JP2014507474A5 - - Google Patents
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- Publication number
- JP2014507474A5 JP2014507474A5 JP2013557804A JP2013557804A JP2014507474A5 JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5 JP 2013557804 A JP2013557804 A JP 2013557804A JP 2013557804 A JP2013557804 A JP 2013557804A JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5
- Authority
- JP
- Japan
- Prior art keywords
- pirfenidone
- medicament
- medicament according
- food
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960003073 pirfenidone Drugs 0.000 claims 23
- 239000003814 drug Substances 0.000 claims 16
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 7
- 235000013305 food Nutrition 0.000 claims 6
- 230000002411 adverse Effects 0.000 claims 3
- 206010028813 Nausea Diseases 0.000 claims 2
- 208000032140 Sleepiness Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000002173 dizziness Diseases 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010000059 abdominal discomfort Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 230000036211 photosensitivity Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450489P | 2011-03-08 | 2011-03-08 | |
| US61/450,489 | 2011-03-08 | ||
| PCT/US2012/027872 WO2012122165A2 (en) | 2011-03-08 | 2012-03-06 | Substituted n-aryl pyridinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Division JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507474A JP2014507474A (ja) | 2014-03-27 |
| JP2014507474A5 true JP2014507474A5 (OSRAM) | 2015-04-09 |
Family
ID=46798751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557804A Pending JP2014507474A (ja) | 2011-03-08 | 2012-03-06 | 置換ｎ−アリールピリジノン |
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9018232B2 (OSRAM) |
| EP (1) | EP2683379A4 (OSRAM) |
| JP (2) | JP2014507474A (OSRAM) |
| KR (1) | KR20140011355A (OSRAM) |
| CN (1) | CN103561741A (OSRAM) |
| AU (1) | AU2012225611B2 (OSRAM) |
| BR (1) | BR112013022766A2 (OSRAM) |
| CA (1) | CA2828895A1 (OSRAM) |
| WO (1) | WO2012122165A2 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5587184B2 (ja) | 2007-06-20 | 2014-09-10 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 繊維症阻害剤としての置換ｎ−アリールピリジノン |
| AU2012225611B2 (en) * | 2011-03-08 | 2016-09-15 | Auspex Pharmaceuticals, Inc. | Substituted N-Aryl pyridinones |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| CN105315198A (zh) * | 2015-11-02 | 2016-02-10 | 重庆康乐制药有限公司 | 一种吡非尼酮的晶型及其制备方法 |
| CN105330598B (zh) * | 2015-12-02 | 2017-11-14 | 新发药业有限公司 | 一种吡非尼酮的制备方法 |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| CN106748984A (zh) * | 2016-11-22 | 2017-05-31 | 斯芬克司药物研发（天津）股份有限公司 | 6‑羟甲基‑1‑苯基吡啶‑2‑酮及其制备方法与应用 |
| WO2020003107A1 (en) * | 2018-06-29 | 2020-01-02 | Zenvision Pharma Llp | Low dose oral pharmaceutical composition of pirfenidone or salt thereof |
| CN121108041A (zh) * | 2018-09-14 | 2025-12-12 | 纯技术莱特100股份有限公司 | 富含氘的吡非尼酮及其使用方法 |
| WO2021181368A1 (en) * | 2020-03-13 | 2021-09-16 | Puretech Lyt 100, Inc. | Methods of treating respiratory disease with deupirfenidone |
| AU2023243218A1 (en) * | 2022-03-31 | 2024-09-19 | Puretech Lyt 100, Inc. | Methods of treating interstitial lung diseases and other fibrotic-mediated pulmonary diseases and disorders with deupirfenidone |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215719A (ja) | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| KR20040068613A (ko) | 1994-03-25 | 2004-07-31 | 이소테크니카 인코포레이티드 | 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5962478A (en) | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| EP1134290A3 (en) | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| AU2001258825A1 (en) | 2000-05-29 | 2001-12-11 | Shionogi And Co., Ltd. | Method for labeling with tritium |
| SI1490064T1 (sl) | 2002-02-14 | 2010-01-29 | Pharmacia Corp | Substituirani piridinoni kot modulatorji p38 MAP kinaze |
| JP2006502152A (ja) | 2002-08-28 | 2006-01-19 | インターミューン インコーポレイテッド | 線維性疾患治療用の併用療法 |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| WO2005013917A2 (en) | 2003-02-28 | 2005-02-17 | Intermune, Inc. | Combination therapy for treating alphavirus infection and liver fibrosis |
| WO2004105684A2 (en) | 2003-05-16 | 2004-12-09 | Intermune, Inc. | Combination therapy for proliferative disorders |
| WO2005038056A1 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Combination therapy for the treatment of viral diseases |
| WO2005040758A2 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| JP4072623B2 (ja) | 2004-03-09 | 2008-04-09 | 独立行政法人産業技術総合研究所 | ピリジン−ｎ−オキシド類の製造方法 |
| WO2005110478A2 (en) | 2004-04-13 | 2005-11-24 | Intermune, Inc. | Combination therapy for treating fibrotic disorders |
| ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
| US20080033011A1 (en) | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| US20070203202A1 (en) * | 2005-12-02 | 2007-08-30 | Robinson Cynthia Y | Methods of reducing adverse events associated with pirfenidone therapy |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JP2010502702A (ja) | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
| US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
| JP5587184B2 (ja) | 2007-06-20 | 2014-09-10 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 繊維症阻害剤としての置換ｎ−アリールピリジノン |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| US20100190731A1 (en) | 2009-01-26 | 2010-07-29 | Jeff Olgin | Methods for treating acute myocardial infarctions and associated disorders |
| AU2012225611B2 (en) * | 2011-03-08 | 2016-09-15 | Auspex Pharmaceuticals, Inc. | Substituted N-Aryl pyridinones |
| HK1197159A1 (en) * | 2011-05-25 | 2015-01-09 | Intermune, Inc. | Pirfenidone and anti-fibrotic therapy in selected patients |
-
2012
- 2012-03-06 AU AU2012225611A patent/AU2012225611B2/en not_active Ceased
- 2012-03-06 US US14/003,106 patent/US9018232B2/en not_active Expired - Fee Related
- 2012-03-06 BR BR112013022766A patent/BR112013022766A2/pt not_active IP Right Cessation
- 2012-03-06 CN CN201280012472.8A patent/CN103561741A/zh active Pending
- 2012-03-06 JP JP2013557804A patent/JP2014507474A/ja active Pending
- 2012-03-06 KR KR20137025865A patent/KR20140011355A/ko not_active Withdrawn
- 2012-03-06 WO PCT/US2012/027872 patent/WO2012122165A2/en not_active Ceased
- 2012-03-06 CA CA 2828895 patent/CA2828895A1/en not_active Abandoned
- 2012-03-06 EP EP12755283.4A patent/EP2683379A4/en not_active Withdrawn
-
2015
- 2015-01-14 US US14/596,727 patent/US20150126562A1/en not_active Abandoned
-
2016
- 2016-12-16 JP JP2016244433A patent/JP2017057220A/ja active Pending
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