JP2014172966A - Coating agent for forming a non-adsorbent layer and non-adsorbent laminate - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a coating agent for forming a non-adsorbent layer capable of forming, at a low cost, a non-adsorbent layer having a sufficiently high non-adsorbency and a low-cost non-adsorbent laminate excellent in terms of non-adsorbency.SOLUTION: The coating agent of the present invention for forming a non-adsorbent layer is provided for conferring, when coated on a substrate, non-adsorbency onto the substrate and includes: a main agent consisting of a polymer; a curative possessing a reactive functional group; and a dispersion medium, whereas the polymer constituting the main agent includes a nitrile group-containing acrylic monomer unit and a reactive functional group-containing acrylic monomer unit including a reactive functional group reactive with the reactive functional group of the curative. It is desirable for the content of the nitrile group-containing acrylic monomer unit included within the main agent of the coating agent of the present invention for forming a non-adsorbent layer to be 15 mass% or higher. The non-adsorbent laminate of the present invention includes a substrate and a non-adsorbent layer formed by coating, atop the substrate, the coating agent for forming a non-adsorbent layer.

Description

  The present invention relates to a coating agent for forming a non-adsorbing layer, which is applied to a substrate such as a plastic film and imparts non-adsorbing properties to the substrate. Moreover, it is related with the laminated body which has non-adsorbability.

As a packaging material for packaging drugs, foods, etc., non-adsorbable films that are difficult to adsorb substances contained in drugs, foods, etc. may be used. Non-adsorptive films include, for example, a laminate of a metal foil and a plastic film, a laminate of a metal deposition layer and a plastic film, a laminate of a metal oxide deposition layer and a plastic film, a polyester film, and ethylene-vinyl alcohol. Copolymer films, polyacrylonitrile films and the like are known. Among these, polyacrylonitrile films are widely known as being excellent in non-adsorption.
A conventional polyacrylonitrile film is a film having a thickness of about 20 to 30 μm formed by extrusion molding. This polyacrylonitrile film is usually laminated with another plastic film and provided as a packaging material (Patent Document 1).

The polyacrylonitrile film is not inexpensive, and the conventional polyacrylonitrile film is very excellent in non-adsorbability, and it has been required to reduce the thickness and reduce the cost. However, in extrusion molding, there is a limit to reducing the thickness of the obtained film, and cost reduction has not been realized.
Therefore, it has been proposed that a thin non-adsorbing layer is formed by applying a coating agent containing polyacrylonitrile particles and polyester particles to a substrate to obtain a packaging material (Patent Document 2). However, the packaging material described in Patent Document 2 has insufficient non-adsorbability.

Japanese Patent Laid-Open No. 8-143452 JP 2012-184357 A

  An object of this invention is to provide the coating agent for non-adsorption layer formation which can form the non-adsorption layer which has sufficiently high non-adsorption property at low cost. An object is to provide a non-adsorbent laminate having low cost and excellent non-adsorbability.

The present invention has the following aspects.
[1] A coating agent for forming a non-adsorbing layer that is applied to a base material to impart non-adsorptive properties to the base material, comprising a polymer main agent, a curing agent having a reactive functional group, and a dispersion The polymer constituting the main agent is a reactive functional group-containing acrylic monomer having a nitrile group-containing acrylic monomer unit and a reactive functional group capable of reacting with the reactive functional group of the curing agent. A coating agent for forming a non-adsorbing layer comprising a body unit.
[2] The coating agent for forming a non-adsorbing layer according to [1], wherein the content of the nitrile group-containing acrylic monomer unit in the main agent is 15% by mass or more.
[3] The molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent, (B) / (A) is 0.5 or more and 5.0 or less [1] Or the coating agent for non-adsorption layer forming as described in [2].
[4] A non-adsorbing layer formed by applying a base material and the non-adsorbing layer forming coating agent according to any one of [1] to [3] to the base material. Adsorbent laminate.

The coating agent for forming a non-adsorbing layer of the present invention can form a non-adsorbing layer having a sufficiently high non-adsorbing property at a low cost.
The non-adsorbing laminate of the present invention is low in cost and excellent in non-adsorbing properties.

It is a graph which shows the adsorption amount of 1-menthol in the non-adsorbent laminated body of Examples 1-3 and the comparative example 1. FIG. 3 is a graph showing the amount of dl-camphor adsorbed in the non-adsorbent laminates of Examples 1 to 3 and Comparative Example 1. FIG. It is a graph which shows the adsorption amount of 1-menthol in the non-adsorbable laminated body of Examples 1, 4, 5 and Comparative Examples 2, 3. It is a graph which shows the adsorption amount of dl-camphor in the non-adsorbent laminated body of Examples 1, 4, 5 and Comparative Examples 2, 3.

<Non-adsorbing layer forming coating agent>
The coating agent for forming a non-adsorbing layer of the present invention (hereinafter abbreviated as “coating agent”) is applied to a base material to impart non-adsorbing property to the base material. Containing a dispersion medium. Here, the non-adsorptive property means that it is difficult to adsorb active ingredients contained in foods, pharmaceuticals, cosmetics and the like.
Examples of active ingredients that require suppression of adsorption include limonene contained in orange juice and the like as volatile ingredients, methyl salicylate, l-menthol, and dl-camphor contained in pharmaceuticals. As active ingredients that require suppression of adsorption, non-volatile ingredients include various drugs used as anti-inflammatory analgesics, such as ketoprofen, flurbiprofen, and loxoprofen sodium hydrate.

(Main agent)
The main agent is a polymer containing a nitrile group-containing acrylic monomer unit and a reactive functional group-containing acrylic monomer unit other than the nitrile group-containing acrylic monomer unit. The reactive functional group-containing acrylic monomer unit is an acrylic monomer unit having a reactive functional group (for example, a hydroxy group, a carboxyl group, an epoxy group, etc.) that can react with the reactive functional group of the curing agent.
The main agent may contain other monomer units other than the nitrile group-containing acrylic monomer and the reactive functional group-containing acrylic monomer unit.

Examples of the nitrile group-containing acrylic monomer include acrylonitrile and methacrylonitrile.
Examples of the reactive functional group-containing acrylic monomer include a hydroxy group-containing acrylic monomer, a carboxyl group-containing acrylic monomer, and an epoxy group-containing acrylic monomer. In terms of easy control of the reaction rate, the reactive functional group-containing acrylic monomer is preferably a hydroxy group-containing acrylic monomer.
Examples of the hydroxy group-containing acrylic monomer include 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, 2-hydroxyethyl acrylate, and hydroxypropyl acrylate.
Examples of the carboxyl group-containing acrylic monomer include acrylic acid, methacrylic acid, maleic acid, and itaconic acid.
Examples of the epoxy group-containing acrylic monomer include glycidyl acrylate and glycidyl methacrylate.
Other monomers include acrylic acid alkyl esters (eg, methyl acrylate, ethyl acrylate, isopropyl acrylate, n-butyl acrylate, 2-ethylhexyl acrylate, etc.), methacrylic acid alkyl esters (eg, methacrylic acid). Methyl, ethyl methacrylate, isopropyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, n-hexyl methacrylate, lauryl methacrylate, etc.), aromatic vinyl (for example, styrene, vinyl toluene, etc.), vinyl acetate, acrylamide, N-methylol acrylamide, diacetone acrylamide, dimethylaminoethyl methacrylate and the like can be mentioned.

The content of the nitrile group-containing acrylic monomer unit in the main agent is preferably 15% by mass or more, and more preferably 15 to 40% by mass. If the content of the nitrile group-containing acrylic monomer unit is equal to or higher than the lower limit, higher non-adsorption can be obtained, and if the content is equal to or lower than the upper limit, the main agent is easily dissolved or dispersed in the dispersion medium. The coating agent can be easily prepared.
When the main ingredient contains other monomer units, the content of other monomer units is preferably 30 to 85% by mass, more preferably 35 to 70% by mass, and 40 to 60% by mass. % Is more preferable. If the content of other monomer units is not less than the lower limit, the main agent can be easily dissolved or dispersed in the dispersion medium, and if it is not more than the upper limit, sufficient non-adsorption can be ensured.

The mass average molecular weight of the main agent is preferably 10,000 to 100,000, more preferably 20,000 to 70,000. If the mass average molecular weight is not less than the lower limit, blocking after coating can be prevented, and if it is not more than the upper limit, compatibility with the curing agent can be improved. Here, the mass average molecular weight is a value obtained by measuring by gel permeation chromatography and using polystyrene as a standard substance.
The glass transition point (Tg) of the main agent is preferably 50 to 200 ° C, more preferably 70 to 150 ° C. If the glass transition point is not less than the lower limit, blocking after coating can be prevented, and if it is not more than the upper limit, the reactivity with the curing agent can be improved. Here, the glass transition point is a value measured using a differential thermal analyzer.

(Curing agent)
The curing agent has a reactive functional group, and reacts with the reactive functional group of the main agent to crosslink and cure the main agent.
When the main agent has a hydroxy group-containing acrylic monomer unit, the curing agent is preferably a diisocyanate compound whose reactive functional group is an isocyanate group.
Examples of the diisocyanate compound include aromatic diisocyanates such as tolylene diisocyanate and 4,4′-diphenylmethane diisocyanate, aliphatic diisocyanates such as xylylene diisocyanate and hexamethylene diisocyanate, and alicyclic diisocyanates such as isophorone diisocyanate. Further, it may be a polymer, derivative or mixture of these diisocyanate compounds.

  The ratio between the main agent and the curing agent is the molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent, and (B) / (A) is 0.5 or more and 5.0 or less. It is preferable that it is 0.8 or more and 3.5 or less. If (B) / (A) is more than the said lower limit, a main ingredient can fully be hardened, and if it is below the said upper limit, blocking of a non-adsorption layer can be prevented.

(Dispersion medium)
The dispersion medium is a liquid that dissolves or disperses the main agent and the curing agent.
As the dispersion medium, an alcohol solvent, a ketone solvent, an ester solvent, a glycol solvent, or a hydrocarbon solvent can be used.
Examples of alcohol solvents include methanol, ethanol, isopropanol, n-propanol, 1-butanol, and 2-butanol.
Examples of the ketone solvent include acetone, methyl ethyl ketone, methyl isobutyl ketone, and anone.
Examples of ester solvents include ethyl acetate, n-propyl acetate, n-butyl acetate, and isobutyl acetate.
Examples of glycol solvents include butyl cellosolve and propylene glycol monomethyl ether.
Examples of the hydrocarbon solvent include toluene, xylene, n-hexane, and methylcyclohexane.

  The coating agent of the present invention preferably has a solid content concentration of 3 to 50% by mass, more preferably 4 to 40% by mass, and 5 to 30% by mass by including a dispersion medium. More preferably, If the solid content concentration of the coating agent is equal to or higher than the lower limit value, a non-adsorbing layer having a sufficient thickness can be easily formed even by a single coating, and if the solid content concentration is equal to or lower than the upper limit value, the viscosity is appropriately lowered Coating property is improved.

(Other ingredients)
The coating agent of the present invention may contain an antioxidant, an ultraviolet absorber, a light stabilizer, a pigment, a dye, an antifoaming agent, a leveling agent and the like in addition to the main agent, the curing agent and the dispersion medium.

(Function and effect)
When the present inventors examined, the non-adsorption layer formed by the coating of the coating agent containing the said main ingredient, a hardening | curing agent, and a dispersion medium was excellent in non-adsorption property. Further, in the formation of the non-adsorbing layer by coating the coating agent, the non-adsorbing layer can be easily thinned, so that the amount of coating agent used can be reduced. Therefore, according to the coating agent coating, a non-adsorbing layer having excellent non-adsorbing property can be formed at low cost.
The coating agent can be applied to a resin film made of a heat-adhesive resin such as polyethylene or polypropylene. By applying a pattern to these heat-adhesive resin films, heat adhesion as well as non-adsorption can be exhibited.

<Non-adsorbent laminate>
The non-adsorptive laminate of the present invention has a substrate and a non-adsorptive layer formed by applying the non-adsorbing layer forming coating agent to the substrate. The non-adsorbing layer is provided in the innermost layer in contact with the contents such as foods, pharmaceuticals, and cosmetics.

(Base material)
As the substrate, plastic film, paper, non-woven fabric, metal foil, etc. can be used, but the non-adsorbing layer can be formed even if the coating amount of the non-adsorbing layer forming coating agent is small, and transparency is ensured. Since it is easy, a plastic film is preferable.
As resin which comprises a plastic film, polyester, polyamide, polyolefin etc. are mentioned, for example.
Examples of the polyester include polyethylene terephthalate, polybutylene terephthalate, and polyethylene naphthalate. Examples of the polyamide include 6-nylon and 6,6-nylon. Examples of the polyolefin include polypropylene and polyethylene.
In addition, the plastic film may be a uniaxially stretched film, a biaxially stretched film, or an unstretched film, but is excellent in mechanical strength. A biaxially stretched film is preferred.
The base material may contain additives such as an antistatic agent, a slip agent, an antifogging agent, and an ultraviolet absorber as necessary.
The base material may be subjected to surface treatment such as corona discharge treatment, ozone treatment, flame treatment, etc., if necessary.
If necessary, an anchor coating agent such as an isocyanate compound, polyethyleneimine, or modified polybutadiene may be applied to the substrate in advance.
The thickness of the substrate is not particularly limited, but is preferably 12 to 40 μm from the viewpoint of achieving both economy and ease of use.
The substrate may be a single layer or a multilayer.

A printing layer is usually formed on the non-adsorbing laminate, but the arrangement of the printing layer is not particularly limited. For example, a printing layer may be laminated on the surface of the substrate opposite to the non-adsorbing layer, or a printing layer may be formed on the substrate, and a non-adsorbing layer may be provided thereon. Moreover, it is also possible to print a picture in advance on a general-purpose printing substrate such as polyester or stretched polypropylene film, and laminate this using a non-adsorbable laminate and an adhesive. Further, a non-adsorbing layer may be provided on the sealant film after laminating a sealant film such as polyolefin via an adhesive on the printed layer forming surface of the substrate on which the printed layer is formed.
Moreover, in order to give a texture and rigidity to a non-adsorbent laminated body, it is also possible to laminate | stack paper and a nonwoven fabric (basis weight 15-90 g / m < ² >) on the outer side.
For contents that require oxygen barrier properties or light shielding properties, an aluminum foil or an aluminum deposited film can be laminated. However, the non-adsorbent laminate of the present invention preferably does not contain an aluminum layer from the viewpoint of transparency and environmental considerations. Instead of an aluminum layer, a resin film having a gas / water vapor barrier property such as polyvinyl alcohol, ethylene vinyl alcohol copolymer, polyamide, polyvinylidene chloride, a resin film deposited with aluminum oxide or silicon oxide, polyvinyl alcohol, poly It is preferable to laminate a resin film coated with vinylidene chloride and polyacrylic acid.

(Method for producing non-adsorbent laminate)
Examples of the method for producing the non-adsorbent laminate include a method in which the coating agent is applied to at least one surface of the substrate and dried.
There is no restriction | limiting in particular as a coating method of a coating agent, For example, a wire coat method, a roll coat method, a gravure coat method, a bar coat method, a die coat method, a curtain coat method etc. can be applied.
The coating thickness of the coating agent is preferably 0.05 to 10 μm, more preferably 0.1 to 5 μm, in terms of the thickness of the non-adsorbed layer after drying. If the coating thickness is equal to or greater than the lower limit value, the coating can be easily performed by a general-purpose coating apparatus. If the coating thickness is equal to or smaller than the upper limit value, the coating amount is reduced, so that the cost can be sufficiently reduced.
As a drying method after coating, a hot air drying method, an infrared irradiation drying method, or the like can be applied. The drying temperature is preferably 40 to 120 ° C, more preferably 50 to 100 ° C. If a drying temperature is more than the said lower limit, a drying speed can be made quick, and if it is below the said upper limit, it is economical.
After drying, a heat treatment for sufficiently reacting the main agent and the curing agent may be performed. It is preferable that the temperature of heat processing is 30-100 degreeC, and it is more preferable that it is 40-70 degreeC.

(Function and effect)
Since the non-adsorbing laminate of the present invention is obtained by applying the coating agent to a substrate, it has excellent non-adsorbing properties and is low in cost. Moreover, when the present inventors examined, it turned out that the non-adsorption layer formed by application | coating of the said coating agent is excellent also in the aroma retaining property which prevents permeation | transmission of fragrance components, such as menthol.
A non-adsorbent laminate having such a non-adsorbing layer can be suitably used as a packaging material for packaging drugs and foods.

When the non-adsorbent laminate of the present invention is used as a packaging material, the non-adsorbent laminate may be used as a film, or the non-adsorbent laminate may be molded or processed into a bag shape. .
Moreover, you may provide thermal adhesiveness to the non-adsorbable laminated body of this invention. When heat adhesiveness is imparted to the non-adsorbing laminate of the present invention, it exhibits thermal adhesiveness as well as non-adsorbing property, and thus is suitable as a packaging bag manufacturing material. As a method for imparting thermal adhesiveness, a method in which a layer having thermal adhesiveness is laminated on a non-adsorbing layer by pattern coating, a layer having thermal adhesiveness is first formed, and then non-adsorbing to a layer having thermal adhesiveness. The method of forming a layer by pattern coating is mentioned. As the resin having thermal adhesiveness, a vinyl acetate copolymer, a polyester resin, a polyethylene resin, a polypropylene resin, a modified polyolefin resin, or the like can be used.

Contents packaged by non-adsorbent laminates include spices, seasonings, processed fishery products, foods such as confectionery, pharmaceuticals such as oral drugs, transdermal drugs, patches, other cosmetics, and agricultural chemicals. .
In particular, examples of the drug packaged by the non-adsorbable laminate include terpenes such as methyl salicylate, limonene, citral, l-menthol and dl-camphor, aromatic compounds such as salicylic acid and naphthalene, and other vitamins. . In addition, ketoprofen, flurbiprofen, loxoprofen sodium hydrate and the like used as analgesic / anti-inflammatory agents and the like can also be mentioned. In general, it is said that the lower the molecular weight, the easier it is to volatilize and the easier it is to adsorb. Non-adsorbent laminates are more useful.

The present invention will be specifically described below with reference to examples and comparative examples. However, the present invention is not limited to the following examples.
In the following examples, “part” means “part by mass”, and “%” means “% by mass”.

Example 1
A reaction vessel equipped with a reflux condenser, a nitrogen inlet tube, a thermometer, and a stirrer was charged with 100 parts of ethyl acetate, 300 parts of n-propyl acetate, and 500 parts of methyl ethyl ketone, and heated to 90 ° C. to maintain the temperature. . Then, while continuing to stir the inside of the reaction vessel, a mixed solution containing 50 parts of methyl methacrylate, 20 parts of 2-hydroxyethyl methacrylate, 30 parts of acrylonitrile and 3 parts of benzoyl peroxide was added to the reaction vessel at 90 ° C. for 3 hours. The solution was added dropwise and held for another 8 hours. This obtained the main ingredient.
The obtained main component has a solid content concentration of 10%, a mass average molecular weight of 30,000 (measured by the GPC method using SHODEX KF-80M manufactured by Showa Denko KK, based on polystyrene), and a hydroxyl value of 86 mgKOH / g (measured according to JIS K0070). The glass transition point was 93 ° C. (measured according to JIS K7121).
To 100 parts of the main agent, 10 parts of a 75% solid solution of hexamethylene diisocyanate trimer in ethyl acetate (manufactured by Nippon Polyurethane Industry Co., Ltd .: trade name Coronate HL) is added as a curing agent and stirred with a stirrer. An agent was obtained. At this time, the molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent was (B) / (A) = 2.0.
A corona-treated polyethylene terephthalate film (E5100 manufactured by Toyobo Co., Ltd., thickness: 12 μm) was prepared, and a coating agent was applied once to the corona-treated surface of the polyethylene terephthalate film using a # 6 wire bar. Next, the film was dried at 80 ° C. for 1 minute and heat-treated at 50 ° C. for 5 days to form a non-adsorbing layer having a thickness of 1.0 μm. This obtained the non-adsorbable laminated body.

(Example 2)
A non-adsorbent laminate was obtained in the same manner as in Example 1 except that the curing agent was changed to 20 parts with respect to 100 parts of the main agent. The molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent was (B) / (A) = 3.9.

(Example 3)
A non-adsorbent laminate was obtained in the same manner as in Example 1 except that the curing agent was changed to 5 parts with respect to 100 parts of the main agent. The molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent was (B) / (A) = 1.0.

Example 4
A non-adsorbent laminate was obtained in the same manner as in Example 1 except that the addition amount of methyl methacrylate was 60 parts, the addition amount of 2-hydroxyethyl methacrylate was 20 parts, and the addition amount of acrylonitrile was 20 parts.

(Example 5)
A non-adsorbent laminate was obtained in the same manner as in Example 1 except that the addition amount of methyl methacrylate was 65 parts, the addition amount of 2-hydroxyethyl methacrylate was 20 parts, and the addition amount of acrylonitrile was 15 parts.

(Example 6)
On the non-adsorbing layer of the non-adsorbing laminate obtained in Example 1, a resin layer having thermal adhesiveness was formed. Specifically, on the non-adsorbing layer, a thermocompression bonding adhesive (manufactured by Dainichi Seika Co., Ltd., Seicadine) is applied in a pattern by a gravure printing method, and a non-adsorbing laminate having a heat adhering layer Obtained. The coating amount of the thermal adhesive layer was 5 g / m ² when dried.

(Comparative Example 1)
A non-adsorbable laminate was obtained in the same manner as in Example 1 except that the curing agent was changed to 0 part with respect to 100 parts of the main agent.

(Comparative Example 2)
A non-adsorbent laminate was obtained in the same manner as in Example 1 except that the addition amount of methyl methacrylate was 80 parts, the addition amount of 2-hydroxyethyl methacrylate was 20 parts, and the addition amount of acrylonitrile was 0 part. .

(Comparative Example 3)
An adhesive mainly composed of polyurethane resin is applied to a 12 μm thick biaxially stretched polyethylene terephthalate (PET) film, and a 30 μm thick acrylonitrile copolymer film (Tamapoly Co., Ltd. “VALEX”) is used as a sealant layer. Were pasted together. This obtained the non-adsorbable laminated body.

[Evaluation 1]
The non-adsorbent laminate obtained in each Example and each Comparative Example was cut into a circular shape having a diameter of about 100 mm to prepare a test piece. Next, the test piece was sandwiched between a container part and a lid part constituting a separable flask (Shibata scientific capacity 200 ml, inner diameter 86 mm). Next, a commercially available poultice (trade name Salon Pass Ae, manufactured by Hisamitsu Pharmaceutical Co., Ltd., 1-menthol content: 5.71 g / 100 g, dl-camphor content: 1 on the non-adsorbed layer of the non-adsorbed layer laminate. .24 / 100 g) was placed on one sheet (6.5 cm × 4.2 cm), and the container part and the lid part were fixed by sandwiching a clamp between the flange part provided on them. After standing for 3 days in an environment of temperature 40 ° C and relative humidity 75%, the test piece is cut into strips and immersed in 10 ml of methanol to extract l-menthol and dl-camphor at 55 ° C for 3 hours. I let you. The amount of l-menthol and dl-camphor adsorbed per unit area of the non-adsorbent laminate in the extract was measured using gas chromatography. The measurement results are shown in FIGS.

[Evaluation 2]
After the non-adsorbable laminates of Example 6 and Comparative Example 3 were formed into a pouch shape using an impulse sealer so that the non-adsorbed layer was disposed on the inner surface, about 0.1 g of l-menthol was enclosed. Completely sealed. After leaving for 7 days in an environment of a temperature of 40 ° C. and a relative humidity of 75%, sensory evaluation was performed to determine whether menthol odor leaked outside the pouch. None of the pouches produced in Example 6 and Comparative Example 3 had a menthol odor and had sufficient odor retention for menthol.

In Examples 1 to 5 in which a non-adsorbing layer was formed by coating a coating agent containing a main agent containing a nitrile group-containing acrylic monomer unit and a reactive functional group-containing acrylic monomer unit, a curing agent, and a dispersion medium It was excellent in non-adsorbability.
Moreover, it turned out from the result of Examples 1-3 and the comparative example 1 that non-adsorption property is excellent, so that the hardening | curing agent ratio becomes high. However, when the molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent was (B) / (A) = 3.9 or more, a slight stickiness was observed.
Moreover, from the results of Examples 1, 4, 5 and Comparative Example 2, it was found that the non-adsorption property was improved as the content ratio of the nitrile group-containing acrylic monomer unit was increased. When the content ratio of the nitrile group-containing acrylic monomer unit is 15% by mass or more, it has almost the same non-adsorbing property as the non-adsorbing laminate of Comparative Example 3 using a commercially available PAN film, and is 15% by mass. It was found that the above is preferable.
Furthermore, in the non-adsorbable laminated body of Example 6, it turned out that 1-menthol is equipped with the aroma retaining property at least equivalent to the non-adsorbable laminated body of the comparative example 3 using a commercially available PAN film.

Claims (4)

A coating agent for forming a non-adsorbing layer that is applied to a base material to impart non-adsorbing properties to the base material,
A polymer comprising a main agent comprising a polymer, a curing agent having a reactive functional group, and a dispersion medium, and the polymer constituting the main agent includes a nitrile group-containing acrylic monomer unit and a reactive functional group of the curing agent. A coating agent for forming a non-adsorptive layer comprising a reactive functional group-containing acrylic monomer unit having a reactive functional group capable of reacting with.   The coating agent for nonadsorbing layer formation according to claim 1, wherein the content of the nitrile group-containing acrylic monomer unit in the main agent is 15% by mass or more.   The molar ratio of the reactive functional group (A) in the main agent to the reactive functional group (B) in the curing agent, (B) / (A) is 0.5 or more and 5.0 or less. The coating agent for non-adsorption layer formation as described.   The nonadsorbent laminated body which has a base material and the nonadsorbable layer formed by apply | coating the coating agent for nonadsorbable layer forming as described in any one of Claims 1-3 to this base material.

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