JP2014144922A - Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 - Google Patents

Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 Download PDF

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JP2014144922A
JP2014144922A JP2013012868A JP2013012868A JP2014144922A JP 2014144922 A JP2014144922 A JP 2014144922A JP 2013012868 A JP2013012868 A JP 2013012868A JP 2013012868 A JP2013012868 A JP 2013012868A JP 2014144922 A JP2014144922 A JP 2014144922A
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compound
added
mmol
solution
etoac
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JP2014144922A5 (enExample
Inventor
Masaki Otawa
正樹 大多和
Satoshi Omura
智 大村
Toru Nagamitsu
亨 長光
Hiroshi Koda
洋 供田
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Kitasato Institute
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Kitasato Institute
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013012868A 2013-01-28 2013-01-28 Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体 Pending JP2014144922A (ja)

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JP2013012868A JP2014144922A (ja) 2013-01-28 2013-01-28 Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体

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JP2013012868A JP2014144922A (ja) 2013-01-28 2013-01-28 Ａｃａｔ２阻害活性を示すピリピロペンａ構造簡略型誘導体

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JP2014144922A5 JP2014144922A5 (enExample) 2016-06-09

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015198966A1 (ja) * 2014-06-24 2015-12-30 学校法人北里研究所 コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物
CN106032383A (zh) * 2015-03-19 2016-10-19 中国科学院上海药物研究所 一类三环类似物、其制备方法和用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08269065A (ja) * 1995-04-03 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269063A (ja) * 1995-03-28 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
WO2009081957A1 (ja) * 2007-12-25 2009-07-02 The Kitasato Institute Acat 2 阻害活性を有するピリピロペン誘導体
WO2010150739A1 (ja) * 2009-06-23 2010-12-29 学校法人北里研究所 Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体
WO2011122468A1 (ja) * 2010-03-31 2011-10-06 学校法人北里研究所 Ａｃａｔ２阻害活性を示す代謝酵素に安定なピリピロペン誘導体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08269063A (ja) * 1995-03-28 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
JPH08269065A (ja) * 1995-04-03 1996-10-15 Kitasato Inst:The ピリピロペン誘導体
WO2009081957A1 (ja) * 2007-12-25 2009-07-02 The Kitasato Institute Acat 2 阻害活性を有するピリピロペン誘導体
WO2010150739A1 (ja) * 2009-06-23 2010-12-29 学校法人北里研究所 Ａｃａｔ２阻害活性を示す水酸基含有ピリピロペン誘導体
WO2011122468A1 (ja) * 2010-03-31 2011-10-06 学校法人北里研究所 Ａｃａｔ２阻害活性を示す代謝酵素に安定なピリピロペン誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6016017815; 'Ｐｙｒｉｐｙｒｏｐｅｎｅ　Ａの新規低分子誘導体の合成研究' 第２９回メディシナルケミストリーシンポジウム　講演要旨集 , 2010, 第１００-１０１頁 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015198966A1 (ja) * 2014-06-24 2015-12-30 学校法人北里研究所 コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物
JP2016008191A (ja) * 2014-06-24 2016-01-18 学校法人北里研究所 コレステロールアシル転移酵素アイソザイム２（ａｃａｔ２）阻害活性を有する新規医薬化合物
EP3162805A4 (en) * 2014-06-24 2017-05-31 School Juridical Person Kitasato Institute Novel pharmaceutical compound having a cholesterol acyltransferase isozyme 2 (acat2) -inhibiting activity
US9896456B2 (en) 2014-06-24 2018-02-20 School Juridical Person Kitasato Institute Pharmaceutical compound having inhibitory activity against cholesterol acyltransferase isozyme 2 (ACAT2)
CN106032383A (zh) * 2015-03-19 2016-10-19 中国科学院上海药物研究所 一类三环类似物、其制备方法和用途
KR20170125970A (ko) * 2015-03-19 2017-11-15 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 삼환계 유사체, 이의 제조방법과 용도
EP3272755A4 (en) * 2015-03-19 2018-01-24 Shanghai Institute of Materia Medica, Chinese Academy of Sciences Class of tricyclic analogue, preparation method and use thereof
JP2018508560A (ja) * 2015-03-19 2018-03-29 中国科学院上海薬物研究所Ｓｈａｎｇｈａｉ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｍａｔｅｒｉａ Ｍｅｄｉｃａ， Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ Ｏｆ Ｓｃｉｅｎｃｅｓ 三環類似体、その製造方法及び使用
KR101975916B1 (ko) * 2015-03-19 2019-05-07 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 삼환계 유사체, 이의 제조방법과 용도
CN106032383B (zh) * 2015-03-19 2019-08-13 中国科学院上海药物研究所 一类三环类似物、其制备方法和用途

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