cell pellets for immunohistochemistry and methods of use thereof
SG189772A1 (en) 2008-04-11 2013-05-31 Trubion Pharmaceuticals Inc Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US7740844B2 (en) 2008-04-29 2010-06-22 Taiwan Liposome Co. Ltd Anti-VEGF monoclonal antibody
CN104524590B (zh) 2008-04-30 2019-06-21 伊缪诺金公司 交联剂和它们的用途
SG191679A1 (en) 2008-06-16 2013-07-31 Immunogen Inc Novel synergistic effects
AR072804A1 (es) 2008-07-15 2010-09-22 Genentech Inc Conjugados derivados de antraciclina,proceso para su preparacion,composiciones farmaceuticas que los contienen y su uso como agentes antitumorales.
BRPI0921006A2 (pt) 2008-11-13 2015-12-15 Emergent Product Dev Seattle terapias imunoterapêuticas combinadas de cd37 e usos destas
EP2486023A4 (en) * 2009-10-06 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
SI2519543T1 (sl) 2009-12-29 2016-08-31 Emergent Product Development Seattle, Llc Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
WO2011100398A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc. Cd20 antibodies and uses thereof
CN106046159B (zh) 2010-03-12 2020-06-16 德彪发姆国际有限公司 Cd37结合分子及其免疫缀合物
KR20130108069A (ko) 2010-04-15 2013-10-02 알퍼 바이오테크, 엘엘씨 Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도
EP2694105A4 (en) 2011-04-01 2015-04-29 Immunogen Inc CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
MX2014011745A (es) 2012-03-30 2015-01-22 Immunogen Inc Metodos para aumentar la eficacia de terapia basada en cd37.
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014143807A2 (en) 2013-03-15 2014-09-18 Stromatt Scott Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
WO2015116729A2 (en) 2014-01-28 2015-08-06 Emergent Product Development Seattle, Llc Anti-cd37 antibody and anti-cd20 antibody combination therapy for treatment of b-cell malignancies and disorders
WO2015175533A2 (en) 2014-05-13 2015-11-19 Immunogen, Inc. Anti-cd37 immunoconjugate dosing regimens
CA2986437A1 (en) 2015-06-08 2016-12-15 Debiopharm International, S.A. Anti-cd37 immunoconjugate and anti-cd20 antibody combinations
WO2017040247A1 (en) 2015-08-28 2017-03-09 Immunogen, Inc. Antibodies and assays for detection of cd37

Similar Documents

Publication Publication Date Title
JP2014515742A5 (OSRAM)
JP5894912B2 (ja) 抗ヒトcd52免疫グロブリン
JP5841072B2 (ja) Cd20抗体およびその使用
KR101870277B1 (ko) 특히, 대숙주성 이식편병(gvhd)을 예방하기 위한 항 cd4 항체
KR102771979B1 (ko) 형질 전환 성장 인자-베타-반응성 폴리펩티드 및 이의 사용 방법
KR20200110358A (ko) 항-pd-1 항체 및 치료 방법
US12187797B2 (en) SIRP α, SIRP β 1, and SIRP γ antibodies and uses thereof
JP2020513791A5 (OSRAM)
JP2008516970A5 (OSRAM)
JP2012526558A5 (OSRAM)
KR20140031883A (ko) Cd37-결합 분자 및 그의 면역콘주게이트
JP2012500020A5 (OSRAM)
JP2011509245A5 (OSRAM)
JP2022517441A (ja) Btla抗体
WO2007102200A1 (ja) 抗cd20モノクローナル抗体
JP2016507521A5 (OSRAM)
WO2010102792A2 (en) Human antibodies against human fas and their use
WO2022239820A1 (ja) 炎症性疾患を治療又は予防するための抗ヒトpd-1アゴニスト抗体及びこれを含有する医薬組成物
JP7486616B2 (ja) Btla抗体
US20250136707A1 (en) Bispecific chimeric antigen receptors targeting cd20 and bcma
JPWO2021163389A5 (OSRAM)
JP2015533374A5 (OSRAM)
JPWO2021186056A5 (OSRAM)
JP2013508391A5 (OSRAM)
CN113692286A (zh) 一种用于免疫抑制的方法