CA2827329A1 - Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes - Google Patents

Info

Publication number

CA2827329A1

CA2827329A1 CA2827329A CA2827329A CA2827329A1 CA 2827329 A1 CA2827329 A1 CA 2827329A1 CA 2827329 A CA2827329 A CA 2827329A CA 2827329 A CA2827329 A CA 2827329A CA 2827329 A1 CA2827329 A1 CA 2827329A1

Authority

CA

Canada

Prior art keywords

tbx5

mef2c

subject

cardiac

hand2

Prior art date

2011-02-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 210000001054 cardiac fibroblast Anatomy 0.000 title claims abstract description 89
• 230000000747 cardiac effect Effects 0.000 title claims description 84
• 230000008672 reprogramming Effects 0.000 title claims description 17
• 210000004413 cardiac myocyte Anatomy 0.000 title abstract description 107
• 230000008439 repair process Effects 0.000 title abstract description 5
• 238000000034 method Methods 0.000 claims abstract description 121
• 208000010125 myocardial infarction Diseases 0.000 claims abstract description 94
• 101150115978 tbx5 gene Proteins 0.000 claims abstract description 74
• 102100030217 Myocardin Human genes 0.000 claims abstract description 65
• 108010081823 Myocardin Proteins 0.000 claims abstract description 65
• 101150003286 gata4 gene Proteins 0.000 claims abstract description 45
• 210000004027 cell Anatomy 0.000 claims description 281
• 108090000623 proteins and genes Proteins 0.000 claims description 167
• 230000014509 gene expression Effects 0.000 claims description 155
• 102000004169 proteins and genes Human genes 0.000 claims description 67
• 239000013598 vector Substances 0.000 claims description 61
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 26
• 230000001965 increasing effect Effects 0.000 claims description 24
• 230000003247 decreasing effect Effects 0.000 claims description 22
• 230000001177 retroviral effect Effects 0.000 claims description 18
• 238000002560 therapeutic procedure Methods 0.000 claims description 18
• 230000002861 ventricular Effects 0.000 claims description 18
• 108010018650 MEF2 Transcription Factors Proteins 0.000 claims description 16
• 239000013603 viral vector Substances 0.000 claims description 14
• 206010019280 Heart failures Diseases 0.000 claims description 13
• 239000005557 antagonist Substances 0.000 claims description 12
• 239000002876 beta blocker Substances 0.000 claims description 12
• 239000002934 diuretic Substances 0.000 claims description 11
• 239000003527 fibrinolytic agent Substances 0.000 claims description 11
• 150000002632 lipids Chemical class 0.000 claims description 11
• 238000013146 percutaneous coronary intervention Methods 0.000 claims description 11
• 229940097320 beta blocking agent Drugs 0.000 claims description 10
• 230000007423 decrease Effects 0.000 claims description 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
• 201000010099 disease Diseases 0.000 claims description 8
• 206010007572 Cardiac hypertrophy Diseases 0.000 claims description 7
• 208000006029 Cardiomegaly Diseases 0.000 claims description 7
• SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 7
• 229960001138 acetylsalicylic acid Drugs 0.000 claims description 7
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 6
• 230000035699 permeability Effects 0.000 claims description 6
• 239000000006 Nitroglycerin Substances 0.000 claims description 5
• 238000011161 development Methods 0.000 claims description 5
• 230000018109 developmental process Effects 0.000 claims description 5
• 230000003205 diastolic effect Effects 0.000 claims description 5
• 229960003711 glyceryl trinitrate Drugs 0.000 claims description 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
• 230000001882 diuretic effect Effects 0.000 claims description 4
• 239000003112 inhibitor Substances 0.000 claims description 4
• 239000001301 oxygen Substances 0.000 claims description 4
• 229910052760 oxygen Inorganic materials 0.000 claims description 4
• 102000055120 MEF2 Transcription Factors Human genes 0.000 claims description 3
• 230000004872 arterial blood pressure Effects 0.000 claims description 3
• 230000035487 diastolic blood pressure Effects 0.000 claims description 3
• 210000001147 pulmonary artery Anatomy 0.000 claims description 3
• 230000002685 pulmonary effect Effects 0.000 claims description 3
• 102100037310 Serine/threonine-protein kinase D1 Human genes 0.000 claims description 2
• 230000002236 anti-hypertrophic effect Effects 0.000 claims description 2
• 230000003480 fibrinolytic effect Effects 0.000 claims description 2
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims description 2
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims description 2
• 239000007925 intracardiac injection Substances 0.000 claims description 2
• 102000040945 Transcription factor Human genes 0.000 abstract description 39
• 108091023040 Transcription factor Proteins 0.000 abstract description 39
• 238000011282 treatment Methods 0.000 abstract description 27
• 238000001727 in vivo Methods 0.000 abstract description 24
• 238000000338 in vitro Methods 0.000 abstract description 12
• 230000037390 scarring Effects 0.000 abstract description 6
• 230000002107 myocardial effect Effects 0.000 abstract description 5
• 241000699670 Mus sp. Species 0.000 description 69
• 235000018102 proteins Nutrition 0.000 description 61
• 241001430294 unidentified retrovirus Species 0.000 description 56
• 239000000203 mixture Substances 0.000 description 42
• 210000002950 fibroblast Anatomy 0.000 description 38
• 239000003795 chemical substances by application Substances 0.000 description 36
• 241000701161 unidentified adenovirus Species 0.000 description 33
• 241000699666 Mus <mouse, genus> Species 0.000 description 32
• -1 coactivators Proteins 0.000 description 31
• 108020004414 DNA Proteins 0.000 description 29
• 238000004458 analytical method Methods 0.000 description 29
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 28
• 230000004217 heart function Effects 0.000 description 27
• 241000700605 Viruses Species 0.000 description 26
• 230000003612 virological effect Effects 0.000 description 26
• 238000000684 flow cytometry Methods 0.000 description 23
• 239000003814 drug Substances 0.000 description 20
• 238000002347 injection Methods 0.000 description 20
• 239000007924 injection Substances 0.000 description 20
• 210000000107 myocyte Anatomy 0.000 description 19
• 230000000694 effects Effects 0.000 description 18
• 239000003623 enhancer Substances 0.000 description 18
• 239000000243 solution Substances 0.000 description 18
• 238000010186 staining Methods 0.000 description 18
• 210000001519 tissue Anatomy 0.000 description 18
• 235000007688 Lycopersicon esculentum Nutrition 0.000 description 17
• 240000003768 Solanum lycopersicum Species 0.000 description 17
• 239000002502 liposome Substances 0.000 description 17
• 210000004165 myocardium Anatomy 0.000 description 17
• 102000039446 nucleic acids Human genes 0.000 description 17
• 108020004707 nucleic acids Proteins 0.000 description 17
• 150000007523 nucleic acids Chemical class 0.000 description 17
• 238000000746 purification Methods 0.000 description 17
• 108090001090 Lectins Proteins 0.000 description 15
• 102000004856 Lectins Human genes 0.000 description 15
• 210000005240 left ventricle Anatomy 0.000 description 15
• 239000003550 marker Substances 0.000 description 15
• RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 14
• 239000002609 medium Substances 0.000 description 14
• 229960001603 tamoxifen Drugs 0.000 description 14
• 238000010361 transduction Methods 0.000 description 14
• 230000026683 transduction Effects 0.000 description 14
• 102100039229 Myocyte-specific enhancer factor 2C Human genes 0.000 description 13
• 239000003146 anticoagulant agent Substances 0.000 description 13
• 238000012546 transfer Methods 0.000 description 13
• 102100038654 Heart- and neural crest derivatives-expressed protein 2 Human genes 0.000 description 12
• 101000819074 Homo sapiens Transcription factor GATA-4 Proteins 0.000 description 12
• 102100021380 Transcription factor GATA-4 Human genes 0.000 description 12
• 239000011575 calcium Substances 0.000 description 12
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 11
• 101001031594 Homo sapiens Heart- and neural crest derivatives-expressed protein 2 Proteins 0.000 description 11
• 230000004913 activation Effects 0.000 description 11
• 229910052791 calcium Inorganic materials 0.000 description 11
• 230000002068 genetic effect Effects 0.000 description 11
• 230000001939 inductive effect Effects 0.000 description 11
• 208000015181 infectious disease Diseases 0.000 description 11
• 239000002523 lectin Substances 0.000 description 11
• 102000004196 processed proteins & peptides Human genes 0.000 description 11
• 239000000126 substance Substances 0.000 description 11
• 238000013518 transcription Methods 0.000 description 11
• 230000035897 transcription Effects 0.000 description 11
• 101001072202 Homo sapiens Protein disulfide-isomerase Proteins 0.000 description 10
• 102100036352 Protein disulfide-isomerase Human genes 0.000 description 10
• 239000003416 antiarrhythmic agent Substances 0.000 description 10
• 229940079593 drug Drugs 0.000 description 10
• 238000012744 immunostaining Methods 0.000 description 10
• 239000000047 product Substances 0.000 description 10
• 238000011002 quantification Methods 0.000 description 10
• 108020003175 receptors Proteins 0.000 description 10
• 102000005962 receptors Human genes 0.000 description 10
• 239000000523 sample Substances 0.000 description 10
• 229940124549 vasodilator Drugs 0.000 description 10
• 239000003071 vasodilator agent Substances 0.000 description 10
• SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 description 9
• 229940127291 Calcium channel antagonist Drugs 0.000 description 9
• 241000282412 Homo Species 0.000 description 9
• 206010061216 Infarction Diseases 0.000 description 9
• 241001465754 Metazoa Species 0.000 description 9
• 230000015572 biosynthetic process Effects 0.000 description 9
• 239000000480 calcium channel blocker Substances 0.000 description 9
• 230000009787 cardiac fibrosis Effects 0.000 description 9
• 238000009472 formulation Methods 0.000 description 9
• 230000006870 function Effects 0.000 description 9
• 239000003446 ligand Substances 0.000 description 9
• 108020004999 messenger RNA Proteins 0.000 description 9
• 238000004806 packaging method and process Methods 0.000 description 9
• 238000002360 preparation method Methods 0.000 description 9
• 210000002235 sarcomere Anatomy 0.000 description 9
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 8
• 239000000219 Sympatholytic Substances 0.000 description 8
• 206010000891 acute myocardial infarction Diseases 0.000 description 8
• 239000000674 adrenergic antagonist Substances 0.000 description 8
• 239000000872 buffer Substances 0.000 description 8
• 230000006378 damage Effects 0.000 description 8
• 239000013604 expression vector Substances 0.000 description 8
• 210000003953 foreskin Anatomy 0.000 description 8
• 230000006698 induction Effects 0.000 description 8
• 230000007574 infarction Effects 0.000 description 8
• 210000004940 nucleus Anatomy 0.000 description 8
• 239000002245 particle Substances 0.000 description 8
• 230000001105 regulatory effect Effects 0.000 description 8
• 238000001356 surgical procedure Methods 0.000 description 8
• 230000000948 sympatholitic effect Effects 0.000 description 8
• 229960000103 thrombolytic agent Drugs 0.000 description 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
• FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 7
• 101150114527 Nkx2-5 gene Proteins 0.000 description 7
• 239000002253 acid Substances 0.000 description 7
• 229940127219 anticoagulant drug Drugs 0.000 description 7
• 210000004351 coronary vessel Anatomy 0.000 description 7
• 229940030606 diuretics Drugs 0.000 description 7
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 7
• 238000003384 imaging method Methods 0.000 description 7
• 230000000977 initiatory effect Effects 0.000 description 7
• 230000001404 mediated effect Effects 0.000 description 7
• 210000003205 muscle Anatomy 0.000 description 7
• 229920001184 polypeptide Polymers 0.000 description 7
• 230000010076 replication Effects 0.000 description 7
• 239000003981 vehicle Substances 0.000 description 7
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
• 102100023087 Protein S100-A4 Human genes 0.000 description 6
• 238000011529 RT qPCR Methods 0.000 description 6
• 102100024755 T-box transcription factor TBX5 Human genes 0.000 description 6
• 101710167708 T-box transcription factor TBX5 Proteins 0.000 description 6
• 238000001042 affinity chromatography Methods 0.000 description 6
• 239000002160 alpha blocker Substances 0.000 description 6
• 230000003288 anthiarrhythmic effect Effects 0.000 description 6
• 239000003242 anti bacterial agent Substances 0.000 description 6
• 229940030600 antihypertensive agent Drugs 0.000 description 6
• 239000002220 antihypertensive agent Substances 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 238000010790 dilution Methods 0.000 description 6
• 239000012895 dilution Substances 0.000 description 6
• 239000006185 dispersion Substances 0.000 description 6
• 238000002474 experimental method Methods 0.000 description 6
• 230000010354 integration Effects 0.000 description 6
• MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 6
• 210000003141 lower extremity Anatomy 0.000 description 6
• 238000005259 measurement Methods 0.000 description 6
• SLIWIQKBDGZFQR-PIVCGYGYSA-N n-[3-oxo-3',6'-bis[[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]spiro[2-benzofuran-1,9'-xanthene]-5-yl]dodecanamide Chemical compound C=1C(NC(=O)CCCCCCCCCCC)=CC=C2C=1C(=O)OC2(C1=CC=C(O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)C=C1OC1=C2)C1=CC=C2O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O SLIWIQKBDGZFQR-PIVCGYGYSA-N 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 6
• 150000003839 salts Chemical class 0.000 description 6
• 238000011830 transgenic mouse model Methods 0.000 description 6
• YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 5
• 239000005541 ACE inhibitor Substances 0.000 description 5
• 230000004568 DNA-binding Effects 0.000 description 5
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
• 108700019146 Transgenes Proteins 0.000 description 5
• 208000027418 Wounds and injury Diseases 0.000 description 5
• 150000007513 acids Chemical class 0.000 description 5
• 229940088710 antibiotic agent Drugs 0.000 description 5
• 230000001580 bacterial effect Effects 0.000 description 5
• 238000010009 beating Methods 0.000 description 5
• 238000013184 cardiac magnetic resonance imaging Methods 0.000 description 5
• 230000002950 deficient Effects 0.000 description 5
• LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 5
• 238000002592 echocardiography Methods 0.000 description 5
• 230000003176 fibrotic effect Effects 0.000 description 5
• 239000008103 glucose Substances 0.000 description 5
• 210000002064 heart cell Anatomy 0.000 description 5
• 210000002443 helper t lymphocyte Anatomy 0.000 description 5
• 208000014674 injury Diseases 0.000 description 5
• 230000000302 ischemic effect Effects 0.000 description 5
• 238000002955 isolation Methods 0.000 description 5
• 229960001632 labetalol Drugs 0.000 description 5
• 239000000463 material Substances 0.000 description 5
• 239000002105 nanoparticle Substances 0.000 description 5
• 230000000144 pharmacologic effect Effects 0.000 description 5
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 5
• 230000008488 polyadenylation Effects 0.000 description 5
• 230000002265 prevention Effects 0.000 description 5
• QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 5
• 230000004044 response Effects 0.000 description 5
• 210000002966 serum Anatomy 0.000 description 5
• 229940124597 therapeutic agent Drugs 0.000 description 5
• 230000002537 thrombolytic effect Effects 0.000 description 5
• 238000001890 transfection Methods 0.000 description 5
• 238000011144 upstream manufacturing Methods 0.000 description 5
• JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 4
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 4
• JBMKAUGHUNFTOL-UHFFFAOYSA-N Aldoclor Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC=NS2(=O)=O JBMKAUGHUNFTOL-UHFFFAOYSA-N 0.000 description 4
• 108700028369 Alleles Proteins 0.000 description 4
• 241000283707 Capra Species 0.000 description 4
• 108060005980 Collagenase Proteins 0.000 description 4
• 102000029816 Collagenase Human genes 0.000 description 4
• 230000004543 DNA replication Effects 0.000 description 4
• 241000283074 Equus asinus Species 0.000 description 4
• 102000003886 Glycoproteins Human genes 0.000 description 4
• 108090000288 Glycoproteins Proteins 0.000 description 4
• 241001135569 Human adenovirus 5 Species 0.000 description 4
• ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 4
• 241000699660 Mus musculus Species 0.000 description 4
• 102100034099 Myocardin-related transcription factor A Human genes 0.000 description 4
• 101710132126 Myocardin-related transcription factor A Proteins 0.000 description 4
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
• 241001028048 Nicola Species 0.000 description 4
• 108700026244 Open Reading Frames Proteins 0.000 description 4
• 241000700159 Rattus Species 0.000 description 4
• 108010042291 Serum Response Factor Proteins 0.000 description 4
• 102100022056 Serum response factor Human genes 0.000 description 4
• 108010023197 Streptokinase Proteins 0.000 description 4
• 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 4
• 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 4
• 108010046516 Wheat Germ Agglutinins Proteins 0.000 description 4
• GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 4
• 239000004480 active ingredient Substances 0.000 description 4
• 230000001154 acute effect Effects 0.000 description 4
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 4
• 230000002785 anti-thrombosis Effects 0.000 description 4
• 238000013459 approach Methods 0.000 description 4
• 239000012736 aqueous medium Substances 0.000 description 4
• 239000007864 aqueous solution Substances 0.000 description 4
• 150000007658 benzothiadiazines Chemical class 0.000 description 4
• CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 4
• 230000027455 binding Effects 0.000 description 4
• 229960002424 collagenase Drugs 0.000 description 4
• 150000001875 compounds Chemical class 0.000 description 4
• 230000005284 excitation Effects 0.000 description 4
• 238000013401 experimental design Methods 0.000 description 4
• VPSRLGDRGCKUTK-UHFFFAOYSA-N fura-2-acetoxymethyl ester Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC(C(=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=CC2=C1OC(C=1OC(=CN=1)C(=O)OCOC(C)=O)=C2 VPSRLGDRGCKUTK-UHFFFAOYSA-N 0.000 description 4
• 210000003976 gap junction Anatomy 0.000 description 4
• 238000003304 gavage Methods 0.000 description 4
• 239000001963 growth medium Substances 0.000 description 4
• 229960002897 heparin Drugs 0.000 description 4
• 229920000669 heparin Polymers 0.000 description 4
• 229960002474 hydralazine Drugs 0.000 description 4
• WDKXLLJDNUBYCY-UHFFFAOYSA-N ibopamine Chemical compound CNCCC1=CC=C(OC(=O)C(C)C)C(OC(=O)C(C)C)=C1 WDKXLLJDNUBYCY-UHFFFAOYSA-N 0.000 description 4
• 238000003365 immunocytochemistry Methods 0.000 description 4
• 239000004041 inotropic agent Substances 0.000 description 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
• 229940079322 interferon Drugs 0.000 description 4
• 238000004519 manufacturing process Methods 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 238000002493 microarray Methods 0.000 description 4
• 229960003632 minoxidil Drugs 0.000 description 4
• 230000010412 perfusion Effects 0.000 description 4
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 4
• 239000002644 phorbol ester Substances 0.000 description 4
• JZQKKSLKJUAGIC-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CN2 JZQKKSLKJUAGIC-UHFFFAOYSA-N 0.000 description 4
• 230000009467 reduction Effects 0.000 description 4
• 238000004904 shortening Methods 0.000 description 4
• 230000002269 spontaneous effect Effects 0.000 description 4
• 230000008685 targeting Effects 0.000 description 4
• VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 4
• YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 4
• 230000001225 therapeutic effect Effects 0.000 description 4
• 238000013519 translation Methods 0.000 description 4
• 230000002792 vascular Effects 0.000 description 4
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 3
• METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 3
• TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 3
• ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 description 3
• 108010058207 Anistreplase Proteins 0.000 description 3
• 206010007559 Cardiac failure congestive Diseases 0.000 description 3
• 229920001268 Cholestyramine Polymers 0.000 description 3
• GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 3
• 102000001045 Connexin 43 Human genes 0.000 description 3
• 108010069241 Connexin 43 Proteins 0.000 description 3
• 241000701022 Cytomegalovirus Species 0.000 description 3
• WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 3
• LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 3
• JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 description 3
• 108010066671 Enalaprilat Proteins 0.000 description 3
• VXLCNTLWWUDBSO-UHFFFAOYSA-N Ethiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)NC(CC)NC2=C1 VXLCNTLWWUDBSO-UHFFFAOYSA-N 0.000 description 3
• 206010016654 Fibrosis Diseases 0.000 description 3
• INJOMKTZOLKMBF-UHFFFAOYSA-N Guanfacine Chemical compound NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl INJOMKTZOLKMBF-UHFFFAOYSA-N 0.000 description 3
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 3
• 101150036261 HNF1B gene Proteins 0.000 description 3
• 229920000209 Hexadimethrine bromide Polymers 0.000 description 3
• 102000002265 Human Growth Hormone Human genes 0.000 description 3
• 108010000521 Human Growth Hormone Proteins 0.000 description 3
• 239000000854 Human Growth Hormone Substances 0.000 description 3
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
• 108010007859 Lisinopril Proteins 0.000 description 3
• 101000783356 Naja sputatrix Cytotoxin Proteins 0.000 description 3
• 206010028980 Neoplasm Diseases 0.000 description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 3
• 108091006629 SLC13A2 Proteins 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 238000000692 Student's t-test Methods 0.000 description 3
• AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 3
• 102100033121 Transcription factor 21 Human genes 0.000 description 3
• 102100036859 Troponin I, cardiac muscle Human genes 0.000 description 3
• 101710128251 Troponin I, cardiac muscle Proteins 0.000 description 3
• 108020005202 Viral DNA Proteins 0.000 description 3
• 230000002411 adverse Effects 0.000 description 3
• 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 description 3
• 150000003868 ammonium compounds Chemical class 0.000 description 3
• LVEXHFZHOIWIIP-UHFFFAOYSA-N amosulalol Chemical compound COC1=CC=CC=C1OCCNCC(O)C1=CC=C(C)C(S(N)(=O)=O)=C1 LVEXHFZHOIWIIP-UHFFFAOYSA-N 0.000 description 3
• 229950010351 amosulalol Drugs 0.000 description 3
• RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 description 3
• 229940127218 antiplatelet drug Drugs 0.000 description 3
• 229960004676 antithrombotic agent Drugs 0.000 description 3
• BHIAIPWSVYSKJS-UHFFFAOYSA-N arotinolol Chemical compound S1C(SCC(O)CNC(C)(C)C)=NC(C=2SC(=CC=2)C(N)=O)=C1 BHIAIPWSVYSKJS-UHFFFAOYSA-N 0.000 description 3
• 229950010731 arotinolol Drugs 0.000 description 3
• 108010084541 asialoorosomucoid Proteins 0.000 description 3
• 229960002274 atenolol Drugs 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 229960004324 betaxolol Drugs 0.000 description 3
• 239000003613 bile acid Substances 0.000 description 3
• 239000001506 calcium phosphate Substances 0.000 description 3
• 229910000389 calcium phosphate Inorganic materials 0.000 description 3
• 235000011010 calcium phosphates Nutrition 0.000 description 3
• 239000002340 cardiotoxin Substances 0.000 description 3
• 231100000677 cardiotoxin Toxicity 0.000 description 3
• 229960001222 carteolol Drugs 0.000 description 3
• LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 description 3
• 210000000170 cell membrane Anatomy 0.000 description 3
• 210000003169 central nervous system Anatomy 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 229960002155 chlorothiazide Drugs 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• 239000003218 coronary vasodilator agent Substances 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 231100000517 death Toxicity 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 229960004042 diazoxide Drugs 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 229960000648 digitoxin Drugs 0.000 description 3
• WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 3
• 229960005156 digoxin Drugs 0.000 description 3
• LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 3
• 229960002768 dipyridamole Drugs 0.000 description 3
• IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 3
• 239000002612 dispersion medium Substances 0.000 description 3
• 229960003638 dopamine Drugs 0.000 description 3
• RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 3
• 210000002919 epithelial cell Anatomy 0.000 description 3
• 229950007164 ethiazide Drugs 0.000 description 3
• 238000011156 evaluation Methods 0.000 description 3
• 229940125753 fibrate Drugs 0.000 description 3
• 230000004761 fibrosis Effects 0.000 description 3
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 3
• YFHXZQPUBCBNIP-UHFFFAOYSA-N fura-2 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=3OC(=CC=3C=2)C=2OC(=CN=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 YFHXZQPUBCBNIP-UHFFFAOYSA-N 0.000 description 3
• 238000005227 gel permeation chromatography Methods 0.000 description 3
• 239000011521 glass Substances 0.000 description 3
• 229960003602 guanethidine Drugs 0.000 description 3
• ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 description 3
• 150000002357 guanidines Chemical class 0.000 description 3
• 208000019622 heart disease Diseases 0.000 description 3
• 238000004128 high performance liquid chromatography Methods 0.000 description 3
• 238000002744 homologous recombination Methods 0.000 description 3
• 230000006801 homologous recombination Effects 0.000 description 3
• 150000002429 hydrazines Chemical class 0.000 description 3
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 3
• 150000002460 imidazoles Chemical class 0.000 description 3
• 238000003364 immunohistochemistry Methods 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 230000006872 improvement Effects 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 230000003834 intracellular effect Effects 0.000 description 3
• 238000010253 intravenous injection Methods 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 229960002394 lisinopril Drugs 0.000 description 3
• RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 3
• 238000002595 magnetic resonance imaging Methods 0.000 description 3
• 238000012423 maintenance Methods 0.000 description 3
• 210000004962 mammalian cell Anatomy 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• 229960002237 metoprolol Drugs 0.000 description 3
• IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 3
• 244000005700 microbiome Species 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 238000010369 molecular cloning Methods 0.000 description 3
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 3
• 230000035772 mutation Effects 0.000 description 3
• VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 3
• LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 3
• 229960002035 penbutolol Drugs 0.000 description 3
• KQXKVJAGOJTNJS-HNNXBMFYSA-N penbutolol Chemical compound CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 KQXKVJAGOJTNJS-HNNXBMFYSA-N 0.000 description 3
• 229960000989 perhexiline Drugs 0.000 description 3
• CYXKNKQEMFBLER-UHFFFAOYSA-N perhexiline Chemical compound C1CCCNC1CC(C1CCCCC1)C1CCCCC1 CYXKNKQEMFBLER-UHFFFAOYSA-N 0.000 description 3
• 239000002831 pharmacologic agent Substances 0.000 description 3
• 150000003904 phospholipids Chemical class 0.000 description 3
• 229960002508 pindolol Drugs 0.000 description 3
• 239000000106 platelet aggregation inhibitor Substances 0.000 description 3
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 102000040430 polynucleotide Human genes 0.000 description 3
• 108091033319 polynucleotide Proteins 0.000 description 3
• 239000002157 polynucleotide Substances 0.000 description 3
• 239000011148 porous material Substances 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 3
• 229960001289 prazosin Drugs 0.000 description 3
• 238000001556 precipitation Methods 0.000 description 3
• 229940076788 pyruvate Drugs 0.000 description 3
• 229940044551 receptor antagonist Drugs 0.000 description 3
• 239000002464 receptor antagonist Substances 0.000 description 3
• 239000003087 receptor blocking agent Substances 0.000 description 3
• 230000006798 recombination Effects 0.000 description 3
• 238000005215 recombination Methods 0.000 description 3
• 230000002336 repolarization Effects 0.000 description 3
• 239000011347 resin Substances 0.000 description 3
• 229920005989 resin Polymers 0.000 description 3
• 238000000926 separation method Methods 0.000 description 3
• 210000002027 skeletal muscle Anatomy 0.000 description 3
• 210000002460 smooth muscle Anatomy 0.000 description 3
• 239000003195 sodium channel blocking agent Substances 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• 229960005202 streptokinase Drugs 0.000 description 3
• 239000000758 substrate Substances 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 238000012353 t test Methods 0.000 description 3
• 229960001693 terazosin Drugs 0.000 description 3
• 239000005495 thyroid hormone Substances 0.000 description 3
• 229940036555 thyroid hormone Drugs 0.000 description 3
• PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 3
• 229960004605 timolol Drugs 0.000 description 3
• 229960000187 tissue plasminogen activator Drugs 0.000 description 3
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
• PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
• 238000001262 western blot Methods 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• HMJIYCCIJYRONP-UHFFFAOYSA-N (+-)-Isradipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC2=NON=C12 HMJIYCCIJYRONP-UHFFFAOYSA-N 0.000 description 2
• CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 description 2
• KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
• SSEBTPPFLLCUMN-CYBMUJFWSA-N (1r)-2-(tert-butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol Chemical compound CCC1=CC=CC2=C1OC([C@H](O)CNC(C)(C)C)=C2 SSEBTPPFLLCUMN-CYBMUJFWSA-N 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 2
• NXQMNKUGGYNLBY-GFCCVEGCSA-N (2r)-1-(3-methylphenoxy)-3-(propan-2-ylamino)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC(C)=C1 NXQMNKUGGYNLBY-GFCCVEGCSA-N 0.000 description 2
• NXWGWUVGUSFQJC-GFCCVEGCSA-N (2r)-1-[(2-methyl-1h-indol-4-yl)oxy]-3-(propan-2-ylamino)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC2=C1C=C(C)N2 NXWGWUVGUSFQJC-GFCCVEGCSA-N 0.000 description 2
• BUJAGSGYPOAWEI-SECBINFHSA-N (2r)-2-amino-n-(2,6-dimethylphenyl)propanamide Chemical compound C[C@@H](N)C(=O)NC1=C(C)C=CC=C1C BUJAGSGYPOAWEI-SECBINFHSA-N 0.000 description 2
• BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 2
• DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 2
• SGUAFYQXFOLMHL-ACJLOTCBSA-N (R,R)-labetalol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(C(O)=CC=1)C(N)=O)CC1=CC=CC=C1 SGUAFYQXFOLMHL-ACJLOTCBSA-N 0.000 description 2
• PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 description 2
• UUOJIACWOAYWEZ-UHFFFAOYSA-N 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate Chemical compound C1=CC=C2NC(C)=CC2=C1OCC(CNC(C)(C)C)OC(=O)C1=CC=CC=C1 UUOJIACWOAYWEZ-UHFFFAOYSA-N 0.000 description 2
• CJDRUOGAGYHKKD-RQBLFBSQSA-N 1pon08459r Chemical compound CN([C@H]1[C@@]2(C[C@@]3([H])[C@@H]([C@@H](O)N42)CC)[H])C2=CC=CC=C2[C@]11C[C@@]4([H])[C@H]3[C@H]1O CJDRUOGAGYHKKD-RQBLFBSQSA-N 0.000 description 2
• HCYFGRCYSCXKNQ-UHFFFAOYSA-N 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)=O)C=N2 HCYFGRCYSCXKNQ-UHFFFAOYSA-N 0.000 description 2
• SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 2
• JIVPVXMEBJLZRO-CQSZACIVSA-N 2-chloro-5-[(1r)-1-hydroxy-3-oxo-2h-isoindol-1-yl]benzenesulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC([C@@]2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-CQSZACIVSA-N 0.000 description 2
• NMKSAYKQLCHXDK-UHFFFAOYSA-N 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine Chemical compound C=1C=CC=CC=1C(C)NCCC(C=1C=CC=CC=1)C1=CC=CC=C1 NMKSAYKQLCHXDK-UHFFFAOYSA-N 0.000 description 2
• URIZBPYQIRFMBF-UHFFFAOYSA-N 4-[1-[3-methyl-5-(5-oxo-2h-furan-3-yl)-1-benzofuran-2-yl]ethoxy]-4-oxobutanoic acid Chemical compound C1=C2C(C)=C(C(OC(=O)CCC(O)=O)C)OC2=CC=C1C1=CC(=O)OC1 URIZBPYQIRFMBF-UHFFFAOYSA-N 0.000 description 2
• LTSOENFXCPOCHG-GQCTYLIASA-N 4-chloro-6-[[(e)-3-oxobut-1-enyl]amino]-1-n-prop-2-enylbenzene-1,3-disulfonamide Chemical compound CC(=O)\C=C\NC1=CC(Cl)=C(S(N)(=O)=O)C=C1S(=O)(=O)NCC=C LTSOENFXCPOCHG-GQCTYLIASA-N 0.000 description 2
• LBXHRAWDUMTPSE-AOOOYVTPSA-N 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide Chemical compound C[C@H]1CCC[C@@H](C)N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 LBXHRAWDUMTPSE-AOOOYVTPSA-N 0.000 description 2
• KYWCWBXGRWWINE-UHFFFAOYSA-N 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide Chemical compound COC1=CC=C(C(=O)NCC=2C=NC=CC=2)C=C1C(=O)NCC1=CC=CN=C1 KYWCWBXGRWWINE-UHFFFAOYSA-N 0.000 description 2
• RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 2
• VGLGVJVUHYTIIU-UHFFFAOYSA-N 6-chloro-1,1-dioxo-3-[(prop-2-enylthio)methyl]-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(CSCC=C)NS2(=O)=O VGLGVJVUHYTIIU-UHFFFAOYSA-N 0.000 description 2
• BKYKPTRYDKTTJY-UHFFFAOYSA-N 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1CCCC1 BKYKPTRYDKTTJY-UHFFFAOYSA-N 0.000 description 2
• JDCJFONQCRLHND-UHFFFAOYSA-N 6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=C(F)C=C1 JDCJFONQCRLHND-UHFFFAOYSA-N 0.000 description 2
• 206010001258 Adenoviral infections Diseases 0.000 description 2
• FHHHOYXPRDYHEZ-COXVUDFISA-N Alacepril Chemical compound CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 FHHHOYXPRDYHEZ-COXVUDFISA-N 0.000 description 2
• ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 2
• 239000005552 B01AC04 - Clopidogrel Substances 0.000 description 2
• 239000005528 B01AC05 - Ticlopidine Substances 0.000 description 2
• BWSSMIJUDVUASQ-UHFFFAOYSA-N Benzylhydrochlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 BWSSMIJUDVUASQ-UHFFFAOYSA-N 0.000 description 2
• 102400000667 Brain natriuretic peptide 32 Human genes 0.000 description 2
• 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 2
• 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 2
• 241000197194 Bulla Species 0.000 description 2
• 206010006580 Bundle branch block left Diseases 0.000 description 2
• 206010006578 Bundle-Branch Block Diseases 0.000 description 2
• 108090000565 Capsid Proteins Proteins 0.000 description 2
• JOATXPAWOHTVSZ-UHFFFAOYSA-N Celiprolol Chemical compound CCN(CC)C(=O)NC1=CC=C(OCC(O)CNC(C)(C)C)C(C(C)=O)=C1 JOATXPAWOHTVSZ-UHFFFAOYSA-N 0.000 description 2
• 102100023321 Ceruloplasmin Human genes 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 2
• 229920002911 Colestipol Polymers 0.000 description 2
• 108020004635 Complementary DNA Proteins 0.000 description 2
• 102000010970 Connexin Human genes 0.000 description 2
• 108050001175 Connexin Proteins 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 238000000018 DNA microarray Methods 0.000 description 2
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• 206010012812 Diffuse cutaneous mastocytosis Diseases 0.000 description 2
• 108010061435 Enalapril Proteins 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• YARKMNAWFIMDKV-UHFFFAOYSA-N Epanolol Chemical compound C=1C=CC=C(C#N)C=1OCC(O)CNCCNC(=O)CC1=CC=C(O)C=C1 YARKMNAWFIMDKV-UHFFFAOYSA-N 0.000 description 2
• DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• 102100036646 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Human genes 0.000 description 2
• WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz Chemical compound NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-YIXHJXPBSA-N 0.000 description 2
• 239000007995 HEPES buffer Substances 0.000 description 2
• 208000013875 Heart injury Diseases 0.000 description 2
• 208000032843 Hemorrhage Diseases 0.000 description 2
• 102100037907 High mobility group protein B1 Human genes 0.000 description 2
• 101710168537 High mobility group protein B1 Proteins 0.000 description 2
• 102100038720 Histone deacetylase 9 Human genes 0.000 description 2
• 101001072655 Homo sapiens Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Proteins 0.000 description 2
• 241000598171 Human adenovirus sp. Species 0.000 description 2
• OMCPLEZZPVJJIS-UHFFFAOYSA-N Hypadil (TN) Chemical compound C1C(O[N+]([O-])=O)COC2=C1C=CC=C2OCC(O)CNC(C)C OMCPLEZZPVJJIS-UHFFFAOYSA-N 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 206010058179 Hypertensive emergency Diseases 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 102000004877 Insulin Human genes 0.000 description 2
• 108090001061 Insulin Proteins 0.000 description 2
• 102100034349 Integrase Human genes 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• CJDRUOGAGYHKKD-UHFFFAOYSA-N Iso-ajmalin Natural products CN1C2=CC=CC=C2C2(C(C34)O)C1C1CC3C(CC)C(O)N1C4C2 CJDRUOGAGYHKKD-UHFFFAOYSA-N 0.000 description 2
• PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 2
• 239000007836 KH2PO4 Substances 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 239000000232 Lipid Bilayer Substances 0.000 description 2
• 101150107475 MEF2C gene Proteins 0.000 description 2
• 108091054437 MHC class I family Proteins 0.000 description 2
• 102000043131 MHC class II family Human genes 0.000 description 2
• 108091054438 MHC class II family Proteins 0.000 description 2
• 108010059343 MM Form Creatine Kinase Proteins 0.000 description 2
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• 102000003792 Metallothionein Human genes 0.000 description 2
• 108090000157 Metallothionein Proteins 0.000 description 2
• CESYKOGBSMNBPD-UHFFFAOYSA-N Methyclothiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)N(C)C(CCl)NC2=C1 CESYKOGBSMNBPD-UHFFFAOYSA-N 0.000 description 2
• FNQQBFNIYODEMB-UHFFFAOYSA-N Meticrane Chemical compound C1CCS(=O)(=O)C2=C1C=C(C)C(S(N)(=O)=O)=C2 FNQQBFNIYODEMB-UHFFFAOYSA-N 0.000 description 2
• 101100079042 Mus musculus Myef2 gene Proteins 0.000 description 2
• 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 description 2
• ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 2
• JLPDBLFIVFSOCC-UHFFFAOYSA-N Oleandrin Natural products O1C(C)C(O)C(OC)CC1OC1CC(CCC2C3(CC(C(C3(C)CCC32)C=2COC(=O)C=2)OC(C)=O)O)C3(C)CC1 JLPDBLFIVFSOCC-UHFFFAOYSA-N 0.000 description 2
• 229930040373 Paraformaldehyde Natural products 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 2
• 241000276498 Pollachius virens Species 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 108010071690 Prealbumin Proteins 0.000 description 2
• HRSANNODOVBCST-UHFFFAOYSA-N Pronethalol Chemical compound C1=CC=CC2=CC(C(O)CNC(C)C)=CC=C21 HRSANNODOVBCST-UHFFFAOYSA-N 0.000 description 2
• 108010029485 Protein Isoforms Proteins 0.000 description 2
• 102000001708 Protein Isoforms Human genes 0.000 description 2
• 230000006819 RNA synthesis Effects 0.000 description 2
• 244000061121 Rauvolfia serpentina Species 0.000 description 2
• LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 2
• QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 2
• 206010038997 Retroviral infections Diseases 0.000 description 2
• 108010085149 S100 Calcium-Binding Protein A4 Proteins 0.000 description 2
• 208000006117 ST-elevation myocardial infarction Diseases 0.000 description 2
• 102000054727 Serum Amyloid A Human genes 0.000 description 2
• 108700028909 Serum Amyloid A Proteins 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 238000002105 Southern blotting Methods 0.000 description 2
• 108700026226 TATA Box Proteins 0.000 description 2
• HTWFXPCUFWKXOP-UHFFFAOYSA-N Tertatalol Chemical compound C1CCSC2=C1C=CC=C2OCC(O)CNC(C)(C)C HTWFXPCUFWKXOP-UHFFFAOYSA-N 0.000 description 2
• 101710119687 Transcription factor 21 Proteins 0.000 description 2
• 102100029290 Transthyretin Human genes 0.000 description 2
• FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 description 2
• 102000004987 Troponin T Human genes 0.000 description 2
• 108090001108 Troponin T Proteins 0.000 description 2
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 2
• 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 2
• 108700005077 Viral Genes Proteins 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• DXPOSRCHIDYWHW-UHFFFAOYSA-N Xamoterol Chemical compound C=1C=C(O)C=CC=1OCC(O)CNCCNC(=O)N1CCOCC1 DXPOSRCHIDYWHW-UHFFFAOYSA-N 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 229960002122 acebutolol Drugs 0.000 description 2
• 229950003769 acefylline Drugs 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 230000036982 action potential Effects 0.000 description 2
• 239000012190 activator Substances 0.000 description 2
• 239000003043 adrenergic neuron blocking agent Substances 0.000 description 2
• 229960004332 ajmaline Drugs 0.000 description 2
• 229950007884 alacepril Drugs 0.000 description 2
• 208000026935 allergic disease Diseases 0.000 description 2
• 230000007815 allergy Effects 0.000 description 2
• 229960002213 alprenolol Drugs 0.000 description 2
• PAZJSJFMUHDSTF-UHFFFAOYSA-N alprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1CC=C PAZJSJFMUHDSTF-UHFFFAOYSA-N 0.000 description 2
• 229950007522 altizide Drugs 0.000 description 2
• 229950007019 ambuside Drugs 0.000 description 2
• 229960002105 amrinone Drugs 0.000 description 2
• 239000004004 anti-anginal agent Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 229940124345 antianginal agent Drugs 0.000 description 2
• 229940121375 antifungal agent Drugs 0.000 description 2
• 239000003429 antifungal agent Substances 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 229940124572 antihypotensive agent Drugs 0.000 description 2
• 210000001367 artery Anatomy 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• HDWIHXWEUNVBIY-UHFFFAOYSA-N bendroflumethiazidum Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 HDWIHXWEUNVBIY-UHFFFAOYSA-N 0.000 description 2
• 229950010443 benfurodil hemisuccinate Drugs 0.000 description 2
• BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
• NDTSRXAMMQDVSW-UHFFFAOYSA-N benzthiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1N=C2CSCC1=CC=CC=C1 NDTSRXAMMQDVSW-UHFFFAOYSA-N 0.000 description 2
• 229960001541 benzthiazide Drugs 0.000 description 2
• 229950007003 benzylhydrochlorothiazide Drugs 0.000 description 2
• 229960003588 bevantolol Drugs 0.000 description 2
• HXLAFSUPPDYFEO-UHFFFAOYSA-N bevantolol Chemical compound C1=C(OC)C(OC)=CC=C1CCNCC(O)COC1=CC=CC(C)=C1 HXLAFSUPPDYFEO-UHFFFAOYSA-N 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 229960002781 bisoprolol Drugs 0.000 description 2
• VHYCDWMUTMEGQY-UHFFFAOYSA-N bisoprolol Chemical compound CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 VHYCDWMUTMEGQY-UHFFFAOYSA-N 0.000 description 2
• 208000034158 bleeding Diseases 0.000 description 2
• 230000000740 bleeding effect Effects 0.000 description 2
• 208000002352 blister Diseases 0.000 description 2
• 210000004369 blood Anatomy 0.000 description 2
• 239000008280 blood Substances 0.000 description 2
• 230000023555 blood coagulation Effects 0.000 description 2
• 230000036770 blood supply Effects 0.000 description 2
• 229960001035 bopindolol Drugs 0.000 description 2
• 229950006886 bufuralol Drugs 0.000 description 2
• VCVQSRCYSKKPBA-UHFFFAOYSA-N bunitrolol Chemical compound CC(C)(C)NCC(O)COC1=CC=CC=C1C#N VCVQSRCYSKKPBA-UHFFFAOYSA-N 0.000 description 2
• 229950008581 bunitrolol Drugs 0.000 description 2
• HGBFRHCDYZJRAO-UHFFFAOYSA-N butizide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)NC(CC(C)C)NC2=C1 HGBFRHCDYZJRAO-UHFFFAOYSA-N 0.000 description 2
• 229950008955 butizide Drugs 0.000 description 2
• NMBNQRJDEPOXCP-UHFFFAOYSA-N butofilolol Chemical compound CCCC(=O)C1=CC(F)=CC=C1OCC(O)CNC(C)(C)C NMBNQRJDEPOXCP-UHFFFAOYSA-N 0.000 description 2
• 229950009191 butofilolol Drugs 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 229960000830 captopril Drugs 0.000 description 2
• FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 2
• BQXQGZPYHWWCEB-UHFFFAOYSA-N carazolol Chemical compound N1C2=CC=CC=C2C2=C1C=CC=C2OCC(O)CNC(C)C BQXQGZPYHWWCEB-UHFFFAOYSA-N 0.000 description 2
• 229960004634 carazolol Drugs 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 229940097217 cardiac glycoside Drugs 0.000 description 2
• 239000002368 cardiac glycoside Substances 0.000 description 2
• 229960004195 carvedilol Drugs 0.000 description 2
• NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 2
• 125000002091 cationic group Chemical group 0.000 description 2
• 229960002320 celiprolol Drugs 0.000 description 2
• 230000000453 cell autonomous effect Effects 0.000 description 2
• 230000022131 cell cycle Effects 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• UWCBNAVPISMFJZ-UHFFFAOYSA-N cetamolol Chemical compound CNC(=O)COC1=CC=CC=C1OCC(O)CNC(C)(C)C UWCBNAVPISMFJZ-UHFFFAOYSA-N 0.000 description 2
• 229950003205 cetamolol Drugs 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 229960001523 chlortalidone Drugs 0.000 description 2
• 230000001684 chronic effect Effects 0.000 description 2
• 229960005025 cilazapril Drugs 0.000 description 2
• HHHKFGXWKKUNCY-FHWLQOOXSA-N cilazapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N2[C@@H](CCCN2CCC1)C(O)=O)=O)CC1=CC=CC=C1 HHHKFGXWKKUNCY-FHWLQOOXSA-N 0.000 description 2
• 229960002896 clonidine Drugs 0.000 description 2
• 229960004070 clopamide Drugs 0.000 description 2
• 229960003009 clopidogrel Drugs 0.000 description 2
• GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 2
• 238000000576 coating method Methods 0.000 description 2
• 238000002648 combination therapy Methods 0.000 description 2
• 230000001447 compensatory effect Effects 0.000 description 2
• 239000003636 conditioned culture medium Substances 0.000 description 2
• 230000008602 contraction Effects 0.000 description 2
• 230000000875 corresponding effect Effects 0.000 description 2
• 230000008878 coupling Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• 238000005859 coupling reaction Methods 0.000 description 2
• 238000012258 culturing Methods 0.000 description 2
• 229960003206 cyclopenthiazide Drugs 0.000 description 2
• 230000007547 defect Effects 0.000 description 2
• 229960005227 delapril Drugs 0.000 description 2
• WOUOLAUOZXOLJQ-MBSDFSHPSA-N delapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 WOUOLAUOZXOLJQ-MBSDFSHPSA-N 0.000 description 2
• 229950007304 denopamine Drugs 0.000 description 2
• VHSBBVZJABQOSG-MRXNPFEDSA-N denopamine Chemical compound C1=C(OC)C(OC)=CC=C1CCNC[C@@H](O)C1=CC=C(O)C=C1 VHSBBVZJABQOSG-MRXNPFEDSA-N 0.000 description 2
• 229960002086 dextran Drugs 0.000 description 2
• 229940085304 dihydropyridine derivative selective calcium channel blockers with mainly vascular effects Drugs 0.000 description 2
• 229950007942 dilevalol Drugs 0.000 description 2
• 229960001089 dobutamine Drugs 0.000 description 2
• 229960001857 dopexamine Drugs 0.000 description 2
• RYBJORHCUPVNMB-UHFFFAOYSA-N dopexamine Chemical compound C1=C(O)C(O)=CC=C1CCNCCCCCCNCCC1=CC=CC=C1 RYBJORHCUPVNMB-UHFFFAOYSA-N 0.000 description 2
• 229960001389 doxazosin Drugs 0.000 description 2
• XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 238000010828 elution Methods 0.000 description 2
• GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 2
• 229960000873 enalapril Drugs 0.000 description 2
• 229960002680 enalaprilat Drugs 0.000 description 2
• LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 description 2
• PJWPNDMDCLXCOM-UHFFFAOYSA-N encainide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1N(C)CCCC1 PJWPNDMDCLXCOM-UHFFFAOYSA-N 0.000 description 2
• 108700004025 env Genes Proteins 0.000 description 2
• 229940088598 enzyme Drugs 0.000 description 2
• 229960002711 epanolol Drugs 0.000 description 2
• RINBGYCKMGDWPY-UHFFFAOYSA-N epitizide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(CSCC(F)(F)F)NS2(=O)=O RINBGYCKMGDWPY-UHFFFAOYSA-N 0.000 description 2
• 229950010350 epitizide Drugs 0.000 description 2
• AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 2
• 239000003797 essential amino acid Substances 0.000 description 2
• 235000020776 essential amino acid Nutrition 0.000 description 2
• 229960004351 etafenone Drugs 0.000 description 2
• OEGDFSLNGABBKJ-UHFFFAOYSA-N etafenone Chemical compound CCN(CC)CCOC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 OEGDFSLNGABBKJ-UHFFFAOYSA-N 0.000 description 2
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 2
• 210000003527 eukaryotic cell Anatomy 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 210000003414 extremity Anatomy 0.000 description 2
• 229960003580 felodipine Drugs 0.000 description 2
• 229960002602 fendiline Drugs 0.000 description 2
• DBDTUXMDTSTPQZ-UHFFFAOYSA-N fenquizone Chemical compound N1C=2C=C(Cl)C(S(=O)(=O)N)=CC=2C(=O)NC1C1=CC=CC=C1 DBDTUXMDTSTPQZ-UHFFFAOYSA-N 0.000 description 2
• 229960002637 fenquizone Drugs 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 229960002490 fosinopril Drugs 0.000 description 2
• 238000005194 fractionation Methods 0.000 description 2
• 239000012634 fragment Substances 0.000 description 2
• 239000012737 fresh medium Substances 0.000 description 2
• 229960003883 furosemide Drugs 0.000 description 2
• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
• 108700004026 gag Genes Proteins 0.000 description 2
• 239000003457 ganglion blocking agent Substances 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• 238000001415 gene therapy Methods 0.000 description 2
• 108010017007 glucose-regulated proteins Proteins 0.000 description 2
• 150000004676 glycans Chemical class 0.000 description 2
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
• 230000012010 growth Effects 0.000 description 2
• 101150028578 grp78 gene Proteins 0.000 description 2
• 229960004553 guanabenz Drugs 0.000 description 2
• 229960002048 guanfacine Drugs 0.000 description 2
• BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 description 2
• 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 210000002837 heart atrium Anatomy 0.000 description 2
• 230000009067 heart development Effects 0.000 description 2
• 230000004398 heart morphogenesis Effects 0.000 description 2
• 210000005003 heart tissue Anatomy 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• WRYZEGZNBYOMLE-UHFFFAOYSA-N hydracarbazine Chemical compound NNC1=CC=C(C(N)=O)N=N1 WRYZEGZNBYOMLE-UHFFFAOYSA-N 0.000 description 2
• 229950002598 hydracarbazine Drugs 0.000 description 2
• DMDGGSIALPNSEE-UHFFFAOYSA-N hydroflumethiazide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O DMDGGSIALPNSEE-UHFFFAOYSA-N 0.000 description 2
• BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
• 230000001969 hypertrophic effect Effects 0.000 description 2
• 229960004370 ibopamine Drugs 0.000 description 2
• 238000003125 immunofluorescent labeling Methods 0.000 description 2
• NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 description 2
• 229960004569 indapamide Drugs 0.000 description 2
• MPGBPFMOOXKQRX-UHFFFAOYSA-N indenolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CC2 MPGBPFMOOXKQRX-UHFFFAOYSA-N 0.000 description 2
• 229950008838 indenolol Drugs 0.000 description 2
• 229940095990 inderal Drugs 0.000 description 2
• 230000000053 inderal effect Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 229940125396 insulin Drugs 0.000 description 2
• 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• 238000004255 ion exchange chromatography Methods 0.000 description 2
• PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 2
• PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 2
• 208000028867 ischemia Diseases 0.000 description 2
• 238000001155 isoelectric focusing Methods 0.000 description 2
• 229960002725 isoflurane Drugs 0.000 description 2
• 229940093268 isordil Drugs 0.000 description 2
• 229960000201 isosorbide dinitrate Drugs 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 229960004427 isradipine Drugs 0.000 description 2
• 210000003292 kidney cell Anatomy 0.000 description 2
• 229940063699 lanoxin Drugs 0.000 description 2
• 210000005248 left atrial appendage Anatomy 0.000 description 2
• 201000001715 left bundle branch hemiblock Diseases 0.000 description 2
• 229960004194 lidocaine Drugs 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 210000004185 liver Anatomy 0.000 description 2
• 230000033001 locomotion Effects 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 201000005857 malignant hypertension Diseases 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 229960001855 mannitol Drugs 0.000 description 2
• 229960002525 mecamylamine Drugs 0.000 description 2
• IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 description 2
• 229960003134 mepindolol Drugs 0.000 description 2
• 229960003739 methyclothiazide Drugs 0.000 description 2
• VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 2
• 229960003738 meticrane Drugs 0.000 description 2
• 229960002704 metipranolol Drugs 0.000 description 2
• BLWNYSZZZWQCKO-UHFFFAOYSA-N metipranolol hydrochloride Chemical compound [Cl-].CC(C)[NH2+]CC(O)COC1=CC(C)=C(OC(C)=O)C(C)=C1C BLWNYSZZZWQCKO-UHFFFAOYSA-N 0.000 description 2
• 229960002817 metolazone Drugs 0.000 description 2
• AQCHWTWZEMGIFD-UHFFFAOYSA-N metolazone Chemical compound CC1NC2=CC(Cl)=C(S(N)(=O)=O)C=C2C(=O)N1C1=CC=CC=C1C AQCHWTWZEMGIFD-UHFFFAOYSA-N 0.000 description 2
• 239000000693 micelle Substances 0.000 description 2
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
• 235000019796 monopotassium phosphate Nutrition 0.000 description 2
• LFTFGCDECFPSQD-UHFFFAOYSA-N moprolol Chemical compound COC1=CC=CC=C1OCC(O)CNC(C)C LFTFGCDECFPSQD-UHFFFAOYSA-N 0.000 description 2
• 229950002481 moprolol Drugs 0.000 description 2
• RLWRMIYXDPXIEX-UHFFFAOYSA-N muzolimine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)N1N=C(N)CC1=O RLWRMIYXDPXIEX-UHFFFAOYSA-N 0.000 description 2
• 229960001788 muzolimine Drugs 0.000 description 2
• 210000001087 myotubule Anatomy 0.000 description 2
• 229960004255 nadolol Drugs 0.000 description 2
• 239000002078 nanoshell Substances 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 229960001783 nicardipine Drugs 0.000 description 2
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 2
• 229960001597 nifedipine Drugs 0.000 description 2
• 229950000754 nipradilol Drugs 0.000 description 2
• 229960000227 nisoldipine Drugs 0.000 description 2
• 229960005425 nitrendipine Drugs 0.000 description 2
• 229950010050 oleandrin Drugs 0.000 description 2
• JLPDBLFIVFSOCC-XYXFTTADSA-N oleandrin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C[C@@H](CC[C@H]2[C@]3(C[C@@H]([C@@H]([C@@]3(C)CC[C@H]32)C=2COC(=O)C=2)OC(C)=O)O)[C@]3(C)CC1 JLPDBLFIVFSOCC-XYXFTTADSA-N 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 230000008520 organization Effects 0.000 description 2
• 229960004570 oxprenolol Drugs 0.000 description 2
• 229960001818 oxyfedrine Drugs 0.000 description 2
• GDYUVHBMFVMBAF-LIRRHRJNSA-N oxyfedrine Chemical compound COC1=CC=CC(C(=O)CCN[C@@H](C)[C@H](O)C=2C=CC=CC=2)=C1 GDYUVHBMFVMBAF-LIRRHRJNSA-N 0.000 description 2
• 229950006493 paraflutizide Drugs 0.000 description 2
• 229920002866 paraformaldehyde Polymers 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 229960002582 perindopril Drugs 0.000 description 2
• IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 2
• 235000020030 perry Nutrition 0.000 description 2
• JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 2
• 239000002571 phosphodiesterase inhibitor Substances 0.000 description 2
• 230000035479 physiological effects, processes and functions Effects 0.000 description 2
• 229960001006 picotamide Drugs 0.000 description 2
• 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 2
• 229910052697 platinum Inorganic materials 0.000 description 2
• 229920001282 polysaccharide Polymers 0.000 description 2
• 239000005017 polysaccharide Substances 0.000 description 2
• 235000020004 porter Nutrition 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
• REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 2
• 230000008569 process Effects 0.000 description 2
• 230000001737 promoting effect Effects 0.000 description 2
• 229950000992 pronetalol Drugs 0.000 description 2
• 238000012342 propidium iodide staining Methods 0.000 description 2
• 238000001742 protein purification Methods 0.000 description 2
• 239000002510 pyrogen Substances 0.000 description 2
• 229960001455 quinapril Drugs 0.000 description 2
• JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 2
• 150000003246 quinazolines Chemical class 0.000 description 2
• AGMMTXLNIQSRCG-UHFFFAOYSA-N quinethazone Chemical compound NS(=O)(=O)C1=C(Cl)C=C2NC(CC)NC(=O)C2=C1 AGMMTXLNIQSRCG-UHFFFAOYSA-N 0.000 description 2
• 229960000577 quinethazone Drugs 0.000 description 2
• LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
• 229960003401 ramipril Drugs 0.000 description 2
• HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 2
• 238000003753 real-time PCR Methods 0.000 description 2
• 230000010837 receptor-mediated endocytosis Effects 0.000 description 2
• 230000007115 recruitment Effects 0.000 description 2
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 2
• 230000003362 replicative effect Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 229960003147 reserpine Drugs 0.000 description 2
• 230000000241 respiratory effect Effects 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 210000003705 ribosome Anatomy 0.000 description 2
• 210000005241 right ventricle Anatomy 0.000 description 2
• MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 2
• 238000009738 saturating Methods 0.000 description 2
• 231100000241 scar Toxicity 0.000 description 2
• 230000036573 scar formation Effects 0.000 description 2
• OVUOVMIMOCJILI-KFZANIOBSA-N scillarenin Chemical compound C=1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C=C5CC4)C)CC[C@@]32C)C=CC(=O)OC=1 OVUOVMIMOCJILI-KFZANIOBSA-N 0.000 description 2
• 229940082552 sectral Drugs 0.000 description 2
• 229940083542 sodium Drugs 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
• 229940093252 sorbitrate Drugs 0.000 description 2
• VIDRYROWYFWGSY-UHFFFAOYSA-N sotalol hydrochloride Chemical compound Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 VIDRYROWYFWGSY-UHFFFAOYSA-N 0.000 description 2
• 210000000130 stem cell Anatomy 0.000 description 2
• 229930002534 steroid glycoside Natural products 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• PAQZZCOZHPGCFW-UHFFFAOYSA-N sulfinalol Chemical compound C1=CC(OC)=CC=C1CCC(C)NCC(O)C1=CC=C(O)C(S(C)=O)=C1 PAQZZCOZHPGCFW-UHFFFAOYSA-N 0.000 description 2
• 229950005165 sulfinalol Drugs 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• YRCWQPVGYLYSOX-UHFFFAOYSA-N synephrine Chemical compound CNCC(O)C1=CC=C(O)C=C1 YRCWQPVGYLYSOX-UHFFFAOYSA-N 0.000 description 2
• 238000003786 synthesis reaction Methods 0.000 description 2
• 229960003658 talinolol Drugs 0.000 description 2
• MXFWWQICDIZSOA-UHFFFAOYSA-N talinolol Chemical compound C1=CC(OCC(O)CNC(C)(C)C)=CC=C1NC(=O)NC1CCCCC1 MXFWWQICDIZSOA-UHFFFAOYSA-N 0.000 description 2
• XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
• 229960003352 tertatolol Drugs 0.000 description 2
• 229960004559 theobromine Drugs 0.000 description 2
• 239000003451 thiazide diuretic agent Substances 0.000 description 2
• 229960005001 ticlopidine Drugs 0.000 description 2
• 229950000245 toliprolol Drugs 0.000 description 2
• 229940108522 trandate Drugs 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 230000001052 transient effect Effects 0.000 description 2
• 238000010967 transthoracic echocardiography Methods 0.000 description 2
• 229960001288 triamterene Drugs 0.000 description 2
• 229960004813 trichlormethiazide Drugs 0.000 description 2
• LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 2
• YNZXWQJZEDLQEG-UHFFFAOYSA-N trimazosin Chemical compound N1=C2C(OC)=C(OC)C(OC)=CC2=C(N)N=C1N1CCN(C(=O)OCC(C)(C)O)CC1 YNZXWQJZEDLQEG-UHFFFAOYSA-N 0.000 description 2
• 229960002906 trimazosin Drugs 0.000 description 2
• HALWUDBBYKMYPW-STOWLHSFSA-M trimethaphan camsylate Chemical compound C1C[C@@]2(CS([O-])(=O)=O)C(=O)C[C@@H]1C2(C)C.C12C[S+]3CCCC3C2N(CC=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 HALWUDBBYKMYPW-STOWLHSFSA-M 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• UHLOVGKIEARANS-QZHINBJYSA-N tripamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(=O)NN2C[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3C2)=C1 UHLOVGKIEARANS-QZHINBJYSA-N 0.000 description 2
• 229950004678 tripamide Drugs 0.000 description 2
• 210000001364 upper extremity Anatomy 0.000 description 2
• 229960001722 verapamil Drugs 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• 210000002845 virion Anatomy 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 229960004928 xamoterol Drugs 0.000 description 2
• 229960000537 xipamide Drugs 0.000 description 2
• MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 2
• CJDRUOGAGYHKKD-XMTJACRCSA-N (+)-Ajmaline Natural products O[C@H]1[C@@H](CC)[C@@H]2[C@@H]3[C@H](O)[C@@]45[C@@H](N(C)c6c4cccc6)[C@@H](N1[C@H]3C5)C2 CJDRUOGAGYHKKD-XMTJACRCSA-N 0.000 description 1
• XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
• SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
• APUDBKTWDCXQJA-XQBPLPMBSA-N (1R)-4-[(2S,6R)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol Chemical compound C[C@H]1CCC[C@@H](C)N1CCC[C@](O)(C=1N=CC=CC=1)C1=CC=CC=C1 APUDBKTWDCXQJA-XQBPLPMBSA-N 0.000 description 1
• WFTSRDISOMSAQC-ZNFOTRSXSA-N (1R,15S,17R,18R,19S,20S)-3-[2-(diethylamino)ethyl]-6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-11,12,14,15,16,17,18,19,20,21-decahydro-1H-yohimban-19-carboxylic acid methyl ester Chemical compound O([C@@H]1C[C@H]2[C@@H]([C@@H]([C@H]1OC)C(=O)OC)C[C@@H]1C=3N(C4=CC(OC)=CC=C4C=3CCN1C2)CCN(CC)CC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 WFTSRDISOMSAQC-ZNFOTRSXSA-N 0.000 description 1
• QGVLYPPODPLXMB-UBTYZVCOSA-N (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one Chemical compound C1=C(CO)C[C@]2(O)C(=O)C(C)=C[C@H]2[C@@]2(O)[C@H](C)[C@@H](O)[C@@]3(O)C(C)(C)[C@H]3[C@@H]21 QGVLYPPODPLXMB-UBTYZVCOSA-N 0.000 description 1
• APSWDBKJUOEMOA-MTEWDWANSA-N (2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(O)=O APSWDBKJUOEMOA-MTEWDWANSA-N 0.000 description 1
• SBHCLVQMTBWHCD-METXMMQOSA-N (2e,4e,6e,8e,10e)-icosa-2,4,6,8,10-pentaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C(O)=O SBHCLVQMTBWHCD-METXMMQOSA-N 0.000 description 1
• VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 description 1
• LIEMBEWXEZJEEZ-INEUFUBQSA-N (2r,3r)-4-(6-aminopurin-9-yl)-2,3-dihydroxybutanoic acid Chemical compound NC1=NC=NC2=C1N=CN2C[C@@H](O)[C@@H](O)C(O)=O LIEMBEWXEZJEEZ-INEUFUBQSA-N 0.000 description 1
• QIJLJZOGPPQCOG-NFAWXSAZSA-N (2s)-1-[(2s)-3-[(2r)-2-(cyclohexanecarbonylamino)propanoyl]sulfanyl-2-methylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)C1CCCCC1 QIJLJZOGPPQCOG-NFAWXSAZSA-N 0.000 description 1
• YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 1
• STTOCSZNTPWKMI-UHFFFAOYSA-L (5-cyano-5,5-diphenylpentyl)-dimethyl-[2-(4-methylmorpholin-4-ium-4-yl)ethyl]azanium;methyl sulfate Chemical compound COS([O-])(=O)=O.COS([O-])(=O)=O.C1COCC[N+]1(C)CC[N+](C)(C)CCCCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 STTOCSZNTPWKMI-UHFFFAOYSA-L 0.000 description 1
• UQIPVSBPFZSWGD-ILYVXUQDSA-N (8r,9s,13s,14s,16r)-16-chloro-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-one Chemical compound C1C[C@]2(C)C(=O)[C@H](Cl)C[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 UQIPVSBPFZSWGD-ILYVXUQDSA-N 0.000 description 1
• RWIUTHWKQHRQNP-ZDVGBALWSA-N (9e,12e)-n-(1-phenylethyl)octadeca-9,12-dienamide Chemical compound CCCCC\C=C\C\C=C\CCCCCCCC(=O)NC(C)C1=CC=CC=C1 RWIUTHWKQHRQNP-ZDVGBALWSA-N 0.000 description 1
• WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 description 1
• HVAKUYCEWDPRCA-IZZDOVSWSA-N (e)-1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one Chemical compound C1=CC(OC)=CC=C1\C=C\C(=O)C1=CC=C(OC)C=C1OC HVAKUYCEWDPRCA-IZZDOVSWSA-N 0.000 description 1
• BRIPGNJWPCKDQZ-WXXKFALUSA-N (e)-but-2-enedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol Chemical compound OC(=O)\C=C\C(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 BRIPGNJWPCKDQZ-WXXKFALUSA-N 0.000 description 1
• ZHNFLHYOFXQIOW-AHSOWCEXSA-N (s)-[(2r,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dihydrate Chemical compound O.O.OS(O)(=O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-AHSOWCEXSA-N 0.000 description 1
• LJOQGZACKSYWCH-LHHVKLHASA-N (s)-[(2r,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol Chemical compound C1=C(OC)C=C2C([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4CC)=CC=NC2=C1 LJOQGZACKSYWCH-LHHVKLHASA-N 0.000 description 1
• XULIXFLCVXWHRF-UHFFFAOYSA-N 1,2,2,6,6-pentamethylpiperidine Chemical compound CN1C(C)(C)CCCC1(C)C XULIXFLCVXWHRF-UHFFFAOYSA-N 0.000 description 1
• HGLLQAPXHCAZBP-UHFFFAOYSA-N 1,3-dimethyl-7-(morpholin-4-ylmethyl)purine-2,6-dione Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CN1CCOCC1 HGLLQAPXHCAZBP-UHFFFAOYSA-N 0.000 description 1
• RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
• ZZKWNLZUYAGVOT-UHFFFAOYSA-N 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one Chemical compound C1=C(Cl)C=C2N(C(=O)CCN(CC)CC)C3=CC=CC=C3SC2=C1 ZZKWNLZUYAGVOT-UHFFFAOYSA-N 0.000 description 1
• SSMSBSWKLKKXGG-UHFFFAOYSA-N 1-(2-chlorophenyl)-2-isopropylaminoethanol Chemical compound CC(C)NCC(O)C1=CC=CC=C1Cl SSMSBSWKLKKXGG-UHFFFAOYSA-N 0.000 description 1
• KJBSVTAYVZKMDM-UHFFFAOYSA-N 1-(2-nitrophenyl)cyclopropane-1-carboxylic acid Chemical compound C=1C=CC=C([N+]([O-])=O)C=1C1(C(=O)O)CC1 KJBSVTAYVZKMDM-UHFFFAOYSA-N 0.000 description 1
• LUKOGYUKYPZBFP-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-piperidin-1-ylbutan-1-one Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCCCC1 LUKOGYUKYPZBFP-UHFFFAOYSA-N 0.000 description 1
• IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 description 1
• GJHKWLSRHNWTAN-UHFFFAOYSA-N 1-ethoxy-4-(4-pentylcyclohexyl)benzene Chemical compound C1CC(CCCCC)CCC1C1=CC=C(OCC)C=C1 GJHKWLSRHNWTAN-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• SZLZWPPUNLXJEA-UHFFFAOYSA-N 11,17-dimethoxy-18-[3-(3,4,5-trimethoxy-phenyl)-acryloyloxy]-yohimbane-16-carboxylic acid methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(OC)C1OC(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1 SZLZWPPUNLXJEA-UHFFFAOYSA-N 0.000 description 1
• HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 description 1
• 239000003315 2-(4-chlorophenoxy)-2-methylpropanoic acid Substances 0.000 description 1
• YYRYCTNXXHOENE-UHFFFAOYSA-N 2-(morpholin-4-ylmethyl)-2-phenylindene-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C1(C=1C=CC=CC=1)CN1CCOCC1 YYRYCTNXXHOENE-UHFFFAOYSA-N 0.000 description 1
• YREYLAVBNPACJM-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 description 1
• IULOBWFWYDMECP-UHFFFAOYSA-N 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1CCNS(=O)(=O)C1=CC=C(Cl)C=C1 IULOBWFWYDMECP-UHFFFAOYSA-N 0.000 description 1
• ZBIAKUMOEKILTF-UHFFFAOYSA-N 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1CCN(CCCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CC1 ZBIAKUMOEKILTF-UHFFFAOYSA-N 0.000 description 1
• YJIYWYAMZFVECX-UHFFFAOYSA-N 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O YJIYWYAMZFVECX-UHFFFAOYSA-N 0.000 description 1
• RMWVZGDJPAKBDE-UHFFFAOYSA-N 2-acetyloxy-4-(trifluoromethyl)benzoic acid Chemical compound CC(=O)OC1=CC(C(F)(F)F)=CC=C1C(O)=O RMWVZGDJPAKBDE-UHFFFAOYSA-N 0.000 description 1
• MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
• PTKSEFOSCHHMPD-SNVBAGLBSA-N 2-amino-n-[(2s)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Chemical compound COC1=CC=C(OC)C([C@H](O)CNC(=O)CN)=C1 PTKSEFOSCHHMPD-SNVBAGLBSA-N 0.000 description 1
• HGAVKWUHBLHFNP-UHFFFAOYSA-N 2-hydroxy-5-(4-methylphenyl)sulfonyloxybenzenesulfonic acid;piperazine Chemical compound C1CNCCN1.C1=CC(C)=CC=C1S(=O)(=O)OC1=CC=C(O)C(S(O)(=O)=O)=C1 HGAVKWUHBLHFNP-UHFFFAOYSA-N 0.000 description 1
• HPMZBILYSWLILX-UMDUKNJSSA-N 3'''-O-acetyldigitoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HPMZBILYSWLILX-UMDUKNJSSA-N 0.000 description 1
• JXZZEXZZKAWDSP-UHFFFAOYSA-N 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole Chemical compound C1CN(CCC=2C3=CC=CC=C3NC=2)CCC1NC(=O)C1=CC=CC=C1 JXZZEXZZKAWDSP-UHFFFAOYSA-N 0.000 description 1
• VPUNMTHWNSJUOG-XOMUPIDMSA-N 3-[(3s,5r,10s,13r,14s)-3-[(2r,3s,4r,5s,6s)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2h-furan-5-one Chemical compound O[C@H]1[C@H](OC)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@H](CCC2[C@]3(CCC([C@@]3(C)CCC32)C=2COC(=O)C=2)O)[C@]3(C)CC1 VPUNMTHWNSJUOG-XOMUPIDMSA-N 0.000 description 1
• SQVIAVUSQAWMKL-UHFFFAOYSA-N 3-[2-(ethylamino)-1-hydroxyethyl]phenol Chemical compound CCNCC(O)C1=CC=CC(O)=C1 SQVIAVUSQAWMKL-UHFFFAOYSA-N 0.000 description 1
• HAPJROQJVSPKCJ-UHFFFAOYSA-N 3-[4-[2-[6-(dibutylamino)naphthalen-2-yl]ethenyl]pyridin-1-ium-1-yl]propane-1-sulfonate Chemical compound C1=CC2=CC(N(CCCC)CCCC)=CC=C2C=C1C=CC1=CC=[N+](CCCS([O-])(=O)=O)C=C1 HAPJROQJVSPKCJ-UHFFFAOYSA-N 0.000 description 1
• NPOAOTPXWNWTSH-UHFFFAOYSA-N 3-hydroxy-3-methylglutaric acid Chemical compound OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 description 1
• UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
• OVUOVMIMOCJILI-UHFFFAOYSA-N 3alpha-Scillarenin Natural products CC12CCC(C3(CCC(O)C=C3CC3)C)C3C1(O)CCC2C=1C=CC(=O)OC=1 OVUOVMIMOCJILI-UHFFFAOYSA-N 0.000 description 1
• CANLULJYEHSQFU-UHFFFAOYSA-N 4-(1-aminoethyl)benzonitrile Chemical compound CC(N)C1=CC=C(C#N)C=C1 CANLULJYEHSQFU-UHFFFAOYSA-N 0.000 description 1
• YYAMOMYEENPVSP-UHFFFAOYSA-N 4-[(4-sulfamoylphenyl)methyl]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1CC1=CC=C(S(N)(=O)=O)C=C1 YYAMOMYEENPVSP-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 1
• CPDOMNNHJSTWKL-UHFFFAOYSA-N 4-hydroxy-3-[1-(4-hydroxy-2-oxochromen-3-yl)ethyl]chromen-2-one Chemical compound C1=CC=C2OC(=O)C(C(C=3C(OC4=CC=CC=C4C=3O)=O)C)=C(O)C2=C1 CPDOMNNHJSTWKL-UHFFFAOYSA-N 0.000 description 1
• ORLGLBZRQYOWNA-UHFFFAOYSA-N 4-methylpyridin-2-amine Chemical compound CC1=CC=NC(N)=C1 ORLGLBZRQYOWNA-UHFFFAOYSA-N 0.000 description 1
• LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
• OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 1
• HCNBCFYKPSFHLH-UHFFFAOYSA-N 6-(furan-2-yl)pteridine-2,4,7-triamine Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CO1 HCNBCFYKPSFHLH-UHFFFAOYSA-N 0.000 description 1
• LREQLEBVOXIEOM-UHFFFAOYSA-N 6-amino-2-methyl-2-heptanol Chemical compound CC(N)CCCC(C)(C)O LREQLEBVOXIEOM-UHFFFAOYSA-N 0.000 description 1
• SLXKOJJOQWFEFD-UHFFFAOYSA-M 6-aminohexanoate Chemical compound NCCCCCC([O-])=O SLXKOJJOQWFEFD-UHFFFAOYSA-M 0.000 description 1
• SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
• FVNFBBAOMBJTST-UHFFFAOYSA-N 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one Chemical compound O1C(=O)NCC11CCN(CCC=2C=CC=CC=2)CC1 FVNFBBAOMBJTST-UHFFFAOYSA-N 0.000 description 1
• HPMZBILYSWLILX-UHFFFAOYSA-N Acetyl-digitoxine Natural products C1C(OC(C)=O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O HPMZBILYSWLILX-UHFFFAOYSA-N 0.000 description 1
• LPMXVESGRSUGHW-UHFFFAOYSA-N Acolongiflorosid K Natural products OC1C(O)C(O)C(C)OC1OC1CC2(O)CCC3C4(O)CCC(C=5COC(=O)C=5)C4(C)CC(O)C3C2(CO)C(O)C1 LPMXVESGRSUGHW-UHFFFAOYSA-N 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 229920000936 Agarose Polymers 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 239000012103 Alexa Fluor 488 Substances 0.000 description 1
• 241000352333 Amegilla alpha Species 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• 206010002091 Anaesthesia Diseases 0.000 description 1
• 108010001779 Ancrod Proteins 0.000 description 1
• 102100022987 Angiogenin Human genes 0.000 description 1
• 108010072661 Angiotensin Amide Proteins 0.000 description 1
• 102000008873 Angiotensin II receptor Human genes 0.000 description 1
• 108050000824 Angiotensin II receptor Proteins 0.000 description 1
• 108010064733 Angiotensins Proteins 0.000 description 1
• 102000015427 Angiotensins Human genes 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 201000001320 Atherosclerosis Diseases 0.000 description 1
• 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
• 206010003805 Autism Diseases 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• QVZCXCJXTMIDME-UHFFFAOYSA-N Biopropazepan Trimethoxybenzoate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCCN2CCN(CCCOC(=O)C=3C=C(OC)C(OC)=C(OC)C=3)CCC2)=C1 QVZCXCJXTMIDME-UHFFFAOYSA-N 0.000 description 1
• 241000237519 Bivalvia Species 0.000 description 1
• 241000701822 Bovine papillomavirus Species 0.000 description 1
• 241000903210 Bryconamericus alpha Species 0.000 description 1
• RHLJLALHBZGAFM-UHFFFAOYSA-N Bunazosinum Chemical compound C1CN(C(=O)CCC)CCCN1C1=NC(N)=C(C=C(OC)C(OC)=C2)C2=N1 RHLJLALHBZGAFM-UHFFFAOYSA-N 0.000 description 1
• 239000002083 C09CA01 - Losartan Substances 0.000 description 1
• 239000002080 C09CA02 - Eprosartan Substances 0.000 description 1
• 239000004072 C09CA03 - Valsartan Substances 0.000 description 1
• 239000002947 C09CA04 - Irbesartan Substances 0.000 description 1
• VMNRZYKMPOZISX-UHFFFAOYSA-M COC(C[Hg]O)Cc1cccc2cc(C(O)=O)c(=O)oc12 Chemical compound COC(C[Hg]O)Cc1cccc2cc(C(O)=O)c(=O)oc12 VMNRZYKMPOZISX-UHFFFAOYSA-M 0.000 description 1
• QLTVVOATEHFXLT-UHFFFAOYSA-N Cadralazine Chemical compound CCOC(=O)NNC1=CC=C(N(CC)CC(C)O)N=N1 QLTVVOATEHFXLT-UHFFFAOYSA-N 0.000 description 1
• 244000045232 Canavalia ensiformis Species 0.000 description 1
• 235000010520 Canavalia ensiformis Nutrition 0.000 description 1
• 208000020446 Cardiac disease Diseases 0.000 description 1
• 206010007556 Cardiac failure acute Diseases 0.000 description 1
• 208000031229 Cardiomyopathies Diseases 0.000 description 1
• 208000024172 Cardiovascular disease Diseases 0.000 description 1
• 102100027992 Casein kinase II subunit beta Human genes 0.000 description 1
• 101710158100 Casein kinase II subunit beta Proteins 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 101710163595 Chaperone protein DnaK Proteins 0.000 description 1
• JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 1
• 229920001287 Chondroitin sulfate Polymers 0.000 description 1
• 108010077544 Chromatin Proteins 0.000 description 1
• IPOBOOXFSRWSHL-UHFFFAOYSA-N Cibenzoline Chemical compound C=1C=CC=CC=1C1(C=2C=CC=CC=2)CC1C1=NCCN1 IPOBOOXFSRWSHL-UHFFFAOYSA-N 0.000 description 1
• KPSRODZRAIWAKH-JTQLQIEISA-N Ciprofibrate Natural products C1=CC(OC(C)(C)C(O)=O)=CC=C1[C@H]1C(Cl)(Cl)C1 KPSRODZRAIWAKH-JTQLQIEISA-N 0.000 description 1
• BMOVQUBVGICXQN-UHFFFAOYSA-N Clinofibrate Chemical compound C1=CC(OC(C)(CC)C(O)=O)=CC=C1C1(C=2C=CC(OC(C)(CC)C(O)=O)=CC=2)CCCCC1 BMOVQUBVGICXQN-UHFFFAOYSA-N 0.000 description 1
• NENBAISIHCWPKP-UHFFFAOYSA-N Clofenamide Chemical compound NS(=O)(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NENBAISIHCWPKP-UHFFFAOYSA-N 0.000 description 1
• VPMWFZKOWULPGT-UHFFFAOYSA-N Clorexolone Chemical compound C1C=2C=C(Cl)C(S(=O)(=O)N)=CC=2C(=O)N1C1CCCCC1 VPMWFZKOWULPGT-UHFFFAOYSA-N 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010022452 Collagen Type I Proteins 0.000 description 1
• 102000012422 Collagen Type I Human genes 0.000 description 1
• 102100033601 Collagen alpha-1(I) chain Human genes 0.000 description 1
• 102100028257 Collagen alpha-1(XVI) chain Human genes 0.000 description 1
• 208000002330 Congenital Heart Defects Diseases 0.000 description 1
• 102000002585 Contractile Proteins Human genes 0.000 description 1
• 108010068426 Contractile Proteins Proteins 0.000 description 1
• OPHYOSQDKQYDCM-UHFFFAOYSA-N Convallatoxin Natural products CC1OC(OC2CCC3(C=O)C4CCC5(C)C(CCC5(O)C4CCC3(O)C2)C6=CCC(=O)O6)C(O)C(O)C1O OPHYOSQDKQYDCM-UHFFFAOYSA-N 0.000 description 1
• 208000001778 Coronary Occlusion Diseases 0.000 description 1
• 206010011086 Coronary artery occlusion Diseases 0.000 description 1
• 241000557626 Corvus corax Species 0.000 description 1
• 102000001493 Cyclophilins Human genes 0.000 description 1
• 108010068682 Cyclophilins Proteins 0.000 description 1
• XQCGNURMLWFQJR-ZNDDOCHDSA-N Cymarin Chemical compound O1[C@H](C)[C@@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)CC[C@@H]3[C@@]2(C=O)CC1 XQCGNURMLWFQJR-ZNDDOCHDSA-N 0.000 description 1
• XQCGNURMLWFQJR-UESCRGIISA-N Cymarin Natural products O=C[C@@]12[C@@](O)(C[C@@H](O[C@H]3O[C@@H](C)[C@@H](O)[C@@H](OC)C3)CC1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)CC[C@H]21 XQCGNURMLWFQJR-UESCRGIISA-N 0.000 description 1
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
• LIEMBEWXEZJEEZ-UHFFFAOYSA-N D-threo-Leutysin Natural products NC1=NC=NC2=C1N=CN2CC(O)C(O)C(O)=O LIEMBEWXEZJEEZ-UHFFFAOYSA-N 0.000 description 1
• XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
• 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
• 241000450599 DNA viruses Species 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• QEEBRPGZBVVINN-UHFFFAOYSA-N Desacetyl-bufotalin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C=1C=CC(=O)OC=1 QEEBRPGZBVVINN-UHFFFAOYSA-N 0.000 description 1
• CVBMAZKKCSYWQR-BPJCFPRXSA-N Deserpidine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cccc3 CVBMAZKKCSYWQR-BPJCFPRXSA-N 0.000 description 1
• 208000012239 Developmental disease Diseases 0.000 description 1
• 229920004937 Dexon® Polymers 0.000 description 1
• CKNOLMVLQUPVMU-XOMFLMSUSA-N Digitalin Natural products O(C)[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@@H]([C@H](O)C5)C5=CC(=O)OC5)CC4)CC3)CC2)[C@@H]1O CKNOLMVLQUPVMU-XOMFLMSUSA-N 0.000 description 1
• 240000001879 Digitalis lutea Species 0.000 description 1
• JYGLAHSAISAEAL-UHFFFAOYSA-N Diphenadione Chemical compound O=C1C2=CC=CC=C2C(=O)C1C(=O)C(C=1C=CC=CC=1)C1=CC=CC=C1 JYGLAHSAISAEAL-UHFFFAOYSA-N 0.000 description 1
• 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 1
• 108010069091 Dystrophin Proteins 0.000 description 1
• 102000001039 Dystrophin Human genes 0.000 description 1
• ZVXBAHLOGZCFTP-UHFFFAOYSA-N Efloxate Chemical compound C=1C(OCC(=O)OCC)=CC=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 ZVXBAHLOGZCFTP-UHFFFAOYSA-N 0.000 description 1
• 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 description 1
• 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 description 1
• 102100039328 Endoplasmin Human genes 0.000 description 1
• 101710091045 Envelope protein Proteins 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 108010088842 Fibrinolysin Proteins 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• RGLLOUBXMOGLDQ-IVEVATEUSA-N Furazabol Chemical compound C([C@@H]1CC2)C3=NON=C3C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 RGLLOUBXMOGLDQ-IVEVATEUSA-N 0.000 description 1
• 108010052320 GATA4 Transcription Factor Proteins 0.000 description 1
• 102000018715 GATA4 Transcription Factor Human genes 0.000 description 1
• XQLWNAFCTODIRK-UHFFFAOYSA-N Gallopamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC(OC)=C(OC)C(OC)=C1 XQLWNAFCTODIRK-UHFFFAOYSA-N 0.000 description 1
• HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 description 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
• 241000713813 Gibbon ape leukemia virus Species 0.000 description 1
• OCEDEAQHBIGPTE-UHFFFAOYSA-N Gitoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CCOC8=O)C4)OC3C)OC2C OCEDEAQHBIGPTE-UHFFFAOYSA-N 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• MCSPBPXATWBACD-GAYQJXMFSA-N Guanabenz acetate Chemical compound CC(O)=O.NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl MCSPBPXATWBACD-GAYQJXMFSA-N 0.000 description 1
• 101150063295 HAND2 gene Proteins 0.000 description 1
• 108010062347 HLA-DQ Antigens Proteins 0.000 description 1
• 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
• 101150112743 HSPA5 gene Proteins 0.000 description 1
• 206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
• 101710184439 Heart- and neural crest derivatives-expressed protein 2 Proteins 0.000 description 1
• 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
• 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 1
• 108010058611 Helix lectin Proteins 0.000 description 1
• 241000700721 Hepatitis B virus Species 0.000 description 1
• 102000007625 Hirudins Human genes 0.000 description 1
• 108010007267 Hirudins Proteins 0.000 description 1
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
• 102100038885 Histone acetyltransferase p300 Human genes 0.000 description 1
• 108090000246 Histone acetyltransferases Proteins 0.000 description 1
• 102000003893 Histone acetyltransferases Human genes 0.000 description 1
• 108090000353 Histone deacetylase Proteins 0.000 description 1
• 102100039999 Histone deacetylase 2 Human genes 0.000 description 1
• 102100021454 Histone deacetylase 4 Human genes 0.000 description 1
• 108010033040 Histones Proteins 0.000 description 1
• 206010050469 Holt-Oram syndrome Diseases 0.000 description 1
• 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 description 1
• 101000860648 Homo sapiens Collagen alpha-1(XVI) chain Proteins 0.000 description 1
• 101000882390 Homo sapiens Histone acetyltransferase p300 Proteins 0.000 description 1
• 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 description 1
• 101000899259 Homo sapiens Histone deacetylase 4 Proteins 0.000 description 1
• 101001032113 Homo sapiens Histone deacetylase 7 Proteins 0.000 description 1
• 101001032092 Homo sapiens Histone deacetylase 9 Proteins 0.000 description 1
• 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 description 1
• 101100456626 Homo sapiens MEF2A gene Proteins 0.000 description 1
• 101000950687 Homo sapiens Mitogen-activated protein kinase 7 Proteins 0.000 description 1
• 101001126414 Homo sapiens Proteolipid protein 2 Proteins 0.000 description 1
• 101000800546 Homo sapiens Transcription factor 21 Proteins 0.000 description 1
• 101000653735 Homo sapiens Transcriptional enhancer factor TEF-1 Proteins 0.000 description 1
• 101000652726 Homo sapiens Transgelin-2 Proteins 0.000 description 1
• 101000931371 Homo sapiens Zinc finger protein ZFPM2 Proteins 0.000 description 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
• 241000725303 Human immunodeficiency virus Species 0.000 description 1
• LJOQGZACKSYWCH-AFHBHXEDSA-N Hydroquinidine Natural products C1=C(OC)C=C2C([C@@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4CC)=CC=NC2=C1 LJOQGZACKSYWCH-AFHBHXEDSA-N 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• 206010020880 Hypertrophy Diseases 0.000 description 1
• 206010021118 Hypotonia Diseases 0.000 description 1
• 108700002232 Immediate-Early Genes Proteins 0.000 description 1
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 102000000588 Interleukin-2 Human genes 0.000 description 1
• 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
• 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• HUYWAWARQUIQLE-UHFFFAOYSA-N Isoetharine Chemical compound CC(C)NC(CC)C(O)C1=CC=C(O)C(O)=C1 HUYWAWARQUIQLE-UHFFFAOYSA-N 0.000 description 1
• KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 1
• 241000581650 Ivesia Species 0.000 description 1
• SXFPNMRWIWIAGS-UHFFFAOYSA-N Khellin Natural products COC1C2CCOC2C(OC)C3OC(C)CC(=O)C13 SXFPNMRWIWIAGS-UHFFFAOYSA-N 0.000 description 1
• 241001197082 Knodus beta Species 0.000 description 1
• SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 description 1
• WXFIGDLSSYIKKV-RCOVLWMOSA-N L-Metaraminol Chemical compound C[C@H](N)[C@H](O)C1=CC=CC(O)=C1 WXFIGDLSSYIKKV-RCOVLWMOSA-N 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
• 229930188389 Lanatoside Natural products 0.000 description 1
• 240000004322 Lens culinaris Species 0.000 description 1
• 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• 241001625930 Luria Species 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 102000043129 MHC class I family Human genes 0.000 description 1
• 101150078445 MYOCD gene Proteins 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 101001129122 Mannheimia haemolytica Outer membrane lipoprotein 2 Proteins 0.000 description 1
• 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 description 1
• LEROTMJVBFSIMP-UHFFFAOYSA-N Mebutamate Chemical compound NC(=O)OCC(C)(C(C)CC)COC(N)=O LEROTMJVBFSIMP-UHFFFAOYSA-N 0.000 description 1
• PKVZBNCYEICAQP-UHFFFAOYSA-N Mecamylamine hydrochloride Chemical compound Cl.C1CC2C(C)(C)C(NC)(C)C1C2 PKVZBNCYEICAQP-UHFFFAOYSA-N 0.000 description 1
• SMNOERSLNYGGOU-UHFFFAOYSA-N Mefruside Chemical compound C=1C=C(Cl)C(S(N)(=O)=O)=CC=1S(=O)(=O)N(C)CC1(C)CCCO1 SMNOERSLNYGGOU-UHFFFAOYSA-N 0.000 description 1
• 101710201349 Metallothionein B Proteins 0.000 description 1
• 102100031347 Metallothionein-2 Human genes 0.000 description 1
• 101710094505 Metallothionein-2 Proteins 0.000 description 1
• HBNPJJILLOYFJU-VMPREFPWSA-N Mibefradil Chemical compound C1CC2=CC(F)=CC=C2[C@H](C(C)C)[C@@]1(OC(=O)COC)CCN(C)CCCC1=NC2=CC=CC=C2N1 HBNPJJILLOYFJU-VMPREFPWSA-N 0.000 description 1
• 102100037805 Mitogen-activated protein kinase 7 Human genes 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 101100013973 Mus musculus Gata4 gene Proteins 0.000 description 1
• 208000007379 Muscle Hypotonia Diseases 0.000 description 1
• 102100021148 Myocyte-specific enhancer factor 2A Human genes 0.000 description 1
• 102100026925 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform Human genes 0.000 description 1
• WGZDBVOTUVNQFP-UHFFFAOYSA-N N-(1-phthalazinylamino)carbamic acid ethyl ester Chemical compound C1=CC=C2C(NNC(=O)OCC)=NN=CC2=C1 WGZDBVOTUVNQFP-UHFFFAOYSA-N 0.000 description 1
• OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
• MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
• KEECCEWTUVWFCV-UHFFFAOYSA-N N-acetylprocainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(NC(C)=O)C=C1 KEECCEWTUVWFCV-UHFFFAOYSA-N 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 240000002853 Nelumbo nucifera Species 0.000 description 1
• 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
• 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 102000001068 Neural Cell Adhesion Molecules Human genes 0.000 description 1
• 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 description 1
• YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 description 1
• KUEUWHJGRZKESU-UHFFFAOYSA-N Niceritrol Chemical compound C=1C=CN=CC=1C(=O)OCC(COC(=O)C=1C=NC=CC=1)(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 KUEUWHJGRZKESU-UHFFFAOYSA-N 0.000 description 1
• VRAHPESAMYMDQI-UHFFFAOYSA-N Nicomol Chemical compound C1CCC(COC(=O)C=2C=NC=CC=2)(COC(=O)C=2C=NC=CC=2)C(O)C1(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 VRAHPESAMYMDQI-UHFFFAOYSA-N 0.000 description 1
• FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 description 1
• 102000006570 Non-Histone Chromosomal Proteins Human genes 0.000 description 1
• 108010008964 Non-Histone Chromosomal Proteins Proteins 0.000 description 1
• 208000000770 Non-ST Elevated Myocardial Infarction Diseases 0.000 description 1
• 101000642171 Odontomachus monticola U-poneritoxin(01)-Om2a Proteins 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• LPMXVESGRSUGHW-GHYGWZAOSA-N Ouabain Natural products O([C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1)[C@H]1C[C@@H](O)[C@@]2(CO)[C@@](O)(C1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)C[C@@H](O)[C@H]21 LPMXVESGRSUGHW-GHYGWZAOSA-N 0.000 description 1
• 208000012868 Overgrowth Diseases 0.000 description 1
• 102000016387 Pancreatic elastase Human genes 0.000 description 1
• 108010067372 Pancreatic elastase Proteins 0.000 description 1
• DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 description 1
• 206010033698 Papillary muscle rupture Diseases 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
• DPWPWRLQFGFJFI-UHFFFAOYSA-N Pargyline Chemical compound C#CCN(C)CC1=CC=CC=C1 DPWPWRLQFGFJFI-UHFFFAOYSA-N 0.000 description 1
• TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 description 1
• 239000000026 Pentaerythritol tetranitrate Substances 0.000 description 1
• VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 description 1
• UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 description 1
• 108010010336 Platelet Membrane Glycoproteins Proteins 0.000 description 1
• 102000015795 Platelet Membrane Glycoproteins Human genes 0.000 description 1
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
• 208000000474 Poliomyelitis Diseases 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• 241001505332 Polyomavirus sp. Species 0.000 description 1
• TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 description 1
• ADUKCCWBEDSMEB-NSHDSACASA-N Prenalterol Chemical compound CC(C)NC[C@H](O)COC1=CC=C(O)C=C1 ADUKCCWBEDSMEB-NSHDSACASA-N 0.000 description 1
• IFFPICMESYHZPQ-UHFFFAOYSA-N Prenylamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNC(C)CC1=CC=CC=C1 IFFPICMESYHZPQ-UHFFFAOYSA-N 0.000 description 1
• 239000004792 Prolene Substances 0.000 description 1
• MYEJFUXQJGHEQK-ALRJYLEOSA-N Proscillaridin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C=C2CC[C@H]3[C@@]4(O)CC[C@H](C5=COC(=O)C=C5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1 MYEJFUXQJGHEQK-ALRJYLEOSA-N 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 102000001253 Protein Kinase Human genes 0.000 description 1
• 108700040121 Protein Methyltransferases Proteins 0.000 description 1
• 102000055027 Protein Methyltransferases Human genes 0.000 description 1
• 101710188315 Protein X Proteins 0.000 description 1
• 102100030486 Proteolipid protein 2 Human genes 0.000 description 1
• 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 description 1
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
• 229930189630 Protoveratrine Natural products 0.000 description 1
• HYTGGNIMZXFORS-MGYKWWNKSA-N Protoveratrine A Chemical compound O1[C@@]([C@H](CC[C@]23C)OC(=O)[C@@](C)(O)CC)(O)[C@H]3[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3[C@@]12C[C@H]1[C@H](CN2[C@@H](CC[C@H](C)C2)[C@@]2(C)O)[C@@H]2[C@@H](O)[C@H](OC(=O)[C@H](C)CC)[C@@]31O HYTGGNIMZXFORS-MGYKWWNKSA-N 0.000 description 1
• 206010037213 Psychomotor retardation Diseases 0.000 description 1
• YEKQSSHBERGOJK-UHFFFAOYSA-N Pyricarbate Chemical compound CNC(=O)OCC1=CC=CC(COC(=O)NC)=N1 YEKQSSHBERGOJK-UHFFFAOYSA-N 0.000 description 1
• 102000009572 RNA Polymerase II Human genes 0.000 description 1
• 108010009460 RNA Polymerase II Proteins 0.000 description 1
• 238000002123 RNA extraction Methods 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 101000868151 Rattus norvegicus Somatotropin Proteins 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 208000004531 Renal Artery Obstruction Diseases 0.000 description 1
• 206010038378 Renal artery stenosis Diseases 0.000 description 1
• 241001068263 Replication competent viruses Species 0.000 description 1
• 108700008625 Reporter Genes Proteins 0.000 description 1
• 108010034634 Repressor Proteins Proteins 0.000 description 1
• 102000009661 Repressor Proteins Human genes 0.000 description 1
• MMUMZMIKZXSFSD-ADSVITMPSA-N Rescimetol Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)\C=C\C1=CC=C(O)C(OC)=C1 MMUMZMIKZXSFSD-ADSVITMPSA-N 0.000 description 1
• SZLZWPPUNLXJEA-FMCDHCOASA-N Rescinnamine Natural products O=C(O[C@H]1[C@@H](OC)[C@@H](C(=O)OC)[C@@H]2[C@H](C1)CN1[C@@H](c3[nH]c4c(c3CC1)ccc(OC)c4)C2)/C=C/c1cc(OC)c(OC)c(OC)c1 SZLZWPPUNLXJEA-FMCDHCOASA-N 0.000 description 1
• 240000000528 Ricinus communis Species 0.000 description 1
• 235000004443 Ricinus communis Nutrition 0.000 description 1
• CQXADFVORZEARL-UHFFFAOYSA-N Rilmenidine Chemical compound C1CC1C(C1CC1)NC1=NCCO1 CQXADFVORZEARL-UHFFFAOYSA-N 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 241000714474 Rous sarcoma virus Species 0.000 description 1
• 101100111629 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR2 gene Proteins 0.000 description 1
• 108010083387 Saralasin Proteins 0.000 description 1
• 229930187443 Scillaren Natural products 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• 101001010097 Shigella phage SfV Bactoprenol-linked glucose translocase Proteins 0.000 description 1
• 102000007365 Sialoglycoproteins Human genes 0.000 description 1
• 108010032838 Sialoglycoproteins Proteins 0.000 description 1
• JLRNKCZRCMIVKA-UHFFFAOYSA-N Simfibrate Chemical compound C=1C=C(Cl)C=CC=1OC(C)(C)C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 JLRNKCZRCMIVKA-UHFFFAOYSA-N 0.000 description 1
• 102000008063 Small Heat-Shock Proteins Human genes 0.000 description 1
• 108010088928 Small Heat-Shock Proteins Proteins 0.000 description 1
• 108010053551 Sp1 Transcription Factor Proteins 0.000 description 1
• 101100289792 Squirrel monkey polyomavirus large T gene Proteins 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• 244000166550 Strophanthus gratus Species 0.000 description 1
• CPFNIKYEDJFRAT-UHFFFAOYSA-N Strospasid Natural products OC1C(OC)C(O)C(C)OC1OC1CC(CCC2C3(CC(O)C(C3(C)CCC32)C=2COC(=O)C=2)O)C3(C)CC1 CPFNIKYEDJFRAT-UHFFFAOYSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 206010042434 Sudden death Diseases 0.000 description 1
• ZCDNRPPFBQDQHR-SSYATKPKSA-N Syrosingopine Chemical compound C1=C(OC)C(OC(=O)OCC)=C(OC)C=C1C(=O)O[C@H]1[C@H](OC)[C@@H](C(=O)OC)[C@H]2C[C@@H]3C(NC=4C5=CC=C(OC)C=4)=C5CCN3C[C@H]2C1 ZCDNRPPFBQDQHR-SSYATKPKSA-N 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 102100038409 T-box transcription factor TBX3 Human genes 0.000 description 1
• 101710167703 T-box transcription factor TBX3 Proteins 0.000 description 1
• 229920002253 Tannate Polymers 0.000 description 1
• 208000007536 Thrombosis Diseases 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• HXWJFEZDFPRLBG-UHFFFAOYSA-N Timnodonic acid Natural products CCCC=CC=CCC=CCC=CCC=CCCCC(O)=O HXWJFEZDFPRLBG-UHFFFAOYSA-N 0.000 description 1
• NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 description 1
• GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
• 102100030246 Transcription factor Sp1 Human genes 0.000 description 1
• 101710195626 Transcriptional activator protein Proteins 0.000 description 1
• 102100029898 Transcriptional enhancer factor TEF-1 Human genes 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 102100031016 Transgelin-2 Human genes 0.000 description 1
• GSNOZLZNQMLSKJ-UHFFFAOYSA-N Trapidil Chemical compound CCN(CC)C1=CC(C)=NC2=NC=NN12 GSNOZLZNQMLSKJ-UHFFFAOYSA-N 0.000 description 1
• 206010044565 Tremor Diseases 0.000 description 1
• UHWVSEOVJBQKBE-UHFFFAOYSA-N Trimetazidine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCNCC1 UHWVSEOVJBQKBE-UHFFFAOYSA-N 0.000 description 1
• 241000209140 Triticum Species 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 108010030743 Tropomyosin Proteins 0.000 description 1
• 102000005937 Tropomyosin Human genes 0.000 description 1
• 102000004903 Troponin Human genes 0.000 description 1
• 108090001027 Troponin Proteins 0.000 description 1
• 102000013394 Troponin I Human genes 0.000 description 1
• 108010065729 Troponin I Proteins 0.000 description 1
• GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102100039094 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• CKNOLMVLQUPVMU-UHFFFAOYSA-N UNPD183315 Natural products O1C(C)C(OC2C(C(O)C(O)C(CO)O2)O)C(OC)C(O)C1OC(C1)CCC2(C)C1CCC(C1(CC3O)O)C2CCC1(C)C3C1=CC(=O)OC1 CKNOLMVLQUPVMU-UHFFFAOYSA-N 0.000 description 1
• 201000000692 Ulnar-mammary syndrome Diseases 0.000 description 1
• ICMGLRUYEQNHPF-UHFFFAOYSA-N Uraprene Chemical compound COC1=CC=CC=C1N1CCN(CCCNC=2N(C(=O)N(C)C(=O)C=2)C)CC1 ICMGLRUYEQNHPF-UHFFFAOYSA-N 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 208000009982 Ventricular Dysfunction Diseases 0.000 description 1
• 102100035071 Vimentin Human genes 0.000 description 1
• 108010065472 Vimentin Proteins 0.000 description 1
• 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
• 108010067390 Viral Proteins Proteins 0.000 description 1
• GVBNSPFBYXGREE-CXWAGAITSA-N Visnadin Chemical compound C1=CC(=O)OC2=C1C=CC1=C2[C@@H](OC(C)=O)[C@@H](OC(=O)[C@H](C)CC)C(C)(C)O1 GVBNSPFBYXGREE-CXWAGAITSA-N 0.000 description 1
• GVBNSPFBYXGREE-UHFFFAOYSA-N Visnadine Natural products C1=CC(=O)OC2=C1C=CC1=C2C(OC(C)=O)C(OC(=O)C(C)CC)C(C)(C)O1 GVBNSPFBYXGREE-UHFFFAOYSA-N 0.000 description 1
• BLGXFZZNTVWLAY-CCZXDCJGSA-N Yohimbine Natural products C1=CC=C2C(CCN3C[C@@H]4CC[C@@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-CCZXDCJGSA-N 0.000 description 1
• 102100020996 Zinc finger protein ZFPM2 Human genes 0.000 description 1
• 108091007916 Zinc finger transcription factors Proteins 0.000 description 1
• 102000038627 Zinc finger transcription factors Human genes 0.000 description 1
• OEXHQOGQTVQTAT-BZQJJPTISA-N [(1s,5r)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate Chemical compound C([C@H]1CC[C@@H](C2)[N+]1(C)C(C)C)C2OC(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-BZQJJPTISA-N 0.000 description 1
• YFGQJKBUXPKSAW-ZUDKKNPISA-N [(2r,3r,4s)-6-[(2r,3s,4s)-4-hydroxy-6-[(2r,3s,4s)-4-hydroxy-6-[[(3s,9s,10s,13r,17r)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2h-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-2-methyloxan-3-yl]oxy-2-methyloxan-3-y Chemical compound O([C@H]1[C@@H](OC(C)=O)CC(O[C@@H]1C)O[C@H]1[C@@H](O)CC(O[C@@H]1C)O[C@H]1[C@@H](O)CC(O[C@@H]1C)O[C@@H]1CC2[C@]([C@@H]3C(C4(CC[C@@H]([C@@]4(C)CC3)C=3COC(=O)C=3)O)CC2)(C)CC1)C1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O YFGQJKBUXPKSAW-ZUDKKNPISA-N 0.000 description 1
• VRGWBRLULZUWAJ-XFFXIZSCSA-N [(2s)-2-[(1r,3z,5s,8z,12z,15s)-5,17-dihydroxy-4,8,12,15-tetramethyl-16-oxo-18-bicyclo[13.3.0]octadeca-3,8,12,17-tetraenyl]propyl] acetate Chemical compound C1\C=C(C)/CC\C=C(C)/CC[C@H](O)\C(C)=C/C[C@@H]2C([C@@H](COC(C)=O)C)=C(O)C(=O)[C@]21C VRGWBRLULZUWAJ-XFFXIZSCSA-N 0.000 description 1
• SRHWTZAMPFLHAX-WDZFZDKYSA-N [(z)-1-pyridin-4-ylethylideneamino]thiourea Chemical compound NC(=S)N/N=C(/C)C1=CC=NC=C1 SRHWTZAMPFLHAX-WDZFZDKYSA-N 0.000 description 1
• YOKPRDAUBGOISU-UHFFFAOYSA-N [1-(3-methylbutoxy)-3-morpholin-4-ylpropan-2-yl] 3,4,5-trimethoxybenzoate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OC(COCCC(C)C)CN2CCOCC2)=C1 YOKPRDAUBGOISU-UHFFFAOYSA-N 0.000 description 1
• HNOMCFWTCNOVHP-UHFFFAOYSA-M [3-[(3-carboxy-2,2,3-trimethylcyclopentanecarbonyl)amino]-2-methoxypropyl]mercury(1+) hydroxide Chemical compound COC(CNC(=O)C1CCC(C)(C(O)=O)C1(C)C)C[Hg]O HNOMCFWTCNOVHP-UHFFFAOYSA-M 0.000 description 1
• OUHCZCFQVONTOC-UHFFFAOYSA-N [3-acetyloxy-2,2-bis(acetyloxymethyl)propyl] acetate Chemical compound CC(=O)OCC(COC(C)=O)(COC(C)=O)COC(C)=O OUHCZCFQVONTOC-UHFFFAOYSA-N 0.000 description 1
• GRALFSQRIBJAHX-UHFFFAOYSA-N [4-(diethylamino)-3-methylbutan-2-yl] 4-(2-methylpropoxy)benzoate Chemical compound CCN(CC)CC(C)C(C)OC(=O)C1=CC=C(OCC(C)C)C=C1 GRALFSQRIBJAHX-UHFFFAOYSA-N 0.000 description 1
• JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 description 1
• 230000005856 abnormality Effects 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 108010076089 accutase Proteins 0.000 description 1
• 229950005879 acecainide Drugs 0.000 description 1
• 229960002054 acenocoumarol Drugs 0.000 description 1
• VABCILAOYCMVPS-UHFFFAOYSA-N acenocoumarol Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=C([N+]([O-])=O)C=C1 VABCILAOYCMVPS-UHFFFAOYSA-N 0.000 description 1
• BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
• 229960000571 acetazolamide Drugs 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 229960003635 acetyldigitoxin Drugs 0.000 description 1
• DFDGRKNOFOJBAJ-UHFFFAOYSA-N acifran Chemical compound C=1C=CC=CC=1C1(C)OC(C(O)=O)=CC1=O DFDGRKNOFOJBAJ-UHFFFAOYSA-N 0.000 description 1
• 229950000146 acifran Drugs 0.000 description 1
• 229940099983 activase Drugs 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000008649 adaptation response Effects 0.000 description 1
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 1
• 230000001464 adherent effect Effects 0.000 description 1
• 239000000048 adrenergic agonist Substances 0.000 description 1
• 239000000808 adrenergic beta-agonist Substances 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• GRTOGORTSDXSFK-XJTZBENFSA-N ajmalicine Chemical compound C1=CC=C2C(CCN3C[C@@H]4[C@H](C)OC=C([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 GRTOGORTSDXSFK-XJTZBENFSA-N 0.000 description 1
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
• 239000002170 aldosterone antagonist Substances 0.000 description 1
• 229940083712 aldosterone antagonist Drugs 0.000 description 1
• WNMJYKCGWZFFKR-UHFFFAOYSA-N alfuzosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(C)CCCNC(=O)C1CCCO1 WNMJYKCGWZFFKR-UHFFFAOYSA-N 0.000 description 1
• 229960004607 alfuzosin Drugs 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 description 1
• CJCSPKMFHVPWAR-JTQLQIEISA-N alpha-methyl-L-dopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 description 1
• 229960002266 amezinium metilsulfate Drugs 0.000 description 1
• ZEASXVYVFFXULL-UHFFFAOYSA-N amezinium metilsulfate Chemical compound COS([O-])(=O)=O.COC1=CC(N)=CN=[N+]1C1=CC=CC=C1 ZEASXVYVFFXULL-UHFFFAOYSA-N 0.000 description 1
• 229940100095 amicar Drugs 0.000 description 1
• XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 1
• 229960002576 amiloride Drugs 0.000 description 1
• 235000001014 amino acid Nutrition 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• KZTZJUQNSSLNAG-UHFFFAOYSA-N aminoethyl nitrate Chemical compound NCCO[N+]([O-])=O KZTZJUQNSSLNAG-UHFFFAOYSA-N 0.000 description 1
• NGXUUAFYUCOICP-UHFFFAOYSA-N aminometradine Chemical compound CCN1C(=O)C=C(N)N(CC=C)C1=O NGXUUAFYUCOICP-UHFFFAOYSA-N 0.000 description 1
• 229960001887 aminometradine Drugs 0.000 description 1
• 229950011175 aminopicoline Drugs 0.000 description 1
• FRQGJOFRWIILCX-UHFFFAOYSA-N aminoxytriphene Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 FRQGJOFRWIILCX-UHFFFAOYSA-N 0.000 description 1
• 229950009931 aminoxytriphene Drugs 0.000 description 1
• 229960005260 amiodarone Drugs 0.000 description 1
• FXNYSZHYMGWWEZ-UHFFFAOYSA-N amisometradine Chemical compound CC(=C)CN1C(N)=CC(=O)N(C)C1=O FXNYSZHYMGWWEZ-UHFFFAOYSA-N 0.000 description 1
• 229950008305 amisometradine Drugs 0.000 description 1
• 229960000528 amlodipine Drugs 0.000 description 1
• HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 239000001166 ammonium sulphate Substances 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• 229960003173 amoproxan Drugs 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• HSNWZBCBUUSSQD-UHFFFAOYSA-N amyl nitrate Chemical compound CCCCCO[N+]([O-])=O HSNWZBCBUUSSQD-UHFFFAOYSA-N 0.000 description 1
• 230000037005 anaesthesia Effects 0.000 description 1
• OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 description 1
• 229960001694 anagrelide Drugs 0.000 description 1
• 229960004233 ancrod Drugs 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 238000002399 angioplasty Methods 0.000 description 1
• 229950006323 angiotensin ii Drugs 0.000 description 1
• JYPVVOOBQVVUQV-CGHBYZBKSA-N angiotensinamide Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=C(O)C=C1 JYPVVOOBQVVUQV-CGHBYZBKSA-N 0.000 description 1
• 229960001119 angiotensinamide Drugs 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• XRCFXMGQEVUZFC-UHFFFAOYSA-N anisindione Chemical compound C1=CC(OC)=CC=C1C1C(=O)C2=CC=CC=C2C1=O XRCFXMGQEVUZFC-UHFFFAOYSA-N 0.000 description 1
• 229960002138 anisindione Drugs 0.000 description 1
• 229960000983 anistreplase Drugs 0.000 description 1
• 230000003276 anti-hypertensive effect Effects 0.000 description 1
• 230000002959 anti-hypotensive effect Effects 0.000 description 1
• 230000001857 anti-mycotic effect Effects 0.000 description 1
• 229940127090 anticoagulant agent Drugs 0.000 description 1
• 239000002543 antimycotic Substances 0.000 description 1
• 210000002376 aorta thoracic Anatomy 0.000 description 1
• NZLBHDRPUJLHCE-UHFFFAOYSA-N aprindine Chemical compound C1C2=CC=CC=C2CC1N(CCCN(CC)CC)C1=CC=CC=C1 NZLBHDRPUJLHCE-UHFFFAOYSA-N 0.000 description 1
• 229960004957 aprindine Drugs 0.000 description 1
• 229960000271 arbutin Drugs 0.000 description 1
• KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 description 1
• 229960003856 argatroban Drugs 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 150000003975 aryl alkyl amines Chemical class 0.000 description 1
• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000003416 augmentation Effects 0.000 description 1
• 230000003190 augmentative effect Effects 0.000 description 1
• FMTFZYKYVZBISL-HUVRVWIJSA-N azacosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](N(C)CCCN(C)C)[C@@]1(C)CC2 FMTFZYKYVZBISL-HUVRVWIJSA-N 0.000 description 1
• 229950005866 azacosterol Drugs 0.000 description 1
• 229950009336 azamethonium bromide Drugs 0.000 description 1
• YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
• IIOPLILENRZKRV-UHFFFAOYSA-N azosemide Chemical compound C=1C=CSC=1CNC=1C=C(Cl)C(S(=O)(=O)N)=CC=1C1=NN=N[N]1 IIOPLILENRZKRV-UHFFFAOYSA-N 0.000 description 1
• 229960004988 azosemide Drugs 0.000 description 1
• 229960003060 bambuterol Drugs 0.000 description 1
• ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• YWQGBCXVCXMSLJ-UHFFFAOYSA-N beclobrate Chemical compound C1=CC(OC(C)(CC)C(=O)OCC)=CC=C1CC1=CC=C(Cl)C=C1 YWQGBCXVCXMSLJ-UHFFFAOYSA-N 0.000 description 1
• 229950009252 beclobrate Drugs 0.000 description 1
• 229960004374 befunolol Drugs 0.000 description 1
• ZPQPDBIHYCBNIG-UHFFFAOYSA-N befunolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1OC(C(C)=O)=C2 ZPQPDBIHYCBNIG-UHFFFAOYSA-N 0.000 description 1
• FYJJXENSONZJRG-UHFFFAOYSA-N bencyclane Chemical compound C=1C=CC=CC=1CC1(OCCCN(C)C)CCCCCC1 FYJJXENSONZJRG-UHFFFAOYSA-N 0.000 description 1
• 229960000945 bencyclane Drugs 0.000 description 1
• YTLQFZVCLXFFRK-UHFFFAOYSA-N bendazol Chemical compound N=1C2=CC=CC=C2NC=1CC1=CC=CC=C1 YTLQFZVCLXFFRK-UHFFFAOYSA-N 0.000 description 1
• 229950000900 bendazol Drugs 0.000 description 1
• 229960003515 bendroflumethiazide Drugs 0.000 description 1
• 229960001264 benfluorex Drugs 0.000 description 1
• 229960004411 benziodarone Drugs 0.000 description 1
• CZCHIEJNWPNBDE-UHFFFAOYSA-N benziodarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(O)C(I)=C1 CZCHIEJNWPNBDE-UHFFFAOYSA-N 0.000 description 1
• CJAVTWRYCDNHSM-UHFFFAOYSA-N benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester Chemical compound C=1C=CC=CC=1C(=O)OCCNC(C)CC1=CC=CC(C(F)(F)F)=C1 CJAVTWRYCDNHSM-UHFFFAOYSA-N 0.000 description 1
• XSCHRSMBECNVNS-UHFFFAOYSA-N benzopyrazine Natural products N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 description 1
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 description 1
• 229960004980 betanidine Drugs 0.000 description 1
• NIVZHWNOUVJHKV-UHFFFAOYSA-N bethanidine Chemical compound CN\C(=N/C)NCC1=CC=CC=C1 NIVZHWNOUVJHKV-UHFFFAOYSA-N 0.000 description 1
• 229960004383 bietaserpine Drugs 0.000 description 1
• 239000003012 bilayer membrane Substances 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 229950004495 binifibrate Drugs 0.000 description 1
• BFYRHDVAEJIBON-UHFFFAOYSA-N binifibrate Chemical compound C=1C=CN=CC=1C(=O)OCC(COC(=O)C=1C=NC=CC=1)OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 BFYRHDVAEJIBON-UHFFFAOYSA-N 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 229960004620 bitolterol Drugs 0.000 description 1
• FZGVEKPRDOIXJY-UHFFFAOYSA-N bitolterol Chemical compound C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)CNC(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 FZGVEKPRDOIXJY-UHFFFAOYSA-N 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000036772 blood pressure Effects 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 210000000984 branchial region Anatomy 0.000 description 1
• KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 description 1
• 229960004895 bretylium tosylate Drugs 0.000 description 1
• 229940097683 brevibloc Drugs 0.000 description 1
• NPUZIGSOEWMFKK-UHFFFAOYSA-N bromindione Chemical compound C1=CC(Br)=CC=C1C1C(=O)C2=CC=CC=C2C1=O NPUZIGSOEWMFKK-UHFFFAOYSA-N 0.000 description 1
• 229950004502 bromindione Drugs 0.000 description 1
• 206010006514 bruxism Diseases 0.000 description 1
• CJGYSWNGNKCJSB-YVLZZHOMSA-N bucladesine Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](OC(=O)CCC)[C@@H]2N1C(N=CN=C2NC(=O)CCC)=C2N=C1 CJGYSWNGNKCJSB-YVLZZHOMSA-N 0.000 description 1
• 229960005263 bucladesine Drugs 0.000 description 1
• CIJVBYRUFLGDHY-UHFFFAOYSA-N bucumolol Chemical compound O1C(=O)C=CC2=C1C(OCC(O)CNC(C)(C)C)=CC=C2C CIJVBYRUFLGDHY-UHFFFAOYSA-N 0.000 description 1
• 229950002568 bucumolol Drugs 0.000 description 1
• DQGFCLJXYFXXIJ-LFIBNONCSA-N budralazine Chemical compound C1=CC=C2C(N/N=C(C)/C=C(C)C)=NN=CC2=C1 DQGFCLJXYFXXIJ-LFIBNONCSA-N 0.000 description 1
• 229950001730 budralazine Drugs 0.000 description 1
• RFIXURDMUINBMD-UHFFFAOYSA-N bufeniode Chemical compound C=1C(I)=C(O)C(I)=CC=1C(O)C(C)NC(C)CCC1=CC=CC=C1 RFIXURDMUINBMD-UHFFFAOYSA-N 0.000 description 1
• 229950003250 bufeniode Drugs 0.000 description 1
• AKLNLVOZXMQGSI-UHFFFAOYSA-N bufetolol Chemical compound CC(C)(C)NCC(O)COC1=CC=CC=C1OCC1OCCC1 AKLNLVOZXMQGSI-UHFFFAOYSA-N 0.000 description 1
• 229950009385 bufetolol Drugs 0.000 description 1
• ATLJNLYIJOCWJE-CWMZOUAVSA-N bufogenin Chemical compound C=1([C@H]2C[C@H]3O[C@@]43[C@H]3[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC3)C)CC[C@@]42C)C=CC(=O)OC=1 ATLJNLYIJOCWJE-CWMZOUAVSA-N 0.000 description 1
• 229950006858 bufogenin Drugs 0.000 description 1
• 229960004064 bumetanide Drugs 0.000 description 1
• MAEIEVLCKWDQJH-UHFFFAOYSA-N bumetanide Chemical compound CCCCNC1=CC(C(O)=O)=CC(S(N)(=O)=O)=C1OC1=CC=CC=C1 MAEIEVLCKWDQJH-UHFFFAOYSA-N 0.000 description 1
• WWGZXRYELYWJBD-UHFFFAOYSA-N bunaftine Chemical compound C1=CC=C2C(C(=O)N(CCN(CC)CC)CCCC)=CC=CC2=C1 WWGZXRYELYWJBD-UHFFFAOYSA-N 0.000 description 1
• 229960005458 bunaftine Drugs 0.000 description 1
• 229960002467 bunazosin Drugs 0.000 description 1
• 229960000330 bupranolol Drugs 0.000 description 1
• HQIRNZOQPUAHHV-UHFFFAOYSA-N bupranolol Chemical compound CC1=CC=C(Cl)C(OCC(O)CNC(C)(C)C)=C1 HQIRNZOQPUAHHV-UHFFFAOYSA-N 0.000 description 1
• KHBXORBAOCQNMC-UHFFFAOYSA-N butan-2-yl-[2-hydroxy-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]azanium;chloride Chemical compound [Cl-].C1CCCC2=CC(C(O)C[NH2+]C(C)CC)=CC=C21 KHBXORBAOCQNMC-UHFFFAOYSA-N 0.000 description 1
• HZIYHIRJHYIRQO-UHFFFAOYSA-N butazolamide Chemical compound CCCC(=O)NC1=NN=C(S(N)(=O)=O)S1 HZIYHIRJHYIRQO-UHFFFAOYSA-N 0.000 description 1
• 229950000426 butazolamide Drugs 0.000 description 1
• 229950003097 butidrine Drugs 0.000 description 1
• ZKSIPEYIAHUPNM-ZEQRLZLVSA-N butobendine Chemical compound C([C@H](CC)N(C)CCN(C)[C@@H](CC)COC(=O)C=1C=C(OC)C(OC)=C(OC)C=1)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZKSIPEYIAHUPNM-ZEQRLZLVSA-N 0.000 description 1
• 229950001141 butobendine Drugs 0.000 description 1
• 229960005211 cadralazine Drugs 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 229950008603 camphotamide Drugs 0.000 description 1
• 229960005057 canrenone Drugs 0.000 description 1
• UJVLDDZCTMKXJK-WNHSNXHDSA-N canrenone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CCC(=O)C=C3C=C2)C)CC[C@@]11C)C[C@@]11CCC(=O)O1 UJVLDDZCTMKXJK-WNHSNXHDSA-N 0.000 description 1
• 229950007443 capobenic acid Drugs 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 229960005003 carbocromen Drugs 0.000 description 1
• KLOIYEQEVSIOOO-UHFFFAOYSA-N carbocromen Chemical compound CC1=C(CCN(CC)CC)C(=O)OC2=CC(OCC(=O)OCC)=CC=C21 KLOIYEQEVSIOOO-UHFFFAOYSA-N 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 229960001386 carbuterol Drugs 0.000 description 1
• KEMXXQOFIRIICG-UHFFFAOYSA-N carbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(NC(N)=O)=C1 KEMXXQOFIRIICG-UHFFFAOYSA-N 0.000 description 1
• 230000001269 cardiogenic effect Effects 0.000 description 1
• 206010007625 cardiogenic shock Diseases 0.000 description 1
• 230000003177 cardiotonic effect Effects 0.000 description 1
• 229940072282 cardura Drugs 0.000 description 1
• FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 description 1
• 229940063628 catapres Drugs 0.000 description 1
• 238000005341 cation exchange Methods 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000032823 cell division Effects 0.000 description 1
• 230000007910 cell fusion Effects 0.000 description 1
• 239000006285 cell suspension Substances 0.000 description 1
• 230000003833 cell viability Effects 0.000 description 1
• 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 239000000919 ceramic Substances 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• PBKVEOSEPXMKDN-LZHUFOCISA-N chembl2311030 Chemical class CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)CC)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 PBKVEOSEPXMKDN-LZHUFOCISA-N 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 210000003837 chick embryo Anatomy 0.000 description 1
• IHJCXVZDYSXXFT-UHFFFAOYSA-N chloraminophenamide Chemical compound NC1=CC(Cl)=C(S(N)(=O)=O)C=C1S(N)(=O)=O IHJCXVZDYSXXFT-UHFFFAOYSA-N 0.000 description 1
• YRZQHIVOIFJEEE-UHFFFAOYSA-N chlorazanil Chemical compound NC1=NC=NC(NC=2C=CC(Cl)=CC=2)=N1 YRZQHIVOIFJEEE-UHFFFAOYSA-N 0.000 description 1
• 229950002325 chlorazanil Drugs 0.000 description 1
• DXXUGBPKQDTBQW-UHFFFAOYSA-L chlorisondamine Chemical compound [Cl-].[Cl-].ClC1=C(Cl)C(Cl)=C(Cl)C2=C1C[N+](CC[N+](C)(C)C)(C)C2 DXXUGBPKQDTBQW-UHFFFAOYSA-L 0.000 description 1
• 229950002565 chlorisondamine Drugs 0.000 description 1
• BJFGVYCULWBXKF-UHFFFAOYSA-M chlormerodrin Chemical compound Cl[Hg]CC(OC)CNC(N)=O BJFGVYCULWBXKF-UHFFFAOYSA-M 0.000 description 1
• 229950002901 chlormerodrin Drugs 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
• 229940059329 chondroitin sulfate Drugs 0.000 description 1
• 210000003483 chromatin Anatomy 0.000 description 1
• 238000011210 chromatographic step Methods 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 229960004757 cibenzoline Drugs 0.000 description 1
• AJPLPOWGYORUIF-UHFFFAOYSA-N ciclosidomine Chemical compound C1CCCCC1C(/[O-])=N/C(ON=1)=C[N+]=1N1CCOCC1 AJPLPOWGYORUIF-UHFFFAOYSA-N 0.000 description 1
• 229950008471 ciclosidomine Drugs 0.000 description 1
• LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
• 229960000876 cinnarizine Drugs 0.000 description 1
• DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 description 1
• 229960002174 ciprofibrate Drugs 0.000 description 1
• KPSRODZRAIWAKH-UHFFFAOYSA-N ciprofibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C1C(Cl)(Cl)C1 KPSRODZRAIWAKH-UHFFFAOYSA-N 0.000 description 1
• 235000020639 clam Nutrition 0.000 description 1
• 229960001117 clenbuterol Drugs 0.000 description 1
• STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 description 1
• 229950003072 clinofibrate Drugs 0.000 description 1
• 229960002883 clofenamide Drugs 0.000 description 1
• 229960001214 clofibrate Drugs 0.000 description 1
• KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
• TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 description 1
• 229950008441 clofibric acid Drugs 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 229950004347 clonitrate Drugs 0.000 description 1
• SUAJWTBTMNHVBZ-UHFFFAOYSA-N clonitrate Chemical compound [O-][N+](=O)OCC(CCl)O[N+]([O-])=O SUAJWTBTMNHVBZ-UHFFFAOYSA-N 0.000 description 1
• 229960004893 cloranolol Drugs 0.000 description 1
• XYCMOTOFHFTUIU-UHFFFAOYSA-N cloranolol Chemical compound CC(C)(C)NCC(O)COC1=CC(Cl)=CC=C1Cl XYCMOTOFHFTUIU-UHFFFAOYSA-N 0.000 description 1
• 229960005315 clorexolone Drugs 0.000 description 1
• 229960001261 cloridarol Drugs 0.000 description 1
• KBFBRIPYVVGWRS-UHFFFAOYSA-N cloridarol Chemical compound C=1C2=CC=CC=C2OC=1C(O)C1=CC=C(Cl)C=C1 KBFBRIPYVVGWRS-UHFFFAOYSA-N 0.000 description 1
• 229960001307 clorindione Drugs 0.000 description 1
• NJDUWAXIURWWLN-UHFFFAOYSA-N clorindione Chemical compound C1=CC(Cl)=CC=C1C1C(=O)C2=CC=CC=C2C1=O NJDUWAXIURWWLN-UHFFFAOYSA-N 0.000 description 1
• 229950011462 clorprenaline Drugs 0.000 description 1
• 239000000701 coagulant Substances 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 229940097479 colestid Drugs 0.000 description 1
• GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 description 1
• 229960002604 colestipol Drugs 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 238000004440 column chromatography Methods 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 238000012790 confirmation Methods 0.000 description 1
• 208000028831 congenital heart disease Diseases 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000008828 contractile function Effects 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• HULMNSIAKWANQO-JQKSAQOKSA-N convallatoxin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)CC[C@@H]3[C@@]2(C=O)CC1 HULMNSIAKWANQO-JQKSAQOKSA-N 0.000 description 1
• 229940088540 cordarone Drugs 0.000 description 1
• 229940097488 corgard Drugs 0.000 description 1
• 208000029078 coronary artery disease Diseases 0.000 description 1
• 210000000877 corpus callosum Anatomy 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 229940072645 coumadin Drugs 0.000 description 1
• BUCJFFQZPGTGPX-UHFFFAOYSA-N coumetarol Chemical compound C1=CC=C2OC(=O)C(C(C=3C(OC4=CC=CC=C4C=3O)=O)COC)=C(O)C2=C1 BUCJFFQZPGTGPX-UHFFFAOYSA-N 0.000 description 1
• 229950001111 coumetarol Drugs 0.000 description 1
• 229940009995 cryptenamine Drugs 0.000 description 1
• 210000004748 cultured cell Anatomy 0.000 description 1
• 238000011498 curative surgery Methods 0.000 description 1
• ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
• WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
• ZGFASEKBKWVCGP-UHFFFAOYSA-N cyclocoumarol Chemical compound C12=CC=CC=C2OC(=O)C2=C1OC(OC)(C)CC2C1=CC=CC=C1 ZGFASEKBKWVCGP-UHFFFAOYSA-N 0.000 description 1
• 229950002423 cyclocoumarol Drugs 0.000 description 1
• 229960003176 cyclothiazide Drugs 0.000 description 1
• BOCUKUHCLICSIY-QJWLJZLASA-N cyclothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2C1[C@H](C=C2)C[C@H]2C1 BOCUKUHCLICSIY-QJWLJZLASA-N 0.000 description 1
• 229960003083 cymarin Drugs 0.000 description 1
• 230000000120 cytopathologic effect Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
• DKRSEIPLAZTSFD-UHFFFAOYSA-N d-quinotoxine Natural products C12=CC(OC)=CC=C2N=CC=C1C(=O)CCC1CCNCC1C=C DKRSEIPLAZTSFD-UHFFFAOYSA-N 0.000 description 1
• 229950008150 daltroban Drugs 0.000 description 1
• RFWZESUMWJKKRN-UHFFFAOYSA-N dapiprazole Chemical compound CC1=CC=CC=C1N1CCN(CCC=2N3CCCCC3=NN=2)CC1 RFWZESUMWJKKRN-UHFFFAOYSA-N 0.000 description 1
• 229960002947 dapiprazole Drugs 0.000 description 1
• OBATZBGFDSVCJD-UHFFFAOYSA-N de-O-acetyl-lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(O)C1OC1OC(CO)C(O)C(O)C1O OBATZBGFDSVCJD-UHFFFAOYSA-N 0.000 description 1
• JWPGJSVJDAJRLW-UHFFFAOYSA-N debrisoquin Chemical compound C1=CC=C2CN(C(=N)N)CCC2=C1 JWPGJSVJDAJRLW-UHFFFAOYSA-N 0.000 description 1
• 229960004096 debrisoquine Drugs 0.000 description 1
• 229960004120 defibrotide Drugs 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000007850 degeneration Effects 0.000 description 1
• 229960001993 deserpidine Drugs 0.000 description 1
• ISMCNVNDWFIXLM-WCGOZPBSSA-N deserpidine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 ISMCNVNDWFIXLM-WCGOZPBSSA-N 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 229960001324 deslanoside Drugs 0.000 description 1
• OBATZBGFDSVCJD-LALPQLPRSA-N deslanoside Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OBATZBGFDSVCJD-LALPQLPRSA-N 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 229960001912 dicoumarol Drugs 0.000 description 1
• DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 description 1
• HIZKPJUTKKJDGA-UHFFFAOYSA-N dicumarol Natural products O=C1OC2=CC=CC=C2C(=O)C1CC1C(=O)C2=CC=CC=C2OC1=O HIZKPJUTKKJDGA-UHFFFAOYSA-N 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 229950004590 digitalin Drugs 0.000 description 1
• CKNOLMVLQUPVMU-YMMLYESFSA-N digitalin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@H]4[C@H]([C@]3(C[C@@H]2O)O)CC[C@H]2[C@]4(C)CC[C@@H](C2)O[C@H]2[C@H](O)[C@H]([C@H]([C@@H](C)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)OC)=CC(=O)OC1 CKNOLMVLQUPVMU-YMMLYESFSA-N 0.000 description 1
• 229960002877 dihydralazine Drugs 0.000 description 1
• VQKLRVZQQYVIJW-UHFFFAOYSA-N dihydralazine Chemical compound C1=CC=C2C(NN)=NN=C(NN)C2=C1 VQKLRVZQQYVIJW-UHFFFAOYSA-N 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• 229960001079 dilazep Drugs 0.000 description 1
• 229960004166 diltiazem Drugs 0.000 description 1
• HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
• 229960002547 dimetofrine Drugs 0.000 description 1
• ZKGDBJAHIIXDDW-UHFFFAOYSA-N dimetofrine Chemical compound CNCC(O)C1=CC(OC)=C(O)C(OC)=C1 ZKGDBJAHIIXDDW-UHFFFAOYSA-N 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• OHDICGSRVLBVLC-UHFFFAOYSA-N dioxethedrin Chemical compound CCNC(C)C(O)C1=CC=C(O)C(O)=C1 OHDICGSRVLBVLC-UHFFFAOYSA-N 0.000 description 1
• 229950005373 dioxethedrin Drugs 0.000 description 1
• 229960000267 diphenadione Drugs 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 229910000397 disodium phosphate Inorganic materials 0.000 description 1
• 235000019800 disodium phosphate Nutrition 0.000 description 1
• RQXWFEXQGWCOGQ-UHFFFAOYSA-K disodium;carboxylatomethylsulfanyl-[3-[(3-carboxylato-2,2,3-trimethylcyclopentanecarbonyl)amino]-2-methoxypropyl]mercury Chemical compound [Na+].[Na+].[O-]C(=O)CS[Hg]CC(OC)CNC(=O)C1CCC(C)(C([O-])=O)C1(C)C RQXWFEXQGWCOGQ-UHFFFAOYSA-K 0.000 description 1
• CGDDQFMPGMYYQP-UHFFFAOYSA-N disopyramide phosphate Chemical compound OP(O)(O)=O.C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 CGDDQFMPGMYYQP-UHFFFAOYSA-N 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• RCFKEIREOSXLET-UHFFFAOYSA-N disulfamide Chemical compound CC1=CC(Cl)=C(S(N)(=O)=O)C=C1S(N)(=O)=O RCFKEIREOSXLET-UHFFFAOYSA-N 0.000 description 1
• 229950008177 disulfamide Drugs 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 229960003722 doxycycline Drugs 0.000 description 1
• HTAFVGKAHGNWQO-UHFFFAOYSA-N droprenilamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNC(C)CC1CCCCC1 HTAFVGKAHGNWQO-UHFFFAOYSA-N 0.000 description 1
• 229950011072 droprenilamine Drugs 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000013583 drug formulation Substances 0.000 description 1
• 238000002651 drug therapy Methods 0.000 description 1
• 241001493065 dsRNA viruses Species 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 238000003708 edge detection Methods 0.000 description 1
• 230000002526 effect on cardiovascular system Effects 0.000 description 1
• 229960003859 efloxate Drugs 0.000 description 1
• JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 238000004520 electroporation Methods 0.000 description 1
• 230000013020 embryo development Effects 0.000 description 1
• 210000002253 embryonic cardiomyocyte Anatomy 0.000 description 1
• OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 1
• 229960001142 encainide Drugs 0.000 description 1
• 210000002889 endothelial cell Anatomy 0.000 description 1
• 229960002029 endralazine Drugs 0.000 description 1
• ALAXZYHFVBSJKZ-UHFFFAOYSA-N endralazine Chemical compound C1CC=2N=NC(NN)=CC=2CN1C(=O)C1=CC=CC=C1 ALAXZYHFVBSJKZ-UHFFFAOYSA-N 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 108010048367 enhanced green fluorescent protein Proteins 0.000 description 1
• 229960000610 enoxaparin Drugs 0.000 description 1
• 229960000972 enoximone Drugs 0.000 description 1
• ZJKNESGOIKRXQY-UHFFFAOYSA-N enoximone Chemical compound C1=CC(SC)=CC=C1C(=O)C1=C(C)NC(=O)N1 ZJKNESGOIKRXQY-UHFFFAOYSA-N 0.000 description 1
• 230000006862 enzymatic digestion Effects 0.000 description 1
• 229960002179 ephedrine Drugs 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 description 1
• 229960004563 eprosartan Drugs 0.000 description 1
• 229940040520 ergoloid mesylates Drugs 0.000 description 1
• 229960003745 esmolol Drugs 0.000 description 1
• AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 description 1
• 229960003199 etacrynic acid Drugs 0.000 description 1
• 229950002456 etafedrine Drugs 0.000 description 1
• IRVLBORJKFZWMI-JQWIXIFHSA-N etafedrine Chemical compound CCN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 IRVLBORJKFZWMI-JQWIXIFHSA-N 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• OUZWUKMCLIBBOG-UHFFFAOYSA-N ethoxzolamide Chemical compound CCOC1=CC=C2N=C(S(N)(=O)=O)SC2=C1 OUZWUKMCLIBBOG-UHFFFAOYSA-N 0.000 description 1
• 229950005098 ethoxzolamide Drugs 0.000 description 1
• 229960002822 ethyl biscoumacetate Drugs 0.000 description 1
• SEGSDVUVOWIWFX-UHFFFAOYSA-N ethyl biscoumacetate Chemical compound C1=CC=C2C(=O)C(C(C=3C(C4=CC=CC=C4OC=3O)=O)C(=O)OCC)=C(O)OC2=C1 SEGSDVUVOWIWFX-UHFFFAOYSA-N 0.000 description 1
• UPCIBFUJJLCOQG-UHFFFAOYSA-L ethyl-[2-[2-[ethyl(dimethyl)azaniumyl]ethyl-methylamino]ethyl]-dimethylazanium;dibromide Chemical compound [Br-].[Br-].CC[N+](C)(C)CCN(C)CC[N+](C)(C)CC UPCIBFUJJLCOQG-UHFFFAOYSA-L 0.000 description 1
• LENNRXOJHWNHSD-UHFFFAOYSA-N ethylnorepinephrine Chemical compound CCC(N)C(O)C1=CC=C(O)C(O)=C1 LENNRXOJHWNHSD-UHFFFAOYSA-N 0.000 description 1
• 229960002267 ethylnorepinephrine Drugs 0.000 description 1
• WNKCJOWTKXGERE-UHFFFAOYSA-N etifelmine Chemical compound C=1C=CC=CC=1C(=C(CN)CC)C1=CC=CC=C1 WNKCJOWTKXGERE-UHFFFAOYSA-N 0.000 description 1
• 229950005475 etifelmine Drugs 0.000 description 1
• 229960004695 etilefrine Drugs 0.000 description 1
• 229960003501 etofibrate Drugs 0.000 description 1
• XXRVYAFBUDSLJX-UHFFFAOYSA-N etofibrate Chemical compound C=1C=CN=CC=1C(=O)OCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 XXRVYAFBUDSLJX-UHFFFAOYSA-N 0.000 description 1
• 229950009036 etofylline clofibrate Drugs 0.000 description 1
• KYAKGJDISSNVPZ-UHFFFAOYSA-N etofylline clofibrate Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KYAKGJDISSNVPZ-UHFFFAOYSA-N 0.000 description 1
• 229960004514 etozolin Drugs 0.000 description 1
• ZCKKHYXUQFTBIK-KTKRTIGZSA-N etozoline Chemical compound O=C1N(C)C(=C/C(=O)OCC)/SC1N1CCCCC1 ZCKKHYXUQFTBIK-KTKRTIGZSA-N 0.000 description 1
• 238000002270 exclusion chromatography Methods 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• DOBLSWXRNYSVDC-UHFFFAOYSA-N fenalcomine Chemical compound C1=CC(C(O)CC)=CC=C1OCCNC(C)CC1=CC=CC=C1 DOBLSWXRNYSVDC-UHFFFAOYSA-N 0.000 description 1
• 229950009129 fenalcomine Drugs 0.000 description 1
• 229960002297 fenofibrate Drugs 0.000 description 1
• YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
• 229960002724 fenoldopam Drugs 0.000 description 1
• TVURRHSHRRELCG-UHFFFAOYSA-N fenoldopam Chemical compound C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 TVURRHSHRRELCG-UHFFFAOYSA-N 0.000 description 1
• 229960001022 fenoterol Drugs 0.000 description 1
• 229960002912 fenspiride Drugs 0.000 description 1
• 230000020764 fibrinolysis Effects 0.000 description 1
• 239000010419 fine particle Substances 0.000 description 1
• 229960000449 flecainide Drugs 0.000 description 1
• 229950011336 floredil Drugs 0.000 description 1
• MXVLJFCCQMXEEE-UHFFFAOYSA-N floredil Chemical compound CCOC1=CC(OCC)=CC(OCCN2CCOCC2)=C1 MXVLJFCCQMXEEE-UHFFFAOYSA-N 0.000 description 1
• 229960001606 flosequinan Drugs 0.000 description 1
• UYGONJYYUKVHDD-UHFFFAOYSA-N flosequinan Chemical compound C1=C(F)C=C2N(C)C=C(S(C)=O)C(=O)C2=C1 UYGONJYYUKVHDD-UHFFFAOYSA-N 0.000 description 1
• 229960005298 fluindione Drugs 0.000 description 1
• NASXCEITKQITLD-UHFFFAOYSA-N fluindione Chemical compound C1=CC(F)=CC=C1C1C(=O)C2=CC=CC=C2C1=O NASXCEITKQITLD-UHFFFAOYSA-N 0.000 description 1
• SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
• 229960000326 flunarizine Drugs 0.000 description 1
• 229960002848 formoterol Drugs 0.000 description 1
• BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 229950010710 furazabol Drugs 0.000 description 1
• 229950001523 furterene Drugs 0.000 description 1
• VRGWBRLULZUWAJ-UHFFFAOYSA-N fusaproliferin Natural products C1C=C(C)CCC=C(C)CCC(O)C(C)=CCC2C(C(COC(C)=O)C)=C(O)C(=O)C21C VRGWBRLULZUWAJ-UHFFFAOYSA-N 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 101150098622 gag gene Proteins 0.000 description 1
• 229960000457 gallopamil Drugs 0.000 description 1
• FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
• 229950008114 ganglefene Drugs 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 238000001641 gel filtration chromatography Methods 0.000 description 1
• 229960003627 gemfibrozil Drugs 0.000 description 1
• 238000001476 gene delivery Methods 0.000 description 1
• 238000010363 gene targeting Methods 0.000 description 1
• 231100000025 genetic toxicology Toxicity 0.000 description 1
• 230000001738 genotoxic effect Effects 0.000 description 1
• 231100000734 genotoxic potential Toxicity 0.000 description 1
• 229960005059 gepefrine Drugs 0.000 description 1
• WTDGMHYYGNJEKQ-ZETCQYMHSA-N gepefrine Chemical compound C[C@H](N)CC1=CC=CC(O)=C1 WTDGMHYYGNJEKQ-ZETCQYMHSA-N 0.000 description 1
• 210000002816 gill Anatomy 0.000 description 1
• 229940118313 gitalin Drugs 0.000 description 1
• LKRDZKPBAOKJBT-CNPIRKNPSA-N gitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(C[C@H](O)[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LKRDZKPBAOKJBT-CNPIRKNPSA-N 0.000 description 1
• 229950000974 gitoxin Drugs 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 229950006795 guanacline Drugs 0.000 description 1
• WQVAYGCXSJMPRT-UHFFFAOYSA-N guanacline Chemical compound CC1=CCN(CCN=C(N)N)CC1 WQVAYGCXSJMPRT-UHFFFAOYSA-N 0.000 description 1
• 229960003845 guanadrel Drugs 0.000 description 1
• HPBNRIOWIXYZFK-UHFFFAOYSA-N guanadrel Chemical compound O1C(CNC(=N)N)COC11CCCCC1 HPBNRIOWIXYZFK-UHFFFAOYSA-N 0.000 description 1
• 229960004614 guanazodine Drugs 0.000 description 1
• ZCVAIGPGEINFCX-UHFFFAOYSA-N guanazodine Chemical compound NC(=N)NCC1CCCCCCN1 ZCVAIGPGEINFCX-UHFFFAOYSA-N 0.000 description 1
• XIHXRRMCNSMUET-UHFFFAOYSA-N guanoclor Chemical compound NC(=N)NNCCOC1=C(Cl)C=CC=C1Cl XIHXRRMCNSMUET-UHFFFAOYSA-N 0.000 description 1
• 229960001016 guanoxabenz Drugs 0.000 description 1
• QKIQJNNDIWGVEH-UUILKARUSA-N guanoxabenz Chemical compound ONC(/N)=N/N=C/C1=C(Cl)C=CC=C1Cl QKIQJNNDIWGVEH-UUILKARUSA-N 0.000 description 1
• 229960000760 guanoxan Drugs 0.000 description 1
• HIUVKVDQFXDZHU-UHFFFAOYSA-N guanoxan Chemical compound C1=CC=C2OC(CNC(=N)N)COC2=C1 HIUVKVDQFXDZHU-UHFFFAOYSA-N 0.000 description 1
• 230000010247 heart contraction Effects 0.000 description 1
• 208000025339 heart septal defect Diseases 0.000 description 1
• 238000003505 heat denaturation Methods 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 229910001385 heavy metal Inorganic materials 0.000 description 1
• 230000003067 hemagglutinative effect Effects 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
• 208000031169 hemorrhagic disease Diseases 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• 210000003494 hepatocyte Anatomy 0.000 description 1
• 229960005402 heptaminol Drugs 0.000 description 1
• 229950002932 hexamethonium Drugs 0.000 description 1
• 229960002212 hexobendine Drugs 0.000 description 1
• KRQAMFQCSAJCRH-UHFFFAOYSA-N hexobendine Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCCN(C)CCN(C)CCCOC(=O)C=2C=C(OC)C(OC)=C(OC)C=2)=C1 KRQAMFQCSAJCRH-UHFFFAOYSA-N 0.000 description 1
• 229960000708 hexoprenaline Drugs 0.000 description 1
• OXLZNBCNGJWPRV-UHFFFAOYSA-N hexoprenaline Chemical compound C=1C=C(O)C(O)=CC=1C(O)CNCCCCCCNCC(O)C1=CC=C(O)C(O)=C1 OXLZNBCNGJWPRV-UHFFFAOYSA-N 0.000 description 1
• 229940006607 hirudin Drugs 0.000 description 1
• WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 210000003917 human chromosome Anatomy 0.000 description 1
• YOJQZPVUNUQTDF-UHFFFAOYSA-N hydrastinine Chemical compound C1=C2C(O)N(C)CCC2=CC2=C1OCO2 YOJQZPVUNUQTDF-UHFFFAOYSA-N 0.000 description 1
• 235000011167 hydrochloric acid Nutrition 0.000 description 1
• 229960002003 hydrochlorothiazide Drugs 0.000 description 1
• 229960003313 hydroflumethiazide Drugs 0.000 description 1
• 229960000811 hydroquinidine Drugs 0.000 description 1
• 150000004679 hydroxides Chemical class 0.000 description 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
• 238000012872 hydroxylapatite chromatography Methods 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 238000013388 immunohistochemistry analysis Methods 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• UCEWGESNIULAGX-UHFFFAOYSA-N indecainide Chemical compound C1=CC=C2C(CCCNC(C)C)(C(N)=O)C3=CC=CC=C3C2=C1 UCEWGESNIULAGX-UHFFFAOYSA-N 0.000 description 1
• 229950004448 indecainide Drugs 0.000 description 1
• 229960003422 indobufen Drugs 0.000 description 1
• AYDXAULLCROVIT-UHFFFAOYSA-N indobufen Chemical compound C1=CC(C(C(O)=O)CC)=CC=C1N1C(=O)C2=CC=CC=C2C1 AYDXAULLCROVIT-UHFFFAOYSA-N 0.000 description 1
• 229960002056 indoramin Drugs 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000001524 infective effect Effects 0.000 description 1
• 230000036512 infertility Effects 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 239000002054 inoculum Substances 0.000 description 1
• 150000007529 inorganic bases Chemical class 0.000 description 1
• 238000002743 insertional mutagenesis Methods 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 230000003601 intercostal effect Effects 0.000 description 1
• 210000002570 interstitial cell Anatomy 0.000 description 1
• 238000010212 intracellular staining Methods 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 230000001534 intropic effect Effects 0.000 description 1
• 229960002198 irbesartan Drugs 0.000 description 1
• YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 description 1
• OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 description 1
• 229960001268 isoetarine Drugs 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• 229940039009 isoproterenol Drugs 0.000 description 1
• 229960002479 isosorbide Drugs 0.000 description 1
• 229960001557 itramin tosilate Drugs 0.000 description 1
• 229940072289 kerlone Drugs 0.000 description 1
• FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 description 1
• 229960005417 ketanserin Drugs 0.000 description 1
• 229960002801 khellin Drugs 0.000 description 1
• HSMPDPBYAYSOBC-UHFFFAOYSA-N khellin Chemical compound O1C(C)=CC(=O)C2=C1C(OC)=C1OC=CC1=C2OC HSMPDPBYAYSOBC-UHFFFAOYSA-N 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 108010034897 lentil lectin Proteins 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 229940096773 levatol Drugs 0.000 description 1
• 229960000831 levobunolol Drugs 0.000 description 1
• IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 description 1
• 229960001941 lidoflazine Drugs 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• KSMAGQUYOIHWFS-UHFFFAOYSA-N lofexidine Chemical compound N=1CCNC=1C(C)OC1=C(Cl)C=CC=C1Cl KSMAGQUYOIHWFS-UHFFFAOYSA-N 0.000 description 1
• 229960005209 lofexidine Drugs 0.000 description 1
• 229940089504 lopressor Drugs 0.000 description 1
• 229960001725 lorajmine Drugs 0.000 description 1
• LAHDERDHXJFFJU-ZWNKPRIXSA-N lorajmine Chemical compound CN([C@H]1[C@@H]2C3)C4=CC=CC=C4[C@]11C[C@@H]4N2[C@H](O)[C@@H](CC)[C@H]3[C@@H]4[C@H]1OC(=O)CCl LAHDERDHXJFFJU-ZWNKPRIXSA-N 0.000 description 1
• XHOJAWVAWFHGHL-UHFFFAOYSA-N lorcainide Chemical compound C1CN(C(C)C)CCC1N(C=1C=CC(Cl)=CC=1)C(=O)CC1=CC=CC=C1 XHOJAWVAWFHGHL-UHFFFAOYSA-N 0.000 description 1
• 229960001074 lorcainide Drugs 0.000 description 1
• 229960004773 losartan Drugs 0.000 description 1
• KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 1
• PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• JSJCTEKTBOKRST-UHFFFAOYSA-N mabuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(C(F)(F)F)=C1 JSJCTEKTBOKRST-UHFFFAOYSA-N 0.000 description 1
• 229950004407 mabuterol Drugs 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• 229940091250 magnesium supplement Drugs 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 238000013507 mapping Methods 0.000 description 1
• 230000035800 maturation Effects 0.000 description 1
• 229960004119 mebutamate Drugs 0.000 description 1
• ORAUEDBBTFLQSK-UHFFFAOYSA-N medibazine Chemical compound C=1C=C2OCOC2=CC=1CN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 ORAUEDBBTFLQSK-UHFFFAOYSA-N 0.000 description 1
• 229950000437 medibazine Drugs 0.000 description 1
• 101150014102 mef-2 gene Proteins 0.000 description 1
• 229960004678 mefruside Drugs 0.000 description 1
• 229960001961 meglutol Drugs 0.000 description 1
• 229950008446 melinamide Drugs 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 210000004779 membrane envelope Anatomy 0.000 description 1
• 229950009531 meobentine Drugs 0.000 description 1
• SPLVKBMIQSSFFN-UHFFFAOYSA-N meobentine Chemical compound CNC(=NC)NCC1=CC=C(OC)C=C1 SPLVKBMIQSSFFN-UHFFFAOYSA-N 0.000 description 1
• 229950005795 meralluride Drugs 0.000 description 1
• 229960000224 mersalyl Drugs 0.000 description 1
• 230000010012 metabolic coupling Effects 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
• 229960003663 metaraminol Drugs 0.000 description 1
• 229960004083 methazolamide Drugs 0.000 description 1
• FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 description 1
• 229960005405 methoxyphenamine Drugs 0.000 description 1
• OEHAYUOVELTAPG-UHFFFAOYSA-N methoxyphenamine Chemical compound CNC(C)CC1=CC=CC=C1OC OEHAYUOVELTAPG-UHFFFAOYSA-N 0.000 description 1
• COAPCKUZMKOWBC-ZEJGPHSTSA-N methyl (1s,4ar,4bs,7e,8r,8as,9s,10ar)-9-hydroxy-1,4a,8-trimethyl-7-[2-[2-(methylamino)ethoxy]-2-oxoethylidene]-3,4,4b,5,6,8,8a,9,10,10a-decahydro-2h-phenanthrene-1-carboxylate Chemical compound [C@H]1([C@@](CCC2)(C)C(=O)OC)[C@@]2(C)[C@H]2CC\C(=C/C(=O)OCCNC)[C@H](C)[C@@H]2[C@@H](O)C1 COAPCKUZMKOWBC-ZEJGPHSTSA-N 0.000 description 1
• RWXOJPNUXMEPLE-UHFFFAOYSA-N methyl 6,18-dimethoxy-3-nitro-17-(3,4,5-trimethoxybenzoyl)oxy-11,12,14,15,16,17,18,19,20,21-decahydro-1h-yohimban-19-carboxylate Chemical compound C1C2CN3CCC(C4=CC=C(OC)C=C4N4[N+]([O-])=O)=C4C3CC2C(C(=O)OC)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 RWXOJPNUXMEPLE-UHFFFAOYSA-N 0.000 description 1
• ZOSQTCOGKFRDET-UHFFFAOYSA-L methyl sulfate;trimethyl-[3-(3,5,8,8-tetramethyl-3-azoniabicyclo[3.2.1]octan-3-yl)propyl]azanium Chemical compound COS([O-])(=O)=O.COS([O-])(=O)=O.C1[N+](C)(CCC[N+](C)(C)C)CC2(C)CCC1C2(C)C ZOSQTCOGKFRDET-UHFFFAOYSA-L 0.000 description 1
• ABJKIHHNDMEBNA-UHFFFAOYSA-N methylchromone Chemical group C1=CC=C2C(=O)C(C)=COC2=C1 ABJKIHHNDMEBNA-UHFFFAOYSA-N 0.000 description 1
• 229950009263 methylchromone Drugs 0.000 description 1
• 229950005579 metochalcone Drugs 0.000 description 1
• VLPIATFUUWWMKC-UHFFFAOYSA-N mexiletine Chemical compound CC(N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-UHFFFAOYSA-N 0.000 description 1
• 229960003404 mexiletine Drugs 0.000 description 1
• 229960004438 mibefradil Drugs 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 229960001094 midodrine Drugs 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 description 1
• 229960003574 milrinone Drugs 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 229940064639 minipress Drugs 0.000 description 1
• 208000019266 moderate heart failure Diseases 0.000 description 1
• 230000020654 modulation by virus of host translation Effects 0.000 description 1
• 239000002808 molecular sieve Substances 0.000 description 1
• 229960002608 moracizine Drugs 0.000 description 1
• FUBVWMNBEHXPSU-UHFFFAOYSA-N moricizine Chemical compound C12=CC(NC(=O)OCC)=CC=C2SC2=CC=CC=C2N1C(=O)CCN1CCOCC1 FUBVWMNBEHXPSU-UHFFFAOYSA-N 0.000 description 1
• 229960005181 morphine Drugs 0.000 description 1
• 229950006549 moveltipril Drugs 0.000 description 1
• 210000000663 muscle cell Anatomy 0.000 description 1
• 230000004118 muscle contraction Effects 0.000 description 1
• 210000002464 muscle smooth vascular Anatomy 0.000 description 1
• 101150008049 mx gene Proteins 0.000 description 1
• 230000023105 myelination Effects 0.000 description 1
• 108010065781 myosin light chain 2 Proteins 0.000 description 1
• OOVXZFCPCSVSEM-NADOGSGZSA-N mytatrienediol Chemical compound C1C[C@]2(C)[C@@H](O)[C@@](C)(O)C[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 OOVXZFCPCSVSEM-NADOGSGZSA-N 0.000 description 1
• GACQNVJDWUAPFY-UHFFFAOYSA-N n'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride Chemical compound Cl.NCCNCCNCCNCCN GACQNVJDWUAPFY-UHFFFAOYSA-N 0.000 description 1
• QPHACUMLBDXKIF-UHFFFAOYSA-M n,n-diethyl-1-methylpyridin-1-ium-3-carboxamide;4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-2-sulfonate Chemical compound CCN(CC)C(=O)C1=CC=C[N+](C)=C1.C1CC2(C)C(=O)C(S([O-])(=O)=O)C1C2(C)C QPHACUMLBDXKIF-UHFFFAOYSA-M 0.000 description 1
• HHRNQOGXBRYCHF-UHFFFAOYSA-N n-[2-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide Chemical compound CC(C)NCC(O)C1=CC=C(O)C(NS(C)(=O)=O)=C1 HHRNQOGXBRYCHF-UHFFFAOYSA-N 0.000 description 1
• UPZVYDSBLFNMLK-UHFFFAOYSA-N nadoxolol Chemical compound C1=CC=C2C(OCC(O)CC(/N)=N/O)=CC=CC2=C1 UPZVYDSBLFNMLK-UHFFFAOYSA-N 0.000 description 1
• 229960004501 nadoxolol Drugs 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 description 1
• 230000004766 neurogenesis Effects 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 229960003642 nicergoline Drugs 0.000 description 1
• 229960000827 niceritrol Drugs 0.000 description 1
• XPPXHQUWVYMTDM-UHFFFAOYSA-N nicoclonate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)OC(=O)C1=CC=CN=C1 XPPXHQUWVYMTDM-UHFFFAOYSA-N 0.000 description 1
• 229950011138 nicoclonate Drugs 0.000 description 1
• 229950005171 nicofibrate Drugs 0.000 description 1
• RARQHAFNGNPQCZ-UHFFFAOYSA-N nicofibrate Chemical compound C=1C=CN=CC=1COC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 RARQHAFNGNPQCZ-UHFFFAOYSA-N 0.000 description 1
• 229950001071 nicomol Drugs 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• UAORFCGRZIGNCI-UHFFFAOYSA-N nifenalol Chemical compound CC(C)NCC(O)C1=CC=C([N+]([O-])=O)C=C1 UAORFCGRZIGNCI-UHFFFAOYSA-N 0.000 description 1
• 229950000096 nifenalol Drugs 0.000 description 1
• 229960005366 nilvadipine Drugs 0.000 description 1
• 229960000715 nimodipine Drugs 0.000 description 1
• 229940072991 nitro-bid Drugs 0.000 description 1
• 229960002460 nitroprusside Drugs 0.000 description 1
• 229940073015 nitrostat Drugs 0.000 description 1
• 231100000957 no side effect Toxicity 0.000 description 1
• 229960002748 norepinephrine Drugs 0.000 description 1
• SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
• 229940088938 norpace Drugs 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 210000000869 occipital lobe Anatomy 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 238000003305 oral gavage Methods 0.000 description 1
• 229960002657 orciprenaline Drugs 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000007530 organic bases Chemical class 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 229960003343 ouabain Drugs 0.000 description 1
• 229950001773 oxazidione Drugs 0.000 description 1
• 229960003684 oxedrine Drugs 0.000 description 1
• FJCFFCXMEXZEIM-UHFFFAOYSA-N oxiniacic acid Chemical compound OC(=O)C1=CC=C[N+]([O-])=C1 FJCFFCXMEXZEIM-UHFFFAOYSA-N 0.000 description 1
• 229950005065 oxiniacic acid Drugs 0.000 description 1
• 229950003837 ozagrel Drugs 0.000 description 1
• SHZKQBHERIJWAO-AATRIKPKSA-N ozagrel Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1CN1C=NC=C1 SHZKQBHERIJWAO-AATRIKPKSA-N 0.000 description 1
• BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
• DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 description 1
• 229960000903 pantethine Drugs 0.000 description 1
• 235000008975 pantethine Nutrition 0.000 description 1
• 239000011581 pantethine Substances 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 229960001779 pargyline Drugs 0.000 description 1
• 238000004810 partition chromatography Methods 0.000 description 1
• 235000020232 peanut Nutrition 0.000 description 1
• 229950009414 pempidine Drugs 0.000 description 1
• FEDSNBHHWZEYTP-ZFQYHYQMSA-N penbutolol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1.CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 FEDSNBHHWZEYTP-ZFQYHYQMSA-N 0.000 description 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
• 229960004321 pentaerithrityl tetranitrate Drugs 0.000 description 1
• GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 description 1
• 229950000494 pentamethonium bromide Drugs 0.000 description 1
• HSMKTIKKPMTUQH-WBPXWQEISA-L pentolinium tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C([O-])=O.OC(=O)[C@H](O)[C@@H](O)C([O-])=O.C1CCC[N+]1(C)CCCCC[N+]1(C)CCCC1 HSMKTIKKPMTUQH-WBPXWQEISA-L 0.000 description 1
• 229950008637 pentolonium Drugs 0.000 description 1
• 229940043138 pentosan polysulfate Drugs 0.000 description 1
• BRBAEHHXGZRCBK-UHFFFAOYSA-N pentrinitrol Chemical compound [O-][N+](=O)OCC(CO)(CO[N+]([O-])=O)CO[N+]([O-])=O BRBAEHHXGZRCBK-UHFFFAOYSA-N 0.000 description 1
• 229950006286 pentrinitrol Drugs 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 239000000810 peripheral vasodilating agent Substances 0.000 description 1
• 229960002116 peripheral vasodilator Drugs 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 229950001512 phenactropinium chloride Drugs 0.000 description 1
• 229960000280 phenindione Drugs 0.000 description 1
• NFBAXHOPROOJAW-UHFFFAOYSA-N phenindione Chemical compound O=C1C2=CC=CC=C2C(=O)C1C1=CC=CC=C1 NFBAXHOPROOJAW-UHFFFAOYSA-N 0.000 description 1
• VXTWEDPZMSVFEF-UHFFFAOYSA-N pheniprazine Chemical compound NNC(C)CC1=CC=CC=C1 VXTWEDPZMSVFEF-UHFFFAOYSA-N 0.000 description 1
• 229950005573 pheniprazine Drugs 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• 229960004923 phenprocoumon Drugs 0.000 description 1
• DQDAYGNAKTZFIW-UHFFFAOYSA-N phenprocoumon Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC)C1=CC=CC=C1 DQDAYGNAKTZFIW-UHFFFAOYSA-N 0.000 description 1
• MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
• 229960001999 phentolamine Drugs 0.000 description 1
• SBUQZKJEOOQSBV-UHFFFAOYSA-N pholedrine Chemical compound CNC(C)CC1=CC=C(O)C=C1 SBUQZKJEOOQSBV-UHFFFAOYSA-N 0.000 description 1
• 229960001029 pholedrine Drugs 0.000 description 1
• QGVLYPPODPLXMB-QXYKVGAMSA-N phorbol Natural products C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@H]3C=C(CO)C[C@@]4(O)[C@H](C=C(C)C4=O)[C@@]13O)C2(C)C QGVLYPPODPLXMB-QXYKVGAMSA-N 0.000 description 1
• 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
• 235000011007 phosphoric acid Nutrition 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
• KYIAWOXNPBANEW-UHFFFAOYSA-N pildralazine Chemical compound CC(O)CN(C)C1=CC=C(NN)N=N1 KYIAWOXNPBANEW-UHFFFAOYSA-N 0.000 description 1
• 229950007220 pildralazine Drugs 0.000 description 1
• CDHVRXOLGDSJGX-UHFFFAOYSA-N pimefylline Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCNCC1=CC=CN=C1 CDHVRXOLGDSJGX-UHFFFAOYSA-N 0.000 description 1
• 229950010919 pimefylline Drugs 0.000 description 1
• 229960002310 pinacidil Drugs 0.000 description 1
• LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 description 1
• 229950007976 piperoxan Drugs 0.000 description 1
• 229960005414 pirbuterol Drugs 0.000 description 1
• 229960001085 piretanide Drugs 0.000 description 1
• 229950000957 pirifibrate Drugs 0.000 description 1
• YJBIJSVYPHRVCI-UHFFFAOYSA-N pirifibrate Chemical compound C=1C=CC(CO)=NC=1COC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 YJBIJSVYPHRVCI-UHFFFAOYSA-N 0.000 description 1
• 229950008066 pirmenol Drugs 0.000 description 1
• DIIBXMIIOQXTHW-UHFFFAOYSA-N pirozadil Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCC=2N=C(COC(=O)C=3C=C(OC)C(OC)=C(OC)C=3)C=CC=2)=C1 DIIBXMIIOQXTHW-UHFFFAOYSA-N 0.000 description 1
• 229950008646 pirozadil Drugs 0.000 description 1
• 229950010439 plafibride Drugs 0.000 description 1
• DDDQVDIPBFGVIG-UHFFFAOYSA-N plafibride Chemical compound C1COCCN1CNC(=O)NC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 DDDQVDIPBFGVIG-UHFFFAOYSA-N 0.000 description 1
• 229940012957 plasmin Drugs 0.000 description 1
• 108700004029 pol Genes Proteins 0.000 description 1
• 229920001992 poloxamer 407 Polymers 0.000 description 1
• 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
• 229920002791 poly-4-hydroxybutyrate Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 229920000656 polylysine Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000004926 polymethyl methacrylate Substances 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 108010005636 polypeptide C Proteins 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 230000003334 potential effect Effects 0.000 description 1
• 229960001749 practolol Drugs 0.000 description 1
• DURULFYMVIFBIR-UHFFFAOYSA-N practolol Chemical compound CC(C)NCC(O)COC1=CC=C(NC(C)=O)C=C1 DURULFYMVIFBIR-UHFFFAOYSA-N 0.000 description 1
• 229960004215 prajmaline Drugs 0.000 description 1
• UAUHEPXILIZYCU-ALHOSYKFSA-N prajmalium Chemical compound CN([C@H]12)C3=CC=CC=C3[C@]11C[C@@H]3[N@@+](CCC)([C@@H]([C@H]4CC)O)[C@H]2C[C@@H]4[C@@H]3[C@H]1O UAUHEPXILIZYCU-ALHOSYKFSA-N 0.000 description 1
• 229960002965 pravastatin Drugs 0.000 description 1
• TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
• WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 229960004358 prenalterol Drugs 0.000 description 1
• 229960001989 prenylamine Drugs 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 229950002277 primaperone Drugs 0.000 description 1
• 230000001566 pro-viral effect Effects 0.000 description 1
• 229960003912 probucol Drugs 0.000 description 1
• FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
• 229960000244 procainamide Drugs 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• 229960002288 procaterol Drugs 0.000 description 1
• FKNXQNWAXFXVNW-BLLLJJGKSA-N procaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)[C@@H](NC(C)C)CC FKNXQNWAXFXVNW-BLLLJJGKSA-N 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000002062 proliferating effect Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 229930185346 proliferin Natural products 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• JWHAUXFOSRPERK-UHFFFAOYSA-N propafenone Chemical compound CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 1
• 229960000203 propafenone Drugs 0.000 description 1
• 230000001902 propagating effect Effects 0.000 description 1
• XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
• 229960003712 propranolol Drugs 0.000 description 1
• 229940048914 protamine Drugs 0.000 description 1
• 108060006633 protein kinase Proteins 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• MXRGZXBFSKSZPH-UHFFFAOYSA-N protheobromine Chemical compound O=C1N(CC(O)C)C(=O)N(C)C2=C1N(C)C=N2 MXRGZXBFSKSZPH-UHFFFAOYSA-N 0.000 description 1
• 229950001920 protheobromine Drugs 0.000 description 1
• LUMAEVHDZXIGEP-UHFFFAOYSA-N protokylol Chemical compound C=1C=C2OCOC2=CC=1CC(C)NCC(O)C1=CC=C(O)C(O)=C1 LUMAEVHDZXIGEP-UHFFFAOYSA-N 0.000 description 1
• 229950009066 protokylol Drugs 0.000 description 1
• CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 229940070851 pyridinolcarbamate Drugs 0.000 description 1
• NCZXKYCNHGRFHE-UHFFFAOYSA-N pyrinoline Chemical compound C=1C=CC=NC=1C(C=1N=CC=CC=1)(O)C(C=C1)=CC1=C(C=1N=CC=CC=1)C1=CC=CC=N1 NCZXKYCNHGRFHE-UHFFFAOYSA-N 0.000 description 1
• 229950006756 pyrinoline Drugs 0.000 description 1
• 229940073095 questran Drugs 0.000 description 1
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
• 229960001404 quinidine Drugs 0.000 description 1
• 229960000755 quinidine polygalacturonate Drugs 0.000 description 1
• 239000009847 quinidine polygalacturonate Substances 0.000 description 1
• 229960004482 quinidine sulfate Drugs 0.000 description 1
• ZLQMRLSBXKQKMG-UHFFFAOYSA-N rauniticine Natural products COC(=O)C1=CC2CC3N(CCc4c3[nH]c5ccccc45)CC2C(C)O1 ZLQMRLSBXKQKMG-UHFFFAOYSA-N 0.000 description 1
• 230000008707 rearrangement Effects 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000001172 regenerating effect Effects 0.000 description 1
• 230000011371 regulation of developmental process Effects 0.000 description 1
• 230000037425 regulation of transcription Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 229960002720 reproterol Drugs 0.000 description 1
• WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 1
• 229950002609 rescimetol Drugs 0.000 description 1
• 229960001965 rescinnamine Drugs 0.000 description 1
• SMSAPZICLFYVJS-QEGASFHISA-N rescinnamine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)\C=C\C1=CC(OC)=C(OC)C(OC)=C1 SMSAPZICLFYVJS-QEGASFHISA-N 0.000 description 1
• ATLJNLYIJOCWJE-UHFFFAOYSA-N resibufogenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C=1C=CC(=O)OC=1 ATLJNLYIJOCWJE-UHFFFAOYSA-N 0.000 description 1
• 230000036387 respiratory rate Effects 0.000 description 1
• 208000023504 respiratory system disease Diseases 0.000 description 1
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 229960000764 rilmenidine Drugs 0.000 description 1
• 229960001457 rimiterol Drugs 0.000 description 1
• IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
• 229960001634 ritodrine Drugs 0.000 description 1
• IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
• 229960000804 ronifibrate Drugs 0.000 description 1
• AYJVGKWCGIYEAK-UHFFFAOYSA-N ronifibrate Chemical compound C=1C=CN=CC=1C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 AYJVGKWCGIYEAK-UHFFFAOYSA-N 0.000 description 1
• 229960002052 salbutamol Drugs 0.000 description 1
• 229930182490 saponin Natural products 0.000 description 1
• 150000007949 saponins Chemical class 0.000 description 1
• PFGWGEPQIUAZME-NXSMLHPHSA-N saralasin Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 PFGWGEPQIUAZME-NXSMLHPHSA-N 0.000 description 1
• 229960004785 saralasin Drugs 0.000 description 1
• 108010073863 saruplase Proteins 0.000 description 1
• NXJOCELNFPGKIV-ARHXXGKOSA-N scillaren A Chemical compound C=1([C@@H]2[C@@]3(C)CC[C@@H]4[C@@]5(C)CC[C@@H](C=C5CC[C@H]4[C@@]3(O)CC2)O[C@@H]2O[C@H]([C@@H]([C@@H](O)[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)C=CC(=O)OC=1 NXJOCELNFPGKIV-ARHXXGKOSA-N 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 239000013605 shuttle vector Substances 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229960004058 simfibrate Drugs 0.000 description 1
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
• 229950005143 sitosterol Drugs 0.000 description 1
• 230000022379 skeletal muscle tissue development Effects 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 210000001057 smooth muscle myoblast Anatomy 0.000 description 1
• 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• 229920002351 sodium apolate Polymers 0.000 description 1
• 229940054269 sodium pyruvate Drugs 0.000 description 1
• BDFXZRBRZBBYDN-UHFFFAOYSA-L sodium;[3-(3-carboxylatopropanoylcarbamoylamino)-2-methoxypropyl]mercury(1+);1,3-dimethyl-7h-purine-2,6-dione;hydroxide Chemical compound [OH-].[Na+].O=C1N(C)C(=O)N(C)C2=C1NC=N2.COC(C[Hg+])CNC(=O)NC(=O)CCC([O-])=O BDFXZRBRZBBYDN-UHFFFAOYSA-L 0.000 description 1
• QGGPRJRKWYRGKR-UHFFFAOYSA-M sodium;[3-[[2-(carboxylatomethoxy)benzoyl]amino]-2-methoxypropyl]mercury;hydrate Chemical group O.[Na+].COC(C[Hg])CNC(=O)C1=CC=CC=C1OCC([O-])=O QGGPRJRKWYRGKR-UHFFFAOYSA-M 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 210000001082 somatic cell Anatomy 0.000 description 1
• 238000000527 sonication Methods 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
• 229960002370 sotalol Drugs 0.000 description 1
• 229950010289 soterenol Drugs 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 229960002256 spironolactone Drugs 0.000 description 1
• LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 230000007480 spreading Effects 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 230000010473 stable expression Effects 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 108091007196 stromelysin Proteins 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003456 sulfonamides Chemical class 0.000 description 1
• XMFCOYRWYYXZMY-UHFFFAOYSA-N sulmazole Chemical compound COC1=CC(S(C)=O)=CC=C1C1=NC2=NC=CC=C2N1 XMFCOYRWYYXZMY-UHFFFAOYSA-N 0.000 description 1
• 229950006153 sulmazole Drugs 0.000 description 1
• 230000010741 sumoylation Effects 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000011477 surgical intervention Methods 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 229950006534 syrosingopine Drugs 0.000 description 1
• 229940037128 systemic glucocorticoids Drugs 0.000 description 1
• 229940106719 tambocor Drugs 0.000 description 1
• 238000010863 targeted diagnosis Methods 0.000 description 1
• 238000002626 targeted therapy Methods 0.000 description 1
• 229960003080 taurine Drugs 0.000 description 1
• 229950009303 teclothiazide Drugs 0.000 description 1
• GUTZRTRUIMWMJZ-UHFFFAOYSA-N teclothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)(Cl)Cl)NS2(=O)=O GUTZRTRUIMWMJZ-UHFFFAOYSA-N 0.000 description 1
• 229940065385 tenex Drugs 0.000 description 1
• 229940108485 tenormin Drugs 0.000 description 1
• 229960000195 terbutaline Drugs 0.000 description 1
• 229960005383 terodiline Drugs 0.000 description 1
• UISARWKNNNHPGI-UHFFFAOYSA-N terodiline Chemical compound C=1C=CC=CC=1C(CC(C)NC(C)(C)C)C1=CC=CC=C1 UISARWKNNNHPGI-UHFFFAOYSA-N 0.000 description 1
• 238000012360 testing method Methods 0.000 description 1
• 238000011285 therapeutic regimen Methods 0.000 description 1
• 230000008719 thickening Effects 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 210000000779 thoracic wall Anatomy 0.000 description 1
• 230000002446 thrombocytic effect Effects 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 229950000464 thyropropic acid Drugs 0.000 description 1
• VRORTNGXAKZJML-UHFFFAOYSA-N thyropropic acid Chemical compound IC1=CC(CCC(=O)O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 VRORTNGXAKZJML-UHFFFAOYSA-N 0.000 description 1
• 229940034208 thyroxine Drugs 0.000 description 1
• XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
• 229960000822 tiadenol Drugs 0.000 description 1
• WRCITXQNXAIKLR-UHFFFAOYSA-N tiadenol Chemical compound OCCSCCCCCCCCCCSCCO WRCITXQNXAIKLR-UHFFFAOYSA-N 0.000 description 1
• CVWILQHZFWRYPB-UHFFFAOYSA-N tiamenidine Chemical compound CC1=CSC(Cl)=C1NC1=NCCN1 CVWILQHZFWRYPB-UHFFFAOYSA-N 0.000 description 1
• 229950000164 tiamenidine Drugs 0.000 description 1
• 229940028869 ticlid Drugs 0.000 description 1
• AGHANLSBXUWXTB-UHFFFAOYSA-N tienilic acid Chemical compound ClC1=C(Cl)C(OCC(=O)O)=CC=C1C(=O)C1=CC=CS1 AGHANLSBXUWXTB-UHFFFAOYSA-N 0.000 description 1
• 229960000356 tienilic acid Drugs 0.000 description 1
• 230000036964 tight binding Effects 0.000 description 1
• 229960001060 tioclomarol Drugs 0.000 description 1
• WRGOVNKNTPWHLZ-UHFFFAOYSA-N tioclomarol Chemical compound C=1C=C(Cl)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=C(Cl)S1 WRGOVNKNTPWHLZ-UHFFFAOYSA-N 0.000 description 1
• 239000003106 tissue adhesive Substances 0.000 description 1
• 229960002872 tocainide Drugs 0.000 description 1
• 229950001089 todralazine Drugs 0.000 description 1
• JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 description 1
• 229960002312 tolazoline Drugs 0.000 description 1
• 229960001580 tolonidine Drugs 0.000 description 1
• KWBTZIFLQYYPTH-UHFFFAOYSA-N tolonidine Chemical compound ClC1=CC(C)=CC=C1NC1=NCCN1 KWBTZIFLQYYPTH-UHFFFAOYSA-N 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 229960005461 torasemide Drugs 0.000 description 1
• 210000003437 trachea Anatomy 0.000 description 1
• GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
• 229960000401 tranexamic acid Drugs 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 108091006108 transcriptional coactivators Proteins 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 229960000363 trapidil Drugs 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• 229960005204 tretoquinol Drugs 0.000 description 1
• RGVPOXRFEPSFGH-AWEZNQCLSA-N tretoquinol Chemical compound COC1=C(OC)C(OC)=CC(C[C@H]2C3=CC(O)=C(O)C=C3CCN2)=C1 RGVPOXRFEPSFGH-AWEZNQCLSA-N 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• 229960002268 triflusal Drugs 0.000 description 1
• 229960001177 trimetazidine Drugs 0.000 description 1
• 229940035742 trimethaphan Drugs 0.000 description 1
• CHQOEHPMXSHGCL-UHFFFAOYSA-N trimethaphan Chemical compound C12C[S+]3CCCC3C2N(CC=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 CHQOEHPMXSHGCL-UHFFFAOYSA-N 0.000 description 1
• 229940029774 trimethaphan camsylate Drugs 0.000 description 1
• 229950005894 trimethidinium methosulfate Drugs 0.000 description 1
• PYIHTIJNCRKDBV-UHFFFAOYSA-L trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C PYIHTIJNCRKDBV-UHFFFAOYSA-L 0.000 description 1
• SYHDSBBKRLVLFF-UHFFFAOYSA-N triparanol Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(O)(C=1C=CC(C)=CC=1)CC1=CC=C(Cl)C=C1 SYHDSBBKRLVLFF-UHFFFAOYSA-N 0.000 description 1
• 229950005498 triparanol Drugs 0.000 description 1
• 238000001665 trituration Methods 0.000 description 1
• 229960002485 trolnitrate Drugs 0.000 description 1
• HWKQNAWCHQMZHK-UHFFFAOYSA-N trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 1
• 229960000859 tulobuterol Drugs 0.000 description 1
• 102000003390 tumor necrosis factor Human genes 0.000 description 1
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
• 229910052721 tungsten Inorganic materials 0.000 description 1
• 239000010937 tungsten Substances 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 229940035893 uracil Drugs 0.000 description 1
• 229960001130 urapidil Drugs 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 229960005356 urokinase Drugs 0.000 description 1
• 238000002255 vaccination Methods 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• 238000010200 validation analysis Methods 0.000 description 1
• 229960004699 valsartan Drugs 0.000 description 1
• SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
• 230000006459 vascular development Effects 0.000 description 1
• 208000019553 vascular disease Diseases 0.000 description 1
• 210000005166 vasculature Anatomy 0.000 description 1
• 239000005526 vasoconstrictor agent Substances 0.000 description 1
• 230000000304 vasodilatating effect Effects 0.000 description 1
• 229940099270 vasotec Drugs 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000006815 ventricular dysfunction Effects 0.000 description 1
• 210000003501 vero cell Anatomy 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1
• 210000005048 vimentin Anatomy 0.000 description 1
• 229960003353 viquidil Drugs 0.000 description 1
• DKRSEIPLAZTSFD-LSDHHAIUSA-N viquidil Chemical compound C12=CC(OC)=CC=C2N=CC=C1C(=O)CC[C@@H]1CCNC[C@@H]1C=C DKRSEIPLAZTSFD-LSDHHAIUSA-N 0.000 description 1
• 230000029812 viral genome replication Effects 0.000 description 1
• 229940063670 visken Drugs 0.000 description 1
• 229960000821 visnadine Drugs 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 150000003722 vitamin derivatives Chemical class 0.000 description 1
• 239000011800 void material Substances 0.000 description 1
• 229960005080 warfarin Drugs 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 210000004885 white matter Anatomy 0.000 description 1
• IYEPZNKOJZOGJG-UHFFFAOYSA-N xenbucin Chemical compound C1=CC(C(C(O)=O)CC)=CC=C1C1=CC=CC=C1 IYEPZNKOJZOGJG-UHFFFAOYSA-N 0.000 description 1
• 229950005298 xenbucin Drugs 0.000 description 1
• 229940072358 xylocaine Drugs 0.000 description 1
• 229960000317 yohimbine Drugs 0.000 description 1
• BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
• AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1