JP2014503521A - 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 - Google Patents
過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 Download PDFInfo
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- JP2014503521A JP2014503521A JP2013543704A JP2013543704A JP2014503521A JP 2014503521 A JP2014503521 A JP 2014503521A JP 2013543704 A JP2013543704 A JP 2013543704A JP 2013543704 A JP2013543704 A JP 2013543704A JP 2014503521 A JP2014503521 A JP 2014503521A
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- Prior art keywords
- imidazo
- pyrazin
- cyclopropyl
- amino
- alkyl
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- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 229960002730 vapreotide Drugs 0.000 description 1
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- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
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- NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
- 229960000922 vinflunine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000341 volatile oil Chemical class 0.000 description 1
- 229950001212 volociximab Drugs 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
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- 235000016804 zinc Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195702 | 2010-12-17 | ||
| EP10195702.5 | 2010-12-17 | ||
| PCT/EP2011/072583 WO2012080229A1 (en) | 2010-12-17 | 2011-12-13 | Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503521A true JP2014503521A (ja) | 2014-02-13 |
| JP2014503521A5 JP2014503521A5 (https=) | 2015-01-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543704A Pending JP2014503521A (ja) | 2010-12-17 | 2011-12-13 | 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130303532A1 (https=) |
| EP (1) | EP2651948A1 (https=) |
| JP (1) | JP2014503521A (https=) |
| CN (1) | CN103415518A (https=) |
| CA (1) | CA2821829A1 (https=) |
| WO (1) | WO2012080229A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017510595A (ja) * | 2014-04-07 | 2017-04-13 | ネザーランズ トランスレーショナル リサーチ センター ビー．ブイ． | （５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| US9284317B2 (en) * | 2010-12-17 | 2016-03-15 | Bayer Intellectual Property Gmbh | Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| US9573954B2 (en) | 2012-11-16 | 2017-02-21 | University Health Network | Pyrazolopyrimidine compounds |
| JP6095857B2 (ja) * | 2013-11-15 | 2017-03-15 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
| FI3283642T3 (fi) | 2015-04-17 | 2024-01-11 | Crossfire Oncology Holding B V | Prognostisia biomarkkereita ttk-inhibiittorikemoterapiaan |
| AU2017299850B2 (en) * | 2016-07-18 | 2021-05-27 | University Health Network | Solid forms of TTK inhibitor |
| KR102660894B1 (ko) * | 2021-09-17 | 2024-04-26 | 기초과학연구원 | 피리미딘-2-아민 화합물의 제조방법 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009832A1 (en) * | 2003-02-20 | 2005-01-13 | Sugen, Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| JP2010502726A (ja) * | 2006-09-05 | 2010-01-28 | エモリー・ユニバーシティ | 感染の予防または治療のためのチロシンキナーゼ阻害剤 |
| WO2010124826A1 (en) * | 2009-04-29 | 2010-11-04 | Bayer Schering Pharma Aktiengesellschaft | Substituted imidazoquinoxalines |
| JP2010536825A (ja) * | 2007-08-21 | 2010-12-02 | ビオフォーカス ディーピーアイ リミテッド | 肝炎などのウイルス感染の治療用イミダゾ［１，２−ａ］ピラジン化合物 |
| WO2011013729A1 (ja) * | 2009-07-30 | 2011-02-03 | オンコセラピー・サイエンス株式会社 | Ｔｔｋ阻害作用を有する縮合イミダゾール誘導体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| IL127566A0 (en) | 1996-08-28 | 1999-10-28 | Pfizer | Substituted 6,5-hetero- bicyclic derivatives |
| WO2007025090A2 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| MX2010002115A (es) * | 2007-08-23 | 2010-06-01 | Aztrazeneca Ab | 2-anilinopurin-8-onas como inhibidores de ttk/mps1 para el tratamiento de trastornos .proliferativos. |
| TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
| CA2772790C (en) | 2009-09-04 | 2017-06-27 | Benjamin Bader | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| EP2343295A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
-
2011
- 2011-12-13 CN CN2011800677581A patent/CN103415518A/zh active Pending
- 2011-12-13 JP JP2013543704A patent/JP2014503521A/ja active Pending
- 2011-12-13 CA CA2821829A patent/CA2821829A1/en not_active Abandoned
- 2011-12-13 WO PCT/EP2011/072583 patent/WO2012080229A1/en not_active Ceased
- 2011-12-13 US US13/994,865 patent/US20130303532A1/en not_active Abandoned
- 2011-12-13 EP EP11796995.6A patent/EP2651948A1/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009832A1 (en) * | 2003-02-20 | 2005-01-13 | Sugen, Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| JP2010502726A (ja) * | 2006-09-05 | 2010-01-28 | エモリー・ユニバーシティ | 感染の予防または治療のためのチロシンキナーゼ阻害剤 |
| JP2010536825A (ja) * | 2007-08-21 | 2010-12-02 | ビオフォーカス ディーピーアイ リミテッド | 肝炎などのウイルス感染の治療用イミダゾ［１，２−ａ］ピラジン化合物 |
| WO2010124826A1 (en) * | 2009-04-29 | 2010-11-04 | Bayer Schering Pharma Aktiengesellschaft | Substituted imidazoquinoxalines |
| WO2011013729A1 (ja) * | 2009-07-30 | 2011-02-03 | オンコセラピー・サイエンス株式会社 | Ｔｔｋ阻害作用を有する縮合イミダゾール誘導体 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017510595A (ja) * | 2014-04-07 | 2017-04-13 | ネザーランズ トランスレーショナル リサーチ センター ビー．ブイ． | （５，６−ジヒドロ）ピリミド［４，５−ｅ］インドリジン |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130303532A1 (en) | 2013-11-14 |
| EP2651948A1 (en) | 2013-10-23 |
| WO2012080229A1 (en) | 2012-06-21 |
| CA2821829A1 (en) | 2012-06-21 |
| CN103415518A (zh) | 2013-11-27 |
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