JP2014506259A - Ｉｌ−２１リガンド - Google Patents

Ｉｌ−２１リガンド Download PDF

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Publication number
JP2014506259A
JP2014506259A JP2013548861A JP2013548861A JP2014506259A JP 2014506259 A JP2014506259 A JP 2014506259A JP 2013548861 A JP2013548861 A JP 2013548861A JP 2013548861 A JP2013548861 A JP 2013548861A JP 2014506259 A JP2014506259 A JP 2014506259A
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JP
Japan
Prior art keywords
seq
hil
antibody
nnc
ligand
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Application number
JP2013548861A
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English (en)
Japanese (ja)
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JP2014506259A5 (cg-RX-API-DMAC7.html
Inventor
ラーシュ・アンデシュ・スヴェンソン
メッテ・ダール・アンデルセン
イェンス・ブラインホルト
シャーロット・ヴィーベリ
ベーリット・オールセン・クローグ
ドロテ・ルンズゴー
ハネ・ベネディクト・ラスムッセン
Original Assignee
ノヴォ ノルディスク アー／エス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ノヴォ ノルディスク アー／エス filed Critical ノヴォ ノルディスク アー／エス
Publication of JP2014506259A publication Critical patent/JP2014506259A/ja
Publication of JP2014506259A5 publication Critical patent/JP2014506259A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013548861A 2011-01-17 2012-01-17 Ｉｌ−２１リガンド Withdrawn JP2014506259A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP11151073.1 2011-01-17
EP11151073 2011-01-17
US201161434989P 2011-01-21 2011-01-21
US61/434,989 2011-01-21
EP11168328.0 2011-05-31
EP11168328 2011-05-31
US201161493002P 2011-06-03 2011-06-03
US61/493,002 2011-06-03
EP11187212.3 2011-10-31
EP11187212 2011-10-31
PCT/EP2012/050633 WO2012098113A1 (en) 2011-01-17 2012-01-17 Il-21 ligands

Publications (2)

Publication Number Publication Date
JP2014506259A true JP2014506259A (ja) 2014-03-13
JP2014506259A5 JP2014506259A5 (cg-RX-API-DMAC7.html) 2015-03-05

Family

ID=46515179

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013548861A Withdrawn JP2014506259A (ja) 2011-01-17 2012-01-17 Ｉｌ−２１リガンド

Country Status (5)

Country Link
US (1) US20130323259A1 (cg-RX-API-DMAC7.html)
EP (1) EP2665750A1 (cg-RX-API-DMAC7.html)
JP (1) JP2014506259A (cg-RX-API-DMAC7.html)
CN (1) CN103443124A (cg-RX-API-DMAC7.html)
WO (1) WO2012098113A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1963369T3 (pl) 2005-11-28 2013-10-31 Zymogenetics Inc Antagoniści IL-21
EP2746293A1 (en) 2012-12-21 2014-06-25 Novo Nordisk A/S Anti-IL21 antibodies for use in the treatment of cardiovascular diseases
US20140178395A1 (en) 2012-12-21 2014-06-26 Novo Nordisk A/S Treatment of nephropathy
US20160347833A1 (en) * 2014-02-07 2016-12-01 Novo Nordisk A/S Antibody process
AR099625A1 (es) 2014-03-21 2016-08-03 Lilly Co Eli Anticuerpos de il-21
JP6672175B2 (ja) 2014-05-07 2020-03-25 ノヴォ ノルディスク アー／エス Ｇｌｐ−１及び抗ｉｌ−２１を使用した１型糖尿病の治療
PT3151921T (pt) 2014-06-06 2019-11-21 Bristol Myers Squibb Co Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos
ES2810856T3 (es) 2015-06-03 2021-03-09 Bristol Myers Squibb Co Anticuerpos ANTI-GITR para diagnóstico de cáncer
BR112018010172A2 (pt) 2015-11-19 2018-11-21 Bristol Myers Squibb Co anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos
KR20200006115A (ko) 2017-05-16 2020-01-17 브리스톨-마이어스 스큅 컴퍼니 항-gitr 효능제 항체에 의한 암의 치료
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521797A (ja) * 2004-11-29 2008-06-26 ジュリアーニ インターナショナル リミテッド インターロイキン−２１の抗原性エピトープ、関連抗体及び医療分野におけるそれらの使用
JP2008148710A (ja) * 2002-12-24 2008-07-03 Rinat Neuroscience Corp 抗ｎｇｆ抗体およびそれらを使用する方法
WO2009047360A1 (en) * 2007-10-11 2009-04-16 Novo Nordisk A/S Il-21 antibodies
JP2009517405A (ja) * 2005-11-28 2009-04-30 ザイモジェネティクス， インコーポレイテッド Ｉｌ−２１アンタゴニスト
JP2009520468A (ja) * 2005-12-23 2009-05-28 ヴィヴェンティア バイオテック インコーポレーティッド 融合タンパク質ライブラリーの作製法およびスクリーニング法、ならびにそれらの使用
WO2009132821A1 (en) * 2008-04-28 2009-11-05 Giuliani International Limited Interleukin (il-21) binding proteins and methods of making and using same
WO2010027981A1 (en) * 2008-09-03 2010-03-11 Genentech, Inc. Multispecific antibodies
JP2010088451A (ja) * 2002-05-20 2010-04-22 Abmaxis Inc タンパク質ライブラリーのｉｎｓｉｌｉｃｏ作成と選択
WO2010055366A2 (en) * 2007-12-07 2010-05-20 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
WO2010127113A2 (en) * 2009-04-29 2010-11-04 Centocor Ortho Biotech Inc. Toll-like receptor 3 antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE541931T1 (de) 1999-12-23 2012-02-15 Genentech Inc Il-17-homologe polypeptide und ihre therapeutische verwendung

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010088451A (ja) * 2002-05-20 2010-04-22 Abmaxis Inc タンパク質ライブラリーのｉｎｓｉｌｉｃｏ作成と選択
JP2008148710A (ja) * 2002-12-24 2008-07-03 Rinat Neuroscience Corp 抗ｎｇｆ抗体およびそれらを使用する方法
JP2008521797A (ja) * 2004-11-29 2008-06-26 ジュリアーニ インターナショナル リミテッド インターロイキン−２１の抗原性エピトープ、関連抗体及び医療分野におけるそれらの使用
JP2009517405A (ja) * 2005-11-28 2009-04-30 ザイモジェネティクス， インコーポレイテッド Ｉｌ−２１アンタゴニスト
JP2009520468A (ja) * 2005-12-23 2009-05-28 ヴィヴェンティア バイオテック インコーポレーティッド 融合タンパク質ライブラリーの作製法およびスクリーニング法、ならびにそれらの使用
WO2009047360A1 (en) * 2007-10-11 2009-04-16 Novo Nordisk A/S Il-21 antibodies
WO2010055366A2 (en) * 2007-12-07 2010-05-20 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
WO2009132821A1 (en) * 2008-04-28 2009-11-05 Giuliani International Limited Interleukin (il-21) binding proteins and methods of making and using same
WO2010027981A1 (en) * 2008-09-03 2010-03-11 Genentech, Inc. Multispecific antibodies
WO2010127113A2 (en) * 2009-04-29 2010-11-04 Centocor Ortho Biotech Inc. Toll-like receptor 3 antagonists

Also Published As

Publication number Publication date
CN103443124A (zh) 2013-12-11
WO2012098113A1 (en) 2012-07-26
US20130323259A1 (en) 2013-12-05
EP2665750A1 (en) 2013-11-27

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