JP2014509511A5 - - Google Patents
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- Publication number
- JP2014509511A5 JP2014509511A5 JP2013556834A JP2013556834A JP2014509511A5 JP 2014509511 A5 JP2014509511 A5 JP 2014509511A5 JP 2013556834 A JP2013556834 A JP 2013556834A JP 2013556834 A JP2013556834 A JP 2013556834A JP 2014509511 A5 JP2014509511 A5 JP 2014509511A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- double
- seq
- acid molecule
- stranded nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 14
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 6
- 102100012096 TLR2 Human genes 0.000 claims 6
- 101700064022 TLR2 Proteins 0.000 claims 6
- 229920000272 Oligonucleotide Polymers 0.000 claims 5
- 230000000692 anti-sense Effects 0.000 claims 5
- 206010049460 Abasia Diseases 0.000 claims 4
- 229920000972 Sense strand Polymers 0.000 claims 4
- 230000000295 complement Effects 0.000 claims 4
- 229920003028 Threose nucleic acid Polymers 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- DWRXFEITVBNRMK-JXOAFFINSA-N 5-Methyluridine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 DWRXFEITVBNRMK-JXOAFFINSA-N 0.000 claims 2
- OIRDTQYFTABQOQ-GAWUUDPSSA-N 9-β-D-XYLOFURANOSYL-ADENINE Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@H](O)[C@H]1O OIRDTQYFTABQOQ-GAWUUDPSSA-N 0.000 claims 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N DEOXYTHYMIDINE Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N Deoxyribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 2
- 108020004999 Messenger RNA Proteins 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010060872 Transplant failure Diseases 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 229920002106 messenger RNA Polymers 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims 2
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- OIRDTQYFTABQOQ-SXVXDFOESA-N Adenosine Natural products Nc1ncnc2c1ncn2[C@@H]3O[C@@H](CO)[C@H](O)[C@@H]3O OIRDTQYFTABQOQ-SXVXDFOESA-N 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010022114 Injury Diseases 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 208000004296 Neuralgia Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- PTJWIQPHWPFNBW-GBNDHIKLSA-N Pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims 1
- DRTQHJPVMGBUCF-UCVXFZOQSA-N Uridine Natural products O[C@H]1[C@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UCVXFZOQSA-N 0.000 claims 1
- 229940045145 Uridine Drugs 0.000 claims 1
- 230000001154 acute Effects 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000302 ischemic Effects 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 229920000023 polynucleotide Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448707P | 2011-03-03 | 2011-03-03 | |
| US61/448,707 | 2011-03-03 | ||
| PCT/US2012/027174 WO2012118911A1 (en) | 2011-03-03 | 2012-03-01 | Oligonucleotide modulators of the toll-like receptor pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017081112A Division JP6407347B2 (ja) | 2011-03-03 | 2017-04-17 | Ｔｏｌｌ様受容体経路のオリゴヌクレオチド修飾因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509511A JP2014509511A (ja) | 2014-04-21 |
| JP2014509511A5 true JP2014509511A5 (US07794700-20100914-C00152.png) | 2015-04-16 |
| JP6132775B2 JP6132775B2 (ja) | 2017-05-24 |
Family
ID=45816002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013556834A Expired - Fee Related JP6132775B2 (ja) | 2011-03-03 | 2012-03-01 | Ｔｏｌｌ様受容体経路のオリゴヌクレオチド修飾因子 |
| JP2017081112A Expired - Fee Related JP6407347B2 (ja) | 2011-03-03 | 2017-04-17 | Ｔｏｌｌ様受容体経路のオリゴヌクレオチド修飾因子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017081112A Expired - Fee Related JP6407347B2 (ja) | 2011-03-03 | 2017-04-17 | Ｔｏｌｌ様受容体経路のオリゴヌクレオチド修飾因子 |
Country Status (9)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2818662C (en) | 2010-10-22 | 2021-07-06 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid molecule inducing rna interference, and uses thereof |
| US9796979B2 (en) | 2011-03-03 | 2017-10-24 | Quark Pharmaceuticals Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| JP6000287B2 (ja) | 2011-03-03 | 2016-09-28 | クォーク ファーマシューティカルズ インコーポレーティッドＱｕａｒｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 肺疾患および損傷を治療するための組成物および方法 |
| WO2013169382A1 (en) * | 2012-05-07 | 2013-11-14 | DePuy Synthes Products, LLC | Methods and devices for treating intervertebral disc disease |
| KR101567576B1 (ko) | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| CN103757024B (zh) * | 2014-01-29 | 2015-10-28 | 中国人民解放军第二军医大学 | 一种干扰tlr4受体的小rna及其应用 |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| CN104450710B (zh) * | 2014-11-28 | 2018-06-05 | 广州市锐博生物科技有限公司 | 抑制myd88基因的寡聚核酸及其应用 |
| HUE057431T2 (hu) | 2015-04-03 | 2022-05-28 | Univ Massachusetts | Oligonukleotid vegyületek preeklampszia és más angiogén rendellenességek kezelésére |
| LT3277814T (lt) | 2015-04-03 | 2020-10-26 | University Of Massachusetts | Oligonukleotidų junginiai, skirti nukreipimui į hantingtino mrnr |
| US20180216114A1 (en) * | 2015-07-27 | 2018-08-02 | Alnylam Pharmaceuticals, Inc. | Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof |
| EP3334499A4 (en) | 2015-08-14 | 2019-04-17 | University of Massachusetts | BIOACTIVE CONJUGATES FOR THE RELEASE OF OLIGONUCLEOTIDES |
| WO2017037324A1 (es) * | 2015-09-04 | 2017-03-09 | Servicio Andaluz De Salud | Biomarcadores para la esclerosis lateral amiotrófica (ela) |
| CN108699556B (zh) * | 2015-11-16 | 2023-02-17 | 奥利克斯医药有限公司 | 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性 |
| AU2017210726B2 (en) | 2016-01-31 | 2023-08-03 | University Of Massachusetts | Branched oligonucleotides |
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| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| CN110770343A (zh) | 2017-02-10 | 2020-02-07 | 成均馆大学校产学协力团 | 用于rna干扰的长双链rna |
| WO2020011869A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting tlr2 |
| SG11202101288TA (en) | 2018-08-10 | 2021-03-30 | Univ Massachusetts | Modified oligonucleotides targeting snps |
| EP4168546A1 (en) | 2020-06-18 | 2023-04-26 | Alnylam Pharmaceuticals, Inc. | Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof |
| CA3174095A1 (en) | 2021-06-23 | 2022-12-29 | Vignesh Narayan HARIHARAN | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
| WO2023117738A1 (en) | 2021-12-20 | 2023-06-29 | F. Hoffmann-La Roche Ag | Threose nucleic acid antisense oligonucleotides and methods thereof |
| WO2024023254A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
| WO2024023256A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
| EP4332221A1 (en) | 2022-08-29 | 2024-03-06 | Roche Innovation Center Copenhagen A/S | Threose nucleic acid antisense oligonucleotides and methods thereof |
| WO2024126654A1 (en) | 2022-12-14 | 2024-06-20 | F. Hoffmann-La Roche Ag | Antisense oligonucleotides targeting actl6b |
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-
2012
- 2012-03-01 US US14/002,901 patent/US9487778B2/en active Active
- 2012-03-01 CN CN201280020460.XA patent/CN103562387A/zh active Pending
- 2012-03-01 WO PCT/US2012/027174 patent/WO2012118911A1/en active Application Filing
- 2012-03-01 AU AU2012223366A patent/AU2012223366B2/en not_active Ceased
- 2012-03-01 SG SG2013066220A patent/SG193280A1/en unknown
- 2012-03-01 CA CA2828544A patent/CA2828544A1/en not_active Abandoned
- 2012-03-01 SG SG10201604479YA patent/SG10201604479YA/en unknown
- 2012-03-01 EP EP12708475.4A patent/EP2681315B1/en not_active Not-in-force
- 2012-03-01 JP JP2013556834A patent/JP6132775B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-02 IL IL228260A patent/IL228260B/en active IP Right Grant
-
2017
- 2017-04-17 JP JP2017081112A patent/JP6407347B2/ja not_active Expired - Fee Related
