JP2014506448A - 凝固因子の阻害剤に対する結合タンパク質 - Google Patents

凝固因子の阻害剤に対する結合タンパク質 Download PDF

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Publication number
JP2014506448A
JP2014506448A JP2013549784A JP2013549784A JP2014506448A JP 2014506448 A JP2014506448 A JP 2014506448A JP 2013549784 A JP2013549784 A JP 2013549784A JP 2013549784 A JP2013549784 A JP 2013549784A JP 2014506448 A JP2014506448 A JP 2014506448A
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Japan
Prior art keywords
antibody
antigen
binding fragment
seq
cdr
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Pending
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JP2013549784A
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Japanese (ja)
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JP2014506448A5 (enExample
Inventor
フランク・ディットマー
アンヤ・ビュッフミュラー
クリストフ・ゲルデス
アドリアン・テルステーゲン
マルク・イェアン・グノート
ラルス・リンデン
アクセル・ハレンガ
ヨアンナ・グルジンスカ−ゲーベル
マリオ・イェスケ
マルティナ・シェフェル
イェルク・ビルケンフェルト
ホルガー・パウルゼン
リカルダ・フィナーン
アンケ・マイヤー−バルトシュミット
アンドレア・アイカー
ジモーネ・グレフェン
ズザンネ・シュタイニヒ
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Application filed by Bayer Intellectual Property GmbH filed Critical Bayer Intellectual Property GmbH
Publication of JP2014506448A publication Critical patent/JP2014506448A/ja
Publication of JP2014506448A5 publication Critical patent/JP2014506448A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013549784A 2011-01-19 2012-01-17 凝固因子の阻害剤に対する結合タンパク質 Pending JP2014506448A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11151410 2011-01-19
EP11151410.5 2011-01-19
PCT/EP2012/050595 WO2012098089A1 (en) 2011-01-19 2012-01-17 Binding proteins to inhibitors of coagulation factors

Publications (2)

Publication Number Publication Date
JP2014506448A true JP2014506448A (ja) 2014-03-17
JP2014506448A5 JP2014506448A5 (enExample) 2015-03-05

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ID=45491612

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JP2013549784A Pending JP2014506448A (ja) 2011-01-19 2012-01-17 凝固因子の阻害剤に対する結合タンパク質

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Country Link
US (1) US20140050743A1 (enExample)
EP (1) EP2665751A1 (enExample)
JP (1) JP2014506448A (enExample)
CN (1) CN103619883A (enExample)
AR (1) AR084886A1 (enExample)
CA (1) CA2824885A1 (enExample)
WO (1) WO2012098089A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102039189B1 (ko) 2016-03-23 2019-11-01 서울대학교산학협력단 중증열성혈소판감소증후군 바이러스의 외막 당단백질에 결합하는 항체 및 이의 용도
GB201618432D0 (en) 2016-11-01 2016-12-14 Matn Scient Ltd Detection and treatment of demyelinating diseases
KR20240148935A (ko) * 2017-02-01 2024-10-11 노보 노르디스크 에이/에스 응고촉진 항체
NL2036011B1 (en) * 2023-10-12 2025-04-30 Synapse Res Institute Molecules for reversing anti-coagulant activity of direct oral anticoagulants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539945A (ja) * 2007-09-28 2010-12-24 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤に対する抗体およびその使用の方法
JP2013517317A (ja) * 2010-01-20 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗凝固薬の解毒剤

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US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1997008320A1 (en) 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
ZA985247B (en) 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
US6669937B2 (en) * 2000-04-20 2003-12-30 The Board Of Trustees Of The University Of Arkansas Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
KR100863113B1 (ko) 2001-06-20 2008-10-13 다이이찌 산쿄 가부시키가이샤 디아민 유도체
ATE439360T1 (de) 2001-09-21 2009-08-15 Bristol Myers Squibb Co Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
US8359965B2 (en) 2007-09-17 2013-01-29 Oxford J Craig Apparatus and method for broad spectrum radiation attenuation
AU2009314153B2 (en) * 2008-11-14 2015-09-17 Alexion Pharmaceuticals, Inc. Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539945A (ja) * 2007-09-28 2010-12-24 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤に対する抗体およびその使用の方法
JP2013517317A (ja) * 2010-01-20 2013-05-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗凝固薬の解毒剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6015048481; ＥＩＧＥＮＢＲＯＴ　Ｃ．，　ｅｔ　ａｌ．: Ｊ　Ｍｏｌ　Ｂｉｏｌ Ｖｏｌ．３３１, 2003, ｐ．４３３-４４６ *

Also Published As

Publication number Publication date
EP2665751A1 (en) 2013-11-27
WO2012098089A1 (en) 2012-07-26
CN103619883A (zh) 2014-03-05
AR084886A1 (es) 2013-07-10
US20140050743A1 (en) 2014-02-20
CA2824885A1 (en) 2012-07-26

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