JP2014005231A5 - - Google Patents
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- JP2014005231A5 JP2014005231A5 JP2012141488A JP2012141488A JP2014005231A5 JP 2014005231 A5 JP2014005231 A5 JP 2014005231A5 JP 2012141488 A JP2012141488 A JP 2012141488A JP 2012141488 A JP2012141488 A JP 2012141488A JP 2014005231 A5 JP2014005231 A5 JP 2014005231A5
- Authority
- JP
- Japan
- Prior art keywords
- biological material
- solution
- fructose
- clarification
- clearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012141488A JP5967528B2 (ja) | 2012-06-22 | 2012-06-22 | 生物材料を透明化する方法および生物材料用透明化処理キット |
| US14/408,647 US9933342B2 (en) | 2012-06-22 | 2013-06-21 | Method for rendering biological material transparent and processing kit for rendering biological material transparent |
| EP13806589.1A EP2866017B1 (en) | 2012-06-22 | 2013-06-21 | Method for rendering biological material transparent |
| PCT/JP2013/067085 WO2013191274A1 (ja) | 2012-06-22 | 2013-06-21 | 生物材料を透明化する方法および生物材料用透明化処理キット |
| US15/901,618 US10883903B2 (en) | 2012-06-22 | 2018-02-21 | Method for rendering biological material transparent and processing kit for rendering biological material transparent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012141488A JP5967528B2 (ja) | 2012-06-22 | 2012-06-22 | 生物材料を透明化する方法および生物材料用透明化処理キット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014005231A JP2014005231A (ja) | 2014-01-16 |
| JP2014005231A5 true JP2014005231A5 (https=) | 2015-06-25 |
| JP5967528B2 JP5967528B2 (ja) | 2016-08-10 |
Family
ID=49768865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012141488A Expired - Fee Related JP5967528B2 (ja) | 2012-06-22 | 2012-06-22 | 生物材料を透明化する方法および生物材料用透明化処理キット |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9933342B2 (https=) |
| EP (1) | EP2866017B1 (https=) |
| JP (1) | JP5967528B2 (https=) |
| WO (1) | WO2013191274A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2711682B1 (en) | 2011-05-20 | 2019-07-10 | Riken | Clarifying reagent for biological materials and use thereof |
| KR102148747B1 (ko) | 2012-08-09 | 2020-08-27 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 현미경적 분석을 위한 생물학적 표본을 준비하기 위한 방법과 조성물 |
| EP3108218A4 (en) | 2014-02-21 | 2017-11-15 | Massachusetts Institute Of Technology | Expansion microscopy |
| CN106164736A (zh) | 2014-05-30 | 2016-11-23 | 斯坦福大学托管董事会 | 用于对大的完整组织样品进行成像的方法及装置 |
| CN106662511B (zh) * | 2014-07-07 | 2020-05-22 | 林志勇 | 组织透明溶液及其应用 |
| JP6687949B2 (ja) * | 2015-01-20 | 2020-04-28 | 国立研究開発法人理化学研究所 | 生物材料用透明化試薬、システム及びその利用 |
| JP6781421B2 (ja) * | 2015-03-18 | 2020-11-04 | 国立研究開発法人理化学研究所 | 生物材料の観察方法および透明化方法 |
| US10059990B2 (en) | 2015-04-14 | 2018-08-28 | Massachusetts Institute Of Technology | In situ nucleic acid sequencing of expanded biological samples |
| US11408890B2 (en) | 2015-04-14 | 2022-08-09 | Massachusetts Institute Of Technology | Iterative expansion microscopy |
| US10526649B2 (en) | 2015-04-14 | 2020-01-07 | Massachusetts Institute Of Technology | Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information |
| EP3332258B1 (en) | 2015-08-07 | 2020-01-01 | Massachusetts Institute of Technology | Protein retention expansion microscopy |
| US10364457B2 (en) | 2015-08-07 | 2019-07-30 | Massachusetts Institute Of Technology | Nanoscale imaging of proteins and nucleic acids via expansion microscopy |
| WO2017093323A1 (en) * | 2015-12-01 | 2017-06-08 | Universität Duisburg-Essen | Non-hazardous optical clearing of biological samples |
| JP6601842B2 (ja) * | 2015-12-17 | 2019-11-06 | 国立大学法人名古屋大学 | 植物組織透明化剤 |
| WO2017139501A1 (en) | 2016-02-10 | 2017-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | Rna fixation and detection in clarity-based hydrogel tissue |
| EP3450953B1 (en) * | 2016-04-28 | 2025-11-19 | Riken | Composition for preparing biological material having excellent light transmissivity and use of composition |
| KR20190038474A (ko) | 2016-08-10 | 2019-04-08 | 가부시키가이샤 시세이도 | 투명 피부 시료 |
| JP2018044800A (ja) * | 2016-09-13 | 2018-03-22 | 国立大学法人 東京大学 | 生物試料の透明化方法 |
| CN106769298B (zh) * | 2016-12-12 | 2019-04-16 | 中国科学院植物研究所 | 一种植物组织的显微观察方法 |
| CN106901865B (zh) * | 2017-01-06 | 2019-10-01 | 华中科技大学 | 一种颅骨光透明处理方法及其应用 |
| WO2018136856A1 (en) | 2017-01-23 | 2018-07-26 | Massachusetts Institute Of Technology | Multiplexed signal amplified fish via splinted ligation amplification and sequencing |
| CN107069391B (zh) * | 2017-02-10 | 2020-07-17 | 北京大学 | 飞秒脉冲激光调制器及具有其的微型双光子显微成像装置 |
| WO2018157074A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for diagnosing neoplastic lesions |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| CN107132101B (zh) * | 2017-03-28 | 2019-10-11 | 中国科学院深圳先进技术研究院 | 一种组织光透明剂及其制备方法和应用 |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| WO2019156957A1 (en) | 2018-02-06 | 2019-08-15 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2020013833A1 (en) | 2018-07-13 | 2020-01-16 | Massachusetts Institute Of Technology | Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm) |
| CA3130889A1 (en) | 2019-02-22 | 2020-08-27 | Massachusetts Institute Of Technology | Iterative direct expansion microscopy |
| US12265004B2 (en) | 2019-11-05 | 2025-04-01 | Massachusetts Institute Of Technology | Membrane probes for expansion microscopy |
| US11802822B2 (en) | 2019-12-05 | 2023-10-31 | Massachusetts Institute Of Technology | Multiplexed expansion (MultiExM) pathology |
| US12275920B2 (en) | 2020-06-28 | 2025-04-15 | Sunghee Lee Dimauro | Compositions and methods for clarification of biological materials |
| ES3024711T3 (en) * | 2020-12-17 | 2025-06-05 | Quader Diagnostik Gmbh | Method for optically clarifying a tissue sample with an embedding medium |
| US20240167922A1 (en) | 2021-03-12 | 2024-05-23 | Kyoto University | Transparentizing reagent and transparentizing method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3883365A (en) * | 1972-01-04 | 1975-05-13 | Suomen Sokeri Oy | PH adjustment in fructose crystallization for increased yield |
| JPH0774121B2 (ja) | 1992-09-01 | 1995-08-09 | 哲 濱田 | 生物体の内部透視が可能な標本製造方法 |
| US6232092B1 (en) * | 1998-10-02 | 2001-05-15 | Rogers Imaging Corporation | Method for preparing biological specimens for visual analysis |
| US6472216B1 (en) | 2001-07-24 | 2002-10-29 | Ann-Shyn Chiang | Aqueous tissue clearing solution |
| US6703242B1 (en) * | 2002-01-02 | 2004-03-09 | Vladimir V. Senatorov | Dark-field microscopy visualization of unstained axonal pathways using oil of wintergreen |
| US8189737B2 (en) | 2006-01-26 | 2012-05-29 | The Board Of Regents, The University Of Texas System, A Texas Institution Of Higher Learning | Process and apparatus for microCT imaging of ex vivo specimens |
| JP5388090B2 (ja) | 2008-05-29 | 2014-01-15 | 国立大学法人東北大学 | 強膜透明化による角膜移植材料調製方法 |
| CN102859344A (zh) * | 2010-03-12 | 2013-01-02 | 独立行政法人理化学研究所 | 用于生物材料的澄清试剂和其用途 |
| JP2012141488A (ja) | 2011-01-05 | 2012-07-26 | Smk Corp | 反強誘電性液晶素子 |
-
2012
- 2012-06-22 JP JP2012141488A patent/JP5967528B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-21 WO PCT/JP2013/067085 patent/WO2013191274A1/ja not_active Ceased
- 2013-06-21 US US14/408,647 patent/US9933342B2/en active Active
- 2013-06-21 EP EP13806589.1A patent/EP2866017B1/en not_active Not-in-force
-
2018
- 2018-02-21 US US15/901,618 patent/US10883903B2/en active Active
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