JP6078480B2 - 移植可能な膨潤性生体吸収性ポリマー - Google Patents

移植可能な膨潤性生体吸収性ポリマー Download PDF

Info

Publication number
JP6078480B2
JP6078480B2 JP2013557126A JP2013557126A JP6078480B2 JP 6078480 B2 JP6078480 B2 JP 6078480B2 JP 2013557126 A JP2013557126 A JP 2013557126A JP 2013557126 A JP2013557126 A JP 2013557126A JP 6078480 B2 JP6078480 B2 JP 6078480B2
Authority
JP
Japan
Prior art keywords
polymer
group
monomer
drug
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013557126A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014511426A (ja
JP2014511426A5 (enExample
Inventor
モワンヌ、ロランス
ローラン、アレクサンドル
ワセフ、ミッシェル
ベドゥエ、ローラン
ルゲ、ステファニー
ベレ、ヴァレンティン
セルヴァイス、エメライン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assistance Publique Hopitaux de Paris APHP
Original Assignee
Assistance Publique Hopitaux de Paris APHP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique Hopitaux de Paris APHP filed Critical Assistance Publique Hopitaux de Paris APHP
Publication of JP2014511426A publication Critical patent/JP2014511426A/ja
Publication of JP2014511426A5 publication Critical patent/JP2014511426A5/ja
Application granted granted Critical
Publication of JP6078480B2 publication Critical patent/JP6078480B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1807—C7-(meth)acrylate, e.g. heptyl (meth)acrylate or benzyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1811—C10or C11-(Meth)acrylate, e.g. isodecyl (meth)acrylate, isobornyl (meth)acrylate or 2-naphthyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • C08F222/1025—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate of aromatic dialcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F224/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
JP2013557126A 2011-03-09 2012-03-09 移植可能な膨潤性生体吸収性ポリマー Active JP6078480B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161450725P 2011-03-09 2011-03-09
US61/450,725 2011-03-09
EP11305254 2011-03-09
EP11305254.2 2011-03-09
PCT/EP2012/054177 WO2012120138A1 (en) 2011-03-09 2012-03-09 Implantable swellable bio-resorbable polymer

Publications (3)

Publication Number Publication Date
JP2014511426A JP2014511426A (ja) 2014-05-15
JP2014511426A5 JP2014511426A5 (enExample) 2016-01-21
JP6078480B2 true JP6078480B2 (ja) 2017-02-08

Family

ID=44318232

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013557126A Active JP6078480B2 (ja) 2011-03-09 2012-03-09 移植可能な膨潤性生体吸収性ポリマー

Country Status (6)

Country Link
US (1) US9320806B2 (enExample)
EP (1) EP2683750B1 (enExample)
JP (1) JP6078480B2 (enExample)
AU (1) AU2012224524B2 (enExample)
ES (1) ES2632769T3 (enExample)
WO (1) WO2012120138A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
CN101903051B (zh) 2007-12-21 2013-07-31 微温森公司 用于生物医药用途的水凝胶细丝
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
BRPI1014645B1 (pt) 2009-04-30 2020-07-07 Technip France método e sistema para compartilhar linhas de amarração
AU2010313530B2 (en) 2009-10-26 2015-12-17 Microvention, Inc. Embolization device constructed from expansile polymer
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
CA2923753C (en) 2013-09-19 2021-10-12 Terumo Corporation Polymer particles
BR112016005768B1 (pt) 2013-09-19 2021-09-21 Microvention, Inc Películas de polímero
EP3065719A4 (en) 2013-11-08 2017-08-09 Terumo Corporation Polymer particles
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
CN110433326A (zh) * 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
EP3416626A4 (en) 2016-02-17 2019-10-30 Biosphere Medical, Inc. MICRO BEARINGS AS THERAPEUTIC COMPOUNDS AND ASSOCIATED METHODS OF USE
CA3038642C (en) 2016-09-28 2021-11-02 Terumo Corporation Polymer particles comprising polymerizable pharmaceutical agents
EP3668491A4 (en) 2017-08-16 2021-06-16 Biosphere Medical, Inc. MICROBALLS AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE
CN114555659B (zh) * 2019-10-07 2024-09-20 法国加栢 不可降解的不透射线栓塞微球
WO2021069527A1 (fr) 2019-10-07 2021-04-15 Guerbet Microsphere d'embolisation non degradable
WO2021071432A1 (en) * 2019-10-11 2021-04-15 Nanyang Technological University Degradable polymeric materials
CN113209370B (zh) * 2020-01-21 2023-11-28 渼颜空间(河北)生物科技有限公司 可生物降解的注射填充物及其制备方法和其应用
EP3936114A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microspheres for local delivering of glycopeptide antibiotics and polycationic peptide antibiotics
EP3936112A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microspheres for delivering buprenorphine
EP3936113A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microsphere for delivering travoprost
WO2022187725A1 (en) * 2021-03-05 2022-09-09 Sensorium Bio Inc. Cell culture system and methods of using
DE102022200882A1 (de) 2022-01-26 2023-07-27 Henkel Ag & Co. Kgaa Polymere schmutzablösevermögende Wirkstoffe
DE102022200881A1 (de) 2022-01-26 2023-07-27 Henkel Ag & Co. Kgaa Farbschützende Waschmittel
EP4299080A1 (fr) 2022-06-28 2024-01-03 Guerbet Monomère radio-opaque et microsphères d'embolisation le comprenant
CN114957588B (zh) * 2022-06-28 2023-10-24 瑞聚再生(厦门)医学科技有限公司 一种可生物吸收神经支架及其制备方法
JP2024142376A (ja) * 2023-03-30 2024-10-11 国立大学法人福井大学 重合性組成物、共重合体、共重合体の製造方法及び共重合体製造用キット
CN116747349B (zh) * 2023-06-01 2025-12-05 广州远想医学生物技术有限公司 一种注射用多孔微球、其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10174711A (ja) * 1996-09-23 1998-06-30 Focal Inc コンプライアントな組織シーラント
US6153211A (en) * 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
WO2004087777A2 (en) * 2003-03-28 2004-10-14 Carnegie Mellon University Degradable polymers
JP2006232890A (ja) * 2005-02-22 2006-09-07 National Institute Of Advanced Industrial & Technology 吸水性を有する生分解性架橋ポリマー及びその製造方法
WO2007016371A2 (en) * 2005-07-28 2007-02-08 Akina, Inc. Readily shapeable xerogels having controllably delayed swelling properties
EP1934265A4 (en) * 2005-09-15 2009-06-24 Univ Utah Res Found POLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME
JP4879554B2 (ja) * 2005-10-21 2012-02-22 株式会社メニコン ポストインプリント可能なヒドロゲル材料の製造方法
US20080275139A1 (en) 2005-12-19 2008-11-06 Capsutech Ltd. Cyclodextrin-Containing Polymers and Uses Thereof
US20080199510A1 (en) * 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
US8277832B2 (en) 2007-10-10 2012-10-02 The University Of Kansas Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
WO2009132206A1 (en) * 2008-04-25 2009-10-29 Liquidia Technologies, Inc. Compositions and methods for intracellular delivery and release of cargo
CN102098973B (zh) * 2008-07-15 2013-08-14 皇家飞利浦电子股份有限公司 用于安全消融的设备、系统和方法
EP2295480A1 (en) 2009-09-10 2011-03-16 Occlugel Implantable bio-resorbable polymer

Also Published As

Publication number Publication date
AU2012224524B2 (en) 2016-03-31
JP2014511426A (ja) 2014-05-15
ES2632769T3 (es) 2017-09-15
AU2012224524A1 (en) 2013-09-26
EP2683750A1 (en) 2014-01-15
US9320806B2 (en) 2016-04-26
US20130344159A1 (en) 2013-12-26
WO2012120138A1 (en) 2012-09-13
EP2683750B1 (en) 2017-04-19

Similar Documents

Publication Publication Date Title
JP6078480B2 (ja) 移植可能な膨潤性生体吸収性ポリマー
JP5792729B2 (ja) 移植可能な生体吸収性ポリマー
Abasalizadeh et al. Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting
Malikmammadov et al. PCL and PCL-based materials in biomedical applications
Kim et al. Stimuli-responsive injectable in situ-forming hydrogels for regenerative medicines
CN112266368B (zh) 光交联水凝胶材料的制备、原料、产品及应用
Ren et al. Effective bone regeneration using thermosensitive poly (N-isopropylacrylamide) grafted gelatin as injectable carrier for bone mesenchymal stem cells
Dash et al. Chitosan—A versatile semi-synthetic polymer in biomedical applications
US10064948B2 (en) Implantable bio-resorbable polymer charged with fragile macromolecules
CN112384258A (zh) 用于细胞和组织递送的纳米纤维-水凝胶复合物
US20120063997A1 (en) Delivery system with scaffolds
KR20160098343A (ko) 조직표면 및 재료의 부착 방법 및 이의 생물의학적 용도
JP2014511426A5 (enExample)
WO2010127254A2 (en) Thermoresponsive, biodegradable, elastomeric material and uses therefor
Chiang et al. A smart injectable composite hydrogel with magnetic navigation and controlled glutathione release for promoting in situ chondrocyte array and self-healing in damaged cartilage tissue
Banerjee et al. Interpenetrating polymer network (IPN): a novel biomaterial
Luckanagul et al. Thermo-responsive polymers and their application as smart biomaterials
Yadav et al. Comprehensive Exploration on Chemical Functionalization and Crosslinked Injectable Hyaluronic Acid Hydrogels for Tissue Engineering Applications
CA3143568A1 (en) Crosslinkable hydrogel compositions
Fazljou et al. Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting
PHUL et al. Physical, Chemical and Biological Properties of Injectable Smart Hydrogels
WO2024030660A2 (en) Cholesterol-modified hyaluronic acids
Kondiah Design and Development of a Novel 3D Bioprinted Bone Tissue Engineered Drug Delivery Scaffold for the Treatment of Bone Fractures
HK40046056A (en) Nanofiber-hydrogel composites for cell and tissue delivery
Klouda Development of a Thermoresponsive and Chemically Crosslinkable Hydrogel System for Craniofacial Bone Tissue Engineering

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150309

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150309

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150724

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151118

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20151118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160419

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160707

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160920

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160920

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20161220

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170116

R150 Certificate of patent or registration of utility model

Ref document number: 6078480

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313115

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250