JP2014507142A5 - - Google Patents
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- JP2014507142A5 JP2014507142A5 JP2013553482A JP2013553482A JP2014507142A5 JP 2014507142 A5 JP2014507142 A5 JP 2014507142A5 JP 2013553482 A JP2013553482 A JP 2013553482A JP 2013553482 A JP2013553482 A JP 2013553482A JP 2014507142 A5 JP2014507142 A5 JP 2014507142A5
- Authority
- JP
- Japan
- Prior art keywords
- oligopeptide
- amino acid
- acid sequence
- composition
- kcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108010038807 Oligopeptides Proteins 0.000 claims 33
- 102000015636 Oligopeptides Human genes 0.000 claims 33
- 150000001413 amino acids Chemical group 0.000 claims 29
- 238000000034 method Methods 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 230000002163 immunogen Effects 0.000 claims 13
- 235000001014 amino acid Nutrition 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 8
- 150000001720 carbohydrates Chemical class 0.000 claims 8
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 2
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 102000028861 calmodulin binding Human genes 0.000 claims 2
- 108091000084 calmodulin binding Proteins 0.000 claims 2
- 239000005090 green fluorescent protein Substances 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 231100000617 superantigen Toxicity 0.000 claims 2
- -1 superantigens Proteins 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108050001427 Avidin/streptavidin Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101710179002 Hemolytic toxin Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- 241001195348 Nusa Species 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 101100408135 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) phnA gene Proteins 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102000044159 Ubiquitin Human genes 0.000 claims 1
- 108090000848 Ubiquitin Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- OPGTXAUDXWCGFI-UHFFFAOYSA-N [1-[[6-[[3-(3-dodecanoyloxytetradecanoylamino)-6-(hydroxymethyl)-5-phosphonooxy-4-(3-tetradecanoyloxytetradecanoyloxy)oxan-2-yl]oxymethyl]-2,4,5-trihydroxyoxan-3-yl]amino]-1-oxotetradecan-3-yl] hexadecanoate Chemical compound OC1C(O)C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(O)OC1COC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)C(OP(O)(O)=O)C(CO)O1 OPGTXAUDXWCGFI-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 229940037003 alum Drugs 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 102000005936 beta-Galactosidase Human genes 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 108010090623 galactose binding protein Proteins 0.000 claims 1
- 102000021529 galactose binding proteins Human genes 0.000 claims 1
- 150000002333 glycines Chemical class 0.000 claims 1
- 230000005745 host immune response Effects 0.000 claims 1
- 230000008348 humoral response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 101150066555 lacZ gene Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- 238000006384 oligomerization reaction Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 101150044170 trpE gene Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440757P | 2011-02-08 | 2011-02-08 | |
| US61/440,757 | 2011-02-08 | ||
| US201161554750P | 2011-11-02 | 2011-11-02 | |
| US61/554,750 | 2011-11-02 | ||
| PCT/US2012/024031 WO2012109167A1 (en) | 2011-02-08 | 2012-02-06 | Immunogenic composition comprising alpha-hemolysin oligopeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507142A JP2014507142A (ja) | 2014-03-27 |
| JP2014507142A5 true JP2014507142A5 (OSRAM) | 2015-03-19 |
Family
ID=46638917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553482A Pending JP2014507142A (ja) | 2011-02-08 | 2012-02-06 | α溶血素オリゴペプチドを含む免疫原性組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9109036B2 (OSRAM) |
| EP (1) | EP2672989A4 (OSRAM) |
| JP (1) | JP2014507142A (OSRAM) |
| AU (1) | AU2012214677B2 (OSRAM) |
| CA (1) | CA2825770A1 (OSRAM) |
| WO (1) | WO2012109167A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX367082B (es) * | 2012-11-06 | 2019-08-05 | Medimmune Llc | Anticuerpos anti toxina alfa de s. aureus (anti-ta) y sus usos. |
| ES3031233T3 (en) * | 2012-12-28 | 2025-07-07 | Qiagen Sciences Llc | A cell mediated immune response assay |
| US9815872B2 (en) | 2013-06-19 | 2017-11-14 | Integrated Biotherapeutics, Inc. | Toxoid peptides derived from phenol soluble modulin, delta toxin, superantigens, and fusions thereof |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9017698B2 (en) | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| JP2017504325A (ja) * | 2014-01-14 | 2017-02-09 | インテグレイテッド バイオセラピューティクス，インコーポレイテッド | バクテリオシンの細胞壁ターゲティングドメインを用いた細菌感染部位への免疫学的機能のターゲティング方法 |
| US10080790B2 (en) | 2014-09-19 | 2018-09-25 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
| US20180141981A1 (en) * | 2015-01-06 | 2018-05-24 | Integrated Biotherapeutics, Inc. | Immunogenic composition comprising engineered alpha-hemolysin oligopeptides |
| US20190271022A1 (en) * | 2016-10-27 | 2019-09-05 | Medimmune, Llc | Signal Polypeptide For Improved Secretion Of Protein |
| CA3069747A1 (en) | 2017-07-27 | 2019-01-31 | Mohammad Javad Aman | Immunogenic composition comprising a fusion peptide derived from superantigen toxoids |
| IT202000025423A1 (it) | 2020-10-27 | 2022-04-27 | Ulisse Biomed S P A | Uso di proteine per il trattamento di patologie associate a tossine formanti pori o a proteine virali |
| CA3204730A1 (en) * | 2021-01-15 | 2022-07-21 | Gowrishankar MUTHUKRISHNAN | Staphylococcus aureus antigen-based nucleic acid vaccines |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1499035A (en) | 1975-04-10 | 1978-01-25 | Ts Nii Gematologii I Perelivan | Antistaphylococcus human immune globulin and method of preparing same |
| US4327082A (en) | 1979-07-12 | 1982-04-27 | Adcock-Ingram Laboratories Limited | Mastitis vaccination |
| RU2402347C2 (ru) * | 2004-09-22 | 2010-10-27 | ГлаксоСмитКлайн Байолоджикалз с.а. | Иммуногенная композиция |
| US20100203024A1 (en) | 2006-05-30 | 2010-08-12 | Terman David S | Sickled Erythrocytes, Nucleated Precursors & Erythroleukemia Cells for Targeted Delivery of Oncolytic Viruses, Anti-tumor Proteins, Plasmids, Toxins, Hemolysins & Chemotherapy |
| WO2007145689A1 (en) | 2006-06-12 | 2007-12-21 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| US7754225B2 (en) | 2006-07-20 | 2010-07-13 | Glaxosmithkline Biologicals S.A. | Method of protecting against staphylococcal infection |
| JP5658564B2 (ja) * | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| EP2208787A1 (en) | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| NZ612315A (en) * | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| BR112012010223A2 (pt) * | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| KR20140066212A (ko) * | 2011-09-01 | 2014-05-30 | 노파르티스 아게 | 스타필로코쿠스 아우레우스 항원의 보조제 첨가된 조제물 |
| WO2013092985A1 (en) | 2011-12-23 | 2013-06-27 | Novartis Ag | Stable compositions for immunising against staphylococcus aureus |
-
2012
- 2012-02-06 JP JP2013553482A patent/JP2014507142A/ja active Pending
- 2012-02-06 WO PCT/US2012/024031 patent/WO2012109167A1/en not_active Ceased
- 2012-02-06 CA CA2825770A patent/CA2825770A1/en not_active Abandoned
- 2012-02-06 US US13/984,226 patent/US9109036B2/en active Active
- 2012-02-06 EP EP12744843.9A patent/EP2672989A4/en not_active Withdrawn
- 2012-02-06 AU AU2012214677A patent/AU2012214677B2/en active Active
-
2015
- 2015-08-05 US US14/818,817 patent/US20160039888A1/en not_active Abandoned
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