JP4756491B2 - Skin patch sheet and laminate - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
  The present invention relates to a skin patch sheet such as a shipping agent sheet containing a drug.WithMore specifically, it is a skin patch sheet in which a film made of a thermoplastic resin is used as a base material and an adhesive layer is formed on the surface of the film, and after being attached to the skin, the film base material can be removed and used. Material peeling type skin patch sheet and itsLaminateIt is about.
[0002]
[Prior art]
  Skin patch sheets such as shipping agent sheets containing agents such as skin irritants and anti-inflammatory analgesics, pack sheets for removing wrinkles for cosmetics, and cooling sheets for removing heat from fever have been known in the past. It is also widely used in the fields of cosmetics and miscellaneous goods.
[0003]
  These skin patch sheets have a pressure-sensitive adhesive layer containing a drug and a pressure-sensitive adhesive layer.AppliedThe adhesive is generally based on a water-soluble polymer as the pressure-sensitive adhesive, but those based on rubber, solution and emulsion polymer are also known. ing.
[0004]
  Examples based on water-soluble polymers include gelatin andcaseinNatural polymers such as dextrin, modified natural polymers such as dextrin, methylcellulose, ethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, polyvinyl alcohol copolymers, sodium polyacrylate copolymers, polyvinylpyrrolidone copolymers, etc. The main component is water-soluble polymers such as synthetic polymers, and various chemicals are added depending on the application of the skin patch sheet. Further, moisturizers and inorganic fillers are added as necessary, and insolubilized with a crosslinking agent. The water-impregnated gel material thus prepared is applied to a substrate as an adhesive and prepared.
[0005]
  In general, a nonwoven fabric or a knitted fabric is used as a base material used for applying the adhesive made of the water-impregnated gel to form a skin patch sheet.
[0006]
  Nonwoven fabrics and knitted fabrics as base materials have advantages such as good breathability and excellent stretchability.The
  On the other hand, the chemicals and moisture contained in the adhesive are easily volatilized, and in some cases, it can be solidified. And easily peels offThe
  In addition, there is a drawback that the product does not have a transparency, and the nonwoven fabric is also more expensive than other substrates.
[0007]
  In addition, non-woven fabrics and knitted fabrics are used as base materials for adhesives based on rubber, solutions or emulsion polymers, and thermoplastic resin films are also used as base materials.The
  These pressure-sensitive adhesives have an affinity for non-polar surfaces such as thermoplastic resin films, and good adhesiveness is obtained, so various products are widely industrialized.
[0008]
  In addition, in these skin patch sheets, in the storage, storage, processing, transportation, etc. of the original fabric, and also in the skin patch sheets as products, in order to protect the adhesive layer, in other words, it is adhesive. Release paper is often used so that various articles do not touch and adhere to the adhesive layer.
[0009]
[Problems to be solved by the invention]
  Recently, in addition to ship agent sheets containing drugs such as skin irritants and anti-inflammatory analgesics, new products such as a pack sheet for removing wrinkles for cosmetics and a cooling sheet for removing heat from heat generation have been commercialized.
  However, simply applying a water-impregnated adhesive based on water-soluble polymer to a substrate such as a conventional nonwoven fabric or knitted fabric does not provide sufficient performance, and is water-soluble. There are limits to product development with polymers.
[0010]
  In order to overcome this limitation, it has been attempted to apply a water-impregnated gel-like adhesive to a base material made of a thermoplastic resin film.The
  HoweverStill, no method has been found that can apply a pressure-sensitive adhesive composed of a water-impregnated gel with an appropriate bonding strength on the surface of a nonpolar thermoplastic resin film.
[0011]
  In addition, the skin patch sheet required after sticking a film substrate made of thermoplastic resin is a problem that when the film substrate is stuck to the skin and used, the film substrate impedes air permeability, and skin irritation or swelling tends to occur. HaveThe
  for that reason,Although the film base material is provided with pores, such processing causes another problem of increasing the price of the film base material.
[0012]
  Furthermore, since these skin patch sheets are composed of the film base, the adhesive and the release paper as described above, a skin patch sheet that does not require a release paper is used because of the importance of resource saving and environmental protection. There is a strong demand, but no satisfactory product has been obtained.
[0013]
  In view of the present situation, the present invention has been intensively studied.did.
  as a result,A film substrate made of a thermoplastic resin;Consists of a water-impregnated gel containing a poly (sodium acrylate) polymer as the main componentBy forming an intermediate resin layer with a specific polymer as the main component between the pressure-sensitive adhesive layers, the film base material is removed and used after the skin patch sheet is applied to the skin. Knew that a good and flexible skin patch sheet with excellent texture could be obtainedIt was.
  Furthermore, the adhesive layer is an environmentally friendly skin patch sheet that can be laminated without using release paper because it does not exhibit adhesive strength on the surface of the film base material on which the intermediate resin layer is not applied. I learned that and completed this inventionIt has been made.
[0014]
[Means for solving the problems]
  That is, the skin patch sheet according to claim 1 of the present invention is
  A film substrate made of a thermoplastic resin;A skin patch sheet comprising a water-impregnated gel-like pressure-sensitive adhesive layer mainly composed of a sodium polyacrylate polymer,
  The film substrate andBetween the adhesive layer,
  An intermediate resin layer composed mainly of an amino group-containing vinyl polymer soluble in water or a water-soluble organic solvent or a mixed solvent thereof has a thickness of 50 μm to 1 mm.Being formed
It is characterized by.
[0015]
  Also,According to claim 7 of the present inventionSkinThe attached sheet is
  A skin patch sheet comprising a film base material comprising the thermoplastic resin according to claim 1, an intermediate resin layer and an adhesive layer,
  After sticking on the skin which is an adherend using the pressure-sensitive adhesive layer, only the film substrate is peeled off and used.
It is characterized by.
[0016]
  further,Claim 8 of the present inventionSkin patch sheet laminateIs
  A skin patch sheet comprising a film base material comprising the thermoplastic resin according to claim 1, an intermediate resin layer, and an adhesive layer,
  In the case of paperboard, the adhesive layer is laminated without being abutted, and in the case of long, it is laminated by winding it into a cylindrical shape
It is characterized by.
[0017]
DETAILED DESCRIPTION OF THE INVENTION
  <Amino group-containing vinyl polymer>
  In this invention, the skin patch sheet isAmino groups that are soluble in water or water-soluble organic solvents or mixed solvents thereofIt has an intermediate resin layer with a film thickness of 50 μm to 1 mm mainly composed of a vinyl-containing polymer.is there.
  Amino groupContaining vinyl polymeras,By polymerizing vinyl monomers with amino groupsWhat is obtained is preferred.
[0018]
  The amino groupPreferred examples of the vinyl monomer having acrylamide include acrylamide monomers, acrylic acid or methacrylic acid aminoalkyl ester monomers, and vinyl monomers containing a morpholine ring.
[0019]
  Specific examples of the vinyl monomer having an amino group include acrylamide monomers such as acrylamide, methacrylamide, dimethylacrylamide, diethylacrylamide, and dimethylaminopropylacrylamide.
[0020]
  Examples of acrylic acid or methacrylic acid aminoalkyl ester monomers include dimethylaminoethyl acrylate, diethylaminoethyl acrylate, dimethylaminoethyl methacrylate, and diethylaminoethyl methacrylate.The
  Furthermore, vinyl monomers obtained by imparting cationicity to these with mineral acids (hydrochloric acid, nitric acid, sulfuric acid, etc.), dimethyl sulfuric acid, diethyl sulfuric acid, methyl chloride, ethyl chloride, and the like can be mentioned.
[0021]
  further,SaidExamples of the vinyl monomer containing a morpholine ring include acryloylmorpholine.
[0022]
  AboveAmino groupThe vinyl-containing polymer may be a copolymer of a vinyl monomer having an amino group as described above and another vinyl monomer, and the vinyl monomer having an amino group is used as a constituent monomer. If the content is 5% by mass or more, the intended effect of the present invention can be obtained.
[0023]
  Examples of other vinyl monomers that can be copolymerized with a vinyl monomer having an amino group include styrene, alkyl vinyl ether, vinylidene chloride, acrylic acid, sodium acrylate, potassium acrylate, acrylic esters, and methacrylic acid. , Sodium methacrylate, potassium methacrylate, methacrylates, vinyl acetate, acrylonitrile, methacrylonitrile and the like.
[0024]
  Among these monomers, acrylic acid esters and methacrylic acid esters are preferred.Yes.
  Specific examples thereof include methyl acrylate, ethyl acrylate, butyl acrylate, 2-ethylhexyl acrylate, methyl methacrylate, ethyl methacrylate, butyl methacrylate, 2-ethylhexyl methacrylate, glycidyl acrylate, and hydroxyethyl acrylate. , Hydroxypropyl acrylate, methoxyethyl acrylate, ethylene glycol mono and diacrylate, polyethylene glycol mono and diacrylate, glycidyl methacrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, methoxyethyl methacrylate, ethylene glycol mono and dimethacrylate And polyethylene glycol mono and dimethacrylate.
[0025]
  Similarly, maleic acid and its esters, fumaric acid and its esters, itaconic acid and its esters, and the like can also be mentioned.
  Furthermore, trimethoxyvinylsilane, triethoxyvinylsilane, γ-methacryloxypropyltrimethoxysilane and the like can be used as necessary.
[0026]
  Of this inventionAmino groupAs the containing vinyl polymer, those containing 5% by mass or more of a vinyl monomer having an amino group as a constituent monomer as described above are preferable.Yes.
  More preferably, it is in the range of 10% by mass to 90% by mass.
[0027]
  When the constituent ratio is less than 10% by mass, particularly less than 5% by mass, the affinity of the intermediate resin layer mainly composed of the obtained vinyl polymer is too low.The
  As a result, it is a water-impregnated gelSodium polyacrylate polymerWhen the film base material is removed after the skin adhesive sheet is attached to the skin, the intermediate resin layer containing the vinyl polymer as a main component becomes a film. Peeled together with the base material, easily retaining the shape of the adhesive layerYes.
  When it exceeds 90% by mass, the smoothness tends to be inferior when a resin containing the vinyl polymer as a main component is applied to a thermoplastic resin film to form an intermediate resin layer.
[0028]
  Of this inventionAmino groupThe containing vinyl polymer is soluble in water, a water-soluble organic solvent, or a mixed solvent thereof, including the case of a copolymer with the vinyl monomer exemplified above..
[0029]
  The main component of the intermediate resin layer as described aboveAmino groupThe vinyl-containing polymer can be obtained as a solution in an aqueous medium or an aqueous medium containing a water-soluble organic solvent after bulk polymerization of a predetermined proportion of vinyl monomer with a normal radical initiator.
[0030]
  Alternatively, a predetermined proportion of the vinyl monomer can be dissolved or dispersed in an aqueous medium, a water-soluble organic solvent or an aqueous medium containing a water-soluble organic solvent, and obtained by polymerization with a normal radical initiator.
[0031]
  Further, in the polymerization, an effective amount of a polyalkenyl polyether monomer, a polyvalent vinyl monomer or a crosslinkable monomer selected from a mixture thereof can be used in combination to form a crosslinked vinyl polymer. .
[0032]
  Specific examples of the crosslinkable monomer include tetraallyloxyethane, allylpentaerythritol, allyl acrylate, allyl methacrylate, trimethylolpropane diallyl ether, diallyl phthalate, ethylene glycol diacrylate, polyethylene, including those exemplified above. Examples include glycol diacrylate, ethylene glycol dimethacrylate, and polyethylene glycol dimethacrylate.
[0033]
  Examples of the water-soluble organic solvent used in the polymerization include methanol, ethanol, butanol, propanol, ethylene glycol, propylene glycol, methyl cellosolve, ethyl cellosolve, butyl cellosolve, dioxane, tetrahydrofuran and the like.
[0034]
  Obtained in this wayAmino groupWhen the vinyl-containing polymer contains acrylic acid or methacrylic acid aminoalkyl ester monomers as constituent monomers, mineral acids (hydrochloric acid, nitric acid, sulfuric acid, etc.), dimethyl sulfuric acid, diethyl sulfuric acid, chlorinated It is also possible to use it with a cationic property such as methyl or ethyl chloride.
[0035]
  Amino groupThe average degree of polymerization of the vinyl-containing polymer is preferably 50 to 10,000, more preferably 100 to 2,000.
  Amino groupWhen the average degree of polymerization of the vinyl-containing polymer is less than 50, the mechanical strength of the obtained intermediate resin layer is lowered, whereas when it exceeds 10,000, the viscosity becomes too high and it is difficult to apply to the film substrate. Become.
[0036]
  Amino groupContaining vinyl polymersoWhen forming the intermediate resin layer, it can be performed with one kind of polymer or with a plurality of polymers in combination.The
  Furthermore, general water-soluble polymers such as gelatin andcaseinNatural polymers such as dextrin, methylcellulose, ethylcellulose, hydroxyethylcellulose, carboxymethylcellulose and other modified natural polymers, polyvinyl alcohol copolymers, sodium polyacrylate copolymers, polyvinylpyrrolidone copolymers, etc. These synthetic polymers can be used in combination.
[0037]
  When using a water-soluble polymer together,Amino groupIt is preferable that the content of the vinyl-containing polymer is not less than 10% by mass of the constituent components of the intermediate resin layer.Yes.
  More preferablyAmino groupThe amount of the vinyl-containing polymer is 20% by mass or more, particularly preferably 30% by mass or more.
  Amino groupWhen the content of the vinyl-containing polymer is less than 10% by weight, the affinity with water becomes too low and the gel is a water-impregnated gel.Sodium polyacrylate polymerAffinity with the pressure-sensitive adhesive layer containing as a main component may be weakened, which may be a problem.
[0038]
  The amino groupAn appropriate amount of a silane coupling agent, an antioxidant, an ultraviolet absorber, an antiblocking agent, a surfactant, a viscosity improver, a leveling agent, etc. may be added to the vinyl-containing polymer.Yes.
  further,Amino groupIt is possible to add a water-soluble or water-dispersible cross-linking agent to the vinyl-containing polymer and apply it to a thermoplastic resin film, followed by post-crosslinking to introduce a cross-linked structure into the intermediate resin layer, which is a preferred method .
[0039]
  The water-soluble or water-dispersible crosslinking agent can be arbitrarily selected from those that can be dissolved or uniformly dispersed in an aqueous medium containing water or a water-soluble organic solvent, such as an epoxy compound, a blocked isocyanate compound, a polyol compound, and the like. Can be mentioned.
[0040]
  Commercially available compounds can also be used as crosslinking agents.The
  Examples of commercially available products include Denacol EX series (Nagase Kasei) as an epoxy compound, and Bernock D-500 (Dainippon Ink) as a blocked isocyanate compound.
[0041]
  In order to form an intermediate resin layer by coating on a film substrate made of a thermoplastic resin,Amino groupThe intermediate resin containing the vinyl-containing polymer as a main component is preferably used as a solution whose viscosity is adjusted in the range of 2,000 mPa · s or less, more preferably 1,000 mPa · s or less, particularly 10 to 500 mPa · s. It is preferable.
  If the solution is less than 10 mPa · s, the viscosity is too low, and dripping easily occurs when applied. If it exceeds 2,000 mPa · s, application at high speed becomes difficult.
[0042]
  The viscosity can be adjusted by adjusting an aqueous medium or an aqueous medium containing a water-soluble organic solvent, or using a viscosity improver.
[0043]
  Amino groupThe ratio of the solid content of the intermediate resin solution containing the vinyl-containing polymer as a main component may be arbitrarily set according to the viscosity adjustment.Yes.
  In application, the content is preferably 5% by mass or more, and if the solution concentration is less than 5% by mass, the drying step after application becomes longer, which is not preferable.
[0044]
  <Adhesive>
  In the skin patch sheet of this invention, an intermediate resin layer is formed on one surface of a film substrate made of a thermoplastic resin, and then the upper surface of the intermediate resin layer is formed.Sodium polyacrylate polymerIt is manufactured by applying an adhesive mainly composed of
[0045]
  The pressure-sensitive adhesive mainly composed of this sodium polyacrylate polymerVarious drugs are added depending on the purpose.The
  Furthermore, a water-impregnated gel-like material which is insolubilized with a crosslinking agent or the like by adding a humectant and an inorganic filler as required is used as an adhesive.
[0046]
  As the drug, for example, methyl salicylate, L-menthol, camphor, mint oil, thymol, diphenhydrane, chlorferamine maleate and the like are generally used in combination depending on the purpose.
[0047]
  Examples of the humectant include glycerin, propylene glycol, and sorbitol. Examples of the inorganic filler include kaolin, titanium oxide, and calcium carbonate.
  Moreover, viscosity modifiers such as polybutene and polyisobutylene can be used in combination.
[0048]
  Examples of the crosslinking agent include aldehydes and ketones such as acetaldehyde, glutaraldehyde, glyoxal, dialdehyde starch, and dimethyl ketone.The
  further,Examples include basic aluminum salts such as dihydroxyaluminum aminoacetate and inorganic compounds such as aluminum chloride, aluminum sulfate, aluminum nitrate, aluminum hydroxide, and potassium alum.
[0049]
  <Preparation of film substrate and skin patch sheet>
  In the present invention, a film made of a thermoplastic resin is used as the film substrate.
  This film is obtained by processing a thermoplastic resin into a sheet by calendering, T-die extrusion, inflation, casting, pressing, or the like, and may further be processed into a film by uniaxial stretching or biaxial stretching.
[0050]
  Examples of the thermoplastic resin include polyethylene terephthalate resin, polyethylene resin, polypropylene resin, nylon resin, soft vinyl chloride resin, urethane resin, and acrylic resin.
  Olefinic films such as polyethylene resin and polypropylene resin are preferably subjected to surface treatment such as corona treatment because adhesion is improved.
  Moreover, in order to make peeling with an adhesive layer easy, what performed the mold release process by the silicone mold release agent etc. on the one side may be used.
[0051]
  As described aboveAmino groupThe intermediate resin solution containing the vinyl-containing polymer as a main component is applied to the film substrate with a roll coater, a knife coater, or the like, and then dried to form an intermediate resin layer.
[0052]
  In application, the film thickness may be adjusted by repeating application and drying several times as necessary.
  In some cases, different vinyl copolymers may be used to form multiple layers.
[0053]
  The film thickness after drying is adjusted to 50 μm to 1 mm, preferably 100 μm to 0.5 mm.
  If the film thickness after drying is less than 50 μm, the shape-retaining property of the pressure-sensitive adhesive layer after removing the film substrate is inferior, and if it exceeds 1 mm, the fit after applying to the skin is impaired.Will be.
[0054]
  When the intermediate resin contains a water-soluble or water-dispersible cross-linking agent, after being applied to the film substrate, post-crosslinking is performed by heating, and the cross-linked structure is introduced into the intermediate resin layer.
[0055]
  CrosslinkerAmino groupA cross-linked structure is introduced by a cross-linking reaction with a functional group in a vinyl-containing polymer and other water-soluble polymers.is there.
  thisBy introducing the crosslinked structure, the coating strength of the intermediate resin layer, the adhesion to the substrate, and the water resistance are improved.
[0056]
  Since the pressure-sensitive adhesive layer applied to the surface of the intermediate resin layer is a water-impregnated gel, an improvement in water resistance is particularly preferable because it improves the durability of the skin patch sheet.
[0057]
  In this invention, the film substrate surface on which the intermediate resin layer of the skin patch sheet is not applied exhibits adhesion to the adhesive.Absent.
  ThatTherefore, it is possible to roll up a long sheet, and it can be laminated in a roll shape or a paperboard shape, a release paper-free product that does not use a release paper can be obtained, and a thermoplastic that does not have an intermediate resin layer Of course, it is possible to further improve the releasability by pre-treating the resin film surface with a silicone release agent or the like in advance.
[0058]
[Action]
  This inventionofThe skin patch sheet is a film substrate made of a thermoplastic resin,Sodium polyacrylate polymerBy forming an intermediate resin layer between the pressure-sensitive adhesive layers, the skin adhesive sheet is affixed to the skin, and then the film base material is removed for use. Excellent skin patch sheet can be obtainedThe
  AlsoIn addition, an environment-friendly and environmentally friendly skin patch sheet that does not require release paper that becomes waste can be obtained, and a release paper-free product can be obtained.
[0059]
【Example】
  Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples.
  In the following examples, “part” represents “part by mass”.
  In addition, an aqueous solution product (hereinafter abbreviated as DAC) having a solid content of 75% by weight of 2- (trimethylammonio) ethyl acrylate chloride used in the examples is a commercially available product (manufactured by Toagosei Co., Ltd.). , N-dimethylaminomethacrylic acid dimethyl sulfate aqueous solution product having a solid content of 80% by weight (hereinafter abbreviated as DQS) is a commercially available Blemmer DQS (trademark manufactured by NOF Corporation), a radical polymerization agent is Azobisisobutyronitrile (hereinafter abbreviated as AIBN) was used.
[0060]
  <Example 1>
  [Contains amino groupPreparation of vinyl copolymer)
  60 parts methyl methacrylate
  15 parts ethyl acrylate
  Acrylamide 10 parts
  20 parts dimethylaminoethyl acrylate
  AIBN 0.8 parts
  200 parts of isopropyl alcohol
  Nitrogen gas was blown into the mixture, and the polymerization vessel was purged with nitrogen. Then, the liquid temperature was raised to 70 ° C., the liquid temperature was maintained at 70 to 80 ° C., and the mixture was cooled and polymerized after 3 hours. Ended.
  A pale yellow transparent liquid with a viscosity of 500 mPa · s at a temperature of 25 ° C.Contains amino groupA vinyl copolymer was obtained.
[0061]
  [Preparation of intermediate resin and application to film substrate]
  Obtained aboveContains amino groupIn order to adjust the viscosity of the vinyl copolymer solution to 100 mPa · s, an appropriate amount of ion-exchanged water is added, and the PET film is 150 g / m in terms of solid content.²And dried at a temperature of 110 ° C. for 1 minute.
[0062]
  (Preparation of adhesive)
  A pressure-sensitive adhesive, which is a water-impregnated gel material mainly composed of a sodium polyacrylate copolymer, was prepared with the following composition.
  The cross-linking agent was dihydroxyaluminum aminoacetate and a commercially available glycinal (trade name, manufactured by Kyowa Chemical Industry Co., Ltd.) was used.
  Sodium polyacrylate 8 parts
  Polyacrylic acid 2 parts
  Glycinal 0.3 parts
  30 parts glycerin
  1 part of L-menthol
  Methyl salicylate 1.4 parts
  57.3 parts of ion-exchanged water
[0063]
  [Production and evaluation results of skin patch sheet]
  Apply the adhesive prepared above to a PET film coated with an intermediate resin layer to a thickness of 500 μm,TheProduced.
  The skin patch sheet was cut into an appropriate size, and was applied to a human skin and pressure-bonded with the palm of the hand, and then only the PET film was peeled off while being attached to the skin.
  The intermediate resin layer was on the pressure-sensitive adhesive layer side, and did not migrate to the PET film surface.
  Further, the film was left attached to the skin, peeled off from the skin after 1 hour, and the adhesive residue was visually examined. As a result, no adhesive remained on the skin side and a good result was shown.
[0064]
  Furthermore, after packaging with an aluminum vapor deposition film and leaving it to stand at a temperature of 40 ° C. for 6 months, the same examination was performed, and the same good results as immediately after the production were obtained.
[0065]
  <Example 2>
  Obtained with the following prescriptionContains amino group200 g / m in terms of solid content on PET film using vinyl copolymer²A skin patch sheet was prepared in the same manner as in Example 1 except thatIt was.
  Also,A skin patch sheet was prepared by the same method as described in Example 1, and the film peeling and the adhesive residue were examined by the same method. As a result, it was good immediately after the preparation and after being left at a temperature of 40 ° C. for 6 months. Results were obtained.
  [Preparation of vinyl copolymer]
  50 parts isobutyl acrylate
  10 parts methyl methacrylate
  DQS 50 parts
  AIBN 0.8 parts
  Isopropyl alcohol 100 parts
  200 parts of ion exchange water
  A polymerization reaction was carried out in the same manner as in Example 1.
[0066]
  <Example 3>
  Obtained with the following prescriptionContains amino groupUsing vinyl polymer, 100 g / m in terms of solid content on PET film²A skin patch sheet was prepared in the same manner as in Example 1 except thatIt was.
  Also,A skin patch sheet was prepared by the same method as described in Example 1, and the film peeling and the adhesive residue were examined by the same method. As a result, it was good immediately after the preparation and after being left at a temperature of 40 ° C. for 6 months. Results were obtained.
  [Preparation of vinyl copolymer]
  60 parts methyl methacrylate
  10 parts ethyl acrylate
  Methacrylic acid 10 parts
  DQS 25 parts
  AIBN 0.5 part
  Isopropyl alcohol 100 parts
  200 parts of ion exchange water
  A polymerization reaction was carried out in the same manner as in Example 1.
[0067]
  <Example 4>
  Obtained in Example 2Contains amino groupUsing a resin solution obtained by blending 30 parts of a vinyl-based copolymer solution and a poval resin aqueous solution adjusted to 25% by mass with a composition of 70 parts, 100 g / m in terms of solid content on a PET film.²ApplyIt was.
  AlsoA skin patch sheet was prepared in the same manner as in Example 1, a skin patch sheet was prepared in exactly the same manner as described in Example 1, and film peeling and adhesive residue were examined in the same manner. However, good results were obtained immediately after the production and after being left at a temperature of 40 ° C. for 6 months.
  As the poval resin, Kuraray Poval PVA-217 (manufactured by Kuraray Co., Ltd.) was used.
[0068]
  <Example 5>
  Obtained in Example 3Contains amino groupAdd 10 parts by weight of Denacol EX314 (manufactured by Nagase Kasei Co., Ltd .; trademark) to 100 parts by weight of the vinyl copolymer and mix evenlyIt was.
  Then, it is 60 g / m in terms of solid content on the PET film.²A skin patch sheet was prepared by the same method as that described in Example 1 except that the film was applied, and the film was peeled off and the adhesive residue was examined by the same method. Even after being left for 6 months, good results were obtained.
[0069]
  <Example 6>
  [Rewind and evaluation results of skin patch sheet]
  The skin patch sheet obtained in Example 1 was used to wind up the adhesive surface on the PET film surface (back surface) to which the adhesive was not applied.
  After leaving at room temperature for a whole day and after rewinding, the PSA film was peeled off satisfactorily without any adhesive remaining on the back surface.
  Similarly, after leaving at 40 ° C. for 6 months, it was peeled off well, and it was confirmed that lamination was possible without release paper.
[0070]
  <Comparative Example 1>
  A pressure-sensitive adhesive similar to that of Example 1 was applied to a PET film having no intermediate resin layer in a thickness of 2 mm to produce a skin patch sheet.
  As in the examples, this skin patch sheet was cut into an appropriate size, and after being bonded to the human skin with the palm of the hand, the PET film was peeled off in a state of being stuck to the skin. It did not transfer to the PET film surface.
  Furthermore, when the adhesive layer was left on the skin and peeled off from the skin after 1 hour and an attempt was made to visually check the adhesive residue, the adhesive layer did not peel off the skin well because there was no intermediate resin layer.
[0071]
【The invention's effect】
  The skin patch sheet of this invention isSodium polyacrylate polymerOn the surface of the pressure-sensitive adhesive layer, which is a water-impregnated gel based onAmino groups that are soluble in water or water-soluble organic solvents or mixed solvents thereofBy applying an intermediate resin layer composed mainly of a vinyl-containing polymer, the film base material can be removed and used after being applied to the skin.The
  As a result, it has good breathability, excellent flexibility that fits the skin, and after use, the intermediate resin layer retains the cohesive strength of the adhesive, so the adhesive layer peels smoothly and smoothly from the skin. It is possibleThe
  AlsoIn addition, an excellent effect is obtained in that an environment-friendly skin patch sheet that does not require release paper that becomes dust is obtained.
[0072]
  Also, the skin patch sheet of the present inventionCan be laminated without release paperAfter sticking on the skin, remove the film base and useBecause you canThe air permeability can be kept good.

Claims (8)

A skin patch sheet comprising a film substrate made of a thermoplastic resin and a water-impregnated gel-like adhesive layer mainly composed of a sodium polyacrylate polymer,
Between the film substrate and the pressure-sensitive adhesive layer,
A skin patch sheet, characterized in that an intermediate resin layer composed mainly of an amino group-containing vinyl polymer soluble in water, a water-soluble organic solvent or a mixed solvent thereof is formed with a thickness of 50 μm to 1 mm. . The intermediate resin layer is
The skin patch sheet according to claim 1, wherein the skin patch sheet is formed from an amino group- containing vinyl polymer and a water-soluble or water-dispersible crosslinking agent. The amino group- containing vinyl polymer is
The skin patch sheet according to claim 1 or 2, which is a polymer having an average degree of polymerization of 50 to 10,000 . The intermediate resin layer is
The skin according to any one of claims 1 to 3 , wherein the skin is formed by application of a resin solution containing an amino group-containing vinyl polymer whose viscosity is adjusted to 2000 mPa · s or less as a main component. Affixed sheet. The amino group- containing vinyl polymer is
The skin patch sheet according to any one of claims 1 to 4, wherein the amino group-containing vinyl monomer is a constituent monomer. The amino group-containing vinyl monomer is
The skin patch sheet according to claim 5, which is an acrylamide monomer, an acrylic acid or methacrylic acid aminoalkyl ester monomer, or a vinyl monomer containing a morpholine ring. A skin patch sheet comprising a film base material comprising the thermoplastic resin according to claim 1, an intermediate resin layer and an adhesive layer,
A skin patch sheet characterized by being used by peeling and removing only a film substrate after being stuck on the skin as an adherend using the pressure-sensitive adhesive layer . A skin patch sheet comprising a film base material comprising the thermoplastic resin according to claim 1, an intermediate resin layer, and an adhesive layer,
In the case of paperboard, it is laminated without the adhesive layer being abutted.
A laminated body of a skin patch sheet characterized by.