JP2014511427A5 - - Google Patents
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- Publication number
- JP2014511427A5 JP2014511427A5 JP2013557127A JP2013557127A JP2014511427A5 JP 2014511427 A5 JP2014511427 A5 JP 2014511427A5 JP 2013557127 A JP2013557127 A JP 2013557127A JP 2013557127 A JP2013557127 A JP 2013557127A JP 2014511427 A5 JP2014511427 A5 JP 2014511427A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- group
- polymer according
- methylene
- methacrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 30
- 239000000178 monomer Substances 0.000 claims 11
- 229920001223 polyethylene glycol Polymers 0.000 claims 10
- 229920001400 block copolymer Polymers 0.000 claims 7
- 239000003431 cross linking reagent Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000012986 chain transfer agent Substances 0.000 claims 5
- -1 t-butylaminoethyl (methyl) acrylate Chemical compound 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000007943 implant Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 4
- 230000000379 polymerizing effect Effects 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 239000012798 spherical particle Substances 0.000 claims 3
- JIFCOORMJVPBTN-UHFFFAOYSA-N 2-methylidene-1,3,6-trioxocane Chemical compound C=C1OCCOCCO1 JIFCOORMJVPBTN-UHFFFAOYSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229920001427 mPEG Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000017423 tissue regeneration Effects 0.000 claims 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 1
- LMAUULKNZLEMGN-UHFFFAOYSA-N 1-ethyl-3,5-dimethylbenzene Chemical compound CCC1=CC(C)=CC(C)=C1 LMAUULKNZLEMGN-UHFFFAOYSA-N 0.000 claims 1
- VDNJGYSBTLOSGU-UHFFFAOYSA-N 2-(diethylamino)prop-2-enoic acid Chemical compound CCN(CC)C(=C)C(O)=O VDNJGYSBTLOSGU-UHFFFAOYSA-N 0.000 claims 1
- PWKDHWCKSUMJID-UHFFFAOYSA-N 2-methylidene-1,3-dioxane Chemical compound C=C1OCCCO1 PWKDHWCKSUMJID-UHFFFAOYSA-N 0.000 claims 1
- AVUFZLGLMCACRE-UHFFFAOYSA-N 2-methylidene-1,3-dioxepane Chemical compound C=C1OCCCCO1 AVUFZLGLMCACRE-UHFFFAOYSA-N 0.000 claims 1
- VHMYBWIOLGKSHO-UHFFFAOYSA-N 2-methylidene-1,3-dioxolane Chemical compound C=C1OCCO1 VHMYBWIOLGKSHO-UHFFFAOYSA-N 0.000 claims 1
- FHTWQMHOTBIHEP-UHFFFAOYSA-N 2-methylidene-4-phenyl-1,3-dioxolane Chemical compound O1C(=C)OCC1C1=CC=CC=C1 FHTWQMHOTBIHEP-UHFFFAOYSA-N 0.000 claims 1
- NTVCIOGUJHBVBO-UHFFFAOYSA-N 4,5-dihydro-3h-dioxepine Chemical compound C1COOC=CC1 NTVCIOGUJHBVBO-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 208000022211 Arteriovenous Malformations Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 239000004971 Cross linker Substances 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108091027757 Deoxyribozyme Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 208000018525 Postpartum Hemorrhage Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 230000005744 arteriovenous malformation Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- 229940097362 cyclodextrins Drugs 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 208000001780 epistaxis Diseases 0.000 claims 1
- DUDCYUDPBRJVLG-UHFFFAOYSA-N ethoxyethane methyl 2-methylprop-2-enoate Chemical compound CCOCC.COC(=O)C(C)=C DUDCYUDPBRJVLG-UHFFFAOYSA-N 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 1
- 238000009499 grossing Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 229920002521 macromolecule Polymers 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 208000011309 nasal bleeding Diseases 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- 229920001690 polydopamine Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 230000009759 skin aging Effects 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- SJMYWORNLPSJQO-UHFFFAOYSA-N tert-butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)(C)C SJMYWORNLPSJQO-UHFFFAOYSA-N 0.000 claims 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450733P | 2011-03-09 | 2011-03-09 | |
| EP11305253.4 | 2011-03-09 | ||
| US61/450,733 | 2011-03-09 | ||
| EP11305253 | 2011-03-09 | ||
| PCT/EP2012/054178 WO2012120139A1 (en) | 2011-03-09 | 2012-03-09 | Implantable bio-resorbable polymer charged with fragile macromolecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511427A JP2014511427A (ja) | 2014-05-15 |
| JP2014511427A5 true JP2014511427A5 (enExample) | 2015-04-30 |
| JP6063876B2 JP6063876B2 (ja) | 2017-01-18 |
Family
ID=44278759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557127A Active JP6063876B2 (ja) | 2011-03-09 | 2012-03-09 | 不安定な高分子を担持した移植用生体吸収性ポリマー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10064948B2 (enExample) |
| EP (1) | EP2683753B1 (enExample) |
| JP (1) | JP6063876B2 (enExample) |
| AU (1) | AU2012224525B2 (enExample) |
| ES (1) | ES2601211T3 (enExample) |
| WO (1) | WO2012120139A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| US20160166701A1 (en) * | 2013-07-05 | 2016-06-16 | Therakine Biodelivery Gmbh | Delivery composition for topical applications and injections and ophthalmic formulations, methods for manufacturing thereof, and methods for delivery of a drug-delivery composition |
| WO2015017519A1 (en) | 2013-07-30 | 2015-02-05 | Phaserx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
| CA2940955C (en) * | 2014-02-26 | 2022-03-15 | University Of Massachusetts Medical School | Amphiphilic degradable polymers for immobilization and sustained delivery of biomolecules |
| AU2016372321B2 (en) * | 2015-12-18 | 2019-01-24 | Samyang Holdings Corporation | Method for preparing polymeric micelle containing anionic drug |
| GB201613970D0 (en) * | 2016-08-15 | 2016-09-28 | Xeros Ltd | Method for applying a treatment agent to a substrate |
| WO2018126084A1 (en) * | 2016-12-30 | 2018-07-05 | Phaserx, Inc. | Branched peg molecules and related compositions and methods |
| CN109666106A (zh) * | 2018-12-28 | 2019-04-23 | 河南省科学院能源研究所有限公司 | 一种具有近红外响应温度敏感特性的水凝胶复合材料及其制备方法 |
| WO2021069527A1 (fr) | 2019-10-07 | 2021-04-15 | Guerbet | Microsphere d'embolisation non degradable |
| CN114555659B (zh) * | 2019-10-07 | 2024-09-20 | 法国加栢 | 不可降解的不透射线栓塞微球 |
| CN111450308B (zh) * | 2020-06-09 | 2021-07-13 | 北京化工大学 | 一种多功能止血海绵及其制备方法与应用 |
| DK4167957T3 (da) * | 2020-06-19 | 2025-01-20 | Re Vana Therapeutics Ltd | Biologisk nedbrydelige sammensætninger og implantater |
| EP3936112A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for delivering buprenorphine |
| EP3936114A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for local delivering of glycopeptide antibiotics and polycationic peptide antibiotics |
| EP4299080A1 (fr) | 2022-06-28 | 2024-01-03 | Guerbet | Monomère radio-opaque et microsphères d'embolisation le comprenant |
| EP4534196A1 (en) * | 2023-10-06 | 2025-04-09 | Nouryon Chemicals International B.V. | Biodegradable core-shell microspheres |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9306038A (pt) * | 1992-02-28 | 1998-01-13 | Univ Texas | Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada |
| US20080131512A1 (en) | 1996-07-01 | 2008-06-05 | Wilhelmus Everhardus Hennink | Biodegradable hydrogels |
| JPH10174711A (ja) * | 1996-09-23 | 1998-06-30 | Focal Inc | コンプライアントな組織シーラント |
| US5854382A (en) * | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
| KR100727219B1 (ko) * | 2004-11-08 | 2007-06-13 | 주식회사 엘지화학 | (메타)아크릴 시럽의 제조 방법 |
| JP2006232890A (ja) * | 2005-02-22 | 2006-09-07 | National Institute Of Advanced Industrial & Technology | 吸水性を有する生分解性架橋ポリマー及びその製造方法 |
| EP2295480A1 (en) | 2009-09-10 | 2011-03-16 | Occlugel | Implantable bio-resorbable polymer |
-
2012
- 2012-03-09 WO PCT/EP2012/054178 patent/WO2012120139A1/en not_active Ceased
- 2012-03-09 JP JP2013557127A patent/JP6063876B2/ja active Active
- 2012-03-09 US US14/003,528 patent/US10064948B2/en active Active
- 2012-03-09 EP EP12707631.3A patent/EP2683753B1/en active Active
- 2012-03-09 ES ES12707631.3T patent/ES2601211T3/es active Active
- 2012-03-09 AU AU2012224525A patent/AU2012224525B2/en active Active
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