JP2014074021A5 - - Google Patents
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- Publication number
- JP2014074021A5 JP2014074021A5 JP2013189949A JP2013189949A JP2014074021A5 JP 2014074021 A5 JP2014074021 A5 JP 2014074021A5 JP 2013189949 A JP2013189949 A JP 2013189949A JP 2013189949 A JP2013189949 A JP 2013189949A JP 2014074021 A5 JP2014074021 A5 JP 2014074021A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- amino
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052736 halogen Inorganic materials 0.000 claims 36
- 150000002367 halogens Chemical class 0.000 claims 34
- 125000000753 cycloalkyl group Chemical group 0.000 claims 33
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000002950 monocyclic group Chemical group 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- -1 bicyclic aromatic hydrocarbon Chemical class 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 150000002825 nitriles Chemical class 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 239000004215 Carbon black (E152) Substances 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 229930195733 hydrocarbon Natural products 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- XRHKIJYUEWQSTI-UHFFFAOYSA-N 4-[(1-cyclopropyl-4-methylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound C12=CC=CC=C2C(C)=C(N(CC=2C=CC(OC(F)(F)F)=CC=2)S(=O)(=O)C=2C=CC(=CC=2)C(O)=O)N=C1C1CC1 XRHKIJYUEWQSTI-UHFFFAOYSA-N 0.000 claims 2
- MGBBEJWYTMWVHK-UHFFFAOYSA-N 4-[(1-methoxy-4-methylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound CC=1C2=CC=CC=C2C(OC)=NC=1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C=C1 MGBBEJWYTMWVHK-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- TXMQIHYKAVMTEJ-UHFFFAOYSA-N 4-[(1,1-dimethyl-2,3-dihydroinden-5-yl)methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2C(C(CC2)(C)C)=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 TXMQIHYKAVMTEJ-UHFFFAOYSA-N 0.000 claims 1
- AAENMKAJIMWPPB-UHFFFAOYSA-N 4-[(1,4-dimethylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound CC=1C2=CC=CC=C2C(C)=NC=1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C=C1 AAENMKAJIMWPPB-UHFFFAOYSA-N 0.000 claims 1
- SHCCVBRTRWJHRO-UHFFFAOYSA-N 4-[(2,2-dimethyl-1,3-dihydroinden-5-yl)methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2CC(C)(C)CC2=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 SHCCVBRTRWJHRO-UHFFFAOYSA-N 0.000 claims 1
- GVOVGKUDPJTPBF-UHFFFAOYSA-N 4-[(3,3-dimethyl-2h-1-benzofuran-6-yl)methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2C(C(CO2)(C)C)=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 GVOVGKUDPJTPBF-UHFFFAOYSA-N 0.000 claims 1
- KRIIBQONOJTIAK-UHFFFAOYSA-N 4-[(3-methylquinolin-2-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound CC1=CC2=CC=CC=C2N=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C=C1 KRIIBQONOJTIAK-UHFFFAOYSA-N 0.000 claims 1
- GMWTTYHRMXYYDL-UHFFFAOYSA-N 4-[(4-chloroisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)Cl)CC1=CC=C(OC(F)(F)F)C=C1 GMWTTYHRMXYYDL-UHFFFAOYSA-N 0.000 claims 1
- RLONLJJPXIVWOF-UHFFFAOYSA-N 4-[(4-cyclopropylisoquinolin-3-yl)-[5-(trifluoromethoxy)-2,3-dihydro-1h-inden-1-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C1CC1)C1C2=CC=C(OC(F)(F)F)C=C2CC1 RLONLJJPXIVWOF-UHFFFAOYSA-N 0.000 claims 1
- CWEFDWIKLABKBX-UHFFFAOYSA-N 4-[(4-cyclopropylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C1CC1)CC1=CC=C(OC(F)(F)F)C=C1 CWEFDWIKLABKBX-UHFFFAOYSA-N 0.000 claims 1
- OHLJJJUHLATDOU-UHFFFAOYSA-N 4-[(4-cyclopropylisoquinolin-3-yl)-[[5-(trifluoromethyl)pyridin-2-yl]methyl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C1CC1)CC1=CC=C(C(F)(F)F)C=N1 OHLJJJUHLATDOU-UHFFFAOYSA-N 0.000 claims 1
- MHTJVQCBCQAXGP-UHFFFAOYSA-N 4-[(4-methyl-1-propan-2-ylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound CC=1C2=CC=CC=C2C(C(C)C)=NC=1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C=C1 MHTJVQCBCQAXGP-UHFFFAOYSA-N 0.000 claims 1
- NUNSQYXIXZGBEL-UHFFFAOYSA-N 4-[(4-methylisoquinolin-3-yl)-(5,6,7,8-tetrahydronaphthalen-2-ylmethyl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2CCCCC2=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 NUNSQYXIXZGBEL-UHFFFAOYSA-N 0.000 claims 1
- XLPMQQKRVFPCJR-UHFFFAOYSA-N 4-[(4-methylisoquinolin-3-yl)-(naphthalen-2-ylmethyl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2C=CC=CC2=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 XLPMQQKRVFPCJR-UHFFFAOYSA-N 0.000 claims 1
- PEWGGUSEAWMCQM-UHFFFAOYSA-N 4-[(4-methylisoquinolin-3-yl)-[[4-(1,1,1-trifluoro-2-methoxypropan-2-yl)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(C)(OC)C(F)(F)F)=CC=C1CN(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)C1=NC=C(C=CC=C2)C2=C1C PEWGGUSEAWMCQM-UHFFFAOYSA-N 0.000 claims 1
- ZNECSAYKPKIUOE-UHFFFAOYSA-N 4-[(4-methylisoquinolin-3-yl)-[[4-(trifluoromethoxy)phenyl]methyl]sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C=C1 ZNECSAYKPKIUOE-UHFFFAOYSA-N 0.000 claims 1
- XOBJCXKPQUTTAF-UHFFFAOYSA-N 4-[(4-tert-butylphenyl)methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(C(C)(C)C)C=C1 XOBJCXKPQUTTAF-UHFFFAOYSA-N 0.000 claims 1
- XZKIPACFKFFKPZ-UHFFFAOYSA-N 4-[2,3-dihydro-1h-inden-5-ylmethyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(CC=1C=C2CCCC2=CC=1)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 XZKIPACFKFFKPZ-UHFFFAOYSA-N 0.000 claims 1
- OWRMBNVULAPTPT-UHFFFAOYSA-N 4-[[3-chloro-4-[cyclopropyl(difluoro)methyl]phenyl]methyl-(1-cyclopropyl-4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound C12=CC=CC=C2C(C)=C(N(CC=2C=C(Cl)C(=CC=2)C(F)(F)C2CC2)S(=O)(=O)C=2C=CC(=CC=2)C(O)=O)N=C1C1CC1 OWRMBNVULAPTPT-UHFFFAOYSA-N 0.000 claims 1
- YTKKSRSSZSDMOY-UHFFFAOYSA-N 4-[[3-chloro-4-[cyclopropyl(difluoro)methyl]phenyl]methyl-(4-cyclopropylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C1CC1)CC1=CC=C(C(F)(F)C2CC2)C(Cl)=C1 YTKKSRSSZSDMOY-UHFFFAOYSA-N 0.000 claims 1
- RWDVLHZFVUVTNK-UHFFFAOYSA-N 4-[[3-chloro-4-[cyclopropyl(difluoro)methyl]phenyl]methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC(C=C1Cl)=CC=C1C(F)(F)C1CC1 RWDVLHZFVUVTNK-UHFFFAOYSA-N 0.000 claims 1
- FFOJCNQKILAZRM-UHFFFAOYSA-N 4-[[3-chloro-4-[cyclopropyl(difluoro)methyl]phenyl]methyl-[4-(trifluoromethyl)isoquinolin-3-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C(F)(F)F)CC1=CC=C(C(F)(F)C2CC2)C(Cl)=C1 FFOJCNQKILAZRM-UHFFFAOYSA-N 0.000 claims 1
- VHGDIDGTJQMZOX-UHFFFAOYSA-N 4-[[3-fluoro-4-(trifluoromethoxy)phenyl]methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(OC(F)(F)F)C(F)=C1 VHGDIDGTJQMZOX-UHFFFAOYSA-N 0.000 claims 1
- BAYKRNPYZMXCFX-UHFFFAOYSA-N 4-[[4-(2-ethoxy-1,1,1-trifluoropropan-2-yl)phenyl]methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound C1=CC(C(C)(OCC)C(F)(F)F)=CC=C1CN(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)C1=NC=C(C=CC=C2)C2=C1C BAYKRNPYZMXCFX-UHFFFAOYSA-N 0.000 claims 1
- OKIIEJGMUVNCQY-UHFFFAOYSA-N 4-[[4-(trifluoromethoxy)phenyl]methyl-[4-(trifluoromethyl)isoquinolin-3-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C(F)(F)F)CC1=CC=C(OC(F)(F)F)C=C1 OKIIEJGMUVNCQY-UHFFFAOYSA-N 0.000 claims 1
- SZDZFJKNRBAWKN-UHFFFAOYSA-N 4-[[4-[cyclopropyl(difluoro)methyl]-3-fluorophenyl]methyl-(4-cyclopropylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C1CC1)CC1=CC=C(C(F)(F)C2CC2)C(F)=C1 SZDZFJKNRBAWKN-UHFFFAOYSA-N 0.000 claims 1
- WBOQRYAJUUACNW-UHFFFAOYSA-N 4-[[4-[cyclopropyl(difluoro)methyl]-3-fluorophenyl]methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC(C=C1F)=CC=C1C(F)(F)C1CC1 WBOQRYAJUUACNW-UHFFFAOYSA-N 0.000 claims 1
- VISXOMCJLWRFBN-UHFFFAOYSA-N 4-[[4-[cyclopropyl(difluoro)methyl]-3-fluorophenyl]methyl-[4-(trifluoromethyl)isoquinolin-3-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1S(=O)(=O)N(C=1C(=C2C=CC=CC2=CN=1)C(F)(F)F)CC1=CC=C(C(F)(F)C2CC2)C(F)=C1 VISXOMCJLWRFBN-UHFFFAOYSA-N 0.000 claims 1
- YAKQACNXAFHVPS-UHFFFAOYSA-N 4-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl-(3-methylquinolin-2-yl)sulfamoyl]benzoic acid Chemical compound CC1=CC2=CC=CC=C2N=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(F)C(C(F)(F)F)=C1 YAKQACNXAFHVPS-UHFFFAOYSA-N 0.000 claims 1
- MZDYCZCRBQEULX-UHFFFAOYSA-N 4-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl-(4-methylisoquinolin-3-yl)sulfamoyl]benzoic acid Chemical compound N1=CC2=CC=CC=C2C(C)=C1N(S(=O)(=O)C=1C=CC(=CC=1)C(O)=O)CC1=CC=C(F)C(C(F)(F)F)=C1 MZDYCZCRBQEULX-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 229940125901 TRPM8 blocker Drugs 0.000 claims 1
- 208000012931 Urologic disease Diseases 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000005338 substituted cycloalkoxy group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000014001 urinary system disease Diseases 0.000 claims 1
- 0 Cc1c(cccc2)c2nc(C)c1* Chemical compound Cc1c(cccc2)c2nc(C)c1* 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013189949A JP5985453B2 (ja) | 2012-09-14 | 2013-09-13 | 医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012203125 | 2012-09-14 | ||
| JP2012203125 | 2012-09-14 | ||
| JP2013189949A JP5985453B2 (ja) | 2012-09-14 | 2013-09-13 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014074021A JP2014074021A (ja) | 2014-04-24 |
| JP2014074021A5 true JP2014074021A5 (enExample) | 2015-11-19 |
| JP5985453B2 JP5985453B2 (ja) | 2016-09-06 |
Family
ID=50748469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013189949A Active JP5985453B2 (ja) | 2012-09-14 | 2013-09-13 | 医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5985453B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014042238A1 (ja) * | 2012-09-14 | 2014-03-20 | 田辺三菱製薬株式会社 | スルホンアミド化合物 |
| CA3022808A1 (en) * | 2016-06-13 | 2017-12-21 | Mitsubishi Tanabe Pharma Corporation | Compositions for treating or preventing vasomotor symptoms |
| JPWO2018117166A1 (ja) * | 2016-12-21 | 2019-10-31 | キッセイ薬品工業株式会社 | チアゾール誘導体、またはその薬理学的に許容される塩 |
| MX2020006468A (es) * | 2017-12-19 | 2021-01-08 | Mitsubishi Tanabe Pharma Corp | Composiciones y metodos para el tratamiento o prevencion de sintomas vasomotores. |
| US20260108507A1 (en) * | 2024-10-23 | 2026-04-23 | Kallyope, Inc. | Compositions for treating or preventing pain |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8790401A1 (es) * | 2007-07-18 | 2009-03-31 | Janssen Pharmaceutica Nv | Sulfonamidas como moduladores de trpm8 |
| WO2010010435A2 (en) * | 2008-07-22 | 2010-01-28 | Glenmark Pharmaceutical S.A. | Fused oxazole and thiazole derivatives as trpms modulators |
| CN102427810A (zh) * | 2009-05-01 | 2012-04-25 | 拉夸里亚创药株式会社 | 作为trpm8拮抗剂的氨磺酰基苯甲酸衍生物 |
| TW201103941A (en) * | 2009-06-10 | 2011-02-01 | Janssen Pharmaceutica Nv | Benzimidazole derivatives useful as TRPM8 channel modulators |
| RU2563030C2 (ru) * | 2011-03-16 | 2015-09-20 | Мицубиси Танабе Фарма Корпорейшн | Сульфонамидные соединения, обладающие антагонистической активностью в отношении trpm8 |
-
2013
- 2013-09-13 JP JP2013189949A patent/JP5985453B2/ja active Active
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