JP2014507442A5 - - Google Patents
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- Publication number
- JP2014507442A5 JP2014507442A5 JP2013555521A JP2013555521A JP2014507442A5 JP 2014507442 A5 JP2014507442 A5 JP 2014507442A5 JP 2013555521 A JP2013555521 A JP 2013555521A JP 2013555521 A JP2013555521 A JP 2013555521A JP 2014507442 A5 JP2014507442 A5 JP 2014507442A5
- Authority
- JP
- Japan
- Prior art keywords
- expression cassette
- tbx5
- mef2c
- subject
- hand2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161445390P | 2011-02-22 | 2011-02-22 | |
| US61/445,390 | 2011-02-22 | ||
| PCT/US2012/026113 WO2012116064A1 (en) | 2011-02-22 | 2012-02-22 | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507442A JP2014507442A (ja) | 2014-03-27 |
| JP2014507442A5 true JP2014507442A5 (enExample) | 2015-04-16 |
Family
ID=45922797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555521A Pending JP2014507442A (ja) | 2011-02-22 | 2012-02-22 | 心臓線維芽細胞の心筋細胞への再プログラム化による心臓修復 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9017661B2 (enExample) |
| EP (1) | EP2678354A1 (enExample) |
| JP (1) | JP2014507442A (enExample) |
| AU (1) | AU2012220702B2 (enExample) |
| CA (1) | CA2827329A1 (enExample) |
| WO (1) | WO2012116064A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6236393B2 (ja) * | 2011-11-09 | 2017-11-22 | セダーズ−シナイ メディカル センター | 転写因子に基づくペースメーカー細胞の生成およびその使用方法 |
| EP3060237B1 (en) * | 2013-10-25 | 2021-08-18 | Wayne State University | Modified reprogramming protein for use in treating a cancer |
| JP2015213441A (ja) * | 2014-05-08 | 2015-12-03 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる培地 |
| EP3177302A4 (en) * | 2014-08-07 | 2018-04-11 | Duke University | Compositions and methods for the reprogramming of cells into cardiomyocytes |
| KR101530278B1 (ko) * | 2014-09-04 | 2015-06-24 | 부산대학교 산학협력단 | 심근전환유전자 및 심혈관재생유전자를 포함하는 아데노부속바이러스를 유효성분으로 포함하는, 허혈성 심장질환 예방 또는 치료용 조성물 |
| US9885018B1 (en) * | 2015-03-16 | 2018-02-06 | The Regents Of The University Of Colorado, A Body Corporate | High efficiency reprogramming of fibroblasts into cardiomyocytes |
| CN110997901A (zh) * | 2017-06-21 | 2020-04-10 | 重组生物科技有限公司 | 细胞重编程为心肌细胞 |
| US20210180023A1 (en) * | 2017-08-15 | 2021-06-17 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of adult cardiac fibroblasts into cardiomyocytes |
| US12042525B2 (en) | 2018-01-05 | 2024-07-23 | University Of Houston System | Serum response factor regenerates senescent cells |
| GB2571704A (en) * | 2018-02-22 | 2019-09-11 | Georg August Univ Gottingen Stiftung Offentlichen Rechts Univer Sitatsmedzin Goettingen | Prevention or treatment of cardiac arrhytmia and sudden cardiac death |
| AU2019333315B2 (en) | 2018-08-30 | 2022-09-29 | Tenaya Therapeutics, Inc. | Cardiac cell reprogramming with myocardin and ASCL1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| WO1999062940A2 (en) | 1998-05-30 | 1999-12-09 | Collateral Therapeutics, Inc. | Methods of altering cardiac cell phenotype |
| AU2002216751A1 (en) * | 2000-06-30 | 2002-01-14 | Collateral Therapeutics, Inc. | Dual recombinant gene therapy compositions and methods of use |
| WO2007056759A2 (en) * | 2005-11-08 | 2007-05-18 | University Of South Florida | Improved method of stem cell therapy for cardiovascular repair |
| US20100172883A1 (en) * | 2007-01-19 | 2010-07-08 | Bruneau Benoit Gaetan | Methods of generating cardiomyocytes |
| WO2009145761A1 (en) * | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| AU2009329893A1 (en) * | 2008-12-23 | 2011-06-30 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification |
| EP2563907B1 (en) * | 2010-04-28 | 2019-06-19 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| CN102947444A (zh) * | 2010-06-23 | 2013-02-27 | 帷幄生物技术公司 | 用于治疗心血管疾病的非遗传修饰性重编程细胞的组合物和方法 |
-
2012
- 2012-02-22 EP EP12711484.1A patent/EP2678354A1/en not_active Withdrawn
- 2012-02-22 AU AU2012220702A patent/AU2012220702B2/en not_active Ceased
- 2012-02-22 US US13/402,609 patent/US9017661B2/en not_active Expired - Fee Related
- 2012-02-22 WO PCT/US2012/026113 patent/WO2012116064A1/en not_active Ceased
- 2012-02-22 CA CA2827329A patent/CA2827329A1/en not_active Abandoned
- 2012-02-22 JP JP2013555521A patent/JP2014507442A/ja active Pending
-
2015
- 2015-04-28 US US14/697,955 patent/US9523079B2/en active Active
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