JP2014511426A5 - - Google Patents
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- JP2014511426A5 JP2014511426A5 JP2013557126A JP2013557126A JP2014511426A5 JP 2014511426 A5 JP2014511426 A5 JP 2014511426A5 JP 2013557126 A JP2013557126 A JP 2013557126A JP 2013557126 A JP2013557126 A JP 2013557126A JP 2014511426 A5 JP2014511426 A5 JP 2014511426A5
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- 229920000642 polymer Polymers 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims 17
- 229920001223 polyethylene glycol Polymers 0.000 claims 10
- 229920001400 block copolymer Polymers 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000004122 cyclic group Chemical group 0.000 claims 6
- -1 t-butylaminoethyl (methyl) acrylate Chemical compound 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 239000004971 Cross linker Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000007943 implant Substances 0.000 claims 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000012986 chain transfer agent Substances 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 3
- 230000000379 polymerizing effect Effects 0.000 claims 3
- 239000012798 spherical particle Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- JIFCOORMJVPBTN-UHFFFAOYSA-N 2-methylidene-1,3,6-trioxocane Chemical compound C=C1OCCOCCO1 JIFCOORMJVPBTN-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960004357 chloramphenicol succinate Drugs 0.000 claims 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229920001427 mPEG Polymers 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 230000017423 tissue regeneration Effects 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- LMAUULKNZLEMGN-UHFFFAOYSA-N 1-ethyl-3,5-dimethylbenzene Chemical compound CCC1=CC(C)=CC(C)=C1 LMAUULKNZLEMGN-UHFFFAOYSA-N 0.000 claims 1
- VDNJGYSBTLOSGU-UHFFFAOYSA-N 2-(diethylamino)prop-2-enoic acid Chemical compound CCN(CC)C(=C)C(O)=O VDNJGYSBTLOSGU-UHFFFAOYSA-N 0.000 claims 1
- PWKDHWCKSUMJID-UHFFFAOYSA-N 2-methylidene-1,3-dioxane Chemical compound C=C1OCCCO1 PWKDHWCKSUMJID-UHFFFAOYSA-N 0.000 claims 1
- AVUFZLGLMCACRE-UHFFFAOYSA-N 2-methylidene-1,3-dioxepane Chemical compound C=C1OCCCCO1 AVUFZLGLMCACRE-UHFFFAOYSA-N 0.000 claims 1
- VHMYBWIOLGKSHO-UHFFFAOYSA-N 2-methylidene-1,3-dioxolane Chemical compound C=C1OCCO1 VHMYBWIOLGKSHO-UHFFFAOYSA-N 0.000 claims 1
- FHTWQMHOTBIHEP-UHFFFAOYSA-N 2-methylidene-4-phenyl-1,3-dioxolane Chemical compound O1C(=C)OCC1C1=CC=CC=C1 FHTWQMHOTBIHEP-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 208000022211 Arteriovenous Malformations Diseases 0.000 claims 1
- LIRCDOVJWUGTMW-ZWNOBZJWSA-N Chloramphenicol succinate Chemical compound OC(=O)CCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 LIRCDOVJWUGTMW-ZWNOBZJWSA-N 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000008450 Intracranial aneurysm Diseases 0.000 claims 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018525 Postpartum Hemorrhage Diseases 0.000 claims 1
- 208000037534 Progressive hemifacial atrophy Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000005744 arteriovenous malformation Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- PFOLLRNADZZWEX-FFGRCDKISA-N bacampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)[C@H](C(S3)(C)C)C(=O)OC(C)OC(=O)OCC)=CC=CC=C1 PFOLLRNADZZWEX-FFGRCDKISA-N 0.000 claims 1
- 229960002699 bacampicillin Drugs 0.000 claims 1
- 229960005274 benzocaine Drugs 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 229960000956 coumarin Drugs 0.000 claims 1
- 235000001671 coumarin Nutrition 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- 229940097362 cyclodextrins Drugs 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229960001259 diclofenac Drugs 0.000 claims 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 208000001780 epistaxis Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- DUDCYUDPBRJVLG-UHFFFAOYSA-N ethoxyethane methyl 2-methylprop-2-enoate Chemical compound CCOCC.COC(=O)C(C)=C DUDCYUDPBRJVLG-UHFFFAOYSA-N 0.000 claims 1
- 208000002980 facial hemiatrophy Diseases 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 238000009499 grossing Methods 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 229960004857 mitomycin Drugs 0.000 claims 1
- 239000002088 nanocapsule Substances 0.000 claims 1
- 239000002077 nanosphere Substances 0.000 claims 1
- 229940053973 novocaine Drugs 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 229960001807 prilocaine Drugs 0.000 claims 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims 1
- 229960004134 propofol Drugs 0.000 claims 1
- 230000009759 skin aging Effects 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- SJMYWORNLPSJQO-UHFFFAOYSA-N tert-butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)(C)C SJMYWORNLPSJQO-UHFFFAOYSA-N 0.000 claims 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000707 tobramycin Drugs 0.000 claims 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 229940072358 xylocaine Drugs 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450725P | 2011-03-09 | 2011-03-09 | |
| US61/450,725 | 2011-03-09 | ||
| EP11305254.2 | 2011-03-09 | ||
| EP11305254 | 2011-03-09 | ||
| PCT/EP2012/054177 WO2012120138A1 (en) | 2011-03-09 | 2012-03-09 | Implantable swellable bio-resorbable polymer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511426A JP2014511426A (ja) | 2014-05-15 |
| JP2014511426A5 true JP2014511426A5 (enExample) | 2016-01-21 |
| JP6078480B2 JP6078480B2 (ja) | 2017-02-08 |
Family
ID=44318232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557126A Active JP6078480B2 (ja) | 2011-03-09 | 2012-03-09 | 移植可能な膨潤性生体吸収性ポリマー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9320806B2 (enExample) |
| EP (1) | EP2683750B1 (enExample) |
| JP (1) | JP6078480B2 (enExample) |
| AU (1) | AU2012224524B2 (enExample) |
| ES (1) | ES2632769T3 (enExample) |
| WO (1) | WO2012120138A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8377091B2 (en) | 2006-06-15 | 2013-02-19 | Microvention, Inc. | Embolization device constructed from expansile polymer |
| CN101903051B (zh) | 2007-12-21 | 2013-07-31 | 微温森公司 | 用于生物医药用途的水凝胶细丝 |
| US10716573B2 (en) | 2008-05-01 | 2020-07-21 | Aneuclose | Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm |
| US10028747B2 (en) | 2008-05-01 | 2018-07-24 | Aneuclose Llc | Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm |
| US10639396B2 (en) | 2015-06-11 | 2020-05-05 | Microvention, Inc. | Polymers |
| BRPI1014645B1 (pt) | 2009-04-30 | 2020-07-07 | Technip France | método e sistema para compartilhar linhas de amarração |
| CN102791183B (zh) | 2009-10-26 | 2015-07-08 | 微排放器公司 | 由可膨胀的聚合物构成的栓塞装置 |
| US9358140B1 (en) | 2009-11-18 | 2016-06-07 | Aneuclose Llc | Stent with outer member to embolize an aneurysm |
| WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
| WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
| CN110279885B (zh) | 2013-09-19 | 2022-07-26 | 泰尔茂株式会社 | 聚合物颗粒 |
| BR112016005768B1 (pt) | 2013-09-19 | 2021-09-21 | Microvention, Inc | Películas de polímero |
| BR112016010067B1 (pt) | 2013-11-08 | 2023-01-10 | Terumo Corporation | Partículas de polímero e métodos de preparação |
| WO2015153996A1 (en) | 2014-04-03 | 2015-10-08 | Micro Vention, Inc. | Embolic devices |
| US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
| JP6599361B2 (ja) * | 2014-04-29 | 2019-10-30 | マイクロベンション インコーポレイテッド | 活性剤を含むポリマー |
| US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
| US10376469B2 (en) | 2016-02-17 | 2019-08-13 | Biosphere Medical, Inc. | Microspheres containing therapeutic agents and related methods of use |
| KR102310696B1 (ko) | 2016-09-28 | 2021-10-12 | 테루모 가부시키가이샤 | 색전 조성물 |
| WO2019035975A1 (en) * | 2017-08-16 | 2019-02-21 | Biosphere Medical, Inc. | MICROSPHERES CONTAINING THERAPEUTIC AGENTS AND ASSOCIATED METHODS OF USE |
| WO2021069528A1 (fr) | 2019-10-07 | 2021-04-15 | Guerbet | Microsphere d'embolisation non degradable radio-opaque |
| EP4041318A1 (fr) | 2019-10-07 | 2022-08-17 | Guerbet | Microsphere d'embolisation non degradable |
| JP2022553490A (ja) * | 2019-10-11 | 2022-12-23 | ナンヤン・テクノロジカル・ユニバーシティー | 分解性高分子材料 |
| CN113209370B (zh) * | 2020-01-21 | 2023-11-28 | 渼颜空间(河北)生物科技有限公司 | 可生物降解的注射填充物及其制备方法和其应用 |
| EP3936113A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microsphere for delivering travoprost |
| EP3936114A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for local delivering of glycopeptide antibiotics and polycationic peptide antibiotics |
| EP3936112A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for delivering buprenorphine |
| WO2022187725A1 (en) * | 2021-03-05 | 2022-09-09 | Sensorium Bio Inc. | Cell culture system and methods of using |
| DE102022200882A1 (de) | 2022-01-26 | 2023-07-27 | Henkel Ag & Co. Kgaa | Polymere schmutzablösevermögende Wirkstoffe |
| DE102022200881A1 (de) | 2022-01-26 | 2023-07-27 | Henkel Ag & Co. Kgaa | Farbschützende Waschmittel |
| CN114957588B (zh) * | 2022-06-28 | 2023-10-24 | 瑞聚再生(厦门)医学科技有限公司 | 一种可生物吸收神经支架及其制备方法 |
| EP4299080A1 (fr) | 2022-06-28 | 2024-01-03 | Guerbet | Monomère radio-opaque et microsphères d'embolisation le comprenant |
| JP2024142376A (ja) * | 2023-03-30 | 2024-10-11 | 国立大学法人福井大学 | 重合性組成物、共重合体、共重合体の製造方法及び共重合体製造用キット |
| CN116747349B (zh) * | 2023-06-01 | 2025-12-05 | 广州远想医学生物技术有限公司 | 一种注射用多孔微球、其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10174711A (ja) * | 1996-09-23 | 1998-06-30 | Focal Inc | コンプライアントな組織シーラント |
| US6153211A (en) * | 1997-07-18 | 2000-11-28 | Infimed, Inc. | Biodegradable macromers for the controlled release of biologically active substances |
| US20070155926A1 (en) | 2003-03-28 | 2007-07-05 | Krzysztof Matyjaszewski | Degradable polymers |
| JP2006232890A (ja) * | 2005-02-22 | 2006-09-07 | National Institute Of Advanced Industrial & Technology | 吸水性を有する生分解性架橋ポリマー及びその製造方法 |
| US20070031499A1 (en) * | 2005-07-28 | 2007-02-08 | Huh Kang M | Readily shapeable xerogels having controllably delayed swelling properties |
| AU2006292752A1 (en) * | 2005-09-15 | 2007-03-29 | University Of Utah Research Foundation | Polymeric compositions and methods of making and using thereof |
| JP4879554B2 (ja) * | 2005-10-21 | 2012-02-22 | 株式会社メニコン | ポストインプリント可能なヒドロゲル材料の製造方法 |
| US20080275139A1 (en) | 2005-12-19 | 2008-11-06 | Capsutech Ltd. | Cyclodextrin-Containing Polymers and Uses Thereof |
| US20080199510A1 (en) * | 2007-02-20 | 2008-08-21 | Xtent, Inc. | Thermo-mechanically controlled implants and methods of use |
| US8277832B2 (en) | 2007-10-10 | 2012-10-02 | The University Of Kansas | Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals |
| WO2009132206A1 (en) | 2008-04-25 | 2009-10-29 | Liquidia Technologies, Inc. | Compositions and methods for intracellular delivery and release of cargo |
| CN102098973B (zh) * | 2008-07-15 | 2013-08-14 | 皇家飞利浦电子股份有限公司 | 用于安全消融的设备、系统和方法 |
| EP2295480A1 (en) | 2009-09-10 | 2011-03-16 | Occlugel | Implantable bio-resorbable polymer |
-
2012
- 2012-03-09 AU AU2012224524A patent/AU2012224524B2/en active Active
- 2012-03-09 EP EP12707789.9A patent/EP2683750B1/en active Active
- 2012-03-09 JP JP2013557126A patent/JP6078480B2/ja active Active
- 2012-03-09 WO PCT/EP2012/054177 patent/WO2012120138A1/en not_active Ceased
- 2012-03-09 US US14/003,514 patent/US9320806B2/en active Active
- 2012-03-09 ES ES12707789.9T patent/ES2632769T3/es active Active
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