JP2013544285A5 - - Google Patents
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- Publication number
- JP2013544285A5 JP2013544285A5 JP2013542100A JP2013542100A JP2013544285A5 JP 2013544285 A5 JP2013544285 A5 JP 2013544285A5 JP 2013542100 A JP2013542100 A JP 2013542100A JP 2013542100 A JP2013542100 A JP 2013542100A JP 2013544285 A5 JP2013544285 A5 JP 2013544285A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxylamine
- triazin
- propylamino
- bis
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41777710P | 2010-11-29 | 2010-11-29 | |
| US61/417,777 | 2010-11-29 | ||
| US201161494268P | 2011-06-07 | 2011-06-07 | |
| US61/494,268 | 2011-06-07 | ||
| PCT/US2011/062386 WO2012074999A1 (en) | 2010-11-29 | 2011-11-29 | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544285A JP2013544285A (ja) | 2013-12-12 |
| JP2013544285A5 true JP2013544285A5 (enExample) | 2015-03-12 |
| JP5907986B2 JP5907986B2 (ja) | 2016-04-26 |
Family
ID=46162783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542100A Active JP5907986B2 (ja) | 2010-11-29 | 2011-11-29 | 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9351972B2 (enExample) |
| EP (1) | EP2646423A4 (enExample) |
| JP (1) | JP5907986B2 (enExample) |
| KR (1) | KR20140049961A (enExample) |
| CN (1) | CN103347866B (enExample) |
| AU (1) | AU2011336764B2 (enExample) |
| BR (1) | BR112013013429A2 (enExample) |
| CA (1) | CA2819333A1 (enExample) |
| SG (2) | SG10201601507YA (enExample) |
| WO (1) | WO2012074999A1 (enExample) |
| ZA (1) | ZA201303960B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102985557B (zh) | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| PE20120693A1 (es) | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| PT3406251T (pt) | 2011-05-03 | 2024-01-24 | Agios Pharmaceuticals Inc | Ativadores da piruvato-cinase para utilização em terapia |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| MD20140023A2 (ro) | 2011-09-22 | 2014-06-30 | Pfizer Inc. | Derivaţi de pirolpirimidină şi purină |
| SMT201800334T1 (it) | 2012-01-06 | 2018-09-13 | Agios Pharmaceuticals Inc | Composti terapeuticamente attivi e loro metodi di utilizzo |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| HK1209118A1 (en) * | 2012-05-29 | 2016-03-24 | Galleon Pharmaceuticals, Inc. | Novel compounds and compositions for treatment of breathing control disorders or diseases |
| WO2014062511A1 (en) | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| BR112015011213A2 (pt) * | 2012-11-15 | 2017-08-29 | Galleon Pharmaceuticals Inc | Composto, composição farmacêutica, método de prevenção ou tratamento de um distúrbio ou doença de controle respiratório em um indivíduo, método de prevenção de desestabilização ou de estabilização do ritmo respiratório em um indivíduo, método de preparação de o,n-dimetil-n-[4-(n-propilamina)-6-(prop-2-inilamina)-[1,3,5]triazin-2-il]-hidroxilamina, e composição. |
| BR112015023671A2 (pt) * | 2013-03-15 | 2017-07-18 | Galleon Pharmaceuticals Inc | novos compostos para modulação controlada de respiração e método de uso dos mesmos. |
| MX375030B (es) | 2013-07-11 | 2025-03-06 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer. |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN105593215B (zh) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015010297A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| PH12021551647A1 (en) | 2014-03-14 | 2022-06-06 | Agios Pharmaceuticals Inc | Pharmaceutical compositions of therapeutically active compounds |
| MX384883B (es) | 2015-06-11 | 2025-03-14 | Agios Pharmaceuticals Inc | Métodos para usar activadores de piruvato cinasa. |
| CA2989885C (en) * | 2015-06-30 | 2025-05-06 | Neurad Ltd. | NEW RESPIRATION REGULATION MODULATION COMPOUNDS AND THEIR MANUFACTURING AND USE PROCESSES |
| HUE067449T2 (hu) | 2015-10-15 | 2024-10-28 | Servier Lab | Ivozidenib, citarabin és daunorubicin vagy idarubicin kombinációs terápa akut mielogén leukémia kezelésére |
| MD3362066T2 (ro) | 2015-10-15 | 2022-08-31 | Les Laboratoires Servier Sas | Terapie combinată pentru tratamentul tumorilor maligne |
| CA3087881A1 (en) | 2017-01-17 | 2018-07-26 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of atp synthase |
| CA3099077A1 (en) | 2017-07-13 | 2019-01-17 | Michael David FORREST | Therapeutic modulators of the reverse mode of atp synthase |
| JP7313341B2 (ja) * | 2017-09-28 | 2023-07-24 | コーニンクレッカ フィリップス エヌ ヴェ | 圧力支援治療中に患者の脳卒中を検出するシステム及び方法 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| BR112021023354A2 (pt) | 2019-05-22 | 2022-09-06 | Enalare Therapeutics Inc | Métodos e composições farmacêuticas para tratar sobredose de fármaco |
| WO2022235771A1 (en) | 2021-05-04 | 2022-11-10 | Enalare Therapeutics Inc. | Large-conductance potassium channel modulators, compositions thereof, methods of manufacturing thereof, and methods of use thereof |
| US12138267B2 (en) | 2021-11-02 | 2024-11-12 | Enalare Therapeutics Inc. | Methods of treating respiratory depression modulated by a non-opioid agent |
| JP2025501169A (ja) * | 2021-12-27 | 2025-01-17 | エナラーレ セラピューティクス インコーポレイテッド | 呼吸刺激薬非経口製剤 |
| KR20240167901A (ko) * | 2022-04-01 | 2024-11-28 | 에날레어 테라퓨틱스 인크. | 호흡 자극제 비강 제형 |
| EP4543455A4 (en) * | 2022-06-24 | 2026-06-03 | Enalare Therapeutics Inc | METHODS OF TREATMENT FOR NEUROLOGICAL VENTILATORY FAILURE |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3037980A (en) | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
| GB1001665A (en) | 1961-06-05 | 1965-08-18 | American Cyanamid Co | Triazine derivatives and process for their preparation |
| KR0155955B1 (ko) | 1989-10-11 | 1998-11-16 | 이따가끼 히로시 | 2 환성 피리미딘 유도체, 그의 제조방법 및 그를 유효성분으로 하는 의약제제 |
| JPH08272059A (ja) | 1995-03-31 | 1996-10-18 | Fuji Photo Film Co Ltd | 多層ハロゲン化銀カラー写真感光材料包装体 |
| JPH09189973A (ja) | 1996-01-08 | 1997-07-22 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤及びこれを用いる写真感光材料 |
| JPH09251197A (ja) | 1996-03-15 | 1997-09-22 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| JPH09304898A (ja) | 1996-05-15 | 1997-11-28 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| HK1045157A1 (zh) * | 1999-01-22 | 2002-11-15 | 依兰制药公司 | 抑制vla-4介导的白细胞粘着的化合物 |
| US6525067B1 (en) * | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
| US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| CA2396693A1 (en) | 1999-12-28 | 2001-07-05 | Stephen T. Wrobleski | Cytokine, especially tnf-alpha, inhibitors |
| HUP0401712A3 (en) * | 2001-06-26 | 2009-06-29 | Bristol Myers Squibb Co | N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them |
| PL369600A1 (en) * | 2001-09-21 | 2005-05-02 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US20030168629A1 (en) | 2001-12-10 | 2003-09-11 | Lazar Warren G. | Reactive liquid polymer crosslinking agent and process for preparation |
| CA2476934C (en) | 2002-02-27 | 2009-06-16 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine |
| BR0309581A (pt) | 2002-05-06 | 2005-03-29 | Genelabs Tech Inc | Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c |
| TW200418498A (en) | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| US7384937B2 (en) | 2002-11-06 | 2008-06-10 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| WO2005009980A1 (en) | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| CN1926140A (zh) * | 2004-03-05 | 2007-03-07 | 大正制药株式会社 | 吡咯并嘧啶衍生物 |
| CN1997706B (zh) * | 2004-03-15 | 2011-08-17 | 霍尼韦尔国际公司 | 纤维素增强树脂组合物 |
| WO2006023703A2 (en) | 2004-08-20 | 2006-03-02 | Cypress Bioscience, Inc. | Method for treating sleep related breathing disorders |
| EP2385042B1 (en) * | 2005-12-29 | 2015-11-25 | Janssen Pharmaceutica N.V. | Prokineticin 1 receptor antagonists |
| CA2652040C (en) * | 2006-05-17 | 2015-07-21 | Albert Einstein College Of Medicine Of Yeshiva University | Prostaglandin transporter inhibitors |
| GB0610317D0 (en) | 2006-05-24 | 2006-07-05 | Medical Res Council | Antiparasitic compounds and compositions |
| EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| US8119798B2 (en) * | 2006-08-01 | 2012-02-21 | Glaxosmithkline Llc | P38 kinase inhibitors |
| US20080119457A1 (en) | 2006-08-24 | 2008-05-22 | Serenex, Inc. | Benzene, Pyridine, and Pyridazine Derivatives |
| WO2008105968A1 (en) * | 2006-11-03 | 2008-09-04 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| WO2009115084A2 (de) | 2008-03-20 | 2009-09-24 | Schebo Biotech Ag | Neue pyrrolopyrimidin-derivate und deren verwendungen |
| CN101885707B (zh) * | 2009-05-15 | 2012-08-29 | 中国科学院化学研究所 | 三嗪类衍生物及其制备方法与作为杀虫剂的用途 |
-
2011
- 2011-11-29 SG SG10201601507YA patent/SG10201601507YA/en unknown
- 2011-11-29 AU AU2011336764A patent/AU2011336764B2/en not_active Expired - Fee Related
- 2011-11-29 CN CN201180066258.6A patent/CN103347866B/zh not_active Expired - Fee Related
- 2011-11-29 KR KR1020137016890A patent/KR20140049961A/ko not_active Ceased
- 2011-11-29 EP EP11845815.7A patent/EP2646423A4/en not_active Withdrawn
- 2011-11-29 CA CA2819333A patent/CA2819333A1/en not_active Abandoned
- 2011-11-29 BR BR112013013429A patent/BR112013013429A2/pt not_active IP Right Cessation
- 2011-11-29 WO PCT/US2011/062386 patent/WO2012074999A1/en not_active Ceased
- 2011-11-29 JP JP2013542100A patent/JP5907986B2/ja active Active
- 2011-11-29 SG SG2013041439A patent/SG190921A1/en unknown
- 2011-11-29 US US13/306,349 patent/US9351972B2/en active Active
-
2013
- 2013-05-30 ZA ZA2013/03960A patent/ZA201303960B/en unknown
-
2016
- 2016-05-16 US US15/155,897 patent/US20160256463A1/en not_active Abandoned
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