JP2014507664A5 - - Google Patents
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- JP2014507664A5 JP2014507664A5 JP2013555560A JP2013555560A JP2014507664A5 JP 2014507664 A5 JP2014507664 A5 JP 2014507664A5 JP 2013555560 A JP2013555560 A JP 2013555560A JP 2013555560 A JP2013555560 A JP 2013555560A JP 2014507664 A5 JP2014507664 A5 JP 2014507664A5
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- JP
- Japan
- Prior art keywords
- cytokinesis
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- hours
- minutes
- duration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000021953 cytokinesis Effects 0.000 claims 58
- 238000000034 method Methods 0.000 claims 17
- 208000036878 aneuploidy Diseases 0.000 claims 8
- 231100001075 aneuploidy Toxicity 0.000 claims 7
- 210000001161 mammalian embryo Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 238000013467 fragmentation Methods 0.000 claims 6
- 238000006062 fragmentation reaction Methods 0.000 claims 6
- 230000000394 mitotic effect Effects 0.000 claims 5
- 230000001413 cellular effect Effects 0.000 claims 3
- 210000000805 cytoplasm Anatomy 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 208000037280 Trisomy Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 208000030454 monosomy Diseases 0.000 claims 2
- 210000000287 oocyte Anatomy 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000019209 Monosomy 22 Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 230000003322 aneuploid effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000013020 embryo development Effects 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 238000002287 time-lapse microscopy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161445863P | 2011-02-23 | 2011-02-23 | |
| US61/445,863 | 2011-02-23 | ||
| US201161537336P | 2011-09-21 | 2011-09-21 | |
| US61/537,336 | 2011-09-21 | ||
| PCT/US2012/026328 WO2012116185A1 (en) | 2011-02-23 | 2012-02-23 | Methods of detecting aneuploidy in human embryos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507664A JP2014507664A (ja) | 2014-03-27 |
| JP2014507664A5 true JP2014507664A5 (https=) | 2015-04-09 |
Family
ID=46721231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555560A Pending JP2014507664A (ja) | 2011-02-23 | 2012-02-23 | ヒト胚における異数性の検出方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9879307B2 (https=) |
| EP (1) | EP2678675B1 (https=) |
| JP (1) | JP2014507664A (https=) |
| CN (1) | CN103460038A (https=) |
| AU (1) | AU2012220540B2 (https=) |
| CA (1) | CA2827945C (https=) |
| DK (1) | DK2678675T3 (https=) |
| ES (1) | ES2657927T3 (https=) |
| HU (1) | HUE036056T2 (https=) |
| IL (1) | IL228066B (https=) |
| PT (1) | PT2678675T (https=) |
| WO (1) | WO2012116185A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10241108B2 (en) | 2013-02-01 | 2019-03-26 | Ares Trading S.A. | Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower development potential |
| US20140220618A1 (en) * | 2013-02-01 | 2014-08-07 | Auxogyn, Inc. | Measuring embryo development and implantation potential with timing and first cytokinesis phenotype parameters |
| US9177192B2 (en) | 2013-02-28 | 2015-11-03 | Progyny, Inc. | Apparatus, method, and system for image-based human embryo cell classification |
| US9404908B2 (en) * | 2013-04-29 | 2016-08-02 | The Board of Truestees of the Leland Stanford Junior University | Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy |
| JP2015114686A (ja) * | 2013-12-09 | 2015-06-22 | 富士フイルム株式会社 | 診療情報表示装置、方法およびプログラム |
| ES2837840T3 (es) | 2014-03-20 | 2021-07-01 | Ares Trading Sa | Medida cuantitativa de la cinética de desarrollo de la morfología de mórula y blastocisto humanos |
| FR3019556A1 (fr) * | 2014-04-07 | 2015-10-09 | Advencis | Dispositif d’incubation et de detection |
| CN104278011B (zh) * | 2014-09-19 | 2017-05-24 | 北京农学院 | RhoA重组蛋白在制备提高胚胎抗冻性以及解冻后复苏率的培养液中的应用 |
| GB2531699A (en) * | 2014-10-03 | 2016-05-04 | Unisense Fertilitech As | Embryo Assessment |
| US11385452B2 (en) * | 2015-03-13 | 2022-07-12 | Genea Ip Holdings Pty Limited | Method and apparatus for microscopy |
| US11494578B1 (en) * | 2015-09-21 | 2022-11-08 | Ares Trading S.A. | Systems and methods for automated assessment of embryo quality using image based features |
| CN109829898B (zh) * | 2019-01-17 | 2023-05-16 | 柳州康云互联科技有限公司 | 一种用于互联网检测中基于神经网络的测量检测系统及方法 |
| CN110363218B (zh) * | 2019-06-06 | 2023-07-11 | 张孝东 | 一种胚胎无创评估方法及装置 |
| CA3144694A1 (en) | 2019-07-25 | 2021-01-28 | Jose A. Horcajadas | Identification of viable human embryos |
| CN112582022B (zh) * | 2020-07-21 | 2021-11-23 | 序康医疗科技（苏州）有限公司 | 用于无创胚胎移植优先级评级的系统和方法 |
| EP4189081A1 (en) * | 2020-07-31 | 2023-06-07 | Kavoussi, Shahryar, K. | Methods for screening embryos |
| US20230326165A1 (en) * | 2020-09-11 | 2023-10-12 | The Brigham And Women's Hospital, Inc. | Determining locations in reproductive cellular structures |
| CN113744892A (zh) * | 2021-09-02 | 2021-12-03 | 上海宝藤生物医药科技股份有限公司 | 胚胎整倍性预测方法、装置、电子设备及存储介质 |
| CN114067317B (zh) * | 2021-11-24 | 2025-03-18 | 北京航空航天大学合肥创新研究院(北京航空航天大学合肥研究生院) | 染色体异常事件的检测方法、装置、电子设备及介质 |
| CN115641364B (zh) * | 2022-12-22 | 2023-03-21 | 武汉互创联合科技有限公司 | 基于胚胎动力学参数的胚胎分裂周期智能预测系统及方法 |
| CN118397621B (zh) * | 2024-06-26 | 2024-08-27 | 武汉互创联合科技有限公司 | 一种基于光流特征融合的多焦距胚胎细胞原核检测方法 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| EP0636186B1 (en) | 1992-04-03 | 1998-11-25 | The Perkin-Elmer Corporation | Probe composition and method |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| US5541081A (en) | 1994-03-22 | 1996-07-30 | President And Fellows Of Harvard College | Process for assessing oocyte and embryo quality |
| WO1997027317A1 (en) | 1996-01-23 | 1997-07-31 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| AU5321296A (en) | 1995-03-24 | 1996-10-16 | University Of Alabama At Birmingham Research Foundation | Human embryo co-culture system and uses thereof |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| JP3660026B2 (ja) | 1995-09-04 | 2005-06-15 | 扶桑薬品工業株式会社 | 体外受精用培地組成物 |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| JP2000500580A (ja) | 1995-11-22 | 2000-01-18 | ユニセンス・エイピイエス | マイクロセンサおよびそのマイクロセンサの使用方法 |
| WO1998006422A1 (en) | 1996-08-13 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Hematopoietic stem cell proliferating agents |
| US6008010A (en) | 1996-11-01 | 1999-12-28 | University Of Pittsburgh | Method and apparatus for holding cells |
| DK172855B1 (da) | 1996-11-12 | 1999-08-16 | Unisense Aps | Fremgangsmåde til måling af koncentrationen af et medium i et miljø, mikrosensor til brug ved fremgangsmåden og anvendelse |
| US6166761A (en) | 1997-01-09 | 2000-12-26 | Interface Multigrad Technology | Method and apparatus for monitoring a biological sample |
| CA2199663C (en) | 1997-03-11 | 2004-08-10 | Ruth Miriam Moses | In vitro maturation and fertilization of mammalian oocytes |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US5961444A (en) | 1997-10-17 | 1999-10-05 | Medworks Corporation | In vitro fertilization procedure using direct vision |
| AUPP421298A0 (en) | 1998-06-19 | 1998-07-09 | Fertilitescentrum Ab | Method and medium for in vitro culture of human embryos |
| CN1263695A (zh) | 1999-02-05 | 2000-08-23 | 黑龙江大学 | 人工合成无融合生殖异源三倍体及单体附加系甜菜 |
| AU2794000A (en) | 1999-02-24 | 2000-09-14 | Novo Nordisk A/S | Treatment of infertility |
| FR2812004B1 (fr) | 2000-07-24 | 2002-12-27 | Ccd Lab | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
| CA2468861C (en) | 2001-12-05 | 2012-06-12 | The Regents Of The University Of California | Robotic microscopy systems |
| ATE398964T1 (de) | 2001-12-21 | 2008-07-15 | Unisense As | Multifaser sensor zum messen der durchblutung |
| US7015031B2 (en) | 2002-01-24 | 2006-03-21 | Genx International, Inc. | Biological specimen-culturing system and method with onboard specimen development sensors |
| US7672369B2 (en) | 2002-02-13 | 2010-03-02 | Reify Corporation | Method and apparatus for acquisition, compression, and characterization of spatiotemporal signals |
| GB0215668D0 (en) | 2002-07-06 | 2002-08-14 | Weatherford Lamb | Coupling tubulars |
| KR20060058664A (ko) | 2002-12-23 | 2006-05-30 | 유니센스 에이/에스 | 실질적인 구형 대사 입자의 개별 대사율의 비침해적 측정방법 및 기구 |
| CN2610349Y (zh) | 2003-04-01 | 2004-04-07 | 北京舒尔德科技发展有限公司 | 多功能显微成像仪 |
| US7106502B1 (en) | 2003-08-21 | 2006-09-12 | The United States Of America As Represented By The Administrator Of National Aeronautics And Space Administration | Operation of a Cartesian robotic system in a compact microscope imaging system with intelligent controls |
| EP1667517B1 (en) | 2003-09-09 | 2010-03-31 | Cryo-Innovation Kft. | Improving post-thaw survival of cryopreserved biological material by hydrostatic pressure challenge |
| HU0302888D0 (en) | 2003-09-09 | 2003-11-28 | Pribenszky Csaba Dr | In creasing of efficacity of stable storage by freezing of embryos in preimplantation stage with pretreatment by pressure |
| GB2409029A (en) | 2003-12-11 | 2005-06-15 | Sony Uk Ltd | Face detection |
| US20060141499A1 (en) | 2004-11-17 | 2006-06-29 | Geoffrey Sher | Methods of determining human egg competency |
| GR1005061B (el) | 2004-12-06 | 2005-12-07 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων (4Α0%) Α | Πρωτεινες με προγνωστικη, διαγνωστικη και θεραπευτικη σημασια για την τρισωμια 21 (συνδρομο down) |
| US8265357B2 (en) | 2005-10-14 | 2012-09-11 | Unisense Fertilitech A/S | Determination of a change in a cell population |
| EP1951037A4 (en) | 2005-11-09 | 2009-11-11 | Scripps Research Inst | SELECTION, REPRODUCTION AND USE OF ANEUPLOID MOSOSIC STEM CELLS |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| JP4921858B2 (ja) | 2006-06-07 | 2012-04-25 | オリンパス株式会社 | 画像処理装置および画像処理プログラム |
| EP2035548B1 (en) | 2006-06-16 | 2010-08-11 | Unisense Fertilitech A/S | Embryo quality assessment based on blastomere division and movement |
| US8428331B2 (en) | 2006-08-07 | 2013-04-23 | Northeastern University | Phase subtraction cell counting method |
| GB0705321D0 (en) | 2007-03-20 | 2007-04-25 | Novocellus Ltd | Method |
| US7940978B2 (en) | 2007-06-05 | 2011-05-10 | General Electric Company | Automatic characterization of cellular motion |
| JP5143227B2 (ja) | 2007-06-29 | 2013-02-13 | ウニセンス フェルティリテック アー／エス | 顕微鏡対象物の監視および／または培養用の機器、システムおよび方法 |
| GB0806281D0 (en) | 2008-04-07 | 2008-05-14 | Univ Leeds | Markers of Oocyte viability |
| WO2009146335A1 (en) | 2008-05-27 | 2009-12-03 | Gene Security Network, Inc. | Methods for embryo characterization and comparison |
| JP2010004789A (ja) | 2008-06-26 | 2010-01-14 | Nikon Corp | 胚観察装置 |
| US20110111447A1 (en) | 2008-07-05 | 2011-05-12 | Unisense Fertilitech A/S | One to one identification system |
| WO2010010201A1 (es) | 2008-07-22 | 2010-01-28 | Equipo Ivi Investigacion Sl | Perfil de expresion genetica como marcador de la receptividad endometrial |
| WO2010021392A1 (ja) | 2008-08-21 | 2010-02-25 | 独立行政法人理化学研究所 | 哺乳動物胚のインビトロ蛍光観察方法及び着床不全又は流産のリスクの低い哺乳動物胚の選択方法 |
| CN101343655B (zh) | 2008-08-29 | 2010-05-12 | 北京林业大学 | 利用细胞间期核染色中心数鉴定杨树多倍体的方法 |
| US20100206316A1 (en) | 2009-01-21 | 2010-08-19 | Scott Jr Richard T | Method for determining chromosomal defects in an ivf embryo |
| HUP0900431A2 (en) | 2009-07-10 | 2011-01-28 | Cryo Innovation Kft | Sample imaging system and pocedure for transmitting imager of cells or tissues located in breeder space towards a data processing device |
| WO2011008932A1 (en) | 2009-07-16 | 2011-01-20 | Molecular Biometrics, Inc. | Methods of assessing embryo outcome |
| PL2827150T3 (pl) | 2009-08-22 | 2021-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Obrazowanie i ocena zarodków, oocytów i komórek macierzystych |
| WO2011071551A1 (en) | 2009-12-08 | 2011-06-16 | Molecular Biometrics, Inc. | Sample cell for spectroscopic analysis, systems and uses thereof |
| EP2348318A1 (en) | 2010-01-21 | 2011-07-27 | Equipo Ivi Investigación, S.L. | Diagnostic method for endometrial receptivity |
| CA2812776C (en) | 2010-09-27 | 2022-05-17 | Auxogyn, Inc. | Apparatus, method, and system for the automated imaging and evaluation of embryos, oocytes, and stem cells |
| GB2484457B (en) | 2010-10-02 | 2015-04-15 | Univ Plymouth | Method and system for determining characteristics of an embryo and uses thereof |
| EP2714895B1 (en) | 2011-05-31 | 2017-10-04 | Unisense Fertilitech A/S | Embryo quality assessment based on blastomere cleavage and morphology |
| EP2855694B1 (en) | 2012-05-31 | 2018-12-26 | Progyny, Inc. | In vitro embryo blastocyst prediction methods |
-
2012
- 2012-02-23 CA CA2827945A patent/CA2827945C/en active Active
- 2012-02-23 EP EP12749372.4A patent/EP2678675B1/en active Active
- 2012-02-23 JP JP2013555560A patent/JP2014507664A/ja active Pending
- 2012-02-23 HU HUE12749372A patent/HUE036056T2/hu unknown
- 2012-02-23 WO PCT/US2012/026328 patent/WO2012116185A1/en not_active Ceased
- 2012-02-23 CN CN2012800176968A patent/CN103460038A/zh active Pending
- 2012-02-23 AU AU2012220540A patent/AU2012220540B2/en active Active
- 2012-02-23 PT PT127493724T patent/PT2678675T/pt unknown
- 2012-02-23 ES ES12749372.4T patent/ES2657927T3/es active Active
- 2012-02-23 DK DK12749372.4T patent/DK2678675T3/en active
- 2012-02-23 US US14/001,243 patent/US9879307B2/en active Active
-
2013
- 2013-08-21 IL IL228066A patent/IL228066B/en active IP Right Grant
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