JP2014180326A - Medical bag - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical bag for holding chemical liquids, blood or the like, which is highly hygienic and excellent in heat resistance, translucency, flexibility, tear strength, impact resistance and drop strength and good in adhesive property with polypropylene port.SOLUTION: A medical bag is a laminate which is layered with at least a first layer, a second layer and a third layer in this order. The medical bag comprises: the first layer made of ethylene-based resin layer I including 51-85 wt.% of an ingredient (A) and 15-49 wt.% of an ingredient (B); the second layer of an ethylene-based resin layer II including 70-99 wt.% of the ingredient (A) and 1-30 wt.% of the ingredient (B); and the third layer of a propylene-based resin layer III including a propylene-based resin composition (X).

Description

  The present invention relates to a medical bag that is excellent in hygiene, heat resistance, transparency, flexibility, tear strength, impact resistance, and bag drop strength, and has good adhesion to a polypropylene resin port.

  Currently, a soft bag made of polyvinyl chloride containing a plasticizer is known as a medical container. Soft bags do not require the introduction of air as in the case of glass or other hard containers, and have advantages such as the safety of the bag itself being squeezed by the atmospheric pressure when the contents are dropped, and the convenience of transportation is high. . However, since the plasticizer and residual monomer contained in the polyvinyl chloride are precipitated as fine particles in the content liquid, there is a problem. Therefore, an alternative material is desired.

  On the other hand, a medical bag using a polymer such as an ethylene-vinyl acetate copolymer or an elastomer as an intermediate layer has been proposed in terms of flexibility, transparency, hygiene, and the like (see Patent Document 1). However, these polymers used for the intermediate layer have a defect that the appearance is inferior, for example, wrinkles are generated during sterilization due to poor heat resistance, or transparency after sterilization is reduced. In addition, pinholes may occur during transportation.

Also known is a laminate in which the outer layer is a polypropylene resin and the intermediate layer is a conventional linear ethylene / α-olefin copolymer (see Patent Document 2). In addition, a laminate has been proposed in which an outer layer is made of a polypropylene resin and an intermediate layer is made of a metallocene catalyst, and an ethylene / α-olefin copolymer having a single melting point (see Patent Document 3). However, medical bags made of these laminates do not have a high level of transparency, strength, flexibility and heat resistance.
Furthermore, there has been proposed a medical container (see Patent Document 4) that is formed of a sheet that is produced with a metallocene-based catalyst and that includes polypropylene having a melting point of 140 ° C. or less as a forming layer. There was a problem that the falling bag strength was not sufficient. A laminate sheet in which another polymer layer is combined with the polypropylene-forming layer is also described, but it has not yet solved the problem of insufficient bag drop strength.

  Further, in the laminate including at least the outer layer, the intermediate layer, and the inner layer in this order, the outer layer is made of a polypropylene resin, and the intermediate layer includes ethylene containing a low crystalline component and a high crystalline component, and α having 3 to 18 carbon atoms. -The laminated body which consists of a copolymer with an olefin is proposed (refer patent document 5). However, after autoclave sterilization, there was a problem that transparency and bag drop strength were not yet sufficient.

  Furthermore, a laminate is proposed in which a propylene-based resin layer is laminated on one side or both sides of an ethylene-based resin layer (see Patent Document 6). However, there is a problem that the layer to which the seal bar is applied dissolves during heat sealing.

  Therefore, there is no problem as described above, that is, not only good hygiene, but also excellent flexibility and transparency, and excellent heat resistance. A medical bag with good strength could not be achieved with conventional multilayer medical bags.

  On the other hand, the medical bag is usually provided with a discharge port for discharging a liquid such as an infusion stored in the bag. The discharge port is composed of a port, a rubber plug, and a cap for fixing the rubber plug, and the infusion solution or the like is discharged by inserting a bottle needle into the rubber plug built in the discharge port. In order to improve the liquid tightness, the rubber plug fixes the port and the cap while leaving a compressive strain. Examples of the fixing method include thermal welding, ultrasonic welding, and mechanical caulking.

Polyethylene ports such as polyethylene (PE) and ethylene-vinyl acetate (EVA) and polypropylene ports are used as the resin ports used for the discharge port, and polypropylene ports are particularly excellent in the following points. .
(1) Compared to PE and EVA, polypropylene (PP) has high rigidity and surface hardness, and therefore has excellent port inner surface wear resistance and penetration resistance. On the other hand, EVA requires reinforcement with hard resin parts on the inner surface, increasing the number of parts and increasing the cost.
(2) When PE is ultrasonically welded, burrs are generated and are likely to become a foreign matter generation source. On the other hand, polypropylene PP is suitable for ultrasonic welding, and can be welded with high airtightness with few burrs in a short time.
(3) PE and EVA are easily deformed and it is difficult to compress rubber, but polypropylene PP has high rigidity and heat resistance, so that cap deformation due to the repulsive force of rubber hardly occurs during sterilization.
Therefore, in addition to the above flexibility and transparency and excellent heat resistance, the medical bag is further required to have particularly good adhesion to a polypropylene port.

JP 58-165866 A JP-A-6-171039 JP-A-9-141793 JP-A-9-99036 JP 2000-343660 A JP 2005-53131 A

Science, 2000, vol. 288, p. 2187-2190

  It is an object of the present invention to provide a medical bag that is excellent in hygiene, heat resistance, transparency, flexibility, tear strength, impact resistance, and bag drop strength, and also has good adhesion to a polypropylene resin port. And

As a result of intensive studies to solve the above problems, the present inventors have found that a medical bag made of a laminate in which a specific ethylene resin and a specific propylene resin are laminated can solve the above problems. As a result, the present invention has been completed.
That is, the present invention is as follows.

(1) A medical bag comprising a laminate in which at least a first layer, a second layer, and a third layer are laminated in this order, wherein the first layer comprises 51 to 85% by weight of the following component (A) and the following component ( B) Ethylene resin layer I comprising 15 to 49% by weight of an ethylene resin layer I, the second layer containing 70 to 99% by weight of the following component (A) and 1 to 30% by weight of the following component (B) A medical bag comprising a layer II, wherein the third layer comprises a propylene-based resin layer III containing the following propylene-based resin composition (X).
Component (A): Copolymer of ethylene and an α-olefin having 3 to 12 carbon atoms produced using a metallocene catalyst having the following properties (Ai) to (A-iv) (Ai) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 20 g / 10 minutes (A-ii) Density is 0.890 to 0.930 g / cm ³
(A-iii) The content of α-olefin is 5 to 40% by weight
(A-iv) The ratio (Mz / Mn) of the Z average molecular weight (Mz) and the number average molecular weight (Mn) determined by gel permeation chromatography (GPC) is 8.0 or less. Component (B): -I) High density polyethylene having the characteristics of (B-ii) (Bi) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 50 g / 10 minutes (B-ii) Density is 0 .940-0.980 g / cm ³
Propylene-based resin composition (X): propylene-based resin composition comprising the following component (C) 50 to 65 wt%, the following component (D) 25 to 35 wt%, and the following component (E) 10 to 20 wt% C): Propylene-ethylene random block copolymer having the following characteristics (Ci) to (C-iii) (Ci) Using a metallocene catalyst, the melting peak temperature in DSC measurement in the first step is The propylene-ethylene random copolymer component (C1) having an ethylene content of 1.5 to 3.0% by weight of 125 to 135 ° C. and an ethylene content of 8 to 14% by weight in the second step Propylene-ethylene random block copolymer obtained by sequential polymerization of propylene-ethylene random copolymer component (C2) by 50 to 40% by weight (C-ii) Melt flow rate (C-iii) Temperature-loss tangent (tan δ) curve obtained by solid viscoelasticity measurement, glass transition observed in the range of −60 to 20 ° C. The expressed temperature-loss tangent (tan δ) curve shows a single peak at 0 ° C. or lower. Component (D): an ethylene-α-olefin copolymer having the following characteristics (Di) to (D-iii): Di) Density is 0.870-0.890 g / cm ³
(D-ii) Melting peak temperature in DSC measurement is 80 ° C. or less (D-iii) Melt flow rate (190 ° C., 21.18 N load) is 2.0 to 5.0 g / 10 min Component (E): -I) -Propylene-ethylene block copolymer having the characteristics of (E-iii) (Ei) Melt flow rate (230 ° C., 21.18 N load) in the first step is in the range of 100-200 g / 10 min. The propylene-ethylene random copolymer component (E2) having 65 to 75% by weight of the polypropylene component (E1), ethylene content of 4 to 8% by weight and weight average molecular weight of 800,000 to 3 million in the second step is 35. Propylene-ethylene block copolymer obtained by sequential polymerization of ˜25 wt% (E-ii) Weight average molecular weight (Mw) and number average molecular weight (Mn) determined by GPC The molecular weight distribution with ratio (Mw / Mn) from 9.0 to 15.0
(E-iii) Melt flow rate (230 ° C., 21.18 N load) of the entire propylene resin component (E) is 2.0 to 8.0 g / 10 min.

(2) The total thickness of the ethylene-based resin layer I and the propylene-based resin layer III is 15 to 60% with respect to the total thickness of the laminate, and is for medical use according to (1) above bag.
(3) The medical bag according to any one of (1) and (2) above, wherein the total thickness of the laminate is 100 to 700 μm.

(4) The medical bag according to any one of (1) to (3), wherein the laminate is formed in a bag shape, the first layer is an outer layer, and the third layer is an inner layer.
(5) The medical bag according to any one of (1) to (3), wherein the third layers of the laminate are opposed to each other and heat-sealed in a bag shape.
(6) An infusion preparation containing the infusion in the medical bag according to (4) or (5) above.

  The medical bag of the present invention has good hygiene and heat resistance, is excellent in flexibility, transparency and tear strength after autoclaving at 115 to 121 ° C., and becomes a problem during transportation or handling. Excellent impact resistance, bag drop strength, heat seal characteristics, and adhesiveness with polypropylene resin port. Moreover, since the medical bag of the present invention uses a polyethylene resin, there is no addition of a plasticizer, and since a resin produced with a metallocene catalyst is used, there is no precipitation of residual monomers, and hygiene is achieved. Also excellent. Therefore, it can be preferably used as a soft container in the medical field such as an infusion bag.

FIG. 1 is a front view of an embodiment of the medical bag of the present invention.

The medical bag of the present invention comprises a laminate in which at least a first layer, a second layer, and a third layer are laminated in this order, and the first layer is composed of 51 to 85% by weight of component (A) and 49 to 49% of component (B). An ethylene resin layer I containing 15% by weight, and an ethylene resin layer II and a third layer in which the second layer contains component (A) 70 to 99% by weight and component (B) 30 to 1% by weight The present invention relates to a medical bag comprising a propylene-based resin layer III containing a propylene-based resin composition (X).
Below, the 1st-3rd layer which comprises the laminated body used for this invention, each component contained in each layer, the formation method of a laminated body and a medical bag, etc. are demonstrated in detail for every item.

1. First layer and second layer (ethylene resin layer I and ethylene resin layer II)
The 1st layer and 2nd layer of the laminated body used for this invention are comprised from an ethylene-type resin layer.
The first layer is composed of an ethylene-based resin layer I containing 51 to 85% by weight of the following component (A) and 49 to 15% by weight of the following component (B), and the second layer is 70 to 99 of the following component (A). It consists of an ethylene-based resin layer II containing 10% by weight and 30 to 1% by weight of the following component (B).
Component (A): Copolymer of ethylene and an α-olefin having 3 to 12 carbon atoms produced using a metallocene catalyst having the following properties (Ai) to (A-iv) (Ai) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 20 g / 10 minutes (A-ii) Density is 0.890 to 0.930 g / cm ³
(A-iii) The content of α-olefin is 5 to 40% by weight
(A-iv) The ratio (Mz / Mn) of the Z average molecular weight (Mz) and the number average molecular weight (Mn) determined by gel permeation chromatography (GPC) is 8.0 or less. Component (B): -I) High density polyethylene having the characteristics of (B-ii) (Bi) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 50 g / 10 minutes (B-ii) Density is 0 .940-0.980 g / cm ³

Since the ethylene-based resin layer I contains an ethylene / α-olefin copolymer and high-density polyethylene in a well-balanced manner, in the medical bag of the present invention, it imparts good heat resistance, that is, prevention of rough appearance after sterilization. It has the function to do. In addition, since the ethylene-based resin layer II contains a larger amount of ethylene / α-olefin copolymer than high-density polyethylene, the medical bag according to the present invention has a function of imparting good flexibility and transparency. Have
Hereinafter, the component (A), the component (B), and the blending ratio of each component contained in the ethylene resin layers I and II will be described in detail.

(1) Kind of component (A) Component (A) used in the present invention is a copolymer of ethylene and an α-olefin having 3 to 12 carbon atoms produced using a metallocene catalyst.
Since component (A) used in the present invention is produced with a metallocene catalyst, it has a function of imparting good transparency, flexibility and strength in the ethylene resin layers I and II.

(1-1) Monomer Configuration The component (A) used in the present invention is a random copolymer of ethylene and a C 3-12 α-olefin having a structural unit derived from ethylene as a main component.
Specific examples of the α-olefin used as a comonomer include propylene, 1-butene, 1-pentene, 1-hexene, 1-octene, 1-heptene, 4-methyl-pentene-1, 4-methyl-hexene-1 4,4-dimethylpentene-1 and the like.
Specific examples of the component (A) include an ethylene / propylene copolymer, an ethylene / 1-butene copolymer, an ethylene / 1-hexene copolymer, an ethylene / 1-octene copolymer, an ethylene / 4-methyl- Examples include pentene-1 copolymer. Moreover, 1 type, or 2 or more types of combination may be sufficient as an alpha olefin.
When combining two kinds of α-olefins to form a terpolymer, ethylene / propylene / hexcenter polymer, ethylene / butene / hexcenter polymer, ethylene / propylene / octene terpolymer, ethylene / butene / octene terpolymer, etc. may be mentioned. It is done.
In addition, the quantity of the ethylene unit in a component (A) is mentioned later as a characteristic (A-iii).

(1-2) Polymerization catalyst and polymerization method The catalyst used for the production of the component (A) is a metallocene catalyst in order to impart flexibility and strength to the ethylene / α-olefin copolymer.
Examples of the metallocene catalyst include JP-A 58-19309, JP-A 60-35006, JP-A 60-35007, JP-A 60-35008, and JP-A 3-163088. Catalysts described in Japanese Patent Application Publication No. 420,436, US Pat. No. 5,055,438, and International Publication No. WO09 / 04257, for example, metallocene compounds, metallocene compounds / alumoxanes Examples thereof include a catalyst and the like, or a catalyst made of a compound that reacts with a metallocene compound and a metallocene compound to form stable ions, as disclosed in, for example, International Publication No. WO09 / 07123.
As the metallocene compound used in the metallocene catalyst, an organic transition metal compound of a IV-VI transition metal compound such as zirconium, titanium or hafnium, preferably a group IV transition metal compound and cyclopentadiene or a cyclopentadiene derivative is used. can do.
As the cyclopentadiene derivative, an alkyl substituent such as pentamethylcyclopentadiene or a compound in which two or more substituents are combined to form a saturated or unsaturated cyclic substituent can be used. Examples thereof include indene, fluorene, azulene, and partial hydrogenated products thereof.
A compound in which a plurality of cyclopentadiene or cyclopentadiene derivatives are bonded by an alkylene group, a silylene group, or the like can also be used.
As a polymerization method, a slurry method in the presence of these catalysts, a gas-bed fluidized bed method (for example, a method described in JP-A-59-23011), a solution method, or a pressure of 200 kg / cm ² or more, Examples thereof include a high-pressure bulk polymerization method or a high-pressure ion polymerization method at a polymerization temperature of 100 ° C. or higher.
In addition, the ethylene / α-olefin copolymer used in the present invention can be appropriately selected from commercially available products. Examples of commercially available products include Kernel (registered trademark) manufactured by Japan Polyethylene Corporation.

(2) Each characteristic of component (A) (A-i) Melt flow rate (MFR)
MFR (190 degreeC, 21.18N load) of the component (A) used for this invention is 0.1-20 g / 10min, Preferably it is 0.5-10 g / 10min, More preferably, it is 1 0.0 to 5 g / 10 min. If the MFR of the component (A) is less than 0.1 g / 10 minutes, the resin pressure is high and the moldability is poor. .
In addition, MFR of a component (A) is the value measured based on JIS-K6922-2: 1997 appendix (190 degreeC, 21.18N load).

(A-ii) Density The density of the component (A) used in the present invention is 0.890 to 0.930 g / cm ³ , preferably 0.890 to 0.925 g / cm ³ , more preferably 0.900. 0.923 g / cm ³ . If the density of the component (A) is less than 0.890 g / cm ³ , the transparency becomes poor after autoclaving at 115 to 121 ° C., whereas if it exceeds 0.930 g / cm ³ , the transparency is poor. , The flexibility is lowered, which is not preferable.
In addition, the density of a component (A) is the value measured based on JIS-K6922-2: 1997 appendix (in the case of a low density polyethylene) (23 degreeC).

(A-iii) Content of α-olefin The content of α-olefin in the component (A) used in the present invention is 5 to 40% by weight, preferably 7 to 35% by weight, more preferably. 8 to 30% by weight. When the content of the α-olefin of the component (A) is less than 5% by weight, the impact strength and flexibility of the film cannot be obtained, while when it exceeds 40% by weight, the heat resistance is impaired.
The α-olefin content is a value measured by ¹³ C-NMR method under the following conditions.
Device: JEOL-GSX270 manufactured by JEOL
Concentration: 300 mg / 2 mL
Solvent: Orthodichlorobenzene

(A-iv) Ratio of Z average molecular weight (Mz) to number average molecular weight (Mn) (Mz / Mn)
Since the Z average molecular weight (Mz) greatly contributes to the average molecular weight of the high molecular weight component, the ratio (Mz / Mn) of Mz to the number average molecular weight (Mn) is the ratio of the weight average molecular weight (Mw) to Mn. It is easier to confirm the presence of a high molecular weight component than (Mw / Mn). The high molecular weight component is a factor that affects the transparency, and when the high molecular weight component is large, the transparency is deteriorated. Therefore, a smaller Mz / Mn is preferable.
Therefore, the ratio (Mz / Mn) between the Z average molecular weight (Mz) and the number average molecular weight (Mn) obtained by gel permeation chromatography (GPC) of the component (A) used in the present invention is 8.0 or less. Yes, preferably 5.0 or less. When Mz / Mn exceeds 8.0, transparency deteriorates. Examples of a method for adjusting Mz / Mn to a predetermined range include a method for selecting an appropriate metallocene catalyst.
In addition, the measurement of (Mz / Mn) is performed by gel permeation chromatography (GPC), and the measurement conditions are as follows.
Apparatus: GPC 150C type manufactured by Waters Inc. Detector: 1A infrared spectrophotometer manufactured by MIRAN (measurement wavelength: 3.42 μm)
Column: Showa Denko AD806M / S 3 (column calibration is Tosoh monodisperse polystyrene (A500, A2500, F1, F2, F4, F10, F20, F40, F288 each 0.5mg / ml solution) The logarithm of the elution volume and molecular weight was approximated by a quadratic equation, and the molecular weight of the sample was converted to polyethylene using the viscosity equation of polystyrene and polyethylene, where the coefficient of the viscosity equation of polystyrene was α = 0. 723, log K = −3.967, and polyethylene has α = 0.733 and log K = −3.407.)
Measurement temperature: 140 ° C
Concentration: 20 mg / 10 mL
Injection volume: 0.2ml
Solvent: orthodichlorobenzene Flow rate: 1.0 ml / min.

(3) Type of component (B) Component (B) used in the present invention is high-density polyethylene.
The density of the component (B) will be described later as the characteristic (B-ii).
Since component (B) used in the present invention has a high melting point, it has a function of imparting good heat resistance in the ethylene-based resin layers I and II.

(3-1) Polymerization Catalyst and Polymerization Method The catalyst used for the production of component (B) is not particularly limited, but a Ziegler type catalyst (ie, a combination of a supported or unsupported halogen-containing titanium compound and an organoaluminum compound). And a Kaminsky catalyst (that is, based on a combination of a supported or unsupported metallocene compound and an organoaluminum compound, particularly an alumoxane).
The Ziegler-type catalyst can be obtained by a usual polymerization method using, for example, a combination catalyst of a solid catalyst component and an organoaluminum compound containing magnesium halide, titanium halide, and an electron donor compound as components.
The method for producing component (B) is not particularly limited as long as a polymer having the desired physical properties can be produced, but the intermediate pressure method is preferred.
The shape of the raw material polyethylene of the component (B) is not limited, and may be any of pellets, powders, and waxes.

(4) Each characteristic of component (B) (Bi) Melt flow rate (MFR)
MFR (190 degreeC, 21.18N load) of the component (B) used for this invention is 0.1-50 g / 10min, Preferably it is 1-30 g / 10min, More preferably, it is 2-9g / 10min. is there. If the MFR of the component (B) is less than 0.1 g / 10 minutes, the dispersibility in the component (A) is lacking, so the heat resistance during autoclave sterilization at 115 ° C or ~ 121 ° C is not improved. It is not preferable. On the other hand, if the MFR exceeds 50 g / 10 min, the film formation stability is not preferred.
In addition, MFR of high density polyethylene is the value measured based on JIS-K6922-2: 1997 appendix (190 degreeC, 21.18N load).

(B-ii) Density The density of the component (B) used in the present invention is 0.940 to 0.980 g / cm ³ , preferably 0.950 to 0.980 g / cm ³ , more preferably 0.953 to 0. 980 g / cm ³ . When the density of the component (B) is less than 0.940 g / cm ³ , the effect of improving the heat resistance in the medical bag is not sufficient, while it is difficult to produce polyethylene exceeding 0.980 g / cm ³ .
In addition, the density of a component (B) is the value measured based on JIS-K6922-2: 1997 annex (23 degreeC).

(5) Mixing ratio of components (A) and (B) in the first layer (ethylene-based resin layer I) The mixing ratio of components (A) and (B) in the ethylene-based resin layer I is the total amount of the ethylene-based resin layer I. The component (A) is 51 to 85% by weight, the component (B) is 15 to 49% by weight, preferably the component (A) is 55 to 80% by weight, and the component (B) is 20 to 45%. More preferably, the component (A) is 57 to 70% by weight and the component (B) is 30 to 43% by weight.
When the blending ratio of the component (B) in the ethylene resin layer I is less than 15% by weight, the effect of improving the heat resistance of the medical bag is not observed. On the other hand, when the blending ratio of the component (B) exceeds 49% by weight, the flexibility and transparency deteriorate, which is not preferable.

(6) Component ratio of components (A) and (B) in second layer (ethylene resin layer II) The component ratio of components (A) and (B) in ethylene resin layer II is the total amount of ethylene resin layer II. The component (A) is 70 to 99% by weight and the component (B) is 1 to 30% by weight, preferably the component (A) is 80 to 97% by weight and the component (B) is 3 to 20%. More preferably, the component (A) is 90 to 96% by weight and the component (B) is 4 to 10% by weight.
When the blending ratio of the component (B) in the ethylene resin layer II is less than 1% by weight, the effect of improving the heat resistance of the medical bag is not observed. On the other hand, when the blending ratio of the component (B) exceeds 30% by weight, flexibility and transparency are deteriorated, which is not preferable.
In addition, since the ethylene resin layer I mainly has heat resistance and the ethylene resin layer II mainly has flexibility and transparency, the blending ratio of the component (B) in the ethylene resin layer I is the ethylene resin layer. It is preferably larger than the blending ratio of component (B) in II.

(7) Other additive components The resin component which comprises the ethylene-type resin layers I and II can mix | blend another additional arbitrary component in the range which does not impair the effect of this invention remarkably. Examples of such optional components include antioxidants, crystal nucleating agents, clearing agents, lubricants, colorants, dispersants, peroxides, fillers, fluorescent brighteners and the like used in ordinary polyolefin resin materials. Can be mentioned.
In addition, the high-pressure radical polymerization method other than the components (A) and (B) of the present application, low-density polyethylene, linear low-density polyethylene, ethylene / α-olefin copolymer, isotactic polypropylene, as long as the effects of the invention are not impaired. , A propylene / α-olefin block copolymer, an olefin-based elastomer, a styrene-based elastomer, and the like can also be mixed.

2. Third layer (propylene resin layer III)
The 3rd layer in the layered product used for the present invention consists of propylene system resin layer III containing the following propylene system resin composition (X).
The polypropylene resin composition (X) is a resin composition comprising component (C) 50 to 65% by weight, component (D) 25 to 35% by weight and component (E) 10 to 20% by weight (provided that component (C) ), The total amount of component (D) and component (E) is 100% by weight).
The propylene-based resin layer III in the present invention is a polypropylene-based resin composition for medical containers described in Japanese Patent No. 5144573310229256, and a specific propylene-ethylene random block copolymer using a metallocene-based catalyst as a main material. In addition, a specific ethylene-α-olefin copolymer and a second propylene-ethylene block copolymer different from the propylene-ethylene block copolymer described above are contained.
By using such a three-component system, moisture permeability is small, transparency and flexibility are provided without using styrenic thermoplastic elastomer, and even better strength (drop resistance, low temperature impact resistance) ) And heat seal characteristics. The medical bag of the present invention is preferably a container body having a drug chamber formed by heat-sealing a sheet formed such that the above-described propylene-based resin composition layer for medical containers is inside the bag; It has a discharge port heat sealed to the container body so as to communicate with the lower end portion of the drug chamber, and a drug stored in the drug chamber. In particular, by using a sheet formed of the above-described propylene-based resin composition for medical containers as an inner layer, the heat sealability at the seal portion with the discharge port becomes good, and the drop resistance of the discharge port seal portion and High impact resistance. Further, the container body is composed of a multilayer sheet formed of the above-mentioned polypropylene resin composition for medical containers and polyethylene resin composition, so that oxygen permeability, moisture permeability is small, neutrality, alkali and acidity. Even under high-pressure steam sterilization under chemical solution filling conditions, the generation of insoluble fine particles is small, and it has transparency and flexibility, and has good strength (drop resistance, low temperature impact resistance).
Furthermore, the propylene-based resin layer III can form a partition weak seal portion from which the internal space can be peeled by adjusting the heat seal conditions. Therefore, the container body divided into the first drug chamber and the second drug chamber by the partition weak seal portion from which the internal space can be peeled off, and the discharge port communicating with the lower end portion of the first drug chamber And a partition having a good heat-seal characteristic, if it is a multi-chamber container comprising the first medicine stored in the first medicine chamber and the second medicine housed in the second medicine chamber It has a weak seal part for use.
Hereinafter, each requirement of the component (C), the component (D), and the component (E) constituting the propylene resin composition (X) contained in the propylene resin layer III will be described in detail.

(1) Component (C)
Component (C) (hereinafter also referred to as “propylene-based resin component (C)”) is a propylene-ethylene random block copolymer, and has the following characteristics (Ci) to (C-iii). Satisfies having.
(Ci) A propylene-ethylene random copolymer component having a melting peak temperature of 125 to 135 ° C. and an ethylene content of 1.5 to 3.0% by weight in DSC measurement in the first step using a metallocene catalyst ( Propylene-ethylene obtained by sequential polymerization of 50 to 40 wt% of C1) and propylene-ethylene random copolymer component (C2) having an ethylene content of 8 to 14 wt% in the second step Random block copolymer (C-ii) Melt flow rate (230 ° C., 21.18 N load) is 4 to 10 g / 10 minutes (C-iii) Temperature-loss tangent (tan δ) curve obtained by solid viscoelasticity measurement A temperature-loss tangent (tan δ) curve representing a glass transition observed in a range of −60 to 20 ° C. shows a single peak at 0 ° C. or lower.

The propylene resin component (C) will be specifically described.
In the present invention, the propylene-based resin component (C), which is a propylene-ethylene random block copolymer used as the main component of the propylene-based resin composition (X), has high transparency, flexibility, and impact resistance. It is a resin provided. The propylene resin composition (X) is particularly effective as a propylene resin composition for medical multi-chamber containers.

(2) Each characteristic of component (C) And propylene-type resin component (C) satisfy | fills each requirements of the following (Ci)-(C-iii).
(Ci) Basic rules The propylene-based resin component (C) uses a metallocene-based catalyst, and the melting peak temperature Tm (C) in DSC measurement in the first step is 125 to 135 ° C., and the ethylene content is 1.5 to 1.5. Propylene-ethylene random copolymer component (C1) in the range of 3.0% by weight is 50 to 60% by weight, and propylene-ethylene random copolymer component (C2) having an ethylene content of 8 to 14% by weight in the second step. ) Is successively polymerized by 50 to 40% by weight.

[Ingredient (C1)]
(C-i-1) Melting peak temperature Tm (C) of component (C1)
The component (C1) produced in the first step is a component that determines crystallinity in the propylene-based resin component (C). For the component (C) to exhibit heat resistance, the component (C1) is melted. The peak temperature Tm (C) needs to be relatively high. On the other hand, if Tm (C) is too high, flexibility is insufficient, and in order to control heat seal characteristics, a second propylene-based resin component (propylene-ethylene random copolymer component described later) ( It is necessary that the difference between the melting peak temperature Tm (E) of E) is large. Therefore, the melting peak temperature Tm (C) of the component (C1) needs to be in the range of 125 to 135 ° C.
That is, when the melting peak temperature Tm (C) is less than 125 ° C., there is a problem in that the container is deformed or crisp (blocking) fusion occurs when autoclaving under high pressure steam sterilization under chemical filling conditions. Since it is easy to occur, Tm (C) needs to be 125 ° C. or higher, and preferably 128 ° C. or higher.
On the other hand, when Tm (C) is high, the heat resistance is improved, but not only the flexibility and transparency are easily inhibited, but also the difference from the melting peak temperature Tm (E) of the component (E) is reduced. In this case, the heat seal curve rises sharply, making it difficult to control multi-stage stable peel strength. Therefore, Tm (C) needs to be 135 ° C. or lower, preferably 133 ° C. or lower. It is.
In the present invention, a DSC manufactured by Seiko Co., Ltd. was used, a sample of 5.0 mg was taken, held at 200 ° C. for 5 minutes, and then crystallized at a rate of temperature decrease of 10 ° C./minute up to 40 ° C. The melting peak temperature when melted at a temperature rising rate of Tm was defined as Tm.
(C-i-2) ethylene content E (C1) of component (C1)
The melting peak temperature Tm (C) of the component (C1) is controlled by the ethylene content, and the ethylene content E (C1) of the component (C1) in the present invention is in the range of 1.5 to 3.0% by weight. When the ethylene content is less than 1.5% by weight, Tm (C) becomes too high, and when it exceeds 3.0% by weight, it becomes too low.
(Ci-3) Proportion W (C1) of component (C1) in propylene-based resin component (C)
The proportion W (C1) of the component (C1) in the propylene-based resin component (C) is a component that imparts heat resistance to the component (C), but if there is too much W (C1), flexibility and impact resistance May not be sufficient, and transparency may be impaired. Therefore, the proportion of component (C1) needs to be 60% by weight or less.
On the other hand, if the proportion of the component (C1) becomes too small, the heat resistance is lowered even if the melting peak temperature Tm (C) is sufficient, and the container is deformed when sterilized under high pressure steam under chemical filling conditions. The ratio of the component (C1) must be 50% by weight or more because a problem such as occurrence of fouling or fusion is likely to occur.

[Ingredient (C2)]
(Ci-4) Ethylene content E in component (C2) E (C2)
The propylene-ethylene random copolymer component (C2) produced in the second step is a component necessary for improving the flexibility, impact resistance and transparency of the propylene-based resin component (C). Generally, in the propylene-ethylene random copolymer, the crystallinity is lowered and the flexibility improving effect is increased by increasing the ethylene content, so that the ethylene content E (C2) in the component (C2) is 8% by weight. That is necessary. When E (C2) is less than 8% by weight, sufficient flexibility cannot be exhibited, and it is preferably 10% by weight or more.
On the other hand, if the ethylene content is increased too much in order to lower the crystallinity of component (C2), the compatibility of component (C1) and component (C2) will decrease, and component (C2) will not be compatible with (C1). To form a domain. In such a phase separation structure, if the refractive index of the matrix and the domain are different, the transparency is drastically lowered. Therefore, the ethylene content of the propylene-ethylene random copolymer component (C2) in the propylene-based resin component (C) used in the present invention needs to be 14% by weight or less, preferably 12% by weight or less. is there.
(Ci-5) Proportion of component (C2) in propylene resin component (C) W (C2)
When the proportion of the component (C2) is too large, the heat resistance is lowered. Therefore, the proportion W (C2) of the component (C2) needs to be suppressed to 50% by weight or less.
On the other hand, if the proportion of the component (C2A2) becomes too small, the effect of improving the flexibility and impact resistance cannot be obtained. Therefore, the proportion of the component (A2C2) needs to be 40% by weight or more.

(2-1) Specific components (C1) and (C2) of ethylene contents E (C1) and E (C2) and component amounts W (C1) and W (C2) of components (C1) and (C2) The ethylene content and the component amount are determined by a material balance at the time of polymerization (material balance) and various known analytical methods. The measurement method used in the present invention will be described below.

[Specification of component amounts of component (C1) and component (C2)]
(2-1-1) Temperature rising elution fractionation method (TREF)
A technique for evaluating the crystallinity distribution of a propylene-ethylene random copolymer by temperature-elevated elution fractionation (TREF) is well known to those skilled in the art. It is shown.
G. Glockner, J. et al. Appl. Polym. Sci. : Appl. Po
lym. Symp. 45, 1-24 (1990)
L. Wild, Adv. Polym. Sci. 98, 1-47 (1990)
J. et al. B. P. Soares, A .; E. Hamielec, Polymer; 36,
8, 1639-1654 (1995)
Component (C) in the present invention has a large difference in crystallinity between components (C1) and (C2), and each crystallinity distribution is narrowed by being produced using a metallocene catalyst. Therefore, there are very few intermediate components between the two, and both can be accurately separated by TREF.
Specifically, in the present invention, the measurement is performed as follows. A sample is dissolved in o-dichlorobenzene (containing 0.5 mg / ml BHT) at 140 ° C. to obtain a solution. This is introduced into a 140 ° C. TREF column, cooled to 100 ° C. at a rate of 8 ° C./min, subsequently cooled to −15 ° C. at a rate of 4 ° C./min, and held for 60 minutes. Thereafter, a component of −15 ° C. o-dichlorobenzene (containing 0.5 mg / ml BHT), which is a solvent, flows through the column at a flow rate of 1 ml / min, and is dissolved in o-dichlorobenzene at −15 ° C. in the TREF column. Is eluted for 10 minutes, and then the column is linearly heated to 140 ° C. at a heating rate of 100 ° C./hour to obtain an elution curve.
In the obtained elution curve, the components (C1) and (C2) show their elution peaks at the respective temperatures T (C1) and T (C2) due to the difference in crystallinity, and the difference is sufficiently large. Separation is possible at T (C3) (= {T (C1) + T (C2)} / 2).
Here, if the integrated amount of the components eluted up to T (C3) is defined as W (C2) wt%, and the integrated amount of the component eluted at T (C3) or higher is defined as W (C1) wt%, W (C2) Corresponds to the amount of the component (C2), and the integrated amount W (C1) of the component eluted at T (C3) or higher corresponds to the amount of the component (C1) having relatively high crystallinity.
The equipment and specifications used for the measurement are shown below.
(TREF part)
TREF column: 4.3 mmφ × 150 mm stainless steel column Column filler: 100 μm Surface inactive glass beads Heating method: Aluminum heat block Cooling method: Peltier element (Peltier element is cooled by water)
Temperature distribution: ± 0.5 ° C
Temperature controller: Chino Corporation Digital Program Controller KP1000 (Valve Oven)
Heating method: Air bath oven Measurement temperature: 140 ° C
Temperature distribution: ± 1 ° C
Valve: 6-way valve 4-way valve (sample injection part)
Injection method: Loop injection method Injection amount: Loop size 0.1ml
Inlet heating method: Aluminum heat block Measurement temperature: 140 ° C
(Detection unit)
Detector: Fixed wavelength infrared detector FOXBORO MIRAN 1A
Detection wavelength: 3.42 μm
High-temperature flow cell: Micro flow cell for LC-IR Optical path length 1.5mm Window shape 2φ x 4mm oval Synthetic sapphire window Measurement temperature: 140 ° C
(Pump part)
Liquid feed pump: SSC-3461 pump manufactured by Senshu Kagaku Co. [Measurement conditions]
Solvent: o-dichlorobenzene (containing 0.5 mg / ml BHT)
Sample concentration: 5 mg / ml
Sample injection volume: 0.1 ml
Solvent flow rate: 1 ml / min

(2-1-2) Identification of ethylene content in components (C1) and (C2) The ethylene content E (C1) and E (C2) of each component is a temperature rising column fractionation method using a preparative fractionator. Each component is separated by, and the ethylene content of each component is determined by NMR.
The temperature rising column fractionation method is a measurement method disclosed in, for example, Macromolecules 21 314-319 (1988). Specifically, the following method was used in the present invention.
(2-1-3) Temperature rising column fractionation A cylindrical column having a diameter of 50 mm and a height of 500 mm is filled with a glass bead carrier (80 to 100 mesh) and maintained at 140 ° C. Next, 200 ml of a sample o-dichlorobenzene solution (10 mg / ml) dissolved at 140 ° C. is introduced into the column. Thereafter, the temperature of the column is cooled to 0 ° C. at a rate of temperature decrease of 10 ° C./hour. After holding at 0 ° C. for 1 hour, the column temperature is heated to T (C3) (obtained by TREF measurement) at a heating rate of 10 ° C./hour and held for 1 hour. Note that the temperature control accuracy of the column through a series of operations is ± 1 ° C.
Then, while maintaining the column temperature at T (C3), 800 ml of T (C3) o-dichlorobenzene is allowed to flow at a flow rate of 20 ml / min. Elute and collect.
Next, the column temperature is increased to 140 ° C. at a rate of temperature increase of 10 ° C./min, left at 140 ° C. for 1 hour, and then 800 ml of o-dichlorobenzene as a solvent at 140 ° C. is flowed at a flow rate of 20 ml / min , T (C3) is eluted and recovered.
The polymer-containing solution obtained by fractionation is concentrated to 20 ml using an evaporator and then precipitated in 5 times the amount of methanol. The precipitated polymer is collected by filtration and dried overnight in a vacuum dryer.

(2-1-4) Measurement of ethylene content by ¹³ C-NMR The ethylene content of each of the components (C1) and (C2) obtained by the above fractionation was measured according to the following conditions by the proton complete decoupling method. , By analyzing the ¹³ C-NMR spectrum.
Model: GSX-400 manufactured by JEOL Ltd. or equivalent device (carbon nuclear resonance frequency of 100 MHz or more)
Solvent: o-dichlorobenzene / heavy benzene = 4/1 (volume ratio)
Concentration: 100 mg / ml
Temperature: 130 ° C
Pulse angle: 90 °
Pulse interval: 15 seconds Integration count: 5,000 times or more The attribution of the spectrum may be performed with reference to, for example, Macromolecules 17 1950 (1984). The spectral attributions measured under the above conditions are shown in Table 1. Symbols such as Sαα in the table follow the notation of Carman et al. (Macromolecules 10 536 (1977)), P represents a methyl carbon, S represents a methylene carbon, and T represents a methine carbon.

Hereinafter, when “P” is a propylene unit in a copolymer chain and “E” is an ethylene unit, six types of triads of PPP, PPE, EPE, PEP, PEE, and EEE may exist in the chain. As described in Macromolecules 15 1150 (1982) and the like, the concentration of these triads and the peak intensity of the spectrum are linked by the following relational expressions (1) to (6).
[PPP] = k × I (Tββ) (1)
[PPE] = k × I (Tβδ) (2)
[EPE] = k × I (Tδδ) (3)
[PEP] = k × I (Sββ) (4)
[PEE] = k × I (Sβδ) (5)
[EEE] = k × {I (Sδδ) / 2 + I (Sγδ) / 4} (6)
Here, [] indicates the fraction of triads, for example, [PPP] is the fraction of PPP triads in all triads.
Therefore, [PPP] + [PPE] + [EPE] + [PEP] + [PEE] + [EEE] = 1 (7)
It is. Further, k is a constant, I indicates the spectral intensity, and for example, I (Tββ) means the intensity of the 28.7 ppm peak attributed to Tββ.
By using the relational expressions (1) to (7) above, the fraction of each triad is obtained, and the ethylene content is obtained from the following expression.
Ethylene content (mol%) = ([PEP] + [PEE] + [EEE]) × 100
Note that the propylene-ethylene random copolymer of the present invention contains a small amount of propylene heterogeneous bonds (2,1-bonds and / or 1,3-bonds), thereby producing the minute peaks shown in Table 2. .

In order to obtain an accurate ethylene content, it is necessary to include these peaks derived from heterogeneous bonds in the calculation, but it is difficult to completely separate and identify the peaks derived from heterogeneous bonds, and the amount of heterogeneous bonds is small. Therefore, the ethylene content of the present invention is obtained by using the relational expressions (1) to (7) as in the analysis of the copolymer produced with a Ziegler-Natta catalyst that does not substantially contain a heterogeneous bond. I will do it.
Conversion from mol% to wt% of ethylene content is performed using the following formula.
Ethylene content (% by weight) = (28 × X / 100) / {28 × X / 100 + 42 × (1−X / 100)} × 100
Here, X is the ethylene content in mol%.

(C-ii) Melt flow rate of propylene-based resin component (C) MFR (C)
The MFR of the propylene-based resin component (C) needs to be in the range of 4 to 10 g / 10 minutes.
Melt flow rate MFR (C) of the entire propylene-based resin component (C) is determined by the MFR of each component (C1) and (C2) (referred to as MFR (C1) and MFR (C2), respectively) and the ratio. However, in the present invention, if the overall MFR is in the range of 4 to 10, each MFR is arbitrary as long as the object of the present invention is not impaired. However, when the MFRs of the two are greatly different, poor appearance or the like may occur. Therefore, it is desirable that both MFR (C1) and MFR (C2) of each component are in the range of 4 to 10 g / 10 minutes.
If the MFR is low, not only will the motor load and tip pressure increase, but the surface on the III layer side of the film will become rough, resulting in a problem of deterioration in appearance, so the MFR needs to be 4 g / 10 min or more. Preferably, it is 5 g / 10 min or more. On the other hand, if the MFR is too high, the molding tends to be unstable, and it is difficult to obtain a uniform film. Therefore, the MFR needs to be 10 g / 10 min or less, and preferably 8 g / 10 min. It is as follows. In addition, the melt flow rate (MFR) of each resin in the present invention is in accordance with JIS K7210 A method condition M. Test temperature: 230 ° C. Nominal load: 2.16 kg Die shape: Diameter 2.095 mm Length 8.00 mm It is measured.

(C-iii) Specification of glass transition temperature by solid viscoelasticity measurement In the propylene resin component (C), in a temperature-loss tangent (tan δ) curve obtained by solid viscoelasticity measurement (DMA), -60 to 20 ° C. It is necessary that the peak of the tan δ curve representing the glass transition observed in the range of 0 shows a single peak at 0 ° C. or lower.
When the propylene-based resin component (C) has a phase separation structure, the glass transition temperature of the amorphous part contained in the component (C1) is different from the glass transition temperature of the amorphous part contained in the component (C2). , There will be multiple peaks. In this case, there arises a problem that the transparency is remarkably deteriorated. Usually, the glass transition temperature in the propylene-ethylene random copolymer is observed in the range of −60 to 20 ° C., and whether or not the phase separation structure is taken can be determined in the tan δ curve in the solid viscoelasticity measurement in this range, Avoidance of the phase separation structure that affects the transparency of the molded product is brought about by having a single peak below 0 ° C. A specific method of solid viscoelasticity measurement (DMA) is described in Examples.

(3) Method for Producing Propylene Resin Component (C) As a method for producing the propylene resin component (C) used in the present invention, the methods described in JP 2005-248156 A and JP 4156491 A can be used. preferable.
As the metallocene catalyst, those disclosed in JP-A-2005-248156 can be used. Representative metallocene compounds include bis (cyclopentadienyl) zirconium dichloride, bis (indenyl) zirconium dichloride, bis (azurenyl) zirconium dichloride, bis (4,5,6,7-tetrahydroindenyl) zirconium dichloride, ( Cyclopentadienyl) (3,4-dimethylcyclopentadienyl) zirconium dichloride, methylenebis (cyclopentadienyl) zirconium dichloride, methylene (cyclopentadienyl) (3,4-dimethylcyclopentadienyl) zirconium dichloride, Isopropylidene (cyclopentadienyl) (3,4-dimethylcyclopentadienyl) zirconium dichloride, methylenebis (indenyl) zirconium dichloride, ethylene 1,2-bis (4-phenyl) Nylindenyl) zirconium dichloride, dimethylsilylene (cyclopentadienyl) (tetramethylcyclopentadienyl) zirconium dichloride, dimethylsilylenebis (indenyl) zirconium dichloride, dimethylsilylene (cyclopentadienyl) (fluorenyl) zirconium dichloride, methylphenylsilylene Bis {1- (2-methyl-4,5-benzoindenyl)} zirconium dichloride, dimethylsilylenebis {1- (2-methyl-4H-azurenyl)} zirconium dichloride, dimethylsilylenebis [1- {2-methyl -4- (4-chlorophenyl) -4H-azurenyl}] zirconium dichloride, dimethylsilylenebis {1- (2-ethyl-4-naphthyl-4H-azurenyl)} zirconium dichloride. De, dimethyl gel Mi Len bis (indenyl) zirconium dichloride, dimethyl gel Mi (cyclopentadienyl) (fluorenyl) such as zirconium dichloride can be exemplified. The metallocene catalyst is not limited to the above.

(4) Component (D)
Next, the ethylene-α-olefin copolymer component (D) contained in the propylene-based resin composition (X) will be described.
The ethylene-α-olefin copolymer component (D) has the following conditions (Di) to (D-iii).
(Di) Density is 0.870-0.890 g / cm ³
(D-ii) Melting peak temperature is 80 ° C. or less (D-iii) Melt flow rate (190 ° C. 2.16 kg) is 2.0 to 5.0 g / 10 minutes And, in the present invention, this ethylene-α-olefin By containing the copolymer component (D), good impact resistance and heat seal characteristics are imparted to the sheet formed using the resin composition.

Component (D) has the effect of improving the impact strength of the composition at low temperatures. The propylene-based resin composition for medical containers according to the present invention may be refrigerated during storage or transportation of the product, or may be placed at a low temperature such as in winter, so that the impact resistance at a low temperature does not occur at this time. is necessary. At this time, if the amount of the component (D) is too small, there arises a problem that the heat seal characteristics are not sufficient and the impact resistance is insufficient.
Moreover, the medical container using propylene-type resin composition (X) is formed by heat-sealing a sheet | seat. Heat sealing is a process in which resin is fused by applying heat and pressure and then cooled and solidified. At this time, the peel strength varies depending on the thickness and shape of the sheet, the seal temperature, the pressure, the time, etc., but in order to control the peel strength, it is important to set a small change in strength with respect to the heat seal temperature. . That is, in the actual heat sealing process, the peel strength is controlled by the temperature of the heating part, but the actual temperature has fluctuations due to disturbances such as errors and ambient temperature, and the change in strength with respect to the heat sealing temperature is abrupt. If it is, peeling strength will change a lot by fluctuation of temperature, and it will be difficult to obtain stable peeling strength. The first heat seal characteristic preferably has a strength range of about 1 to 10 N / 10 mm, which is a weak seal strength that can be peeled relatively easily when the container is squeezed by hand, and more preferably 2 It is to exhibit a weak seal characteristic that can be managed with a set strength of ± 1 N / 10 mm in a strength range of about ˜6 N / 10 mm, and it is important that the influence of the seal strength on the heat seal temperature fluctuation is small.

Component (D) (hereinafter also referred to as “ethylene-α-olefin copolymer component (D)”) is poorly compatible with propylene-based resin components (C) and (E) and takes a phase separation structure to melt. There is a big difference in temperature. Component (D) appears to form domains in propylene-based resin components (C) and (D). Therefore, if the heat sealing temperature is such that the propylene resin components (C) and (E) are not melted and heat-sealed, but the component (D) is at a melting temperature, a small proportion of the components in the entire composition (D) Only the portion where the surface is present is fused, and the weak seal characteristic is controlled by adjusting this amount and the melting temperature in order to show a low fusion strength compared to the whole fusion. It is considered possible.
In addition, when the refractive index of the ethylene-α-olefin copolymer component (D) is significantly different from that of the component (C), the transparency of the composition is deteriorated, so it is also important to match the refractive indexes. These melting temperature and refractive index can be controlled by the density, and it is necessary to set the density within a specific range in order to achieve both heat seal characteristics and transparency.

(5) Each characteristic (Di) density of component (D) For the above reasons, the ethylene-α-olefin copolymer component (D) used in the present invention has a density of 0.870 to 0.890 g / It must be in the range of cm ³ .
If the density is too low, the difference in refractive index is increased and the transparency is deteriorated. When the density is less than 0.870, the transparency required for the present invention cannot be ensured and is 0.870 or more. Is necessary, and preferably 0.875 or more.
On the other hand, if the density becomes too high, the crystallinity becomes high, so that the flexibility, impact resistance and transparency are likely to deteriorate, and the difference between the melting temperature of component (C) and the melting temperature of component (D). When there is no more, it becomes difficult to control the heat seal characteristics, so it is necessary to be 0.890 or less, preferably 0.885 or less.

(D-ii) Melting temperature T (D)
As described above, in order to control the seal strength in a relatively weak heat seal strength region of about 1 to 10 N / 10 mm, it is important to separate the melting temperatures of the component (C) and the component (D). The melting peak temperature T (D) of component (D) needs to be 80 ° C. or lower. If T (D) is 80 ° C or less, the seal strength can be set within the range of ± 1N / 10mm in the strength region of 1-10N / 10mm, and if T (D) exceeds 80 ° C The heat seal temperature range is narrow, and stable heat seal strength cannot be obtained.

(D-iii) Melt flow rate (JIS K7210 A method condition D, 190 ° C. 2.16 kg)
The resin composition of the present invention needs to have an appropriate fluidity in order to ensure moldability. If the viscosity of the component (D) is too high, the fluidity is insufficient, resulting in poor dispersion. By doing so, transparency and impact resistance are likely to be reduced, and problems such as variations in heat seal characteristics are likely to occur. Therefore, the ethylene-α-olefin copolymer component (D) in the present invention needs to have a melt flow rate of 2.0 g / 10 min or more, preferably 2.5 or more. On the other hand, if the melt flow rate is too high, the stability during molding is lowered, and it becomes easy to cause problems such as uneven film thickness and reduced impact resistance. Since it melts at a lower temperature than component (C), if the viscosity is too low, it tends to bleed to the surface due to the heat seal pressure and the heat seal controllability deteriorates, so the melt flow rate is 5.0 g / 10 min or less. And preferably 4.5 g / 10 min or less.

(6) Proportion of component (D) in propylene-based resin composition (X) The proportion of component (D) in propylene-based resin composition (X) needs to be in the range of 25 to 35% by weight. It is. That is, since the component (D) exists as a domain in the component (C) and has a lower melting temperature than the component (C), only the component (D) melts in a low temperature range, so that the heat seal strength is increased. The low area is controlled. At this time, if the amount of the component (D) is too small, the amount of the component (D) on the film surface is decreased, and the strength at the time of weak sealing becomes too low to perform sufficient control, There is a problem that the impact resistance is insufficient and the product is broken during transportation. On the other hand, if the amount is too large, the component (D) is present on the surface in a large amount, which may cause blocking fusion during heat sterilization. The proportion of the component (D) in the present invention in the composition needs to be in the range of 25 to 35% by weight, and if it is less than 25% by weight, the weak sealing property is insufficient and the flexibility The impact resistance becomes insufficient, and when it exceeds 35% by weight, the heat resistance is insufficient, so that it cannot be used.

(7) Manufacturing method of ethylene-α-olefin copolymer component (D) The ethylene-α-olefin copolymer component (D) of the present invention is used for reducing the difference in refractive index from the component (C). It is necessary to lower the density, and it is desirable that the crystallinity and molecular weight distribution are narrow in order to suppress stickiness and bleed out. Therefore, it is desirable to use a metallocene catalyst capable of narrowing crystallinity and molecular weight distribution for the production of component (D).
(7-1) Metallocene Catalyst As the metallocene catalyst, various known catalysts used for the polymerization of ethylene-α-olefin copolymers can be used. Specific examples include metallocene catalysts described in JP-A-58-19309, JP-A-59-95292, JP-A-60-35006, and JP-A-3-16388. .
(7-2) Polymerization method Specific polymerization methods include a slurry method, a gas phase fluidized bed method and a solution method in the presence of these catalysts, or a pressure of 200 kg / cm ² or more, and a polymerization temperature of 100 ° C. or more. And high pressure bulk polymerization method. A preferable production method includes high-pressure bulk polymerization. The ethylene-α-olefin copolymer component (B) can be appropriately selected from those commercially available as metallocene polyethylene. Examples of commercially available products include DuPont Dow Affinity (registered trademark) and Engage (registered trademark), Nippon Polyethylene Corporation Kernel (registered trademark), Exxon Corporation EXACT (registered trademark), and the like.
In these uses, the density, melting peak temperature, and MFR grade, which are requirements of the present invention, may be selected.
Further, the ethylene-α-olefin copolymer may be a copolymer composed of one kind of α-olefin other than ethylene and ethylene as long as the conditions (Di) to (D-iii) are satisfied. And a copolymer comprising two or more α-olefins other than ethylene.

(8) Component (E)
Next, the propylene resin component (E) that is a propylene-ethylene block copolymer contained in the propylene resin composition for medical containers of the present invention will be described.
This propylene-based resin component (E) has conditions (E-i) to (E-iii).
(E-i) 65 to 75% by weight of a polypropylene component (E1) having a melt flow rate of 230 ° C. and 2.16 kg) in the first step in the range of 100 to 200 g / 10 min, and an ethylene content of 4 in the second step. Propylene-ethylene block copolymer (E-) obtained by sequential polymerization of 35 to 25% by weight of a propylene-ethylene random copolymer component (E2) having a weight average molecular weight of 800,000 to 3 million. ii) The molecular weight distribution (Mw / Mn), which is the ratio of the weight average molecular weight (Mw) and the number average molecular weight (Mn) determined by gel permeation chromatography measurement, is 9.0 to 15.0.
(E-iii) Melt flow rate (230 ° C., 2.16 kg) of the entire propylene-based resin component (E) is 2.0 to 8.0 g / 10 minutes.

And in this invention, the favorable heat seal characteristic is provided to the sheet | seat formed using the resin composition by containing the propylene-type resin component (E) which is a 2nd propylene-ethylene block copolymer. Yes.
It is desirable that the propylene-based resin composition for medical containers has multi-stage stable peel strength controllability. In the resin composition of the present invention, by containing the above-mentioned component (D), the sealing temperature in the weak seal strength region that is relatively easily peelable, such as about 1 to 10 N / 10 mm, preferably about 2 to 6 N / 10 mm. In contrast, it is possible to exhibit a stable weak seal characteristic. However, it can be easily peeled off, but in addition to the weak seal region of 1 to 10 N / 10 mm, the second heat seal property is higher, about 2 to 25 N / 10 mm, preferably 4 to 20 N, more preferably 6 to It is desirable to control the seal strength in a 15N peel strength region. Further, in order to obtain a product having a stable peel strength, it is necessary to make the change in strength in this region as small as possible with respect to the heat seal temperature as in the case of 1 to 10 N / 10 mm. At this time, in order to manage the strength at a set strength of ± 2 N / 10 mm in an intensity range of 2 to 25 N / 10 mm, it is necessary to improve the propylene resin component itself, and the propylene resin component (E) controls this. It is an ingredient for.
That is, the propylene-based resin component (C) used as the main component of the propylene-based resin component (X) is manufactured with a metallocene-based catalyst, thereby achieving both high flexibility and transparency. Since the crystallinity distribution of the crystalline component is narrow and melts at a specific temperature at a time, the rise in heat seal strength with respect to temperature is rapid. If the distribution of crystallinity is expanded, the higher the crystallinity, the higher the melting temperature, so the heat-sealing strength against temperature will be gentle, but the effect will be sufficient if the melted components easily flow due to the pressure during heat-sealing. Not. At this time, since the propylene-based resin component (C) produced by the metallocene-based catalyst has a narrow molecular weight distribution and does not have a high-molecular weight component, the propylene-based resin component (E) is easily flown by the pressure during heat sealing. By containing, the crystallinity distribution is given, and at the same time, the molecular weight is also given a distribution, whereby the change in heat seal strength with respect to the temperature on the high strength side can be made gentle.

(9) Each characteristic (E-i) basic rule of component (E) The propylene-based resin component (E) has a melt flow rate (JIS K7210 A method condition M, 230 ° C., 2.16 kg) of 100 in the first step. Propylene-ethylene random copolymer having 65 to 75% by weight of polypropylene component (E1) in the range of ˜200 g / 10 min, ethylene content of 4 to 8% by weight and weight average molecular weight of 80 to 3 million in the second step It is obtained by successively polymerizing 35 to 25% by weight of component (E2).

(E-i-1) Component (E1) The component (E1) is a polypropylene component and is a component having high crystallinity. This component has a higher melting temperature than component (C) in the composition, and is a component for smoothening the change in heat seal strength with respect to temperature by suppressing fusion at the temperature at which component (C) melts. . Therefore, the component (E1) needs to have higher crystallinity than the component (C), and is preferably a polypropylene component composed only of propylene.
(E-i-2) Melt flow rate of component (E1) (JIS K7210 Method A, Condition M, 230 ° C., 2.16 kg)
As will be described later, the component (E2) needs to have a high molecular weight. However, if the molecular weight of the entire component (E) is high, the fluidity is poor and the component (E2) cannot be sufficiently dispersed in the composition. Not only is it insufficient, it also causes flow irregularities and poor appearance called gels and fish eyes, so it is necessary to ensure the fluidity of the entire component (E) by increasing the fluidity of the component (E1). It is. Therefore, the melt flow rate of the component (E1) needs to be at least 100 g / 10 min. On the other hand, even if the melt flow rate is too high, uneven flow tends to occur, impact resistance and flexibility Therefore, the melt flow rate of the component (E1) in the present invention needs to be in the range of 100 to 200 g / 10 minutes.

(Ei-3) Component (E2) Component (E2) is a component for suppressing a rapid increase in heat seal strength by lowering the fluidity when the crystal component of component (C) is melted. . In order to suppress an increase in heat seal strength by lowering the fluidity, it is necessary that the component (E2) is also melted when the component (C) is melted. Therefore, the component (E2), unlike the component (E1), needs to lower the crystallinity, and the crystallinity is controlled by the ethylene content, so the ethylene content should be 4 to 8% by weight. is necessary.
(E-i-4) Weight average molecular weight Component (E2) suppresses rapid increase in heat seal strength by inhibiting component (C) from melting and flowing due to heat seal pressure during heat sealing. is necessary. At this time, if the molecular weight of the component (E2) is low, the effect of inhibiting the flow is insufficient, and the heat seal characteristics cannot be sufficiently improved. Therefore, the component (E2) needs to have a weight average molecular weight (Mw) determined by gel permeation chromatography (GPC) of 800,000 or more. Further, if the molecular weight becomes too high, the dispersibility deteriorates, so it is necessary to be less than 3 million.
(E-i-4) Ratio W (E2) of component (E2) in component (E)
Since the component (E2) has an extremely high molecular weight, if the proportion W (E2) in the component (E) is too large, the component (E) cannot be sufficiently dispersed in the composition, and heat sealing characteristics In addition to not being able to improve the above, it may cause problems such as deterioration of physical properties and poor appearance, so it is necessary to be 35% by weight or less. On the other hand, if the amount of the component (E2) is too small, a large amount of the component (E) is required in the composition in order to exhibit sufficient heat sealing properties, and the flexibility is lowered, and the transparency is also lowered. It is necessary to be 25% by weight or more because there is a risk of incurring.

(9-1) Proportion of component (E) in propylene-based resin composition (X) The proportion of component (E) in propylene-based resin composition (X) is in the range of 10 to 20% by weight. is necessary. In the present invention, the component (E) is a component for improving the heat seal characteristics on the high-strength side, and in order to impart a crystalline distribution to the component (C) and control the melting behavior of the crystal, Including the component (E1) and the component (C2) having a high molecular weight component (E2) in order to suppress the flow due to the pressure at the time of heat sealing, the rapid increase in heat seal strength against temperature is suppressed. ing. When the amount of the component (E) is too small, the high crystalline component and the high molecular weight component are insufficient, and a sufficient effect of improving the heat seal characteristics cannot be obtained. Furthermore, the effect of improving sheet formability due to insufficient melt tension cannot be exhibited. On the other hand, when the amount of the component (E) is too large, physical properties such as flexibility and transparency are significantly deteriorated, and the quality required for the resin composition of the present invention cannot be satisfied.
When the ratio of the component (E) in the composition in the present invention is less than 10% by weight, sufficient heat seal characteristics cannot be imparted, so that it is necessary to be 10% by weight or more, preferably It is 12 wt% or more. On the other hand, if it exceeds 20% by weight, the physical properties deteriorate, so it is necessary to be 20% by weight or less, preferably less than 18% by weight.

(E-ii) About the molecular weight distribution (Mw / Mn) which is the ratio of the weight average molecular weight (Mw) and the number average molecular weight (Mn) determined by gel permeation chromatography measurement (GPC) of the component (E1) Since the component (E) used in the composition is composed of a component (E1) and a component (E2) having greatly different molecular weights, the weight average molecular weight (Mw) and the number average molecular weight (Mn) determined by gel permeation chromatography (GPC) The molecular weight distribution (Mw / Mn), which is the ratio of, is required to be 9.0 or more. When the molecular weight distribution is less than 9.0, the effect of improving the heat seal characteristics is not sufficient, and when it exceeds 15.0, the dispersibility deteriorates.
Moreover, in this invention, molecular weight distribution (Mw / Mn), a weight average molecular weight (Mw), and a number average molecular weight (Mn) say what was measured by the gel permeation chromatography (GPC) method.
Conversion from the retention capacity to the molecular weight in the GPC measurement is performed using a standard curve prepared in advance by standard polystyrene.
Standard polystyrenes used are the following brands manufactured by Tosoh Corporation. F380, F288, F128, F80, F40, F20, F10, F4, F1, A5000, A2500, A1000
A calibration curve is prepared by injecting 0.2 ml of a solution dissolved in o-dichlorobenzene (containing 0.5 mg / ml BHT) so that each is 0.5 mg / ml.
The calibration curve uses a cubic equation obtained by approximation by the least square method. The following numerical value is used for [η] = K × Mα in the viscosity formula used for conversion to molecular weight.
PS: K = 1.38 × 10 −4 α = 0.7
PE: K = 3.92 × 10 −4 α = 0.733
PP: K = 1.03 × 10 −4 α = 0.78
The measurement conditions for GPC are as follows.
Apparatus: GPC (ALC / GPC 150C) manufactured by WATERS
Detector: MIRAN 1A IR detector manufactured by FOXBORO (measurement wavelength: 3.42 μm)
Column: AD806M / S (3 pieces) manufactured by Showa Denko KK
Mobile phase solvent: o-dichlorobenzene Measurement temperature: 140 ° C
Flow rate: 1.0 ml / min
Injection volume: 0.2ml
Sample Preparation Prepare a 1 mg / ml solution using o-dichlorobenzene (containing 0.5 mg / ml BHT) and dissolve it at 140 ° C. for about 1 hour.

(E-iii) Melt flow rate of component (E1) (JIS K7210 A method, condition M, 230 ° C., 2.16 load) Component (E) used in the present invention includes component (E2) having a high molecular weight. Nevertheless, sufficient dispersion is required in the composition. For that purpose, it is necessary that the component (E) has an appropriate fluidity, and the melt flow rate, which is a measure of fluidity, needs to be in the range of 2.0 to 8.0 g / 10 minutes. . When the melt flow rate is less than 2.0, the dispersion deteriorates, causing not only flow irregularities, gels and fish eyes, but also poor appearance, and heat seal characteristics are difficult to stabilize, and sufficient effects can be obtained. Absent. On the other hand, in the case of 8.0 or more, problems such as physical properties such as impact resistance and a decrease in flexibility occur, and it becomes difficult to obtain the effect of improving the heat seal characteristics.

(10) Production method The component (E) is composed of a component (E1) having a low molecular weight and a component (E2) having a very high molecular weight, but these components are extremely different in fluidity, so that both are mixed by melt-kneading. Is virtually impossible. On the other hand, it is not preferable from the viewpoint of cost and environment to blend in a solvent. Therefore, the component (E) used in the present invention needs to be polymerized and dispersed by sequentially polymerizing the component (E1) in the first step and the component (E2) in the second step.
As the catalyst system for obtaining the component (E), a catalyst mainly composed of a titanium-containing solid catalyst component and an organoaluminum compound, or a metallocene transition metal compound having at least one π-electron conjugated ligand is used. Can do. Here, since the component (E2) has a higher effect of improving the heat seal properties as the higher molecular weight component is contained, it is preferably produced from a component mainly composed of a titanium-containing solid catalyst component and an organoaluminum compound.

The titanium-containing solid catalyst component is selected from a known supported catalyst component obtained by contacting a solid magnesium compound, titanium tetrahalide and an electron donating compound, and a known catalyst component containing titanium trichloride as a main component. The aluminum compound of the promoter is represented by the general formula AlR ⁿ X ^3-n (wherein R represents a hydrocarbon group having 2 to 10 carbon atoms, and n represents a number of 3 ≧ n> 1.5). . When the titanium-containing solid catalyst component is a carrier-supported catalyst component containing a solid magnesium compound, it is preferable to use AlR ³ or a mixture of AlR ³ and AlR ² X, while titanium trichloride or titanium trichloride is the main component. When the catalyst component is included as a component, AlR ² X is preferably used. Furthermore, in the present invention, a known electron donating compound can be used as the third component in addition to the catalyst and cocatalyst components. The polymerization reaction for obtaining the component (E) can be carried out in the presence of an inert solvent such as hexane or heptane, in the absence, that is, in the presence of liquid propylene or even in gas phase propylene. The reaction can be carried out batchwise using one polymerization tank, or can be carried out continuously by connecting two or more polymerization tanks in series.

The order of the polymerization may be performed in two stages in which the component (E1) is first polymerized and then the component (E2) is polymerized, and additionally, the polymerization may be performed in three stages and four stages.
The catalyst is generally added prior to polymerization in the first stage. Replenishment of the catalyst in the subsequent stage is not necessarily excluded, but it is preferable to add the catalyst in the first stage in order to obtain characteristics that cannot be obtained by resin blending.
In the step (1) for obtaining the component (E1), propylene is polymerized in the presence of hydrogen. Hydrogen is controlled so that the MFR of the polymer obtained in step (1) is in the range of 100 to 200. In general, the hydrogen concentration (in the case of slurry polymerization, the concentration in the gas phase portion, in the polymerization in liquid propylene or in the gas phase method indicates the content in the monomer) is added in an amount of 1 to 50 mol%, preferably 3 to 30 mol%.
The polymerization temperature in step (1) is generally 40 to 90 ° C., and 65 to 75% by weight of the total polymerization amount is produced.
The step (2) for obtaining the component (E2) is a polymerization for obtaining a high molecular weight component, and the polymerization proceeds in a substantially hydrogen-free state with a hydrogen concentration of 0.1 mol% or less. The weight average molecular weight of the polymer obtained in the step (2) is 800,000 to 3,000,000.
The polymerization temperature is usually 40 to 90 ° C., preferably 50 to 80 ° C., and the monomer concentration is controlled so that ethylene is included as a comonomer and the comonomer content is in the range of 4 to 8% by weight.

(11) Propylene resin composition (X)
The propylene-based resin composition (X) used in the present invention may contain an additional component (additive). As the additive, an antioxidant, a neutralizing agent and the like are used.
Antioxidant is an additive for suppressing thermal stability during molding processing of the resin composition and thermal deterioration of the molded body, and it is necessary to use an additive that has little influence on the contents. Preference is given to tetrakis [methylene-3- (3 ′, 5′-di-t-butyl-4′-hydroxyphenyl) propionate] methane, octadecyl-3- (3,5-di-) as phenolic antioxidants. It is preferable to avoid t-butyl-4-hydroxyphenyl) propionate, tris (2,4-di-t-butylphenyl) phosphite as a phosphorus-based antioxidant, and those that are easily hydrolyzed.
The addition amount is preferably the minimum necessary for ensuring the stability of the resin composition, and is preferably suppressed to 2000 ppm or less. As the neutralizing agent, calcium stearate can be used, but it may cause insoluble fine particles to be generated even after high-pressure steam sterilization depending on the contents, and therefore the addition amount is desirably 200 ppm or less.

3. Laminate The laminate used in the present invention is formed by laminating at least a first layer, a second layer, and a third layer in this order.
The method of forming the laminate used in the present invention is not particularly limited as long as the layers are arranged in the order of the first layer, the second layer, and the third layer. For example, a T-die molding method, an air-cooled inflation molding method, a water-cooling method, and the like. Examples include an inflation molding method and a blow molding method. Among these forming methods, the water-cooled inflation molding method is preferable.
In the case of the water-cooled inflation molding method, the laminate is processed into a bag shape, and it is preferable that the first layer is the inner and outer sides and the third layer is the inner and outer sides.
Further, when the ethylene-based resin layer II and the propylene-based resin layer III are directly laminated, it is preferable that some of the components constituting each layer are manufactured with a metallocene catalyst. It is known that relatively strong interlayer strength is obtained by directly laminating polyethylene produced with a metallocene catalyst and polypropylene made with a metallocene catalyst (see Non-Patent Document 1).
In addition to the ethylene resin layers I and II and the propylene resin layer III, the laminate used in the present invention may be appropriately provided with various layers generally used in such a laminate as necessary. it can. Specifically, an adhesive layer or a gas barrier layer such as saponified ethylene / vinyl acetate copolymer (EVOH) or nylon can be provided between the various layers.
Further, the propylene resin layer III may be laminated on both sides of the ethylene resin layers I and II. In this case, ethylene having a density of 0.88 to 0.930 g / cm ³ is formed on one propylene resin layer. A method of blending 5 to 40% by weight of α-olefin copolymer is also used as a preferable means. In this way, when making a bag, when sealing with a seal bar from a propylene-based resin layer that does not contain ethylene / α-olefin, the seal bar contact surface is taken up by the bar because it can be sealed at a lower temperature. Therefore, it is possible to seal, and work efficiency is improved. A similar effect can be obtained by providing a difference in melting point between the propylene-based resin layers.

  The total thickness of the laminate used in the present invention is preferably 100 to 700 μm from the viewpoint that a film having excellent transparency can be stably formed. Furthermore, the laminate used in the present invention can be subjected to surface treatment such as corona discharge treatment or flame treatment by a method usually used industrially.

  From the viewpoint of maintaining a balance between heat resistance and transparency, the thickness ratio of the ethylene-based resin layer I in the laminate used in the present invention is preferably 10 to 40%, and preferably 20 to 35% with respect to the thickness of the entire laminate. More preferred. Moreover, 30-80% is preferable with respect to the thickness of the whole laminated body, and 30-50% is more preferable with respect to the thickness ratio of the ethylene-based resin layer II from the viewpoint of maintaining transparency and imparting flexibility. Furthermore, the thickness ratio of the propylene-based resin layer III is preferably 10 to 40% and more preferably 20 to 35% with respect to the thickness of the entire laminate from the viewpoint of imparting heat resistance.

  In addition, the total thickness ratio of the ethylene resin layer I and the polypropylene resin layer III in the laminate used in the present invention is preferably 15 to 60%, more preferably 15 to 50% with respect to the thickness of the entire laminate. It is. If the total thickness of the ethylene resin layer I and the propylene resin layer III is less than 15%, the heat resistance is insufficient, and if it exceeds 60%, the flexibility is not preferable.

  The internal haze of the laminate used in the present invention is preferably 32% or less, more preferably 25% or less after autoclaving at 115 ° C. for 30 minutes. If the haze exceeds 32%, the contents are not clearly visible, such as inferior commercial value. In addition, the haze of the film in this invention is measured based on JIS-K7136-2000.

4). Medical Bag The laminate used in the present invention can be used for medical bags and the like. In particular, it can be suitably used for medical bags for 115 ° C. and 121 ° C. autoclave sterilization treatments that require heat resistance. Specific applications of the medical bag include infusion bags, containers for injecting, discharging, and storing body fluids and drug solutions, peritoneal dialysis bags, artificial dialysis bags, and the like.
The method for producing the medical bag is not particularly limited, but the medical bag of the present invention can be obtained by air-cooled inflation molding, water-cooled inflation molding, T-die molding, or the like.

Next, the medical container of this invention is demonstrated using the Example shown on drawing.
FIG. 1 is a front view of an embodiment of the medical bag of the present invention. In addition, the upper side in the figure is described as “upper end” and the lower side is described as “lower end”.
The medical bag 1 of the present invention is a container that communicates with a container body having a drug chamber formed by heat-sealing a sheet formed of the above-described propylene-based resin composition for a medical container, and a lower end portion of the drug chamber. And a discharge port heat sealed to the body. The medical bag 1 of the present invention may be a medical-filled medical bag having a medicine stored in a medicine chamber.
In particular, the medical bag 1 of the illustrated embodiment is a medical multi-chamber container. As a medical bag using the propylene-based resin composition for medical containers of the present invention, it is effective to use a medical multi-chamber container, but it may be a single-chamber medical bag.

The medical bag 1 of this embodiment is made of a flexible material, and is a container main body (soft bag) divided into a first drug chamber 21 and a second drug chamber 22 by a partitioning portion 9 whose internal space can be peeled off. ) 2, the discharge port 3 communicating with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the second drug stored in the second drug chamber 22 With drugs. Furthermore, the medical bag 1 of this embodiment includes a detachable communication inhibiting portion 10 that inhibits communication between the first drug chamber 21 and the discharge port 3.
As shown in FIG. 1, the medical bag 1 includes a soft bag 2, a first medicine, a second medicine, a discharge port 3, and a mixed injection port 4.

In addition, as shown in FIG. 1, the soft bag 2 of the present invention includes a first drug chamber 21, a second drug chamber 22, a partition portion 9, a communication inhibition portion 10, a discharge port attachment portion 27, A mixed injection port mounting portion 28 and a medicine injection portion 29 are provided.
The flexible bag 2 is preferably formed into a cylindrical shape by an inflation molding method. The soft bag 2 may be manufactured by various methods such as a blow molding method. Also, the soft bag 2 has a cylindrical body sealed at the entire outer periphery, only the upper and lower ends are sealed, one sheet is folded in half, and the folded portion (side portion 7 or 8) is not included. It may be a bag-like object such as one sealed on the three sides.
That is, the upper end side seal portion 5 and the lower end side seal portion 6 are provided at the upper end portion and the lower end portion of the soft bag 2. The upper end side seal portion 5 and the lower end side seal portion 6 are wide and strong seal portions. Moreover, the side parts 7 and 8 which are strong seal parts may be provided in the side of the soft bag 2. FIG. Further, as shown in FIG. 1, a discharge port mounting portion 27 for mounting the discharge port 3 and a drug injection for injecting a drug into the first drug chamber 21 are inserted into the lower end side seal portion 6 of the soft bag 2. A portion 29 is provided. The discharge port attaching portion 27 and the drug injecting portion 29 are non-seal portions in which a part of the lower end side seal portion 6 communicates with the inside and the outside of the soft bag 2. And the chemical | medical agent injection | pouring part 29 is sealed by the seal | sticker part 6a after chemical | medical agent injection | pouring. In addition, although it is preferable that the chemical | medical agent injection | pouring part 29 is provided in the lower end side seal part 6, it may be provided in the side parts 7 and 8, and does not need to be provided. The upper end side seal portion 5 is provided with a mixed injection port attaching portion 28 for attaching a mixed injection port. The mixed injection port mounting portion 28 is a non-seal portion in which a part of the upper end side seal portion 5 communicates with the inside and the outside of the soft bag. Note that the mixed injection port attachment portion 28 is not necessarily provided. A similar non-seal part may be provided at the same position as the medicine injection part in the second medicine chamber. In addition, the injection part of the medicine in the second medicine chamber may be provided in the side parts 7 and 8.

As shown in FIG. 1, the soft bag 2 is divided into a first drug chamber 21 and a second drug chamber 22 by a partitioning portion 9. And in the medical bag 1 of this Example, the partition part 9 is formed by the center weak seal part 9a and the side part seal part 9b formed in the both sides part or both sides of the center weak seal part 9a. In the Example of this invention, the partition part 9 is provided so that the whole horizontal direction of the chemical | medical agent chamber of the soft bag 2 may be crossed, as shown in FIG. The central weak seal portion 9a continues between the two side seal portions 9b extending from the side portions (side seal portions) 7 and 8 of the soft bag 2 toward the center of the soft bag 2, respectively. It is provided to connect. The central weak seal portion 9a and the side seal portion 9b are formed by fusing the sheet material of the soft bag 2 so as to be peelable in a strip shape. With such a configuration, only the central weak seal portion 9a is formed near the center of the medicine chamber, and side seal portions 9b are formed on both sides thereof so as to overlap the central weak seal portion 9a. In this embodiment, the side seal portion 9b is wider than the central weak seal portion 9a, and its upper edge is curved toward the upper end side of the flexible bag toward the side portion. . For this reason, when the 2nd chemical | medical agent chamber 22 is compressed, the chemical | medical agent in the chemical | medical agent chamber 22 is comprised so that it may go to the center weak seal | sticker part 9a.
In the medical bag 1 of this embodiment, the side seal portion 9b is wider than the central weak seal portion 9a, but it may be of the same or narrower width.

The partition part 9 of the embodiment peels off when one of the drug chambers is strongly pressed with a finger or the like (for example, when pressed or squeezed), and the first drug chamber 21 and the second drug chamber 22 are peeled off. Can communicate with each other. Further, the central weak seal portion 9a is easier to peel off than the communication inhibition portion 10 when the second drug chamber 22 is compressed.
Further, the side seal portion 9b of the embodiment is more difficult to peel off than the central weak seal portion 9a and the communication inhibition portion 10.
The peeling strength of the partition portion 9 (the weak central seal portion 9a) was not peeled off by the pressure applied to the soft bag 2 in the form of two-fold packaging during transportation, and the soft bag 2 was strongly pressed with fingers (squeezed). It is preferable that it peels occasionally. The partition portion 9 is preferably formed by fusing the soft bag 2. The fusion is preferably thermal fusion, high frequency fusion, ultrasonic fusion or the like. Since the soft bag 2 has the two drug chambers 21 and 22 divided into the partition portions 9 in this way, drugs of different components can be mixed aseptically in the soft bag 2. Moreover, in the Example shown in FIG. 1, although the partition part 9 is provided linearly with respect to the soft bag 2, it is not limited to this. In the embodiment of the present invention, the partition portion 9 is configured by the central weak seal portion 9a and the side seal portion 9b, but is not limited thereto, and is configured by only the central weak seal portion 9a. May be. Moreover, it is preferable that the side part seal part 9b does not peel in a normal usage method. The side seal portion 9b is preferably formed by fusing the soft bag 2 by heat fusion, high frequency fusion, ultrasonic fusion, or the like. The side seal portion 9b may be a strong seal portion that cannot be peeled off.

  Specifically, the seal strength (initial peel strength) of the weak seal portion (central weak seal portion) 9a is preferably 1 to 10 N / 10 mm, and particularly preferably 2 to 6 N / 10 mm. If the seal strength is within this range, the central weak seal part will not be accidentally peeled off during transportation or storage, and the work of peeling the central weak seal part is easy. The seal strength (initial peel strength) of the side seal portion is preferably 3N / 10 mm or more, particularly 4N / 10 mm or more. As the difference in seal strength between the central weak seal portion and the side seal portion (initial peel strength difference), the seal strength of the side seal portion is 3 to 3 from the seal strength (initial peel strength) of the central weak seal portion. It is preferably 30 N / 10 mm, particularly 4 to 25 N / 10 mm larger. In this way, when any one of the drug chambers is pressed, it is possible to prevent the entire weak partitioning part for partitioning from being peeled off at once, and to ensure at least peeling from the central weak sealing part.

In the embodiment of the present invention, the side seal portions 9b are formed on both sides of the central weak seal portion 9a, but the side seal portions 9b may not be formed, and the easily peelable central weak seal is not required. The soft bag 2 may be partitioned only by the part 9a. Further, the portion corresponding to the side seal portion 9b may be a strong seal. Note that the same effect as that of the side weak seal 9b can be obtained by notching a portion corresponding to the side seal 9b and forming the soft bag 2 like a gourd.
When the side seal portion 9b is provided, the length of the central weak seal portion 9a (excluding the side seal portion 9b) is preferably 0.2 to 0.8 with respect to the lateral width of the drug chamber. In particular, it is preferably 0.3 to 0.7. Specifically, the length of the central weak seal portion 9a is preferably 70 to 110 mm, particularly 80 to 100 mm when the width is 190 mm, although it depends on the width of the drug chamber. The width of the central weak seal portion 9a is preferably 8 to 20 mm, particularly 10 to 15 mm. The width of the side seal portion 9b is preferably 6 to 50 mm, particularly 8 to 30 mm.
Moreover, as shown in FIG. 1, it is preferable that the partition part 9 is provided in the position which becomes the upper direction of the communication inhibition part 10 mentioned later, especially the vertical direction. Moreover, it is preferable that the side part seal | sticker part 9b is provided in the both sides of the position which becomes the perpendicular direction upper direction of the communication inhibition part 10, as shown in the figure. By providing the partition portion 9 at such a position, when the partition portion 9 is peeled off, the portion where the communication inhibiting portion 10 of the soft bag 2 is formed swells greatly, so that the communication inhibiting portion 10 is easily peeled off. Become.

Note that the side seal portion 9b may be a seal portion that cannot be substantially peeled off. The part corresponding to the side seal part 9b does not necessarily have to be a peelable seal, and the part may be a strong seal part. In addition, the partition part 9 (central weak seal part 9a) does not need to be formed in strip | belt shape. For example, the partition part 9 (central weak seal part 9a) may be formed in V shape, a semicircle shape, and a semi-elliptical shape. Moreover, the partition part 9 (central weak seal part 9a) may become what peels easily by being produced thinly. Further, in this embodiment, since the discharge port 3 and the weak seal portion 10 for inhibiting communication are provided near the center of the lower portion of the soft bag 2, the central weak seal portion 9 a is correspondingly located near the center of the soft bag 2. Is provided. When the discharge port 3 and the weak seal portion 10 for inhibiting communication are provided at positions close to the side of the soft bag 2, the central weak seal portion 9 a is also near the center in the lateral direction of the soft bag 2. It is preferable to provide it at a position close to the side side.
The volume ratio between the first drug chamber 21 and the second drug chamber 22 divided by the partition 9 is preferably 1: 1 to 1: 5.
The volume of the first drug chamber 21 of the medical bag 1 should be as small as possible. With such a configuration, when the second medicine chamber 22 is compressed (for example, when pressed or squeezed), the weak seal portion 10 for inhibiting communication is easily peeled off with one action.

  The medical bag 1 includes a communication inhibition unit 10. In the medical bag 1 of this embodiment, the communication inhibiting part is formed by a communication inhibiting seal part. And in the medical bag 1 of this Example, the communication inhibition part 10 is formed so that the upper part of the discharge port 3 may be surrounded. A third chamber 23 isolated from the first drug chamber 21 is formed by the communication inhibition unit 10. The third chamber 23 is an empty room. However, the third chamber 23 may contain a predetermined liquid (for example, water for injection or physiological saline). The third chamber 23 may be in a dry state, but may be filled with a small amount of liquid for sterilization. Furthermore, a passage through which a slight amount of moisture such as water vapor passes may be formed in the weak seal portion 10 for inhibiting communication, and may communicate with the first drug chamber 21 at the above level. The weak seal portion 10 for inhibiting communication can be formed by heat sealing (thermal fusion, high frequency fusion, ultrasonic fusion) of the sheet material.

It is preferable that the communication inhibition part 10 is formed at a position below the central weak seal part 9a portion of the partition part 9. By being formed in such a position, when the first drug chamber 21 or the second drug chamber 22 is pressed (for example, when pressed or squeezed), the communication inhibiting unit 10 is peeled off as described above. It becomes easy to do.
In the embodiment shown in FIG. 1, the communication inhibiting portion 10 is formed in an inverted U-shape (in other words, a U-shape) whose legs are open (in other words, a trapezoid whose short side is on the upper side). Further, the communication inhibiting unit 10 may have a triangular shape with the discharge port 3 as a vertex, a triangular shape with the discharge port 3 as a base, a polygonal shape such as a square shape, a substantially semicircular shape, or a substantially semielliptical shape. In addition, when the communication inhibition part 10 has a corner | angular part in an outer periphery, it is preferable that the edge is not formed in a corner | angular part.
The strength for peeling of the communication inhibiting portion 10 is larger than the strength for peeling of the partition weak seal portion (central weak seal portion 9a). Moreover, the weak seal part 10 for communication inhibition is easier to peel off than the side seal part 9b in the embodiment of the present invention.
Moreover, even if the medical bag 1 presses the 1st chemical | medical agent chamber 21, the weak seal part 10 for communication inhibition will peel after peeling of the partition part 9 (central weak seal part 9a). Good. If it is such, the 1st chemical | medical agent chamber 21 of the soft bag 2 can be pressed, and the weak seal part 10 for communication inhibition can be peeled with the force of the fluid at the time of peeling of the partition part 9. FIG.

Further, the weak seal portion 10 for inhibiting communication has the same seal strength as that of the weak seal portion for inhibiting communication, or slightly higher than the seal strength of the partition portion 9 (central weak seal portion 9a). It can be configured by strengthening. The seal strength (initial peel strength) of the weak seal portion for inhibiting communication is 2 to 25 N / 10 mm, preferably 4 to 20 N / 10 mm, and particularly preferably 6 to 15 N / 10 mm.
The seal strength (initial peel strength) of the weak seal portion for inhibiting communication is preferably 2N / 10 mm or more, particularly 4N / 10 mm or more. The difference in seal strength between the central weak seal part and the weak seal part for communication inhibition (initial peel strength difference) cannot be generally described because of the influence of the shape of the container and each seal part. The seal strength of the seal portion is preferably 0.1 to 10 N / 10 mm, particularly 1 to 5 N / 10 mm greater than the seal strength (initial peel strength) of the central weak seal portion.
In this way, when any one of the drug chambers is pressed, the weak seal part for communication inhibition is prevented from being peeled off before the partition part 9, and the peeling from at least the central weak seal part 9a is ensured. It will be a thing.
A specific method for measuring the peel strength can be performed as follows. The measurement value when the medical bag was cut at 10 mm in the width direction of the container at a portion including each measurement target seal part and the seal part of each cut piece was peeled off at a pulling speed of 300 mm / min. Average value.
Further, in the medical bag 1, the ratio of the lateral length of the central weak seal portion 9a to the length (shortest distance) between the upper end of the communication inhibiting weak seal portion 10 and the upper end of the medicine discharge port is 0. It is preferably 2 to 3, more preferably 0.5 to 2. In particular, it is preferably 0.7 to 1.5. Moreover, it is preferable that the width | variety (band width) of the weak seal part 10 for communication inhibition is 2-20 mm, especially 4-12 mm.

As a material for forming such a flexible bag 2, a laminate including the above-described polypropylene resin composition (X) or the like is used. In addition, when forming a soft bag with a multilayered product, it is preferable to use so that the layer which consists of polypropylene resin composition (X) may face each other (in other words, it becomes an inner layer).
The thickness of the sheet material constituting the flexible bag 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. In general, the thickness is preferably about 100 to 700 μm, more preferably about 100 to 550 μm, and still more preferably about 200 to 400 μm. Further, as the soft bag 2, it is preferable to use an extruded film or a blown tube having a tensile elastic modulus of 500 MPa or less, preferably 50 to 300 MPa.
The soft bag 2 was produced by blow molding using the laminate, the one formed by fusing the peripheral portions of two sheets formed by the laminate, and the laminate 2 formed by the laminate. It may be any one formed by folding back one sheet and fusing the remaining three open edges.

  Drugs are stored in the drug rooms 21 and 22 of the soft bag 2. The chemical chambers 21 and 22 are different in that they coexist with each other, such as precipitation due to coexistence, separation of components that may change over time or coloration / decomposition due to temporary heating, etc. It is preferred that the components are contained. As such a drug (infusion solution), for example, it is necessary to mix two or more drugs at the time of infusion, such as peritoneal dialysis solution, transcentral vein infusion, transperipheral vein injection, liquid nutrient, etc. Some are preferable. Examples of the infusion include physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion, glucose solution, water for injection, amino acid electrolyte solution, and the like, but are not limited thereto. For example, a glucose electrolyte solution is stored in one of the drug rooms and an amino acid solution is stored in the other, and water-soluble vitamins such as vitamin B1, vitamin B2, vitamin B6, vitamin C, panthenol, and nicotinamide are stabilized in both chambers. It can be sorted and stored as appropriate in consideration of the properties and the like.

In the medical bag 1, the separation portion 9 and the communication blocking weak seal portion 10 due to the compression of the first drug chamber 21 and the separation portion 9 and the communication inhibition due to the compression of the second drug chamber 22 are pressed. There is a difference in the peeling workability of the weak seal portion 10. The superiority or inferiority in the difference in peeling workability here is a comparison of which one of the drug chambers can be easily peeled off the partition 9 and the weak seal portion 10 for inhibiting communication when both drug chambers are compressed individually. It is a result.
In the medical bag 1 of the present invention, even if the first drug chamber 21 or the second drug chamber 22 is pressed, the partition 9 and the communication blocking unit 10 are peeled in one order in this order. ing. However, in the medical bag 1 of the present invention, as described above, the partitioning part 9 by the compression of the first drug chamber 21 and the separation workability of the communication inhibiting part 10 and the partitioning part 9 by the compression of the second drug chamber 22 are performed. And there is a difference in the peeling workability of the communication inhibiting part 10. This is caused by the ease of deformation of the medicine chamber, the size of the medicine chamber, the amount of medicine filled in the medicine chamber, and the like. And, the superiority or inferiority of workability is determined as to which of the first drug chamber 21 and the second drug chamber 22 is better when the one-action partitioning portion and the communication inhibiting portion are continuously peelable. The standard.

Further, the upper end side seal portion 5 of the soft bag 2 is provided with a hole (hanging portion) 25 for hanging on a hanger or the like.
As shown in FIG. 1, the discharge port 3 is attached to a discharge port attachment portion 27 formed in the lower end side seal portion 6 of the soft bag 2. The discharge port mounting portion 27 is provided at the center of the lower end side seal portion 6. Further, the medical bag 1 includes a mixed injection port 4 for mixing chemical solutions. By doing in this way, components other than the chemical | medical agent put into the medical bag 1 can be mixedly injected before use. The discharge port 3 and the mixed injection port 4 are attached to the soft bag 2 by high frequency fusion, heat fusion, ultrasonic fusion, or the like. As the discharge port 3 and the mixed injection port 4, known ones can be used.

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples. The evaluation methods and resins used in the examples and comparative examples are as follows.
1. Evaluation method of resin physical properties (1) Melt flow rate (MFR): As described above, the MFR of the propylene / α-olefin random copolymer is measured according to JIS K7210 A method condition M, 230 ° C. 21.18 N load. The MFR of the ethylene / α-olefin copolymer and high-density polyethylene was measured in accordance with JIS-K6922-2: 1997 appendix (190 ° C., 21.18 N load).
(2) Tm: As described above, measured by DSC.
(3) Mw / Mn: Measured by GPC as described above.
(4) Mz / Mn: Measured by GPC as described above.
(5) Density: As described above, the density of the ethylene / α-olefin random copolymer is measured according to JIS-K6922-2: 1997 appendix (23 ° C., in the case of low density polyethylene). The density of polyethylene was measured in accordance with JIS-K6922-2: 1997 appendix (23 ° C.).
(6) Glass transition temperature (Tg):
The glass transition temperature (Tg) is determined by solid viscoelasticity measurement (DMA).
The sample used was cut into a strip of 10 mm width × 18 mm length × 2 mm thickness from a 2 mm thick sheet injection molded under the following conditions. The apparatus used was ARES manufactured by Rheometric Scientific. The frequency is 1 Hz. The measurement temperature was raised stepwise from −60 ° C., and the measurement was performed until the sample melted and became impossible to measure. The strain was performed in the range of 0.1 to 0.5%.
[Preparation of specimen]
Standard number: JIS-7152 (ISO294-1)
Molding machine: EC-20 injection molding machine manufactured by Toshiba Machine Molding machine set temperature: 80, 80, 160, 200, 200, 200 ° C from below the hopper
Mold temperature: 40 ℃
Injection speed: 200 mm / sec (speed in the mold cavity)
Holding pressure: 20 MPa
Holding time: 40 seconds Mold shape: Flat plate (thickness 2 mm, width 40 mm, length 80 mm)
The glass transition temperature (Tg) is the same as the temperature showing the peak of the tan δ curve.

2. Molding method of laminate Using a three-layer, three-layer water-cooled inflation molding machine (die diameter: 100 mmφ, die lip: 3 mm, die temperature: 170 ° C.) manufactured by Plako, the thickness of the ethylene-based resin layer I and the propylene-based resin layer III is 50 μm, A tubular laminate having a thickness of 150 μm and a folding diameter of 180 mm of the ethylene-based resin layer II was formed. The ethylene resin layer I was laminated on one side of the ethylene resin layer II, and the propylene resin layer III was laminated on the other side.
In addition, it shape | molded so that a tubular outer side (outer layer) might become the ethylene-type resin layer I, and an inner side (inner layer) might become the propylene-type resin layer III.

3. Laminate Evaluation Method (1) Heat Resistance A cylindrical laminate is cut into a length of 210 mm, one open end cut out is heat-sealed, and a bag having a mouth part where the other open end is opened I made it. Next, 500 ml of distilled water was filled into the mouth portion, and the mouth portion was heat-sealed and sealed. Sealing was performed such that the distance between the heat seal and the heat seal was 180 mm. The sample bag thus obtained is put into a high-temperature and high-pressure cooking sterilization tester (manufactured by Nisaka Manufacturing Co., Ltd., RCS / 40RTGN type), then pressurized, and the ambient temperature is increased to 115 ° C. For 30 minutes.
Then, it cooled to about 40 degreeC and took out this sample bag from the testing machine. Hereinafter, this sterilized “sample bag” is also referred to as “post-sterilized laminate”.
The heat resistance of the laminate was evaluated according to the following criteria.
X: There are many wrinkles. Or, transparency is lowered.
○: Almost no wrinkles. Or not at all.

(2) Internal haze As above-mentioned, it measured based on JIS-K7136-2000. The haze measurement was performed on the molded laminate after sterilization. After the sterilization treatment, the laminate was set in a glass cell containing special liquid paraffin manufactured by Kanto Chemical and measured. When measuring the haze, it was carried out after one week had elapsed after removing the water filled therein.

(3) Tensile modulus (MD)
Based on ISO1184-1983, the tensile elastic modulus of the laminate in the MD direction (film or sheet take-up direction) was measured. It shows that it is excellent in the softness, so that this value is small.
In addition, the tensile elasticity modulus was performed about what drained water from the laminated body after sterilization treatment (use the laminated body after 1 week passes after draining water).

(4) Tear strength Based on JIS K7128-2-1998, the laminate was measured in the MD direction (film or sheet take-off direction).
In addition, the tensile elasticity modulus was performed about what drained water from the laminated body after sterilization treatment (use the laminated body after 1 week passes after draining water).

(5) Bag drop strength After the sterilization treatment, the laminates (2 pieces) were stored at 4 ° C. for 24 hours, and then dropped at a temperature from a height of 2 m onto an iron plate for evaluation. Evaluation was made according to the following criteria.
X: One or two laminates were broken after sterilization.
○: The state did not change from before the drop test, and there was no problem with both.

(6) Adhesiveness of PP port Using a sample bag made of a laminate and a PP port, the Japanese Pharmacopoeia (16th revision) general test The adhesiveness of the PP port was evaluated. Evaluation was made according to the following criteria.
X: Peeling occurs between the laminate and the PP port adhesion portion by the leak test.
○: Peeling does not occur in the laminate and the PP port adhesion part by the leak test.

5. Resin (1) Component (A): Ethylene / α-olefin Copolymer According to Production Example 1 below, (A-1) which is Component (A) in the present invention, and Production Example 2 below, An ethylene / α-olefin copolymer (A-2) different from the component (A) in the present invention was obtained. Table 3 shows the physical properties.
<Production Example 1>
(1-1) A copolymer of ethylene and 1-hexene was produced. The catalyst was prepared by the method described in JP-T-7-508545. That is, to the complex dimethylsilylene bis (4,5,6,7-tetrahydroindenyl) hafnium dimethyl 2.0 mmol, tripentafluorophenyl boron is added in an equimolar amount to the complex, and diluted to 10 liters with toluene. A metallocene catalyst solution was prepared.
(1-2) Polymerization A stirred autoclave-type continuous reactor having an internal volume of 1.5 liters was maintained at a pressure of 130 MPa, and a mixture of ethylene and 1-hexene had a composition of 1-hexene of 39% by weight. The raw material gas was continuously supplied at a rate of 40 kg / hour. The catalyst solution was continuously supplied, and the supply amount was adjusted so that the polymerization temperature was maintained at 164 ° C. The polymer production per hour was about 2.6 kg. After completion of the reaction, an ethylene / 1-hexene copolymer having 1-hexene content = 8 wt%, MFR = 2.2 g / 10 min, density = 0.918 g / cm ³ , and Mz / Mn = 3.5 ( A-1) was obtained.

<Production Example 2>
Catalyst preparation and polymerization were carried out in the same manner as in Production Example 4 except that the composition of 1-hexene at the time of polymerization was changed to 72% by weight and the polymerization temperature was changed to 122 ° C. The polymer production per hour was about 2.1 kg. After completion of the reaction, an ethylene / 1-hexene copolymer having 1-hexene content = 24 wt%, MFR = 2.2 g / 10 min, density = 0.880 g / cm ³ , and Mz / Mn = 3.5 ( A-2) was obtained.

(2) Component (B): High-density polyethylene Novatec HJ562 (MFR: 7 g / 10 min, density: 0.962 g / cm ³ ) manufactured by Nippon Polyethylene Co., Ltd. was used. In Table 3, it was displayed as B-1.
Further, Novatec HM160 (MFR: 5 g / 10 min, density: 0.953 g / cm ³ ) manufactured by Nippon Polyethylene Co., Ltd. was used. In Table 3, it was displayed as B-2.

(3) Propylene resin composition (X)
Propylene resin composition (X) comprising (C-1) which is component (C), (D-1) which is component (D) and (E-1) which is component (E) in the present invention, Obtained by the method described in Example 1 of JP2010-229256A.
Further, a propylene resin composition comprising a propylene-ethylene random block copolymer (C-2) different from the component (C) of the present invention and the above (D-1) and (E-1) is disclosed in JP 2010 It was obtained by the method described in Comparative Example 1 of No. -229256.
Table 4 shows the physical properties of each component, and Table 5 shows the blending ratio of each component.
In (C-1) and (C-2), the peak of the tan δ curve showed a single peak in the solid viscoelasticity measurement.

[Example 1]
In the first layer, an ethylene resin layer I in which (B-1) 2.4% by weight and (B-2) 40% by weight are blended with (A-1) 57.6% by weight, and the second layer is used. For the third layer, (C-1) 58% by weight, (D-1) was used for the third layer. A propylene-based resin layer III comprising 27% by weight and (E-1) 15% by weight was used.
The resin material of each of these layers was set in the above-mentioned three types of three-layer water-cooled inflation molding machine manufactured by Plako, and water-cooled inflation molding was performed under the above conditions to obtain a laminate having a thickness of 250 μm and evaluated. The results are shown in Table 5.

[Example 2]
The blending ratio of the ethylene-based resin layer I of the first layer was (A-1) 67.2% by weight, (B-1) 2.8% by weight, and (B-2) 30% by weight, A laminate was obtained in the same manner as in Example 1. The evaluation results are shown in Table 5.

  Since the laminates of Examples 1 and 2 were excellent in transparency and appearance change (heat resistance) in the autoclave sterilized product at 115 ° C., autoclave sterilization was further performed at 121 ° C. There was no significant decrease in transparency and poor appearance, and there was no problem as a medical bag.

[Comparative Example 1]
Except that the blending ratio of the ethylene-based resin layer I of the first layer was (A-1) 91.2% by weight, (B-1) 3.8% by weight, (B-2) 5% by weight, A laminate was obtained in the same manner as in Example 1. The evaluation results are shown in Table 5.
The laminate of Comparative Example 1 is not preferred because air marks are seen in the bag after sterilization.

[Comparative Example 2]
A laminate was obtained in the same manner as in Example 1 except that the blending ratio of the second layer of the ethylene-based resin layer II was (A-2) 100 wt%. The evaluation results are shown in Table 5.
The laminate of Comparative Example 2 did not retain its form after sterilization and could not be evaluated.

[Comparative Example 3]
A laminate was obtained in the same manner as in Example 1 except that the blending ratio of the propylene-based resin layer III of the third layer was 100% by weight of (PP-2). The evaluation results are shown in Table 5.
Comparative Example 3 could not be molded.

[Comparative Example 4]
A laminate was obtained in the same manner as in Example 1 except that the blending ratio of the third layer was the same as that of the ethylene-based resin layer I of the first layer. The evaluation results are shown in Table 5.
The laminate of Comparative Example 4 had poor adhesion to the PP port.

[Comparative Example 5]
A laminate was obtained in the same manner as in Example 1, except that the blending ratio of the first layer and the third layer was 100% by weight of (PE-4). The evaluation results are shown in Table 5.
The laminate of Comparative Example 5 had poor adhesion to PP ports, appearance after sterilization (heat resistance), and transparency.

  The medical bag of the present invention is excellent in hygiene, heat resistance, transparency, impact resistance and the like, and thus can be suitably used particularly for infusion preparations.

DESCRIPTION OF SYMBOLS 1 Medical bag 2 Container body 3 Discharge port 4 Mixed injection port 5 Upper end side seal part 6 Lower end side seal part 9 Partition part 9a Central weak seal part 9b Side part seal part 10 Weak seal part 21 for communication inhibition 21 1st chemical | medical agent chamber 22 Second drug room

Claims (6)

A medical bag comprising a laminate in which at least a first layer, a second layer and a third layer are laminated in this order,
The first layer is composed of an ethylene-based resin layer I containing 51 to 85% by weight of the following component (A) and 15 to 49% by weight of the following component (B), and the second layer is 70 to 99 of the following component (A). For medical use comprising an ethylene resin layer II containing 1 wt% and 1 to 30 wt% of the following component (B), and a third layer comprising a propylene resin layer III containing the following propylene resin composition (X) bag.
Component (A): Copolymer of ethylene and an α-olefin having 3 to 12 carbon atoms produced using a metallocene catalyst having the following properties (Ai) to (A-iv) (Ai) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 20 g / 10 minutes (A-ii) Density is 0.890 to 0.930 g / cm ³
(A-iii) The content of α-olefin is 5 to 40% by weight
(A-iv) The ratio (Mz / Mn) of the Z average molecular weight (Mz) and the number average molecular weight (Mn) determined by gel permeation chromatography (GPC) is 8.0 or less. Component (B): -I) High density polyethylene having the characteristics of (B-ii) (Bi) Melt flow rate (190 ° C., 21.18 N load) is 0.1 to 50 g / 10 minutes (B-ii) Density is 0 .940-0.980 g / cm ³
Propylene-based resin composition (X): propylene-based resin composition comprising the following component (C) 50 to 65 wt%, the following component (D) 25 to 35 wt%, and the following component (E) 10 to 20 wt% C): Propylene-ethylene random block copolymer having the following characteristics (Ci) to (C-iii) (Ci) Using a metallocene catalyst, the melting peak temperature in DSC measurement in the first step is The propylene-ethylene random copolymer component (C1) having an ethylene content of 1.5 to 3.0% by weight of 125 to 135 ° C. and an ethylene content of 8 to 14% by weight in the second step Propylene-ethylene random block copolymer obtained by sequential polymerization of propylene-ethylene random copolymer component (C2) by 50 to 40% by weight (C-ii) Melt flow rate (C-iii) Temperature-loss tangent (tan δ) curve obtained by solid viscoelasticity measurement, glass transition observed in the range of −60 to 20 ° C. The expressed temperature-loss tangent (tan δ) curve shows a single peak at 0 ° C. or lower. Component (D): an ethylene-α-olefin copolymer having the following characteristics (Di) to (D-iii): Di) Density is 0.870-0.890 g / cm ³
(D-ii) Melting peak temperature in DSC measurement is 80 ° C. or less (D-iii) Melt flow rate (190 ° C., 21.18 N load) is 2.0 to 5.0 g / 10 min Component (E): Propylene-ethylene block copolymer having the characteristics of (Ei) to (E-iii) (Ei) The melt flow rate (230 ° C., 21.18 N load) is 100 to 200 g / 10 min in the first step. Propylene-ethylene random copolymer component (E2) having 65 to 75% by weight of polypropylene component (E1) in the range, ethylene content of 4 to 8% by weight and weight average molecular weight of 800,000 to 3 million in the second step. Propylene-ethylene block copolymer obtained by 35-25% by weight sequential polymerization (E-ii) Weight average molecular weight (Mw) and number average molecular weight (Mn) determined by GPC The molecular weight distribution (Mw / Mn) as a ratio of 9.0 to 15.0
(E-iii) Melt flow rate (230 ° C., 21.18 N load) of the entire propylene resin component (E) is 2.0 to 8.0 g / 10 min.   The medical bag according to claim 1, wherein the total thickness of the ethylene resin layer I and the propylene resin layer III is 15 to 60% with respect to the total thickness of the laminate.   The medical bag according to claim 1 or 2, wherein the total thickness of the laminate is 100 to 700 µm.   The medical bag according to any one of claims 1 to 3, wherein the laminate is formed in a bag shape, the first layer is an outer layer, and the third layer is an inner layer.   The medical bag according to any one of claims 1 to 3, wherein the third layers of the laminate are opposed to each other and heat-sealed in a bag shape.   An infusion preparation containing the infusion in the medical bag according to claim 4 or 5.

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