JP2014513615A5 - - Google Patents
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- JP2014513615A5 JP2014513615A5 JP2014501670A JP2014501670A JP2014513615A5 JP 2014513615 A5 JP2014513615 A5 JP 2014513615A5 JP 2014501670 A JP2014501670 A JP 2014501670A JP 2014501670 A JP2014501670 A JP 2014501670A JP 2014513615 A5 JP2014513615 A5 JP 2014513615A5
- Authority
- JP
- Japan
- Prior art keywords
- implant
- implant device
- ablation region
- activation
- ablation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 54
- 238000002679 ablation Methods 0.000 claims 21
- 210000004204 blood vessel Anatomy 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 9
- 238000001994 activation Methods 0.000 claims 8
- 230000004913 activation Effects 0.000 claims 8
- 210000003492 pulmonary vein Anatomy 0.000 claims 7
- 210000002254 renal artery Anatomy 0.000 claims 7
- 238000010438 heat treatment Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000463 material Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- SDZRWUKZFQQKKV-JHADDHBZSA-N cytochalasin D Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@H]\3[C@]2([C@@H](/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/3)OC(C)=O)C(=O)N1)=C)C)C1=CC=CC=C1 SDZRWUKZFQQKKV-JHADDHBZSA-N 0.000 claims 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 4
- 230000005291 magnetic effect Effects 0.000 claims 4
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 4
- 229960002930 sirolimus Drugs 0.000 claims 4
- 239000002885 antiferromagnetic material Substances 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000002902 ferrimagnetic material Substances 0.000 claims 3
- 239000003302 ferromagnetic material Substances 0.000 claims 3
- OVJBOPBBHWOWJI-FYNXUGHNSA-N (2S)-2-[[(2S)-1-[(2S)-2-[[(aS,1R,3aS,4S,10S,16S,19R,22S,25S,28S,34S,37S,40R,45R,48S,51S,57S,60S,63S,69S,72S,75S,78S,85R,88S,91R,94S)-40-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-25,48,78,88,94-pentakis(4-aminobutyl)-a-(2-amino-2-oxoethyl)-22,63,72-tris(3-amino-3-oxopropyl)-69-benzyl-37-[(1R)-1-hydroxyethyl]-34,60-bis(hydroxymethyl)-51,57,75-trimethyl-16-(2-methylpropyl)-3a-(2-methylsulfanylethyl)-2a,3,5a,9,15,18,21,24,27,33,36,39,47,50,53,56,59,62,65,68,71,74,77,80,87,90,93,96,99-nonacosaoxo-7a,8a,42,43,82,83-hexathia-1a,2,4a,8,14,17,20,23,26,32,35,38,46,49,52,55,58,61,64,67,70,73,76,79,86,89,92,95,98-nonacosazahexacyclo[43.35.25.419,91.04,8.010,14.028,32]nonahectane-85-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CO)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O OVJBOPBBHWOWJI-FYNXUGHNSA-N 0.000 claims 2
- 108030001720 Bontoxilysin Proteins 0.000 claims 2
- 101000997261 Centruroides margaritatus Potassium channel toxin alpha-KTx 2.2 Proteins 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- 101710138657 Neurotoxin Proteins 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 101001049892 Scorpio palmatus Potassium channel toxin alpha-KTx 6.2 Proteins 0.000 claims 2
- 108010084950 Tx3 neurotoxin Proteins 0.000 claims 2
- 230000036760 body temperature Effects 0.000 claims 2
- 229940053031 botulinum toxin Drugs 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- 231100000189 neurotoxic Toxicity 0.000 claims 2
- 230000002887 neurotoxic effect Effects 0.000 claims 2
- 239000002581 neurotoxin Substances 0.000 claims 2
- 231100000618 neurotoxin Toxicity 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 claims 2
- 229950010357 tetrodotoxin Drugs 0.000 claims 2
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 claims 2
- 238000007725 thermal activation Methods 0.000 claims 2
- 230000001960 triggered effect Effects 0.000 claims 2
- 229950009819 zotarolimus Drugs 0.000 claims 2
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 2
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 1
- 238000013021 overheating Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051411 | 2011-04-01 | ||
| IBPCT/IB2011/051411 | 2011-04-01 | ||
| PCT/EP2011/058587 WO2012130337A1 (en) | 2011-04-01 | 2011-05-25 | System, device and method for ablation of a vessel's wall from the inside |
| EPPCT/EP2011/058587 | 2011-05-25 | ||
| PCT/EP2012/055999 WO2012131107A1 (en) | 2011-04-01 | 2012-04-02 | System, device and method for ablation of a vessel's wall from the inside |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513615A JP2014513615A (ja) | 2014-06-05 |
| JP2014513615A5 true JP2014513615A5 (https=) | 2015-05-14 |
| JP6165707B2 JP6165707B2 (ja) | 2017-07-19 |
Family
ID=44119255
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501670A Active JP6165707B2 (ja) | 2011-04-01 | 2012-04-02 | 血管壁を内部から焼灼するシステム、装置及び方法 |
| JP2017150769A Active JP6415655B2 (ja) | 2011-04-01 | 2017-08-03 | 腎動脈を内部から焼灼するインプラント装置及びシステム |
| JP2017195284A Active JP6482625B2 (ja) | 2011-04-01 | 2017-10-05 | 血管壁を内部から焼灼するインプラント装置及びシステム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017150769A Active JP6415655B2 (ja) | 2011-04-01 | 2017-08-03 | 腎動脈を内部から焼灼するインプラント装置及びシステム |
| JP2017195284A Active JP6482625B2 (ja) | 2011-04-01 | 2017-10-05 | 血管壁を内部から焼灼するインプラント装置及びシステム |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9572618B2 (https=) |
| EP (1) | EP2694158B1 (https=) |
| JP (3) | JP6165707B2 (https=) |
| CN (1) | CN103561814B (https=) |
| AU (2) | AU2012237263A1 (https=) |
| BE (1) | BE1019726A3 (https=) |
| BR (2) | BR112013025173B1 (https=) |
| CA (1) | CA2831845C (https=) |
| EA (1) | EA032388B1 (https=) |
| IL (1) | IL228634A (https=) |
| WO (2) | WO2012130337A1 (https=) |
| ZA (1) | ZA201308190B (https=) |
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2011
- 2011-05-25 WO PCT/EP2011/058587 patent/WO2012130337A1/en not_active Ceased
-
2012
- 2012-04-02 EP EP12718611.2A patent/EP2694158B1/en active Active
- 2012-04-02 CN CN201280026752.4A patent/CN103561814B/zh active Active
- 2012-04-02 AU AU2012237263A patent/AU2012237263A1/en not_active Abandoned
- 2012-04-02 JP JP2014501670A patent/JP6165707B2/ja active Active
- 2012-04-02 WO PCT/EP2012/055999 patent/WO2012131107A1/en not_active Ceased
- 2012-04-02 CA CA2831845A patent/CA2831845C/en active Active
- 2012-04-02 BR BR112013025173-5A patent/BR112013025173B1/pt active IP Right Grant
- 2012-04-02 EA EA201301113A patent/EA032388B1/ru unknown
- 2012-04-02 BE BE2012/0223A patent/BE1019726A3/nl active
- 2012-04-02 US US14/008,922 patent/US9572618B2/en active Active
- 2012-10-01 BR BR112014024659-9A patent/BR112014024659B1/pt active IP Right Grant
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2013
- 2013-09-30 IL IL228634A patent/IL228634A/en active IP Right Grant
- 2013-11-01 ZA ZA2013/08190A patent/ZA201308190B/en unknown
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2016
- 2016-10-17 AU AU2016244345A patent/AU2016244345B2/en active Active
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2017
- 2017-01-26 US US15/416,180 patent/US10849676B2/en active Active
- 2017-08-03 JP JP2017150769A patent/JP6415655B2/ja active Active
- 2017-10-05 JP JP2017195284A patent/JP6482625B2/ja active Active
- 2017-11-27 US US15/822,458 patent/US11020164B2/en active Active
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