JP2014507474A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014507474A5 JP2014507474A5 JP2013557804A JP2013557804A JP2014507474A5 JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5 JP 2013557804 A JP2013557804 A JP 2013557804A JP 2013557804 A JP2013557804 A JP 2013557804A JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5
- Authority
- JP
- Japan
- Prior art keywords
- pirfenidone
- medicament
- medicament according
- food
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960003073 pirfenidone Drugs 0.000 claims 23
- 239000003814 drug Substances 0.000 claims 16
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 7
- 235000013305 food Nutrition 0.000 claims 6
- 230000002411 adverse Effects 0.000 claims 3
- 206010028813 Nausea Diseases 0.000 claims 2
- 208000032140 Sleepiness Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000002173 dizziness Diseases 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010000059 abdominal discomfort Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 230000036211 photosensitivity Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450489P | 2011-03-08 | 2011-03-08 | |
| US61/450,489 | 2011-03-08 | ||
| PCT/US2012/027872 WO2012122165A2 (en) | 2011-03-08 | 2012-03-06 | Substituted n-aryl pyridinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Division JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507474A JP2014507474A (ja) | 2014-03-27 |
| JP2014507474A5 true JP2014507474A5 (cg-RX-API-DMAC7.html) | 2015-04-09 |
Family
ID=46798751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557804A Pending JP2014507474A (ja) | 2011-03-08 | 2012-03-06 | 置換ｎ−アリールピリジノン |
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9018232B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2683379A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2014507474A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140011355A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103561741A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012225611B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013022766A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2828895A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012122165A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008157786A1 (en) | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| CA2828895A1 (en) * | 2011-03-08 | 2012-09-13 | Auspex Pharamaceuticals, Inc. | Substituted n-aryl pyridinones |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| CN105315198A (zh) * | 2015-11-02 | 2016-02-10 | 重庆康乐制药有限公司 | 一种吡非尼酮的晶型及其制备方法 |
| CN105330598B (zh) * | 2015-12-02 | 2017-11-14 | 新发药业有限公司 | 一种吡非尼酮的制备方法 |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| CN106748984A (zh) * | 2016-11-22 | 2017-05-31 | 斯芬克司药物研发（天津）股份有限公司 | 6‑羟甲基‑1‑苯基吡啶‑2‑酮及其制备方法与应用 |
| US20210267955A1 (en) * | 2018-06-29 | 2021-09-02 | Zenvision Pharma Llp | Low dose oral pharmaceutical composition of pirfenidone or salt thereof |
| JP2022501427A (ja) | 2018-09-14 | 2022-01-06 | ピュアテック・エル・ワイ・ティ・100・インコーポレイテッドPuretech Lyt 100, Inc. | 重水素を富化したピルフェニドン及びその使用方法 |
| US20230129866A1 (en) * | 2020-03-13 | 2023-04-27 | Puretech Lyt 100, Inc. | Methods of treating respiratory disease with deupirfenidone |
| WO2023192646A1 (en) * | 2022-03-31 | 2023-10-05 | Puretech Lyt 100, Inc. | Methods of treating fibrotic- and collagen-mediated diseases and disorders with deupirfenidone |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215719A (ja) | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| BR9507200A (pt) | 1994-03-25 | 1997-09-16 | Isotechnika Inc | Melhora da eficácia de drogas por deuteração |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5962478A (en) | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| EP1104760B1 (en) | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| EP1134290A3 (en) | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| AU2001258825A1 (en) | 2000-05-29 | 2001-12-11 | Shionogi And Co., Ltd. | Method for labeling with tritium |
| AP1822A (en) | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
| WO2004019863A2 (en) | 2002-08-28 | 2004-03-11 | Intermune, Inc. | Combination therapy for treatment of fibrotic disorders |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US20070072181A1 (en) | 2003-02-28 | 2007-03-29 | Blatt Lawrence M | Combination therapy for treating alphavirus infection and liver fibrosis |
| WO2004105684A2 (en) | 2003-05-16 | 2004-12-09 | Intermune, Inc. | Combination therapy for proliferative disorders |
| WO2005038056A1 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Combination therapy for the treatment of viral diseases |
| US7407973B2 (en) | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| JP4072623B2 (ja) | 2004-03-09 | 2008-04-09 | 独立行政法人産業技術総合研究所 | ピリジン−ｎ−オキシド類の製造方法 |
| WO2005110478A2 (en) | 2004-04-13 | 2005-11-24 | Intermune, Inc. | Combination therapy for treating fibrotic disorders |
| AU2006244072B2 (en) | 2005-05-10 | 2012-09-20 | Intermune, Inc. | Pyridone derivatives for modulating stress-activated protein kinase system |
| US20080033011A1 (en) | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| US20070203202A1 (en) * | 2005-12-02 | 2007-08-30 | Robinson Cynthia Y | Methods of reducing adverse events associated with pirfenidone therapy |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| EP2059241A1 (en) | 2006-09-05 | 2009-05-20 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
| WO2008157786A1 (en) * | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| EP2389227A4 (en) | 2009-01-26 | 2012-08-08 | Intermune Inc | METHOD FOR THE TREATMENT OF ACUTE MYOCARDINE CARDS AND ASSOCIATED ILLNESSES THEREOF |
| CA2828895A1 (en) * | 2011-03-08 | 2012-09-13 | Auspex Pharamaceuticals, Inc. | Substituted n-aryl pyridinones |
| KR20140022048A (ko) * | 2011-05-25 | 2014-02-21 | 인터뮨, 인크. | 선택된 환자에서의 피르페니돈 및 항-섬유성 치료제 |
-
2012
- 2012-03-06 CA CA 2828895 patent/CA2828895A1/en not_active Abandoned
- 2012-03-06 AU AU2012225611A patent/AU2012225611B2/en not_active Ceased
- 2012-03-06 JP JP2013557804A patent/JP2014507474A/ja active Pending
- 2012-03-06 EP EP12755283.4A patent/EP2683379A4/en not_active Withdrawn
- 2012-03-06 CN CN201280012472.8A patent/CN103561741A/zh active Pending
- 2012-03-06 KR KR20137025865A patent/KR20140011355A/ko not_active Withdrawn
- 2012-03-06 BR BR112013022766A patent/BR112013022766A2/pt not_active IP Right Cessation
- 2012-03-06 US US14/003,106 patent/US9018232B2/en not_active Expired - Fee Related
- 2012-03-06 WO PCT/US2012/027872 patent/WO2012122165A2/en not_active Ceased
-
2015
- 2015-01-14 US US14/596,727 patent/US20150126562A1/en not_active Abandoned
-
2016
- 2016-12-16 JP JP2016244433A patent/JP2017057220A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014507474A5 (cg-RX-API-DMAC7.html) | ||
| WO2013170068A3 (en) | Nuclear transport modulators and uses thereof | |
| CN104812762A8 (en) | Substituted annulated pyrimidines and triazines, and use thereof | |
| HK1197017A1 (en) | High capacity diketopiperazine microparticles | |
| WO2014205389A8 (en) | Nuclear transport modulators and uses thereof | |
| JP2012193216A5 (cg-RX-API-DMAC7.html) | ||
| WO2013087716A3 (de) | Fgfr- binder -wirkstoff konjugate und ihre verwendung | |
| HK1206246A1 (en) | Use of high dose laquinimod for treating multiple sclerosis | |
| WO2015003479A3 (zh) | 一种适用于婴幼儿及儿童的口服固体颗粒及其制备方法 | |
| WO2014058979A8 (en) | Laquinimod for reducing thalamic damage in multiple sclerosis | |
| JP2016530291A5 (cg-RX-API-DMAC7.html) | ||
| JP2015533163A5 (cg-RX-API-DMAC7.html) | ||
| EP3162804A8 (en) | New benzodiazepine derivative and use thereof | |
| FI2683245T4 (fi) | Menetelmiä ja koostumuksia masennuksen hoitamiseen syklobentsapriiniä käyttämällä | |
| PH12015500653B1 (en) | Combination drug comprising gemigliptin and metformin, and method for the preparation thereof | |
| WO2012106497A3 (en) | Selection and treatment of subjects | |
| PH12015501377A1 (en) | Solid unit with high fexofenadine content and process for the preparation thereof | |
| JP2017061488A5 (cg-RX-API-DMAC7.html) | ||
| JP2015129124A5 (cg-RX-API-DMAC7.html) | ||
| MX2015015681A (es) | Composicion farmaceutica que comprende fingolimod. | |
| WO2013057569A3 (en) | Extended release pharmaceutical composition containing amoxicillin and clavulanic acid | |
| HRP20160811T1 (hr) | Upotreba odiparcila u liječenju mukopolisaharidoze | |
| WO2012150829A3 (ko) | 신규한 트리아졸로피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 | |
| WO2014184663A3 (en) | Orally dispersible drug formulations | |
| JP2017515849A5 (cg-RX-API-DMAC7.html) |