JP2013545802A - 経口投与用の選択的第Ｘａ因子阻害剤の医薬組成物 - Google Patents

経口投与用の選択的第Ｘａ因子阻害剤の医薬組成物 Download PDF

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Publication number
JP2013545802A
JP2013545802A JP2013544467A JP2013544467A JP2013545802A JP 2013545802 A JP2013545802 A JP 2013545802A JP 2013544467 A JP2013544467 A JP 2013544467A JP 2013544467 A JP2013544467 A JP 2013544467A JP 2013545802 A JP2013545802 A JP 2013545802A
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Japan
Prior art keywords
pharmaceutical composition
inhibitor
dosage form
selective factor
pharmaceutically acceptable
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Pending
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JP2013544467A
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English (en)
Japanese (ja)
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JP2013545802A5 (enExample
Inventor
レナード，トーマス・ダブリュー
コフラン，デイヴィッド・シー
カレン，アラン
Original Assignee
メリオン・リサーチ・Ｉｉｉ・リミテッド
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Application filed by メリオン・リサーチ・Ｉｉｉ・リミテッド filed Critical メリオン・リサーチ・Ｉｉｉ・リミテッド
Publication of JP2013545802A publication Critical patent/JP2013545802A/ja
Publication of JP2013545802A5 publication Critical patent/JP2013545802A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013544467A 2010-12-15 2011-09-23 経口投与用の選択的第Ｘａ因子阻害剤の医薬組成物 Pending JP2013545802A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42326110P 2010-12-15 2010-12-15
US61/423,261 2010-12-15
PCT/US2011/052963 WO2012082209A1 (en) 2010-12-15 2011-09-23 Pharmaceutical compositions of selective factor xa inhibitors for oral administration

Publications (2)

Publication Number Publication Date
JP2013545802A true JP2013545802A (ja) 2013-12-26
JP2013545802A5 JP2013545802A5 (enExample) 2014-10-30

Family

ID=46234738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013544467A Pending JP2013545802A (ja) 2010-12-15 2011-09-23 経口投与用の選択的第Ｘａ因子阻害剤の医薬組成物

Country Status (10)

Country Link
US (1) US20120156294A1 (enExample)
EP (1) EP2651395A4 (enExample)
JP (1) JP2013545802A (enExample)
KR (1) KR20140046395A (enExample)
CN (1) CN103370051A (enExample)
AU (1) AU2011341637A1 (enExample)
BR (1) BR112013014940A2 (enExample)
CA (1) CA2819108A1 (enExample)
MX (1) MX2013006877A (enExample)
WO (1) WO2012082209A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
JP2014501784A (ja) 2011-01-07 2014-01-23 メリオン・リサーチ・Ｉｉｉ・リミテッド 経口投与用の鉄の医薬組成物
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
CN108148102A (zh) * 2016-12-03 2018-06-12 烟台东诚药业集团股份有限公司 喷雾干燥法制备低水分磺达肝癸钠原料药
KR20190130411A (ko) 2018-05-14 2019-11-22 신일제약주식회사 아픽사반 약제학적 제제 및 그의 제조방법
US12213972B2 (en) * 2022-07-27 2025-02-04 Slayback Pharma Llc Stable pharmaceutical compositions of apixaban

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537321A (ja) * 1999-02-22 2002-11-05 エラン コーポレイション ピーエルスィー 促進剤を含む固体経口剤形
JP2004525110A (ja) * 2001-02-16 2004-08-19 清水製薬株式会社 ムコ多糖類製剤およびその製造法
JP2009533349A (ja) * 2006-04-07 2009-09-17 メリオン リサーチ Ｉｉｉ リミテッド 強化剤を含む固体経口投与剤形
WO2010032140A2 (en) * 2008-09-17 2010-03-25 Chiasma Inc. Pharmaceutical compositions and related methods of delivery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
US20070212395A1 (en) * 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
KR20110007242A (ko) * 2008-05-07 2011-01-21 메리온 리서치 Ⅲ 리미티드 펩티드 조성물 및 그의 제조 방법
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537321A (ja) * 1999-02-22 2002-11-05 エラン コーポレイション ピーエルスィー 促進剤を含む固体経口剤形
JP2004525110A (ja) * 2001-02-16 2004-08-19 清水製薬株式会社 ムコ多糖類製剤およびその製造法
JP2009533349A (ja) * 2006-04-07 2009-09-17 メリオン リサーチ Ｉｉｉ リミテッド 強化剤を含む固体経口投与剤形
WO2010032140A2 (en) * 2008-09-17 2010-03-25 Chiasma Inc. Pharmaceutical compositions and related methods of delivery

Also Published As

Publication number Publication date
EP2651395A1 (en) 2013-10-23
CA2819108A1 (en) 2012-06-21
MX2013006877A (es) 2013-07-05
BR112013014940A2 (pt) 2016-09-13
AU2011341637A1 (en) 2013-06-20
WO2012082209A1 (en) 2012-06-21
CN103370051A (zh) 2013-10-23
US20120156294A1 (en) 2012-06-21
EP2651395A4 (en) 2014-05-07
KR20140046395A (ko) 2014-04-18

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