JP2014501139A5 - - Google Patents
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- JP2014501139A5 JP2014501139A5 JP2013544760A JP2013544760A JP2014501139A5 JP 2014501139 A5 JP2014501139 A5 JP 2014501139A5 JP 2013544760 A JP2013544760 A JP 2013544760A JP 2013544760 A JP2013544760 A JP 2013544760A JP 2014501139 A5 JP2014501139 A5 JP 2014501139A5
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| US9731127B2 (en) * | 2013-04-24 | 2017-08-15 | Neurosigma, Inc. | Modulation of autonomic nervous system activity and integrated electrode assemblies for trigeminal neurostimulation |
| US9839777B2 (en) | 2013-08-14 | 2017-12-12 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
| US9427566B2 (en) | 2013-08-14 | 2016-08-30 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
| US9042991B2 (en) | 2013-08-14 | 2015-05-26 | Syntilla Medical LLC | Implantable head mounted neurostimulation system for head pain |
| US12311114B2 (en) | 2013-08-30 | 2025-05-27 | Neuromod Devices Limited | Method and apparatus for treating a neurological disorder |
| US9498635B2 (en) | 2013-10-16 | 2016-11-22 | Syntilla Medical LLC | Implantable head located radiofrequency coupled neurostimulation system for head pain |
| US10960215B2 (en) | 2013-10-23 | 2021-03-30 | Nuxcel, Inc. | Low profile head-located neurostimulator and method of fabrication |
| US10258805B2 (en) | 2013-10-23 | 2019-04-16 | Syntilla Medical, Llc | Surgical method for implantable head mounted neurostimulation system for head pain |
| WO2016119654A1 (zh) * | 2015-01-26 | 2016-08-04 | 周常安 | 生理反馈系统及发光装置 |
| US20170143972A1 (en) * | 2015-11-19 | 2017-05-25 | Boston Scientific Neuromodulation Corporation | Neuromodulation for neuroinflammation treatments with parameters controlled using biomarkers |
| US9717917B2 (en) | 2016-01-06 | 2017-08-01 | Syntilla Medical LLC | Charging system incorporating independent charging and communication with multiple implanted devices |
| US10406360B2 (en) * | 2016-09-13 | 2019-09-10 | Richard Charles Niemtzow | Electrical acupuncture eye treatment |
| US10716951B2 (en) * | 2016-10-17 | 2020-07-21 | Wave Neuroscience, Inc. | High frequency magnetic foot stimulation |
| US10596378B2 (en) * | 2016-10-18 | 2020-03-24 | Joseph Rustick | Method for treatment of depression using synaptic pathway training |
| US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11547854B2 (en) * | 2017-09-29 | 2023-01-10 | Cochlear Limited | Hearing prosthesis |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| WO2019111261A1 (en) * | 2017-12-06 | 2019-06-13 | Technion Research & Development Foundation Limited | Methods of neural inhibition for treating bowel diseases and disorders |
| US11894148B2 (en) * | 2017-12-22 | 2024-02-06 | Electrocore, Inc. | Systems and methods for treating patients with diseases associated with viruses |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| TWI667860B (zh) * | 2018-02-09 | 2019-08-01 | 鉅旺生技股份有限公司 | 植入式醫材遠距離無線充電強化結構 |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US11467665B2 (en) | 2018-06-14 | 2022-10-11 | Meron Gribetz | Virtual user interface system and methods for use thereof |
| CN109045468B (zh) * | 2018-08-09 | 2022-05-24 | 西安科悦医疗技术有限公司 | 一种耳部迷走神经刺激系统及其装置 |
| WO2020056418A1 (en) | 2018-09-14 | 2020-03-19 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11351370B2 (en) | 2018-12-10 | 2022-06-07 | Spark Biomedical, Inc. | Devices and methods for treating cognitive dysfunction and depression using electrical stimulation |
| US11623088B2 (en) | 2018-12-10 | 2023-04-11 | Spark Biomedical, Inc. | Devices and methods for the treatment of substance use disorders |
| US10967182B2 (en) | 2018-12-10 | 2021-04-06 | Spark Biomedical, Inc. | Devices and methods for reducing inflammation using electrical stimulation |
| WO2020123704A1 (en) * | 2018-12-13 | 2020-06-18 | Livanova Usa, Inc. | Neuromodulation therapy for auto-immune and inflammatory disorders |
| WO2020161555A1 (en) | 2019-02-07 | 2020-08-13 | Inner Cosmos Llc | Intracalvarial bci systems and methods for their making, implantation and use |
| US12109412B2 (en) | 2019-04-22 | 2024-10-08 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958954B1 (en) * | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| CN113747936B (zh) | 2019-04-23 | 2024-06-18 | 波士顿科学国际有限公司 | 用于电刺激来治疗癌症的电极 |
| JP7476231B2 (ja) | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
| US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
| CN114423490A (zh) * | 2019-07-14 | 2022-04-29 | 火花生物医学股份有限公司 | 使用耳状刺激设备递送疗法的系统和方法 |
| US11911620B2 (en) | 2019-07-22 | 2024-02-27 | Ismail Mohammed Yousif Musallam | Neuromodulation for treatment of brain and eye strokes and/or acute dysregulated reduced cerebral or ocular blood flow |
| US11235156B2 (en) | 2019-09-11 | 2022-02-01 | Bose Corporation | Wearable audio device with vagus nerve stimulation |
| US11241574B2 (en) | 2019-09-11 | 2022-02-08 | Bose Corporation | Systems and methods for providing and coordinating vagus nerve stimulation with audio therapy |
| WO2021144730A1 (en) | 2020-01-14 | 2021-07-22 | Inner Cosmos Inc. | Devices, systems and methods for cortical stimulation |
| WO2021173509A1 (en) | 2020-02-24 | 2021-09-02 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| EP4146335B1 (en) | 2020-05-04 | 2024-11-13 | BTL Healthcare Technologies a.s. | Device for unattended treatment of a patient |
| US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
| TWI894280B (zh) * | 2020-05-26 | 2025-08-21 | 南韓商愛思阿爾法數字醫療科技有限公司 | 用以治療癌症惡病質之系統、用以治療癌症惡病質之運算系統及其操作方法、以及非暫態電腦可讀取媒體 |
| US20220184405A1 (en) * | 2020-12-11 | 2022-06-16 | Advanced Neuromodulation Systems, Inc. | Systems and methods for labeling data in active implantable medical device systems |
| EP4301457A4 (en) * | 2021-03-04 | 2025-01-08 | Washington University | TRANSCUTANEOUS AURICULAR VAGUS NERVE STIMULATION FOR SUBARACHNOID HEMORRHAGES |
| WO2023091469A1 (en) * | 2021-11-17 | 2023-05-25 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting periosteal tissue for delivery of therapeutics |
| US12017068B2 (en) | 2022-05-27 | 2024-06-25 | Spark Biomedical, Inc. | Devices and methods for treating motion sickness using electrical stimulation |
| US12029893B1 (en) | 2023-06-14 | 2024-07-09 | Spark Biomedical, Inc. | Wearable auricular neurostimulator and methods of use |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279468A (en) | 1963-05-14 | 1966-10-18 | Vine Sidney Le | Electrotherapeutic facial mask apparatus |
| US3709228A (en) | 1971-01-07 | 1973-01-09 | D Barker | Apparatus for facial stimulation |
| US4233986A (en) | 1978-07-18 | 1980-11-18 | Agar Ginosar Electronics And Metal Products | Apparatus and method for controlling pain by transcutaneous electrical stimulation (TES) |
| US4305402A (en) | 1979-06-29 | 1981-12-15 | Katims Jefferson J | Method for transcutaneous electrical stimulation |
| US4635641A (en) | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
| SU1718976A1 (ru) | 1989-10-31 | 1992-03-15 | 1-Й Московский Медицинский Институт Им.И.М.Сеченова | Способ купировани болей при невралгии тройничного нерва |
| RU2086227C1 (ru) | 1994-04-05 | 1997-08-10 | Российский научно-исследовательский нейрохирургический институт им.проф.А.Л.Поленова | Способ лечения поражений нервно-сосудистых структур орбиты |
| JPH07289649A (ja) | 1994-04-22 | 1995-11-07 | Hayashibara Takeshi | 眼神経の刺激信号発生装置 |
| US5540734A (en) | 1994-09-28 | 1996-07-30 | Zabara; Jacob | Cranial nerve stimulation treatments using neurocybernetic prosthesis |
| US5514175A (en) | 1994-11-09 | 1996-05-07 | Cerebral Stimulation, Inc. | Auricular electrical stimulator |
| US5549734A (en) | 1995-03-08 | 1996-08-27 | Astec Industries, Inc. | Baghouse cleaning method |
| JPH08299141A (ja) | 1995-05-08 | 1996-11-19 | Mori Mihoko | 枕カバー |
| US5814095A (en) | 1996-09-18 | 1998-09-29 | Implex Gmbh Spezialhorgerate | Implantable microphone and implantable hearing aids utilizing same |
| US6016449A (en) | 1997-10-27 | 2000-01-18 | Neuropace, Inc. | System for treatment of neurological disorders |
| US20070060975A1 (en) | 1999-07-08 | 2007-03-15 | Mannheimer Jeffrey S | Combination electrode-battery and programming assembly for a miniature wireless transcutaneous electrical neuro or muscular-stimulation unit |
| US7200446B2 (en) | 1999-07-21 | 2007-04-03 | Borkan William N | Catheter leads for the intrathecal space and method of use |
| US6567702B1 (en) | 1999-10-15 | 2003-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | Eliciting analgesia by transcranial electrical stimulation |
| US6466822B1 (en) | 2000-04-05 | 2002-10-15 | Neuropace, Inc. | Multimodal neurostimulator and process of using it |
| US6405079B1 (en) * | 2000-09-22 | 2002-06-11 | Mehdi M. Ansarinia | Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions |
| US7158832B2 (en) | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
| US6549808B1 (en) | 2000-10-19 | 2003-04-15 | Heinz R. Gisel | Devices and methods for the transcutaneous delivery of ions and the electrical stimulation of tissue and cells at targeted areas in the eye |
| US6950707B2 (en) | 2000-11-21 | 2005-09-27 | Advanced Bionics Corporation | Systems and methods for treatment of obesity and eating disorders by electrical brain stimulation and/or drug infusion |
| RU2185092C1 (ru) | 2000-12-21 | 2002-07-20 | Ремнев Андрей Геннадьевич | Способ диагностики поражения первой и второй ветвей тройничного нерва |
| US20060064140A1 (en) | 2001-01-30 | 2006-03-23 | Whitehurst Todd K | Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder |
| US6735475B1 (en) | 2001-01-30 | 2004-05-11 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain |
| US6788975B1 (en) | 2001-01-30 | 2004-09-07 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy |
| US7171276B2 (en) | 2001-06-29 | 2007-01-30 | Abbott Laboratories | Hydrogel and scrim assembly for use with electro-acupuncture device with stimulation electrodes |
| US20030045922A1 (en) | 2001-08-29 | 2003-03-06 | Nancy Northrop | Skin treatment method and apparatus |
| US20140046407A1 (en) | 2001-08-31 | 2014-02-13 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation techniques |
| US8565896B2 (en) | 2010-11-22 | 2013-10-22 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuff with recesses |
| US6954668B1 (en) | 2001-10-11 | 2005-10-11 | Cuozzo John W | Apparatus and method for intra-oral stimulation of the trigeminal nerve |
| US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
| US20030195588A1 (en) | 2002-04-16 | 2003-10-16 | Neuropace, Inc. | External ear canal interface for the treatment of neurological disorders |
| US7003352B1 (en) * | 2002-05-24 | 2006-02-21 | Advanced Bionics Corporation | Treatment of epilepsy by brain stimulation |
| JP2003339884A (ja) * | 2002-05-31 | 2003-12-02 | Fes:Kk | 顔面電気刺激装置 |
| US7158834B2 (en) | 2002-06-13 | 2007-01-02 | Atlantic Medical, Inc. | Method and apparatus for performing microcurrent stimulation (MSC) therapy |
| AU2003265509A1 (en) | 2002-08-19 | 2004-03-03 | Arizona Board Regents | Neurostimulator |
| US20040138097A1 (en) | 2002-11-01 | 2004-07-15 | Bahman Guyuron | Method and treatment for treating and preventing pain associated with compression of a nerve |
| WO2005000090A2 (en) | 2003-05-30 | 2005-01-06 | Medi-Screw, Inc. | Medical implant systems |
| US8190248B2 (en) | 2003-10-16 | 2012-05-29 | Louisiana Tech University Foundation, Inc. | Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto |
| WO2005062829A2 (en) | 2003-12-19 | 2005-07-14 | Advanced Bionics Corporation | Skull-mounted electrical stimulation system and method for treating patients |
| EP1706178B1 (en) | 2004-01-22 | 2013-04-24 | Rehabtronics Inc. | System for routing electrical current to bodily tissues via implanted passive conductors |
| US7844344B2 (en) | 2004-03-30 | 2010-11-30 | Medtronic, Inc. | MRI-safe implantable lead |
| US7565197B2 (en) | 2004-06-18 | 2009-07-21 | Medtronic, Inc. | Conditional requirements for remote medical device programming |
| WO2006019764A2 (en) | 2004-07-15 | 2006-02-23 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
| US20060050912A1 (en) | 2004-09-09 | 2006-03-09 | Earcraft, Inc. | Shell and tip for hearing aid |
| WO2006034305A2 (en) | 2004-09-21 | 2006-03-30 | University Of Florida Research Foundation, Inc. | Multiple lead method for deep brain stimulation |
| JP2008516696A (ja) | 2004-10-18 | 2008-05-22 | ルイジアナ テック ユニバーシティ ファウンデーション | 神経障害の検出、予防および／または治療のための医療装置ならびにその医療装置に関連する方法 |
| US7685817B2 (en) | 2004-10-18 | 2010-03-30 | Ceti, Inc. | Method and system for providing a rotational output using a non-combustion heat source |
| US7613520B2 (en) | 2004-10-21 | 2009-11-03 | Advanced Neuromodulation Systems, Inc. | Spinal cord stimulation to treat auditory dysfunction |
| FR2877583B1 (fr) | 2004-11-10 | 2007-05-11 | Patrick Cosson | Dispositif d'electrotherapie |
| EP1671670A1 (fr) | 2004-12-14 | 2006-06-21 | STX Sprl | Appareil pour l'electro-inhibition des muscles de la face |
| US8825166B2 (en) | 2005-01-21 | 2014-09-02 | John Sasha John | Multiple-symptom medical treatment with roving-based neurostimulation |
| DE102005003735B4 (de) | 2005-01-26 | 2008-04-03 | Cerbomed Gmbh | Vorrichtung zur transkutanen Stimulation eines Nervs des menschlichen Körpers |
| US8700163B2 (en) | 2005-03-04 | 2014-04-15 | Cyberonics, Inc. | Cranial nerve stimulation for treatment of substance addiction |
| JP5086235B2 (ja) | 2005-03-09 | 2012-11-28 | クティセンセ アクティーゼルスカブ | マイクロ電子システムを内部に埋め込んだ三次元接着デバイス |
| US7853321B2 (en) | 2005-03-14 | 2010-12-14 | Boston Scientific Neuromodulation Corporation | Stimulation of a stimulation site within the neck or head |
| US7920915B2 (en) | 2005-11-16 | 2011-04-05 | Boston Scientific Neuromodulation Corporation | Implantable stimulator |
| US20060206165A1 (en) * | 2005-03-14 | 2006-09-14 | Jaax Kristen N | Occipital nerve stimulation to treat headaches and other conditions |
| EP1861160B1 (en) | 2005-03-24 | 2011-11-16 | Metacure Limited | Wireless leads for gastrointestinal tract applications |
| US7499752B2 (en) | 2005-07-29 | 2009-03-03 | Cyberonics, Inc. | Selective nerve stimulation for the treatment of eating disorders |
| US20070025608A1 (en) | 2005-07-29 | 2007-02-01 | Cyberonics, Inc. | Enhancing intrinsic neural activity using a medical device to treat a patient |
| JP2007054299A (ja) | 2005-08-24 | 2007-03-08 | Sharp Corp | 電気治療装置、およびそれを構成するためのシステム |
| JP2007061267A (ja) | 2005-08-30 | 2007-03-15 | Nova Medico:Kk | 鼻炎又は結膜炎治療器具 |
| US20070150027A1 (en) * | 2005-12-22 | 2007-06-28 | Rogers Lesco L | Non-invasive device and method for electrical stimulation of neural tissue |
| US8725243B2 (en) | 2005-12-28 | 2014-05-13 | Cyberonics, Inc. | Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders |
| US20070173908A1 (en) * | 2006-01-20 | 2007-07-26 | Cyberonics, Inc. | Transcutaneous trigeminal nerve stimulation to treat motion sickness |
| ATE441452T1 (de) | 2006-01-23 | 2009-09-15 | Koninkl Philips Electronics Nv | Verbesserte biomedizinische elektrode zur längeren anwendung bei patienten mit einem deckel oder schnapper, der von der haltedichtung isoliert ist |
| US7801601B2 (en) | 2006-01-27 | 2010-09-21 | Cyberonics, Inc. | Controlling neuromodulation using stimulus modalities |
| GB0603464D0 (en) | 2006-02-21 | 2006-04-05 | Goreszeniuk Teodor | Improvements in & relating to external neurostimulation |
| EP3069752B1 (en) | 2006-03-29 | 2018-03-28 | Dignity Health | Microburst electrical stimulation of cranial nerves for the treatment of medical conditions |
| JP2009537226A (ja) | 2006-05-18 | 2009-10-29 | エヌディーアイ メディカル， エルエルシー | 機能的または治療的神経刺激を提供する携帯アッセンブリ、システム、および方法 |
| US20080128215A1 (en) | 2006-05-24 | 2008-06-05 | Gershon Nowitz | Portable Scissor Lift |
| US8909342B2 (en) * | 2006-08-15 | 2014-12-09 | Andres M. Lozano | Method for treating eating disorders |
| US7940933B2 (en) | 2006-08-18 | 2011-05-10 | Medtronic, Inc. | Secure telemetric link |
| US7774072B2 (en) | 2006-11-30 | 2010-08-10 | Medtronic, Inc. | Attached implantable medical elongated members |
| US20080140151A1 (en) | 2006-12-11 | 2008-06-12 | Brodkey Jason A | Nerve stimulation apparatus and method for the treatment of head pain |
| US7890178B2 (en) | 2006-12-15 | 2011-02-15 | Medtronic Xomed, Inc. | Method and apparatus for assisting deglutition |
| US9913593B2 (en) | 2006-12-27 | 2018-03-13 | Cyberonics, Inc. | Low power device with variable scheduling |
| US8696724B2 (en) | 2007-01-11 | 2014-04-15 | Scion Neurostim, Llc. | Devices for vestibular or cranial nerve stimulation |
| US20080171929A1 (en) | 2007-01-11 | 2008-07-17 | Katims Jefferson J | Method for standardizing spacing between electrodes, and medical tape electrodes |
| JP4961558B2 (ja) | 2007-03-30 | 2012-06-27 | 国立大学法人信州大学 | 三叉神経固有知覚枝刺激装置 |
| WO2008128215A1 (en) | 2007-04-13 | 2008-10-23 | Alejandro Covalin | Apparatus and method for the treatment of headache |
| US20080262566A1 (en) | 2007-04-23 | 2008-10-23 | Boston Scientific Neuromodulation Corporation | Methods and systems of treating medication overuse headache |
| US8954162B2 (en) * | 2007-04-25 | 2015-02-10 | Medtronic, Inc. | Medical device implantation |
| CN101686808B (zh) | 2007-07-06 | 2012-11-28 | 皇家飞利浦电子股份有限公司 | 屏蔽的生物医学电极贴片 |
| EP2195084A4 (en) | 2007-09-26 | 2010-10-20 | Univ Duke | METHOD FOR TREATING PARKINSON DISEASE AND OTHER MOTION FLUCTUATIONS |
| US9180303B2 (en) | 2007-10-24 | 2015-11-10 | Medtronic, Inc. | Transmission of power source usage information over a network |
| US8849407B1 (en) | 2008-01-04 | 2014-09-30 | Yuri P. Danilov | Non-invasive neuromodulation (NINM) for rehabilitation of brain function |
| EP2092951A1 (fr) * | 2008-02-20 | 2009-08-26 | Stx-Med Sprl | Appareil pour le traîtement électrothérapeutique des céphalées de tension |
| CA2724234A1 (en) * | 2008-05-13 | 2009-11-19 | Cerbomed Gmbh | Method to enhance neural tissue operation |
| US20090326602A1 (en) * | 2008-06-27 | 2009-12-31 | Arkady Glukhovsky | Treatment of indications using electrical stimulation |
| WO2010009141A1 (en) | 2008-07-14 | 2010-01-21 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and devices for modulating cellular activity using ultrasound |
| US20100030227A1 (en) | 2008-07-31 | 2010-02-04 | Medtronic, Inc. | Medical lead implantation |
| US8512715B2 (en) | 2008-08-14 | 2013-08-20 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
| CN102202725B (zh) | 2008-10-21 | 2016-06-01 | Med-El电气医疗器械有限公司 | 用于面神经刺激的系统和方法 |
| US8666498B2 (en) | 2008-10-27 | 2014-03-04 | Serene Medical, Inc. | Treatment of headache |
| DE102008043973B4 (de) | 2008-11-21 | 2011-12-01 | Burkhard Brocke | Vorrichtung zur transkraniellen Neurostimulation |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
| EP2485799A4 (en) | 2009-10-05 | 2013-05-15 | Univ California | EXTRACRANIAL IMPLANTABLE DEVICES, SYSTEMS AND METHOD FOR THE TREATMENT OF NEUROLOGICAL ILLNESSES |
| US9101766B2 (en) * | 2009-10-16 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Eliciting analgesia by transcranial electrical stimulation |
| US9339645B2 (en) | 2010-05-02 | 2016-05-17 | Nervive, Inc. | Modulating function of the facial nerve system or related neural structures via the ear |
| US8702584B2 (en) | 2010-05-12 | 2014-04-22 | Cefaly Technology Sprl | Neurostimulation method to induce relaxation or sleep |
| WO2012075192A2 (en) | 2010-11-30 | 2012-06-07 | The Regents Of The University Of California | Pulse generator for cranial nerve stimulation |
| EP2651497B1 (en) | 2010-12-14 | 2019-02-20 | The Regents of The University of California | Extracranial implantable systems for the treatment of medical disorders |
| KR20140037803A (ko) | 2010-12-14 | 2014-03-27 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 의료 질환 치료용 장치, 시스템 및 방법 |
| US20120203301A1 (en) | 2011-02-07 | 2012-08-09 | Advanced Neuromodulation Systems, Inc. | Methods using trigeminal nerve stimulation to treat neurological diseases |
| GB2505808A (en) | 2011-05-11 | 2014-03-12 | Alejandro Covalin | Headache-treatment device with gel dispensing kit and method |
| BE1020458A3 (fr) | 2012-01-13 | 2013-10-01 | Stx Med Sprl | Appareil electronique autonome et dipositif de fixation de celui-ci sur une electrode localisee au niveau de la tete pour une utilisation en position couchee du patient. |
| JP2015513980A (ja) | 2012-04-05 | 2015-05-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 脳神経刺激のための皮下電極 |
| US20140039572A1 (en) | 2012-08-03 | 2014-02-06 | Boston Scientific Neuromodulation Corporation | System and method for treating depression and epilepsy |
| CN103830841B (zh) | 2012-11-26 | 2018-04-06 | 赛威医疗公司 | 可穿戴的经皮肤的电刺激设备及其使用方法 |
| US10220211B2 (en) | 2013-01-22 | 2019-03-05 | Livanova Usa, Inc. | Methods and systems to diagnose depression |
-
2011
- 2011-12-14 EP EP11849890.6A patent/EP2651497B1/en active Active
- 2011-12-14 CA CA2821721A patent/CA2821721A1/en not_active Abandoned
- 2011-12-14 WO PCT/US2011/065003 patent/WO2012082961A2/en not_active Ceased
- 2011-12-14 US US13/994,512 patent/US20140142669A1/en not_active Abandoned
- 2011-12-14 JP JP2013544760A patent/JP6559395B2/ja active Active
-
2017
- 2017-06-15 US US15/624,640 patent/US20170348521A1/en not_active Abandoned
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2018
- 2018-04-10 US US15/949,987 patent/US10238862B2/en active Active
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