JP2013545820A5 - - Google Patents
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- Publication number
- JP2013545820A5 JP2013545820A5 JP2013544824A JP2013544824A JP2013545820A5 JP 2013545820 A5 JP2013545820 A5 JP 2013545820A5 JP 2013544824 A JP2013544824 A JP 2013544824A JP 2013544824 A JP2013544824 A JP 2013544824A JP 2013545820 A5 JP2013545820 A5 JP 2013545820A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- occurrence
- alkyl
- phosphonoxy
- phosphono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 phosphonoxy Chemical group 0.000 claims 133
- 125000000623 heterocyclic group Chemical group 0.000 claims 64
- 125000004093 cyano group Chemical group *C#N 0.000 claims 56
- 229910052736 halogen Inorganic materials 0.000 claims 56
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 56
- 150000002367 halogens Chemical class 0.000 claims 55
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 48
- 125000001424 substituent group Chemical group 0.000 claims 40
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 38
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 36
- 125000004043 oxo group Chemical group O=* 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 34
- 125000004429 atom Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 125000004452 carbocyclyl group Chemical group 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 9
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 8
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 1
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000232 haloalkynyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 CC(*1)=Nc2c1ccc(C)c2 Chemical compound CC(*1)=Nc2c1ccc(C)c2 0.000 description 14
- LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1cnc(C)[nH]1 Chemical compound Cc1cnc(C)[nH]1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 3
- BMCNOECRVMTSHG-TWGQIWQCSA-N CCC(CI)N/C=C(/C(C)C)\N Chemical compound CCC(CI)N/C=C(/C(C)C)\N BMCNOECRVMTSHG-TWGQIWQCSA-N 0.000 description 1
- SEDSLMWYUQACGR-UHFFFAOYSA-N Cc1nc(I)c[nH]1 Chemical compound Cc1nc(I)c[nH]1 SEDSLMWYUQACGR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42390010P | 2010-12-16 | 2010-12-16 | |
| US61/423,900 | 2010-12-16 | ||
| PCT/US2011/065486 WO2012083164A1 (en) | 2010-12-16 | 2011-12-16 | Anti-viral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013545820A JP2013545820A (ja) | 2013-12-26 |
| JP2013545820A5 true JP2013545820A5 (cg-RX-API-DMAC7.html) | 2015-02-12 |
Family
ID=45478542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544824A Pending JP2013545820A (ja) | 2010-12-16 | 2011-12-16 | 抗ウイルス性化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20120115918A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2651924A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013545820A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103384664A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2821973A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2013006828A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012083164A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505540C2 (ru) | 2008-12-23 | 2014-01-27 | Эббви Инк. | Антивирусные соединения |
| WO2010075380A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| WO2010120935A1 (en) * | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CN102863428B (zh) | 2011-07-09 | 2014-12-24 | 广东东阳光药业有限公司 | 作为丙型肝炎病毒抑制剂的螺环化合物 |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| US9802949B2 (en) | 2012-11-29 | 2017-10-31 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof |
| TWI585082B (zh) | 2012-11-29 | 2017-06-01 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途 |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
| EP3043803B1 (en) | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| US9738629B2 (en) | 2014-01-23 | 2017-08-22 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as Hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| WO2010096777A1 (en) * | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| US8796466B2 (en) * | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010120935A1 (en) * | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| US8138215B2 (en) * | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2454254A2 (en) * | 2009-07-16 | 2012-05-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of flavivirus infections |
-
2011
- 2011-12-16 CA CA2821973A patent/CA2821973A1/en not_active Abandoned
- 2011-12-16 CN CN2011800677647A patent/CN103384664A/zh active Pending
- 2011-12-16 JP JP2013544824A patent/JP2013545820A/ja active Pending
- 2011-12-16 EP EP11808486.2A patent/EP2651924A1/en not_active Withdrawn
- 2011-12-16 WO PCT/US2011/065486 patent/WO2012083164A1/en not_active Ceased
- 2011-12-16 US US13/328,767 patent/US20120115918A1/en not_active Abandoned
- 2011-12-16 MX MX2013006828A patent/MX2013006828A/es not_active Application Discontinuation
-
2013
- 2013-11-22 US US14/087,480 patent/US20140155382A1/en not_active Abandoned