ES2632769T3 - Polímero biorreabsorbible hinchable implantable - Google Patents

Polímero biorreabsorbible hinchable implantable Download PDF

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Publication number
ES2632769T3
ES2632769T3 ES12707789.9T ES12707789T ES2632769T3 ES 2632769 T3 ES2632769 T3 ES 2632769T3 ES 12707789 T ES12707789 T ES 12707789T ES 2632769 T3 ES2632769 T3 ES 2632769T3
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ES
Spain
Prior art keywords
mol
independently represent
formula
advantageously
monomer
Prior art date
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Active
Application number
ES12707789.9T
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English (en)
Spanish (es)
Inventor
Laurence Moine
Alexandre Laurent
Michel Wassef
Laurent Bedouet
Stéphanie LOUGUET
Valentin VERRET
Emeline SERVAIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Assistance Publique - Hôpitaux de Paris
Université Paris Diderot - Paris 7
OCCLUGEL
Original Assignee
Centre National de la Recherche Scientifique
Assistance Publique - Hôpitaux de Paris
Université Paris Diderot - Paris 7
OCCLUGEL
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1807—C7-(meth)acrylate, e.g. heptyl (meth)acrylate or benzyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1811—C10or C11-(Meth)acrylate, e.g. isodecyl (meth)acrylate, isobornyl (meth)acrylate or 2-naphthyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • C08F222/1025—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate of aromatic dialcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F224/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES12707789.9T 2011-03-09 2012-03-09 Polímero biorreabsorbible hinchable implantable Active ES2632769T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161450725P 2011-03-09 2011-03-09
EP11305254 2011-03-09
US201161450725P 2011-03-09
EP11305254 2011-03-09
PCT/EP2012/054177 WO2012120138A1 (en) 2011-03-09 2012-03-09 Implantable swellable bio-resorbable polymer

Publications (1)

Publication Number Publication Date
ES2632769T3 true ES2632769T3 (es) 2017-09-15

Family

ID=44318232

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12707789.9T Active ES2632769T3 (es) 2011-03-09 2012-03-09 Polímero biorreabsorbible hinchable implantable

Country Status (6)

Country Link
US (1) US9320806B2 (enExample)
EP (1) EP2683750B1 (enExample)
JP (1) JP6078480B2 (enExample)
AU (1) AU2012224524B2 (enExample)
ES (1) ES2632769T3 (enExample)
WO (1) WO2012120138A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
CN101903051B (zh) 2007-12-21 2013-07-31 微温森公司 用于生物医药用途的水凝胶细丝
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
BRPI1014645B1 (pt) 2009-04-30 2020-07-07 Technip France método e sistema para compartilhar linhas de amarração
CN102791183B (zh) 2009-10-26 2015-07-08 微排放器公司 由可膨胀的聚合物构成的栓塞装置
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
CN110279885B (zh) 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
BR112016005768B1 (pt) 2013-09-19 2021-09-21 Microvention, Inc Películas de polímero
BR112016010067B1 (pt) 2013-11-08 2023-01-10 Terumo Corporation Partículas de polímero e métodos de preparação
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
JP6599361B2 (ja) * 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド 活性剤を含むポリマー
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
US10376469B2 (en) 2016-02-17 2019-08-13 Biosphere Medical, Inc. Microspheres containing therapeutic agents and related methods of use
KR102310696B1 (ko) 2016-09-28 2021-10-12 테루모 가부시키가이샤 색전 조성물
WO2019035975A1 (en) * 2017-08-16 2019-02-21 Biosphere Medical, Inc. MICROSPHERES CONTAINING THERAPEUTIC AGENTS AND ASSOCIATED METHODS OF USE
WO2021069528A1 (fr) 2019-10-07 2021-04-15 Guerbet Microsphere d'embolisation non degradable radio-opaque
EP4041318A1 (fr) 2019-10-07 2022-08-17 Guerbet Microsphere d'embolisation non degradable
JP2022553490A (ja) * 2019-10-11 2022-12-23 ナンヤン・テクノロジカル・ユニバーシティー 分解性高分子材料
CN113209370B (zh) * 2020-01-21 2023-11-28 渼颜空间(河北)生物科技有限公司 可生物降解的注射填充物及其制备方法和其应用
EP3936113A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microsphere for delivering travoprost
EP3936114A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microspheres for local delivering of glycopeptide antibiotics and polycationic peptide antibiotics
EP3936112A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microspheres for delivering buprenorphine
WO2022187725A1 (en) * 2021-03-05 2022-09-09 Sensorium Bio Inc. Cell culture system and methods of using
DE102022200882A1 (de) 2022-01-26 2023-07-27 Henkel Ag & Co. Kgaa Polymere schmutzablösevermögende Wirkstoffe
DE102022200881A1 (de) 2022-01-26 2023-07-27 Henkel Ag & Co. Kgaa Farbschützende Waschmittel
CN114957588B (zh) * 2022-06-28 2023-10-24 瑞聚再生(厦门)医学科技有限公司 一种可生物吸收神经支架及其制备方法
EP4299080A1 (fr) 2022-06-28 2024-01-03 Guerbet Monomère radio-opaque et microsphères d'embolisation le comprenant
JP2024142376A (ja) * 2023-03-30 2024-10-11 国立大学法人福井大学 重合性組成物、共重合体、共重合体の製造方法及び共重合体製造用キット
CN116747349B (zh) * 2023-06-01 2025-12-05 广州远想医学生物技术有限公司 一种注射用多孔微球、其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10174711A (ja) * 1996-09-23 1998-06-30 Focal Inc コンプライアントな組織シーラント
US6153211A (en) * 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
US20070155926A1 (en) 2003-03-28 2007-07-05 Krzysztof Matyjaszewski Degradable polymers
JP2006232890A (ja) * 2005-02-22 2006-09-07 National Institute Of Advanced Industrial & Technology 吸水性を有する生分解性架橋ポリマー及びその製造方法
US20070031499A1 (en) * 2005-07-28 2007-02-08 Huh Kang M Readily shapeable xerogels having controllably delayed swelling properties
AU2006292752A1 (en) * 2005-09-15 2007-03-29 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
JP4879554B2 (ja) * 2005-10-21 2012-02-22 株式会社メニコン ポストインプリント可能なヒドロゲル材料の製造方法
US20080275139A1 (en) 2005-12-19 2008-11-06 Capsutech Ltd. Cyclodextrin-Containing Polymers and Uses Thereof
US20080199510A1 (en) * 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
US8277832B2 (en) 2007-10-10 2012-10-02 The University Of Kansas Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
WO2009132206A1 (en) 2008-04-25 2009-10-29 Liquidia Technologies, Inc. Compositions and methods for intracellular delivery and release of cargo
CN102098973B (zh) * 2008-07-15 2013-08-14 皇家飞利浦电子股份有限公司 用于安全消融的设备、系统和方法
EP2295480A1 (en) 2009-09-10 2011-03-16 Occlugel Implantable bio-resorbable polymer

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Publication number Publication date
AU2012224524A1 (en) 2013-09-26
US20130344159A1 (en) 2013-12-26
AU2012224524B2 (en) 2016-03-31
US9320806B2 (en) 2016-04-26
JP6078480B2 (ja) 2017-02-08
WO2012120138A1 (en) 2012-09-13
EP2683750A1 (en) 2014-01-15
JP2014511426A (ja) 2014-05-15
EP2683750B1 (en) 2017-04-19

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