JP2014505012A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014505012A5 JP2014505012A5 JP2013535058A JP2013535058A JP2014505012A5 JP 2014505012 A5 JP2014505012 A5 JP 2014505012A5 JP 2013535058 A JP2013535058 A JP 2013535058A JP 2013535058 A JP2013535058 A JP 2013535058A JP 2014505012 A5 JP2014505012 A5 JP 2014505012A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- amino acid
- acid sequence
- seq
- cell culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39481210P | 2010-10-20 | 2010-10-20 | |
| US61/394,812 | 2010-10-20 | ||
| PCT/US2011/056966 WO2012054654A2 (en) | 2010-10-20 | 2011-10-19 | Anti-folate receptor alpha antibody glycoforms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014505012A JP2014505012A (ja) | 2014-02-27 |
| JP2014505012A5 true JP2014505012A5 (https=) | 2014-12-04 |
Family
ID=45975873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535058A Pending JP2014505012A (ja) | 2010-10-20 | 2011-10-19 | 抗葉酸受容体アルファ抗体の糖型 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120164137A1 (https=) |
| EP (1) | EP2629798A4 (https=) |
| JP (1) | JP2014505012A (https=) |
| KR (1) | KR20140032944A (https=) |
| CN (1) | CN103347537A (https=) |
| AU (2) | AU2011317088B2 (https=) |
| BR (1) | BR112013009275A2 (https=) |
| CA (1) | CA2815080A1 (https=) |
| IL (1) | IL225579A0 (https=) |
| MX (1) | MX2013004202A (https=) |
| RU (1) | RU2013122843A (https=) |
| WO (1) | WO2012054654A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2172487A1 (en) * | 2005-04-22 | 2010-04-07 | Morphotek Inc. | Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells |
| US9512223B2 (en) * | 2012-05-15 | 2016-12-06 | Morphotek, Inc. | Methods for treatment of gastric cancer |
| HUE049693T2 (hu) * | 2012-08-31 | 2020-10-28 | Immunogen Inc | Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására |
| JP6224619B2 (ja) * | 2012-12-07 | 2017-11-01 | 協和発酵キリン株式会社 | 抗ｆｏｌｒ１抗体 |
| US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US20140271622A1 (en) * | 2013-03-14 | 2014-09-18 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| TWI771890B (zh) | 2013-03-14 | 2022-07-21 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
| US9677105B2 (en) | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| AU2014312086B2 (en) | 2013-08-30 | 2020-03-12 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| EP2871190A1 (en) * | 2013-11-11 | 2015-05-13 | ATLAB Pharma | Antibody against GD2-O-acetylated ganglioside with pro-apoptotic activity |
| RS61010B1 (sr) | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3 |
| DK3221355T3 (da) | 2014-11-20 | 2020-12-07 | Hoffmann La Roche | Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler CD3 og folatreceptor 1 (FolR1) samt PD-1-aksebindende antagonister |
| SI3221357T1 (sl) | 2014-11-20 | 2020-09-30 | F. Hoffmann-La Roche Ag | Pogoste lahke verige in načini uporabe |
| ES2784503T3 (es) | 2014-12-01 | 2020-09-28 | Amgen Inc | Procedimiento para manipular el nivel de contenido de glicano de una glicoproteína |
| AU2016323968B2 (en) | 2015-09-17 | 2023-07-06 | Immunogen, Inc. | Therapeutic combinations comprising anti-FOLR1 immunoconjugates |
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| KR102275930B1 (ko) * | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
| CN118344485B (zh) * | 2024-06-18 | 2024-10-15 | 南京欧凯生物科技有限公司 | 抗叶酸及其结合蛋白复合物的单克隆抗体或其抗原结合片段、其制备方法及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004261229A1 (en) * | 2003-07-29 | 2005-02-10 | Eisai, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| CA2556027C (en) * | 2004-02-12 | 2015-11-24 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
| PL1776384T3 (pl) * | 2004-08-04 | 2013-10-31 | Mentrik Biotech Llc | WARIANTY REGIONÓW Fc |
| ZA200708694B (en) * | 2005-04-15 | 2009-01-28 | Immunogen Inc | Elimination of heterogeneous or mixed cell population in tumors |
| EP2172487A1 (en) * | 2005-04-22 | 2010-04-07 | Morphotek Inc. | Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells |
| CN101374546B (zh) * | 2005-12-16 | 2016-03-23 | Ibc医药公司 | 基于免疫球蛋白的多价生物活性装配体 |
| WO2011116387A1 (en) * | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
-
2011
- 2011-10-19 US US13/277,161 patent/US20120164137A1/en not_active Abandoned
- 2011-10-19 AU AU2011317088A patent/AU2011317088B2/en not_active Ceased
- 2011-10-19 RU RU2013122843/10A patent/RU2013122843A/ru not_active Application Discontinuation
- 2011-10-19 KR KR1020137012669A patent/KR20140032944A/ko not_active Withdrawn
- 2011-10-19 MX MX2013004202A patent/MX2013004202A/es unknown
- 2011-10-19 BR BR112013009275A patent/BR112013009275A2/pt not_active Application Discontinuation
- 2011-10-19 CN CN2011800503838A patent/CN103347537A/zh active Pending
- 2011-10-19 JP JP2013535058A patent/JP2014505012A/ja active Pending
- 2011-10-19 CA CA2815080A patent/CA2815080A1/en not_active Abandoned
- 2011-10-19 WO PCT/US2011/056966 patent/WO2012054654A2/en not_active Ceased
- 2011-10-19 EP EP11835098.2A patent/EP2629798A4/en not_active Withdrawn
-
2013
- 2013-04-04 IL IL225579A patent/IL225579A0/en unknown
-
2016
- 2016-04-04 AU AU2016202082A patent/AU2016202082A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014505012A5 (https=) | ||
| RU2013122843A (ru) | Гликоформы антитела против фолатного рецептора альфа | |
| JP7700159B2 (ja) | Ａｘｌまたはｒｏｒ２に対するキメラ抗原受容体およびその使用方法 | |
| RU2577226C2 (ru) | Способ получения биспецифических антител против cd3*cd19 формата флексибоди в клетках млекопитающих | |
| CN107217042B (zh) | 一种生产无岩藻糖基化蛋白的基因工程细胞系及其建立方法 | |
| CN105296433B (zh) | 一种ctla4抗体、其药物组合物及其用途 | |
| WO2018205936A1 (zh) | 双特异性重组蛋白及其应用 | |
| CN111534475B (zh) | 一种细胞表面偶联抗体的方法及其应用 | |
| KR20240025059A (ko) | 세포상해 유도 치료제 | |
| WO2018178047A1 (en) | Multispecific antibody constructs binding to muc1 and cd3 | |
| EP3019528A1 (en) | Improved process for production of monoclonal antibodies | |
| CN107760651A (zh) | 一种细胞培养基及生产蛋白质的方法 | |
| JP2021517805A5 (https=) | ||
| CN106459185A (zh) | 通过调节抗体的含糖量制备抗体的方法 | |
| CN104558192A (zh) | 一种双特异性抗体her2xcd3的构建及应用 | |
| WO2015081389A1 (en) | A method of treating neoplasia | |
| JP2022523063A (ja) | アフリベルセプトの属性、並びにその特性決定及び修飾方法 | |
| CN118221811B (zh) | 靶向prame多肽的单域抗体及其用途 | |
| CN119497718A (zh) | 三特异性抗体及其用途 | |
| CN107840889A (zh) | 高亲和力的抗cd123抗体及其应用 | |
| CN113122605A (zh) | 一种生产抗cd47抗体的培养基及发酵方法 | |
| JPWO2019161167A5 (https=) | ||
| CN107460221A (zh) | 一种降低抗pd‑l1抗体中蛋白聚合物的细胞培养方法 | |
| CN112239504A (zh) | 一种针对pd-l1的纳米抗体及其应用 | |
| US10308969B2 (en) | Method for preparing polymeric protein composed of monomeric protein produced by fusing protein having immunoglobulin fold structure to protein capable of serving as subunit structure |