JP2014114296A5 - - Google Patents
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- Publication number
- JP2014114296A5 JP2014114296A5 JP2014006383A JP2014006383A JP2014114296A5 JP 2014114296 A5 JP2014114296 A5 JP 2014114296A5 JP 2014006383 A JP2014006383 A JP 2014006383A JP 2014006383 A JP2014006383 A JP 2014006383A JP 2014114296 A5 JP2014114296 A5 JP 2014114296A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- calcium
- modulator composition
- calcium modulator
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 28
- 229910052791 calcium Inorganic materials 0.000 claims 28
- 239000011575 calcium Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 18
- 210000002966 serum Anatomy 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000003982 Parathyroid hormone Human genes 0.000 claims 8
- 108090000445 Parathyroid hormone Proteins 0.000 claims 8
- 239000000199 parathyroid hormone Substances 0.000 claims 8
- 229960001319 parathyroid hormone Drugs 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 208000020084 Bone disease Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 206010008723 Chondrodystrophy Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 1
- 208000037848 Metastatic bone disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000002804 Osteochondritis Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 206010052306 Periprosthetic osteolysis Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000008919 achondroplasia Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000008416 bone turnover Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000002849 chondrocalcinosis Diseases 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000028198 tertiary hyperparathyroidism Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85959706P | 2006-11-16 | 2006-11-16 | |
| US60/859,597 | 2006-11-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Division JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014114296A JP2014114296A (ja) | 2014-06-26 |
| JP2014114296A5 true JP2014114296A5 (enExample) | 2015-02-26 |
Family
ID=39468623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Active JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
| JP2014006383A Pending JP2014114296A (ja) | 2006-11-16 | 2014-01-17 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Active JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8987200B2 (enExample) |
| EP (1) | EP2086321B1 (enExample) |
| JP (2) | JP5645408B2 (enExample) |
| KR (1) | KR101552843B1 (enExample) |
| CN (2) | CN101668421B (enExample) |
| AU (1) | AU2007325387B2 (enExample) |
| CA (1) | CA2669914C (enExample) |
| WO (1) | WO2008067199A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| JP5645408B2 (ja) | 2006-11-16 | 2014-12-24 | カイ ファーマシューティカルズ インコーポレーティッド | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
| US8067532B2 (en) * | 2007-01-19 | 2011-11-29 | Kai Pharmaceuticals, Inc. | Modifications of peptide compositions to increase stability and delivery efficiency |
| EP2459208B1 (en) * | 2009-07-29 | 2016-09-28 | Kai Pharmaceuticals, Inc. | Therapeutic agents for reducing parathyroid hormone levels |
| EP2449113B8 (en) * | 2010-07-30 | 2015-11-25 | CureVac AG | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| WO2012050673A1 (en) * | 2010-10-14 | 2012-04-19 | Wisconsin Alumni Research Foundation | Methods for the treatment of x-linked hypophosphatemia and related disorders |
| PT2717896T (pt) | 2011-06-08 | 2016-12-23 | Kai Pharmaceuticals Inc | Agentes terapêuticos para a regulação do fósforo sérico |
| MX355063B (es) | 2011-11-10 | 2018-04-04 | Kai Pharmaceuticals Inc | Calcimiméticos y métodos para su uso. |
| US9579273B2 (en) * | 2011-12-14 | 2017-02-28 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| PE20160549A1 (es) * | 2013-06-28 | 2016-06-15 | Amgen Inc | Formulacion liquida estable de etelcalcetida (amg 416) |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| CA2973883A1 (en) * | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| JP6993961B2 (ja) | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| EP3368062A4 (en) | 2015-10-30 | 2019-07-03 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| KR20180125979A (ko) | 2016-04-01 | 2018-11-26 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| JP7018933B2 (ja) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 気管気管支軟化症の治療方法 |
| US11624060B2 (en) | 2017-02-10 | 2023-04-11 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| KR20190129058A (ko) | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| CN107899019B (zh) * | 2017-11-23 | 2020-04-21 | 湘潭大学 | 一种键合细胞穿透肽的智能型高分子键合药及其制备方法 |
| WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| WO2020033867A2 (en) | 2018-08-10 | 2020-02-13 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| CN112349362B (zh) * | 2019-08-08 | 2025-06-20 | 深圳先进技术研究院 | 一种甲状旁腺激素分泌监测与调控系统 |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12611447B2 (en) | 2020-09-04 | 2026-04-28 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| AU2022218782B2 (en) | 2021-02-12 | 2026-06-25 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
| CN117295510A (zh) * | 2021-06-08 | 2023-12-26 | 北京拓界生物医药科技有限公司 | 一种钙敏感受体激动剂的组合物及其应用 |
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| US5869473A (en) | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
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| JP5645408B2 (ja) | 2006-11-16 | 2014-12-24 | カイ ファーマシューティカルズ インコーポレーティッド | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
| US8067532B2 (en) | 2007-01-19 | 2011-11-29 | Kai Pharmaceuticals, Inc. | Modifications of peptide compositions to increase stability and delivery efficiency |
| AU2008308679B2 (en) | 2007-10-02 | 2015-01-29 | Marina Biotech, Inc. | Lipopeptides for delivery of nucleic acids |
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| EP2459208B1 (en) | 2009-07-29 | 2016-09-28 | Kai Pharmaceuticals, Inc. | Therapeutic agents for reducing parathyroid hormone levels |
-
2007
- 2007-11-16 JP JP2009537400A patent/JP5645408B2/ja active Active
- 2007-11-16 KR KR1020097012356A patent/KR101552843B1/ko active Active
- 2007-11-16 AU AU2007325387A patent/AU2007325387B2/en active Active
- 2007-11-16 US US11/941,857 patent/US8987200B2/en active Active
- 2007-11-16 CA CA2669914A patent/CA2669914C/en active Active
- 2007-11-16 CN CN200780050006.8A patent/CN101668421B/zh active Active
- 2007-11-16 CN CN201410164043.3A patent/CN103961686A/zh active Pending
- 2007-11-16 WO PCT/US2007/085024 patent/WO2008067199A2/en not_active Ceased
- 2007-11-16 EP EP07871514.1A patent/EP2086321B1/en active Active
-
2014
- 2014-01-17 JP JP2014006383A patent/JP2014114296A/ja active Pending
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