JP2014114296A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014114296A5 JP2014114296A5 JP2014006383A JP2014006383A JP2014114296A5 JP 2014114296 A5 JP2014114296 A5 JP 2014114296A5 JP 2014006383 A JP2014006383 A JP 2014006383A JP 2014006383 A JP2014006383 A JP 2014006383A JP 2014114296 A5 JP2014114296 A5 JP 2014114296A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- calcium
- modulator composition
- calcium modulator
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 28
- 229910052791 calcium Inorganic materials 0.000 claims 28
- 239000011575 calcium Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 18
- 210000002966 serum Anatomy 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000003982 Parathyroid hormone Human genes 0.000 claims 8
- 108090000445 Parathyroid hormone Proteins 0.000 claims 8
- 239000000199 parathyroid hormone Substances 0.000 claims 8
- 229960001319 parathyroid hormone Drugs 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 208000020084 Bone disease Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 206010008723 Chondrodystrophy Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 1
- 208000037848 Metastatic bone disease Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000002804 Osteochondritis Diseases 0.000 claims 1
- 201000009859 Osteochondrosis Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 206010052306 Periprosthetic osteolysis Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000008919 achondroplasia Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000008416 bone turnover Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000002849 chondrocalcinosis Diseases 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000028198 tertiary hyperparathyroidism Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85959706P | 2006-11-16 | 2006-11-16 | |
| US60/859,597 | 2006-11-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Division JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014114296A JP2014114296A (ja) | 2014-06-26 |
| JP2014114296A5 true JP2014114296A5 (enExample) | 2015-02-26 |
Family
ID=39468623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Active JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
| JP2014006383A Pending JP2014114296A (ja) | 2006-11-16 | 2014-01-17 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537400A Active JP5645408B2 (ja) | 2006-11-16 | 2007-11-16 | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8987200B2 (enExample) |
| EP (1) | EP2086321B1 (enExample) |
| JP (2) | JP5645408B2 (enExample) |
| KR (1) | KR101552843B1 (enExample) |
| CN (2) | CN103961686A (enExample) |
| AU (1) | AU2007325387B2 (enExample) |
| CA (1) | CA2669914C (enExample) |
| WO (1) | WO2008067199A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE055861T2 (hu) | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez |
| CA2669914C (en) | 2006-11-16 | 2017-11-07 | Kai Pharmaceuticals, Inc. | Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders |
| CA2989778C (en) * | 2007-01-19 | 2020-06-30 | Kai Pharmaceuticals, Inc. | Method of modifying peptide compositions |
| JP5270799B2 (ja) | 2009-07-29 | 2013-08-21 | カイ・ファーマシューティカルズ・インコーポレイテッド | 副甲状腺ホルモンを低減する治療剤 |
| CA2801523C (en) * | 2010-07-30 | 2021-08-03 | Curevac Gmbh | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| WO2012050673A1 (en) * | 2010-10-14 | 2012-04-19 | Wisconsin Alumni Research Foundation | Methods for the treatment of x-linked hypophosphatemia and related disorders |
| CA2837445C (en) | 2011-06-08 | 2022-10-04 | Kai Pharmaceuticals, Inc. | Therapeutic agents for regulating serum phosphorus |
| CN109985228A (zh) | 2011-11-10 | 2019-07-09 | 凯伊药品公司 | 拟钙剂及其使用方法 |
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| CN114376970A (zh) * | 2013-06-28 | 2022-04-22 | 美国安进公司 | Etelcalcetide (AMG 416)的稳定的液体制剂 |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| CA2967851C (en) | 2014-12-05 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| US10603361B2 (en) * | 2015-01-28 | 2020-03-31 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| RU2745528C2 (ru) | 2015-08-17 | 2021-03-26 | Алексион Фармасьютикалз, Инк. | Производство щелочных фосфатаз |
| WO2017058822A1 (en) | 2015-09-28 | 2017-04-06 | Alexion Pharmaceuticals, Inc. | Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| EP3426286A4 (en) | 2016-03-08 | 2019-12-04 | Alexion Pharmaceuticals, Inc. | PROCESS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN |
| EP3436020A4 (en) | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS |
| JP7613826B2 (ja) | 2016-04-01 | 2025-01-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼによって筋力低下を治療すること |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| EP3500289B1 (en) | 2016-08-18 | 2024-10-09 | Alexion Pharmaceuticals, Inc. | Asfotase alfa for use in treating tracheobronchomalacia |
| WO2018148573A1 (en) | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| CA3057502A1 (en) | 2017-03-31 | 2018-10-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia (hpp) in adults and adolescents |
| CN107899019B (zh) * | 2017-11-23 | 2020-04-21 | 湘潭大学 | 一种键合细胞穿透肽的智能型高分子键合药及其制备方法 |
| JP2021519590A (ja) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 糖タンパク質の製造 |
| JP2021534111A (ja) | 2018-08-10 | 2021-12-09 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
| CN112349362B (zh) * | 2019-08-08 | 2025-06-20 | 深圳先进技术研究院 | 一种甲状旁腺激素分泌监测与调控系统 |
| US12433938B2 (en) | 2019-12-09 | 2025-10-07 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| AU2022218782A1 (en) | 2021-02-12 | 2023-08-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
| US20240269227A1 (en) * | 2021-06-08 | 2024-08-15 | Beijing Tuo Jie Biopharmaceutical Co. Ltd. | Calcium-sensing receptor agonist composition and application thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602116A (en) | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5869473A (en) | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| WO1992008476A1 (en) | 1990-11-07 | 1992-05-29 | The Scripps Research Institute | Peptides that inhibit platelet binding of adhesion molecules |
| US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| AU7634694A (en) * | 1993-08-20 | 1995-03-21 | University Of Medicine And Dentistry Of New Jersey | Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same |
| US5783405A (en) | 1994-02-01 | 1998-07-21 | Terrapin Technologies, Inc. | Rapid screening method for effectors of signal transduction |
| CA2145214A1 (en) | 1995-02-28 | 1996-08-29 | Rick E. Preddie | Agents for pre-symptomatic diagnosis, prevention and cure huntington's disease (hd) in humans |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5688489A (en) | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
| US5895368A (en) | 1996-09-23 | 1999-04-20 | Medisystems Technology Corporation | Blood set priming method and apparatus |
| US6165977A (en) | 1996-10-18 | 2000-12-26 | Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific activators of protein kinase C methods and compositions |
| US6258774B1 (en) | 1998-03-19 | 2001-07-10 | University Of Medicine And Dentistry Of New Jersey | Carrier for in vivo delivery of a therapeutic agent |
| JP2000336099A (ja) | 1999-05-27 | 2000-12-05 | Sekisui Chem Co Ltd | ペプチド及びｃ型肝炎抗体検出用試薬 |
| US6274169B1 (en) | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
| US6051567A (en) | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
| IL153378A0 (en) | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
| US20080249016A1 (en) | 2000-09-18 | 2008-10-09 | Sanos Bioscience A/S | Use of GLP-2 in a combination treatment for bone-related disorders |
| US20020168354A1 (en) | 2000-11-10 | 2002-11-14 | Daria Mochly-Rosen | psiepsilonRack peptide composition and method for protection against tissue damage due to ischemia |
| WO2002057413A2 (en) * | 2001-01-18 | 2002-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of delta pkc |
| AU2002240312A1 (en) | 2001-02-08 | 2002-08-19 | Pankaj Paranjp | Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents using polymer conjugates |
| US20030036627A1 (en) | 2001-02-16 | 2003-02-20 | Montelaro Ronald C. | Virus derived antimicrobial peptides |
| WO2002070547A1 (en) | 2001-02-23 | 2002-09-12 | Polyphor Ltd. | Template-fixed peptidomimetics with antimicrobial activity |
| JP2005287302A (ja) | 2002-04-03 | 2005-10-20 | Haruhiko Fujiwara | ポリペプチドの架橋方法 |
| US20040018976A1 (en) | 2002-05-14 | 2004-01-29 | Feder John N. | Polynucleotide encoding novel human G-protein coupled receptors, and splice variants thereof |
| WO2004093821A2 (en) * | 2003-04-22 | 2004-11-04 | Hawaii Biotech, Inc. | Treatment of anthrax infection using inhibitors of lethal factor protease activity |
| EP1680446B1 (en) | 2003-11-05 | 2007-10-31 | Pevion Biotech Ltd. | Compositions comprising melittin-derived peptides and methods for the potentiation of immune responses against target antigens |
| JP2007513974A (ja) * | 2003-12-11 | 2007-05-31 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | プロテインキナーゼｃのアイソザイム特異的アンタゴニスト |
| US7939634B2 (en) | 2004-01-27 | 2011-05-10 | Compugen Ltd. | Polynucleotides encoding polypeptides and methods using same |
| US7265092B2 (en) * | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| CA2621167A1 (en) | 2005-08-30 | 2007-03-08 | Acologix, Inc. | Regulation of mineral and skeletal metabolism |
| EP2194124A1 (en) * | 2005-09-19 | 2010-06-09 | Kai Pharmaceuticals, Inc. | Protein kinase c peptide modulators of angiogenesis |
| WO2007038172A2 (en) * | 2005-09-23 | 2007-04-05 | Nitto Denko Corporation | Guanidinium carriers |
| CA2669914C (en) | 2006-11-16 | 2017-11-07 | Kai Pharmaceuticals, Inc. | Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders |
| CA2989778C (en) | 2007-01-19 | 2020-06-30 | Kai Pharmaceuticals, Inc. | Method of modifying peptide compositions |
| JP5697450B2 (ja) | 2007-10-02 | 2015-04-08 | マリーナ バイオテック，インコーポレイテッド | 核酸の送達のためのリポペプチド |
| WO2009075773A2 (en) | 2007-12-07 | 2009-06-18 | Goldstein Steven A | Identification of toxin ligands |
| JP5270799B2 (ja) | 2009-07-29 | 2013-08-21 | カイ・ファーマシューティカルズ・インコーポレイテッド | 副甲状腺ホルモンを低減する治療剤 |
-
2007
- 2007-11-16 CA CA2669914A patent/CA2669914C/en active Active
- 2007-11-16 EP EP07871514.1A patent/EP2086321B1/en active Active
- 2007-11-16 JP JP2009537400A patent/JP5645408B2/ja active Active
- 2007-11-16 AU AU2007325387A patent/AU2007325387B2/en active Active
- 2007-11-16 KR KR1020097012356A patent/KR101552843B1/ko active Active
- 2007-11-16 CN CN201410164043.3A patent/CN103961686A/zh active Pending
- 2007-11-16 WO PCT/US2007/085024 patent/WO2008067199A2/en not_active Ceased
- 2007-11-16 US US11/941,857 patent/US8987200B2/en active Active
- 2007-11-16 CN CN200780050006.8A patent/CN101668421B/zh active Active
-
2014
- 2014-01-17 JP JP2014006383A patent/JP2014114296A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014114296A5 (enExample) | ||
| WO2009103105A3 (en) | Mimotopes of alpha-synuclein and vaccines thereof for the treatment of neurodegenerative disorders | |
| MY199638A (en) | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant | |
| WO2017020034A8 (en) | Use of c-type natriuretic peptide variants to treat skeletal dysplasia | |
| MX2012008998A (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX342291B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX340016B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| JP2015536991A5 (enExample) | ||
| JP2009273466A5 (enExample) | ||
| WO2015110957A3 (en) | Hybridosomes, compositions comprising the same, processes for their production and uses thereof | |
| WO2011014707A3 (en) | Therapeutic agents for reducing parathyroid hormone levels | |
| WO2008118017A3 (en) | Prame derived peptides and immunogenic compositions comprising these | |
| NZ628987A (en) | Extended recombinant polypeptides and compositions comprising same | |
| HRP20160798T1 (hr) | Rekombinantni antigeni iz rsv | |
| PE20142361A1 (es) | Peptidos terapeuticos | |
| PH12018502465A1 (en) | Mic-1 compounds and use thereof | |
| WO2010131922A3 (en) | Amide compound, preparation method thereof and pharmaceutical composition comprising same | |
| IN2012DN02861A (enExample) | ||
| MX2014004279A (es) | Composiciones que comprenden sulfato de salbutamol. | |
| JOP20210230A1 (ar) | صياغات صيدلانية | |
| WO2015114395A9 (en) | Process for the preparation of vortioxetine salts | |
| MX2015014513A (es) | Composicion que comprende sulfato de salbutamol. | |
| WO2015107363A3 (en) | Mycobacterial antigen composition | |
| WO2010128521A3 (en) | Short-chain peptides as parathyroid hormone (pth) receptor agonist | |
| WO2011011072A3 (en) | Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59 |