JP2014513545A5 - - Google Patents
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- Publication number
- JP2014513545A5 JP2014513545A5 JP2014510762A JP2014510762A JP2014513545A5 JP 2014513545 A5 JP2014513545 A5 JP 2014513545A5 JP 2014510762 A JP2014510762 A JP 2014510762A JP 2014510762 A JP2014510762 A JP 2014510762A JP 2014513545 A5 JP2014513545 A5 JP 2014513545A5
- Authority
- JP
- Japan
- Prior art keywords
- eukaryotic cell
- cell suspension
- rfviii
- shear stress
- power density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003527 eukaryotic cell Anatomy 0.000 claims 16
- 239000006285 cell suspension Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 230000033001 locomotion Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000002736 nonionic surfactant Substances 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 2
- 238000005086 pumping Methods 0.000 claims 2
- 102000001690 Factor VIII Human genes 0.000 claims 1
- 108010054218 Factor VIII Proteins 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical group OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 claims 1
- 229960000301 factor viii Drugs 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166071.8 | 2011-05-13 | ||
| EP11166071 | 2011-05-13 | ||
| US201161489406P | 2011-05-24 | 2011-05-24 | |
| US61/489,406 | 2011-05-24 | ||
| PCT/EP2012/058899 WO2012156356A1 (en) | 2011-05-13 | 2012-05-14 | A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513545A JP2014513545A (ja) | 2014-06-05 |
| JP2014513545A5 true JP2014513545A5 (https=) | 2015-06-18 |
| JP6178786B2 JP6178786B2 (ja) | 2017-08-09 |
Family
ID=45470754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510762A Active JP6178786B2 (ja) | 2011-05-13 | 2012-05-14 | 組換えｆｖｉｉｉの生産において真核細胞の生産性を向上させる方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9115381B2 (https=) |
| EP (3) | EP4353743A3 (https=) |
| JP (1) | JP6178786B2 (https=) |
| KR (1) | KR101980164B1 (https=) |
| CN (1) | CN103517919B (https=) |
| AU (1) | AU2012257736B2 (https=) |
| BR (1) | BR112013028006A2 (https=) |
| CA (1) | CA2835053C (https=) |
| DK (1) | DK3626737T3 (https=) |
| ES (1) | ES2970057T3 (https=) |
| IL (1) | IL229058A (https=) |
| RU (1) | RU2600886C2 (https=) |
| WO (1) | WO2012156356A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6591609B2 (en) | 1997-07-15 | 2003-07-15 | New Power Concepts Llc | Regenerator for a Stirling Engine |
| AU2015269365A1 (en) | 2014-06-04 | 2016-12-15 | Amgen Inc. | Methods for harvesting mammalian cell cultures |
| CN107287265B (zh) * | 2016-03-31 | 2018-09-14 | 正大天晴药业集团南京顺欣制药有限公司 | 一种制备重组人凝血因子ⅷ的方法 |
| WO2020020364A1 (zh) * | 2018-07-26 | 2020-01-30 | 正大天晴药业集团南京顺欣制药有限公司 | 一种制备重组人凝血因子ⅷ的方法 |
| KR102903908B1 (ko) * | 2020-05-20 | 2025-12-23 | 주식회사 엘지화학 | 전기 천공 장치 및 방법 |
| WO2023242238A1 (en) * | 2022-06-15 | 2023-12-21 | UCB Biopharma SRL | Cell culture processes |
| CN120005720B (zh) * | 2025-04-21 | 2025-08-08 | 深圳市茵冠生物科技有限公司 | 一种人工智能的细胞培养监测方法及系统 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6358703B1 (en) * | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| DE60024268T2 (de) * | 1999-07-13 | 2006-08-03 | Biovitrum Ab | Zusammensetzungen mit stabilem faktor viii |
| EE200200538A (et) | 2000-03-22 | 2004-04-15 | Octagene Gmbh | Rekombinantsete verehüübimisfaktorite produtseerimine inimese rakuliinides |
| CA2557046A1 (en) * | 2004-03-05 | 2005-10-13 | John Crowley | Process for cell culturing by continuous perfusion and alternating tangential flow |
| JP2006296423A (ja) * | 2005-03-24 | 2006-11-02 | Hitachi Ltd | 培養槽の制御装置及び培養装置 |
| EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| EP1871801A2 (en) * | 2005-04-01 | 2008-01-02 | Novo Nordisk Health Care AG | Blood coagulation fviii analogues |
| EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| KR101685246B1 (ko) | 2006-07-14 | 2016-12-09 | 디피엑스 홀딩스 비.브이. | 개선된 세포 배양 방법 |
| CN101490239A (zh) * | 2006-07-14 | 2009-07-22 | 帝斯曼知识产权资产管理有限公司 | 改进的细胞培养方法 |
| JPWO2009090787A1 (ja) * | 2008-01-15 | 2011-05-26 | 東レ株式会社 | 生理活性ペプチドまたはタンパク質製造方法、および組換え動物細胞 |
| EP2300497B1 (en) * | 2008-06-24 | 2012-08-08 | Octapharma AG | A process of purifying coagulation factor viii |
| MX2011001624A (es) | 2008-08-21 | 2011-03-28 | Octapharma Ag | Factor viii y ix humano producido en forma recombinante. |
| DE102008049120A1 (de) | 2008-09-26 | 2010-04-01 | Bayer Technology Services Gmbh | Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen |
| EP2216395A1 (en) | 2009-02-09 | 2010-08-11 | Lonza Biologics plc. | Bioreactor for the cultivation of mammalian cells |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
-
2012
- 2012-05-14 ES ES19209635T patent/ES2970057T3/es active Active
- 2012-05-14 CN CN201280021390.XA patent/CN103517919B/zh active Active
- 2012-05-14 CA CA2835053A patent/CA2835053C/en not_active Expired - Fee Related
- 2012-05-14 EP EP23211876.0A patent/EP4353743A3/en not_active Withdrawn
- 2012-05-14 KR KR1020137029808A patent/KR101980164B1/ko not_active Expired - Fee Related
- 2012-05-14 EP EP12721821.2A patent/EP2707387B1/en not_active Revoked
- 2012-05-14 AU AU2012257736A patent/AU2012257736B2/en active Active
- 2012-05-14 BR BR112013028006A patent/BR112013028006A2/pt not_active Application Discontinuation
- 2012-05-14 WO PCT/EP2012/058899 patent/WO2012156356A1/en not_active Ceased
- 2012-05-14 US US14/113,923 patent/US9115381B2/en active Active
- 2012-05-14 EP EP19209635.2A patent/EP3626737B1/en not_active Revoked
- 2012-05-14 DK DK19209635.2T patent/DK3626737T3/da active
- 2012-05-14 JP JP2014510762A patent/JP6178786B2/ja active Active
- 2012-05-14 RU RU2013155382/10A patent/RU2600886C2/ru active
-
2013
- 2013-10-24 IL IL229058A patent/IL229058A/en active IP Right Grant
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