JP2014502628A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014502628A5 JP2014502628A5 JP2013548903A JP2013548903A JP2014502628A5 JP 2014502628 A5 JP2014502628 A5 JP 2014502628A5 JP 2013548903 A JP2013548903 A JP 2013548903A JP 2013548903 A JP2013548903 A JP 2013548903A JP 2014502628 A5 JP2014502628 A5 JP 2014502628A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- million
- dose
- cell
- million cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 25
- 210000000130 stem cell Anatomy 0.000 claims 9
- 210000002950 fibroblast Anatomy 0.000 claims 5
- 210000003289 regulatory T cell Anatomy 0.000 claims 4
- 210000004324 lymphatic system Anatomy 0.000 claims 3
- 108010068370 Glutens Proteins 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 2
- 108010083674 Myelin Proteins Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 235000021312 gluten Nutrition 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 210000005210 lymphoid organ Anatomy 0.000 claims 2
- 210000005012 myelin Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 e.g. Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11250025.1 | 2011-01-12 | ||
| EP11250025 | 2011-01-12 | ||
| PCT/IB2012/000097 WO2012095743A2 (en) | 2011-01-12 | 2012-01-12 | Methods and compositions for use in intralymphatic cellular therapies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190665A Division JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502628A JP2014502628A (ja) | 2014-02-03 |
| JP2014502628A5 true JP2014502628A5 (enExample) | 2015-03-05 |
| JP6018081B2 JP6018081B2 (ja) | 2016-11-02 |
Family
ID=45558792
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548903A Active JP6018081B2 (ja) | 2011-01-12 | 2012-01-12 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
| JP2016190665A Pending JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190665A Pending JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140154274A1 (enExample) |
| EP (1) | EP2663316A2 (enExample) |
| JP (2) | JP6018081B2 (enExample) |
| KR (1) | KR101900664B1 (enExample) |
| ES (1) | ES2479544T1 (enExample) |
| WO (1) | WO2012095743A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| CA2623353C (en) | 2005-09-23 | 2017-02-21 | Cellerix, S.L. | Cell populations having immunoregulatory activity, method for isolation and uses |
| US20160120910A1 (en) * | 2013-06-25 | 2016-05-05 | Tigenix S.A.U. | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| US20150104470A1 (en) * | 2013-10-11 | 2015-04-16 | Neil H. Riordan | Immune modulation by peri-lymphatic or intra-lymphatic cell therapy |
| US20170121685A1 (en) * | 2015-11-02 | 2017-05-04 | Tigenix S.A.U. | Mesenchymal stem cell-derived exosomes and their uses |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| CN109152764A (zh) * | 2016-05-06 | 2019-01-04 | 学校法人大阪医科药科大学 | 用于增强炎性疾病治疗用干细胞的功能的包封抑制素的纳米粒子制剂、以及含有其的炎性疾病治疗用功能增强干细胞 |
| JP6788003B2 (ja) * | 2016-08-26 | 2020-11-18 | 学校法人大阪医科薬科大学 | スタチン封入ナノ粒子を含有する機能増強幹細胞を含む炎症性疾患治療用細胞製剤 |
| CN114555140A (zh) | 2019-10-17 | 2022-05-27 | 泰尔茂株式会社 | 用于处置炎性疾病的细胞培养物 |
| WO2021207192A1 (en) * | 2020-04-08 | 2021-10-14 | Figene, Llc | Methods and compositions for allergy and asthma treatment using fibroblasts |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9694038B2 (en) * | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| CA2493081C (en) * | 2002-07-12 | 2013-04-23 | The Johns Hopkins University | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
| EP2298863B1 (en) * | 2004-03-22 | 2015-07-22 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| EP1729788B1 (en) * | 2004-03-30 | 2009-11-25 | Boston Scientific Limited | Restenosis therapy using mesenchymal stem cells |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| CA2623353C (en) | 2005-09-23 | 2017-02-21 | Cellerix, S.L. | Cell populations having immunoregulatory activity, method for isolation and uses |
| EP2303293A1 (en) * | 2008-05-27 | 2011-04-06 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| CN102428179A (zh) * | 2009-03-06 | 2012-04-25 | 国立大学法人三重大学 | 用于增强t细胞功能的方法 |
| WO2011004264A1 (en) * | 2009-07-09 | 2011-01-13 | Cellerix Sa | Methods and compositions for use in cellular therapies |
| WO2011047345A2 (en) * | 2009-10-15 | 2011-04-21 | Tai June Yoo | Methods of treating diseases of conditions using mesenchymal stem cells |
-
2012
- 2012-01-12 WO PCT/IB2012/000097 patent/WO2012095743A2/en not_active Ceased
- 2012-01-12 JP JP2013548903A patent/JP6018081B2/ja active Active
- 2012-01-12 US US13/979,308 patent/US20140154274A1/en not_active Abandoned
- 2012-01-12 KR KR1020137021276A patent/KR101900664B1/ko active Active
- 2012-01-12 EP EP12701941.2A patent/EP2663316A2/en not_active Ceased
- 2012-01-12 ES ES12701941.2T patent/ES2479544T1/es active Pending
-
2016
- 2016-09-29 JP JP2016190665A patent/JP2017035094A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huang et al. | Potential therapeutic strategies for skeletal muscle atrophy | |
| Kircheis et al. | NF-κB pathway as a potential target for treatment of critical stage COVID-19 patients | |
| Fernandez-Francos et al. | Mesenchymal stem cell-based therapy as an alternative to the treatment of acute respiratory distress syndrome: current evidence and future perspectives | |
| Trompette et al. | Dietary fiber confers protection against flu by shaping Ly6c− patrolling monocyte hematopoiesis and CD8+ T cell metabolism | |
| Marchezan et al. | Immunological dysfunction in autism spectrum disorder: a potential target for therapy | |
| JP2012532859A5 (enExample) | ||
| Wang et al. | Regulation of inflammatory cytokine storms by mesenchymal stem cells | |
| Liu et al. | Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis | |
| ES2479544T1 (es) | Células madre mesenquimales derivadas de tejido adiposo para administración intralinfática en enfermedades autoimmunes e inflamatorias | |
| Kulakova et al. | The contribution of macrophage plasticity to inflammatory arthritis and their potential as therapeutic targets | |
| RU2012104529A (ru) | Способы и композиции для применения в клеточной терапии | |
| Cai et al. | Mesenchymal stem cells and their exocytotic vesicles | |
| Wu et al. | Current understanding of mesenchymal stem cells in liver diseases | |
| Nam et al. | Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis | |
| Harrell et al. | Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS‐CoV‐2‐Induced Acute Respiratory Distress Syndrome | |
| Gardin et al. | Could mesenchymal stem cell-derived exosomes be a therapeutic option for critically Ill COVID-19 patients? | |
| JP2015517488A5 (enExample) | ||
| BR112014010417A2 (pt) | Métodos para o tratamento de cânceres com o uso de formulações orais de análogos de citidina | |
| Gu et al. | Endothelium‐derived engineered extracellular vesicles protect the pulmonary endothelial barrier in acute lung injury | |
| Wang et al. | Honeysuckle‐Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease | |
| Fang et al. | Mechanisms of potential therapeutic utilization of mesenchymal stem cells in COVID-19 treatment | |
| JP2015502135A5 (enExample) | ||
| Koseoglu | New treatment modalities in Alzheimer's disease | |
| Shi et al. | Mesenchymal stem cells and connective tissue diseases: From bench to bedside | |
| Chen et al. | Decoding tumor-fibrosis interplay: mechanisms, impact on progression, and innovative therapeutic strategies |