JP2014512333A5 - - Google Patents
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- Publication number
- JP2014512333A5 JP2014512333A5 JP2013549539A JP2013549539A JP2014512333A5 JP 2014512333 A5 JP2014512333 A5 JP 2014512333A5 JP 2013549539 A JP2013549539 A JP 2013549539A JP 2013549539 A JP2013549539 A JP 2013549539A JP 2014512333 A5 JP2014512333 A5 JP 2014512333A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- metformin
- composition according
- compound
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 5
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 5
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 5
- 229960003105 metformin Drugs 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 3
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 3
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 3
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001280 Prediabetic State Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000012299 nitrogen atmosphere Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161461113P | 2011-01-12 | 2011-01-12 | |
| US61/461,113 | 2011-01-12 | ||
| US13/348,265 US20120178813A1 (en) | 2011-01-12 | 2012-01-11 | Lipid-lowering antidiabetic agent |
| US13/348,265 | 2012-01-11 | ||
| PCT/US2012/021070 WO2012097144A1 (en) | 2011-01-12 | 2012-01-12 | Lipid-lowering antidiabetic agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512333A JP2014512333A (ja) | 2014-05-22 |
| JP2014512333A5 true JP2014512333A5 (https=) | 2015-03-12 |
| JP5911514B2 JP5911514B2 (ja) | 2016-04-27 |
Family
ID=46455756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549539A Expired - Fee Related JP5911514B2 (ja) | 2011-01-12 | 2012-01-12 | 脂質低下抗糖尿病薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20120178813A1 (https=) |
| EP (1) | EP2663186A4 (https=) |
| JP (1) | JP5911514B2 (https=) |
| KR (1) | KR20140092228A (https=) |
| CN (1) | CN103533833B (https=) |
| AU (1) | AU2012205547B2 (https=) |
| BR (1) | BR112013017845A2 (https=) |
| CA (1) | CA2824192A1 (https=) |
| EA (1) | EA201391028A1 (https=) |
| IL (1) | IL227346A0 (https=) |
| MX (1) | MX2013008131A (https=) |
| WO (1) | WO2012097144A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| CN104684889A (zh) * | 2012-07-10 | 2015-06-03 | 西蒂斯制药有限责任公司 | 二甲双胍的三盐形式 |
| US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| WO2014080307A2 (en) * | 2012-11-21 | 2014-05-30 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| SG11201509782TA (en) * | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| WO2014195810A2 (en) * | 2013-06-04 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| WO2015022613A1 (en) * | 2013-08-11 | 2015-02-19 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| CA2947741A1 (en) * | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| US9999626B2 (en) | 2014-06-18 | 2018-06-19 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of active agents |
| US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
| WO2016132186A1 (en) * | 2015-02-20 | 2016-08-25 | Mohan M Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
| US9371276B1 (en) * | 2015-03-21 | 2016-06-21 | Mohan Murali Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| EP3648748A1 (en) | 2017-07-06 | 2020-05-13 | Evonik Operations GmbH | Enteric coated solid dosage form comprising omega-3 fatty acid amino acid salts |
| JP7050148B2 (ja) | 2017-08-15 | 2022-04-07 | エボニック オペレーションズ ゲーエムベーハー | オメガ－３脂肪酸アミノ酸塩の有効成分含有量が高い錠剤 |
| US11497722B2 (en) * | 2017-12-18 | 2022-11-15 | Soochow University | Use of metformin salt in the treatment of cerebral infarction |
| US20220280387A1 (en) | 2019-08-08 | 2022-09-08 | Evonik Operations Gmbh | Down streaming process for the production of polyunsaturated fatty acid salts |
| EP4009961A1 (en) | 2019-08-08 | 2022-06-15 | Evonik Operations GmbH | Solubility enhancement of poorly soluble actives |
| CN113105367B (zh) | 2021-03-30 | 2022-08-02 | 广州大学 | 一类二甲双胍盐及其制备方法和应用 |
| CN116999398A (zh) * | 2022-06-30 | 2023-11-07 | 山东海赜生物科技有限公司 | 一种口服组合物 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| KR100784752B1 (ko) | 2000-02-04 | 2007-12-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 안정한 에멀젼 조성물 |
| US6491950B1 (en) | 2000-08-07 | 2002-12-10 | Kos Pharmaceuticals, Inc. | Controlled release pharmaceutical composition |
| US6667064B2 (en) | 2000-08-30 | 2003-12-23 | Pilot Therapeutics, Inc. | Composition and method for treatment of hypertriglyceridemia |
| US6689385B2 (en) * | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
| FR2818906B1 (fr) * | 2000-12-29 | 2004-04-02 | Dospharma | Association medicamenteuse d'une biguanine et d'un transporteur, par exemple de metformine et d'arginine |
| DE10102050A1 (de) | 2001-01-17 | 2002-07-18 | Basf Ag | Zubereitung zur Verbesserung der Nahrungsverwertung |
| WO2002079139A1 (de) | 2001-03-29 | 2002-10-10 | Basf Aktiengesellschaft | Konjugierte ungesättigte glyceridgemische und verfahren zur ihrer herstellung |
| DE60234780D1 (de) | 2001-08-31 | 2010-01-28 | Univ Rutgers | Verfahren zur behandlung von krankheiten mit pflanzenextrakten |
| ITMI20012384A1 (it) | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| WO2003068209A1 (en) * | 2002-02-14 | 2003-08-21 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
| US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| US7399488B2 (en) * | 2002-07-05 | 2008-07-15 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
| EP2384750A1 (en) * | 2002-09-27 | 2011-11-09 | Martek Biosciences Corporation | Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid |
| ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
| MXPA05009933A (es) * | 2003-03-18 | 2005-11-04 | Novartis Ag | Composiciones que comprenden acidos grasos y aminoacidos. |
| EP1510208A1 (en) | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Pharmaceutical composition comprising a combination of metformin and statin |
| US20080045559A1 (en) | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| WO2005042539A1 (en) | 2003-10-29 | 2005-05-12 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| KR20060108692A (ko) * | 2003-10-31 | 2006-10-18 | 알자 코포레이션 | 메트포르민의 개선된 흡수를 위한 조성물 및 제형 |
| EP1708707A1 (en) | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| WO2005118612A1 (en) | 2004-06-04 | 2005-12-15 | Sonus Pharmaceuticals, Inc. | Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs |
| US20100021555A1 (en) * | 2004-10-15 | 2010-01-28 | Karl Geiringer | Compositions containing high omega-3 and low saturated fatty acid levels |
| WO2006046156A2 (en) | 2004-10-29 | 2006-05-04 | Joan Campbell-Tofte | Anti-diabetic extract isolated from rauvolfia vomitoria and citrus aurantium, and methods of using same |
| US20080200533A1 (en) | 2005-07-04 | 2008-08-21 | Ramu Krishnan | Drug or Pharmaceutical Compounds and a Preparation Thereof |
| EP1960356A2 (en) | 2005-11-03 | 2008-08-27 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
| JP2009526033A (ja) * | 2006-02-07 | 2009-07-16 | オメガトリ エーエス | オメガ３ |
| EP1984355A2 (en) | 2006-02-16 | 2008-10-29 | Takeda Pharmaceutical Company Limited | Cyclic amine compound and use thereof for the prophylaxis or treatment of hypertension |
| US20090047340A1 (en) | 2006-03-29 | 2009-02-19 | Guilford F Timothy | Liposomal reduced glutathione and 1-arginine, including with other ingredient(s), capable of multipath administration for reversal and prevention of obesity and for mitochondrial biogenesis |
| WO2007149313A1 (en) | 2006-06-16 | 2007-12-27 | Indigene Pharmaceuticals Inc. | Metformin r-(+) lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications |
| KR101438177B1 (ko) | 2006-11-01 | 2014-09-05 | 프로노바 바이오파마 너지 에이에스 | 페록시솜 증식자-활성화 수용체의 활성자 또는 조절자인 알파-치환된 오메가-3 지질 |
| WO2008053340A1 (en) * | 2006-11-03 | 2008-05-08 | Pronova Biopharma Norge As | A combination product comprising at least one lipid substituted in the alpha position and at least one hypoglycemic agent |
| US20100105773A1 (en) * | 2006-11-09 | 2010-04-29 | The Children's Medical Center Corporation | Use of resolvins and docosatrienes and analogues thereof for the treatment of angiogenesis and ocular neovascularization |
| CN105152983A (zh) * | 2007-01-29 | 2015-12-16 | 韩诺生物制药株式会社 | N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物 |
| US20090227560A1 (en) | 2007-04-27 | 2009-09-10 | Takanobu Kuroita | Substituted imidazole compound and use thereof |
| TW200904433A (en) | 2007-04-27 | 2009-02-01 | Takeda Pharmaceutical | Substituted imidazole compound and use thereof |
| US20090054513A1 (en) * | 2007-08-22 | 2009-02-26 | Response Scientific, Inc. | Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease |
| CN101855204B (zh) * | 2007-09-21 | 2013-09-11 | 韩兀生物制药株式会社 | N,n-二甲基亚氨二羰酸二酰胺二羧酸盐、其制备方法及其药物组合物 |
| WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
| US20110046053A1 (en) | 2008-05-05 | 2011-02-24 | Oramed Ltd. | Methods and compositions for oral administration of exenatide |
| NZ600238A (en) | 2008-06-19 | 2014-04-30 | Takeda Pharmaceutical | Heterocyclic compound and use thereof |
| SG175390A1 (en) * | 2009-04-29 | 2011-12-29 | Amarin Corp Plc | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| US20110052678A1 (en) | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| EP2861227A4 (en) | 2012-06-17 | 2016-01-27 | Matinas Biopharma Inc | OMEGA-3 PENTAIC ACID COMPOSITIONS AND METHODS OF USE |
-
2012
- 2012-01-11 US US13/348,265 patent/US20120178813A1/en not_active Abandoned
- 2012-01-12 EP EP12734013.1A patent/EP2663186A4/en not_active Withdrawn
- 2012-01-12 MX MX2013008131A patent/MX2013008131A/es not_active Application Discontinuation
- 2012-01-12 CN CN201280005222.1A patent/CN103533833B/zh not_active Expired - Fee Related
- 2012-01-12 CA CA2824192A patent/CA2824192A1/en not_active Abandoned
- 2012-01-12 BR BR112013017845A patent/BR112013017845A2/pt not_active IP Right Cessation
- 2012-01-12 KR KR20137018679A patent/KR20140092228A/ko not_active Withdrawn
- 2012-01-12 AU AU2012205547A patent/AU2012205547B2/en not_active Ceased
- 2012-01-12 EA EA201391028A patent/EA201391028A1/ru unknown
- 2012-01-12 JP JP2013549539A patent/JP5911514B2/ja not_active Expired - Fee Related
- 2012-01-12 WO PCT/US2012/021070 patent/WO2012097144A1/en not_active Ceased
-
2013
- 2013-06-21 US US13/923,829 patent/US8901107B2/en not_active Expired - Fee Related
- 2013-07-04 IL IL227346A patent/IL227346A0/en unknown
- 2013-12-20 US US14/136,843 patent/US9012507B2/en not_active Expired - Fee Related
-
2014
- 2014-10-27 US US14/524,721 patent/US9216951B2/en not_active Expired - Fee Related
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