JP2013544285A5 - - Google Patents
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- Publication number
- JP2013544285A5 JP2013544285A5 JP2013542100A JP2013542100A JP2013544285A5 JP 2013544285 A5 JP2013544285 A5 JP 2013544285A5 JP 2013542100 A JP2013542100 A JP 2013542100A JP 2013542100 A JP2013542100 A JP 2013542100A JP 2013544285 A5 JP2013544285 A5 JP 2013544285A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxylamine
- triazin
- propylamino
- bis
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41777710P | 2010-11-29 | 2010-11-29 | |
| US61/417,777 | 2010-11-29 | ||
| US201161494268P | 2011-06-07 | 2011-06-07 | |
| US61/494,268 | 2011-06-07 | ||
| PCT/US2011/062386 WO2012074999A1 (en) | 2010-11-29 | 2011-11-29 | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544285A JP2013544285A (ja) | 2013-12-12 |
| JP2013544285A5 true JP2013544285A5 (enExample) | 2015-03-12 |
| JP5907986B2 JP5907986B2 (ja) | 2016-04-26 |
Family
ID=46162783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542100A Active JP5907986B2 (ja) | 2010-11-29 | 2011-11-29 | 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9351972B2 (enExample) |
| EP (1) | EP2646423A4 (enExample) |
| JP (1) | JP5907986B2 (enExample) |
| KR (1) | KR20140049961A (enExample) |
| CN (1) | CN103347866B (enExample) |
| AU (1) | AU2011336764B2 (enExample) |
| BR (1) | BR112013013429A2 (enExample) |
| CA (1) | CA2819333A1 (enExample) |
| SG (2) | SG10201601507YA (enExample) |
| WO (1) | WO2012074999A1 (enExample) |
| ZA (1) | ZA201303960B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2406389B1 (en) | 2009-03-13 | 2019-05-08 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| CA2944788C (en) | 2009-06-29 | 2023-08-22 | Agios Pharmaceuticals, Inc. | Compounds, and compositions thereof, which modulate pyruvate kinase m2, and methods of making same |
| CA2793835C (en) | 2009-10-21 | 2021-07-20 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| KR101873543B1 (ko) | 2011-05-03 | 2018-07-02 | 아지오스 파마슈티컬스 아이엔씨. | 치료에 사용하기 위한 피루베이트 키나아제 활성제 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN103814030A (zh) | 2011-09-22 | 2014-05-21 | 辉瑞大药厂 | 吡咯并嘧啶及嘌呤衍生物 |
| SG11201403878QA (en) | 2012-01-06 | 2014-08-28 | Agios Pharmaceuticals Inc | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| KR20150020616A (ko) * | 2012-05-29 | 2015-02-26 | 갈레온 파마슈티칼스, 인코포레이티드 | 호흡 조절 장애 또는 질환 치료용의 신규의 화합물 및 조성물 |
| HK1213798A1 (zh) | 2012-10-15 | 2016-07-15 | 安吉奥斯医药品有限公司 | 治療性化合物和組合物 |
| CA2891342A1 (en) * | 2012-11-15 | 2014-05-22 | Galleon Pharmaceuticals, Inc. | Novel orally bioavailable breathing control modulating compounds, and methods of using same |
| EP2968329A4 (en) | 2013-03-15 | 2016-09-28 | Galleon Pharmaceuticals Inc | NEW BREATHING CONTROL MODULATION COMPOUNDS AND METHODS OF USING THE SAME |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| NZ715738A (en) | 2013-07-11 | 2021-06-25 | Agios Pharmaceuticals Inc | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
| WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2917671A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CA2942072C (en) | 2014-03-14 | 2022-07-26 | Agios Pharmaceuticals, Inc. | Pharmaceutical compositions and use of (s)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-( 4-cyanopyridin-2-yl)-n-( 5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| DK3307271T3 (da) | 2015-06-11 | 2023-10-09 | Agios Pharmaceuticals Inc | Fremgangsmåder til anvendelse af pyruvatkinase-aktivatorer |
| KR102207539B1 (ko) * | 2015-06-30 | 2021-01-26 | 네우라드 리미티드 | 신규한 호흡 제어 조절 화합물, 및 그의 제조 및 사용 방법 |
| DK3362066T3 (da) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | Kombinationsterapi til behandling af maligniteter |
| MA71411A (fr) | 2015-10-15 | 2025-04-30 | Les Laboratoires Servier | Polythérapie pour le traitement de tumeurs malignes |
| CA3087881A1 (en) | 2017-01-17 | 2018-07-26 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of atp synthase |
| US12337000B2 (en) | 2017-07-13 | 2025-06-24 | Michael David FORREST | Therapeutic modulators of the reverse mode of ATP synthase |
| EP3688770A1 (en) * | 2017-09-28 | 2020-08-05 | Koninklijke Philips N.V. | System and method for detecting stroke in patients during pressure support therapy |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| EP3972691A4 (en) * | 2019-05-22 | 2022-11-23 | Pergolizzi, Joseph, V. | PHARMACEUTICAL METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSAGE |
| CN117479945A (zh) * | 2021-05-04 | 2024-01-30 | 依那拉治疗股份有限公司 | 大电导钾通道调节剂、其组合物、其制造方法及其使用方法 |
| WO2023081185A1 (en) * | 2021-11-02 | 2023-05-11 | Enalare Therapeutics Inc. | Methods of treating respiratory depression modulated by a non-opioid agent |
| US20230210857A1 (en) * | 2021-12-27 | 2023-07-06 | Enalare Therapeutics Inc. | Respiratory stimulant parenteral formulations |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3037980A (en) | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
| GB1001665A (en) | 1961-06-05 | 1965-08-18 | American Cyanamid Co | Triazine derivatives and process for their preparation |
| ATE139232T1 (de) | 1989-10-11 | 1996-06-15 | Teijin Ltd | Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung |
| JPH08272059A (ja) * | 1995-03-31 | 1996-10-18 | Fuji Photo Film Co Ltd | 多層ハロゲン化銀カラー写真感光材料包装体 |
| JPH09189973A (ja) | 1996-01-08 | 1997-07-22 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤及びこれを用いる写真感光材料 |
| JPH09251197A (ja) | 1996-03-15 | 1997-09-22 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| JPH09304898A (ja) | 1996-05-15 | 1997-11-28 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| BR0007663A (pt) * | 1999-01-22 | 2002-05-07 | Elan Pharm Inc | Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4 |
| US6525067B1 (en) * | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
| US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| DE60043397D1 (de) | 1999-12-28 | 2010-01-07 | Pharmacopeia Inc | Cytokine, insbesondere tnf-alpha, hemmer |
| HUP0401712A3 (en) * | 2001-06-26 | 2009-06-29 | Bristol Myers Squibb Co | N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them |
| CN1578773A (zh) * | 2001-09-21 | 2005-02-09 | 雷迪美国治疗公司 | 新三嗪化合物的方法和组合物 |
| US20030168629A1 (en) | 2001-12-10 | 2003-09-11 | Lazar Warren G. | Reactive liquid polymer crosslinking agent and process for preparation |
| US20030180287A1 (en) | 2002-02-27 | 2003-09-25 | Immunex Corporation | Polypeptide formulation |
| AU2003232071A1 (en) | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| EA200500584A1 (ru) | 2002-09-30 | 2006-02-24 | Дженелэбс Текнолоджиз, Инк. | Нуклеозидные производные для лечения инфекционных заболеваний, вызванных вирусом гепатита c |
| AU2003291310A1 (en) | 2002-11-06 | 2004-06-03 | Bristol-Myers Squibb Company | Fused heterocyclic compounds and use thereof |
| WO2005009980A1 (en) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| US20070270588A1 (en) * | 2004-03-05 | 2007-11-22 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine Derivatives |
| CN1997706B (zh) | 2004-03-15 | 2011-08-17 | 霍尼韦尔国际公司 | 纤维素增强树脂组合物 |
| US20060039866A1 (en) * | 2004-08-20 | 2006-02-23 | Cypress Bioscience, Inc. | Method for treating sleep-related breathing disorders |
| JP5452934B2 (ja) * | 2005-12-29 | 2014-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン１受容体アンタゴニスト |
| CA2652040C (en) * | 2006-05-17 | 2015-07-21 | Albert Einstein College Of Medicine Of Yeshiva University | Prostaglandin transporter inhibitors |
| GB0610317D0 (en) | 2006-05-24 | 2006-07-05 | Medical Res Council | Antiparasitic compounds and compositions |
| EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| JP2009545598A (ja) * | 2006-08-01 | 2009-12-24 | プリーシス・ファーマシューティカルズ・インコーポレイテッド | Ｐ３８キナーゼ阻害剤 |
| WO2008024978A2 (en) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Tetrahydroindolone and tetrahydroindazolone derivatives |
| US7994317B2 (en) * | 2006-11-03 | 2011-08-09 | GlaxoSmithKline, LLC | sEH inhibitors and their use |
| WO2009115084A2 (de) | 2008-03-20 | 2009-09-24 | Schebo Biotech Ag | Neue pyrrolopyrimidin-derivate und deren verwendungen |
| CN101885707B (zh) * | 2009-05-15 | 2012-08-29 | 中国科学院化学研究所 | 三嗪类衍生物及其制备方法与作为杀虫剂的用途 |
-
2011
- 2011-11-29 EP EP11845815.7A patent/EP2646423A4/en not_active Withdrawn
- 2011-11-29 AU AU2011336764A patent/AU2011336764B2/en not_active Expired - Fee Related
- 2011-11-29 CN CN201180066258.6A patent/CN103347866B/zh not_active Expired - Fee Related
- 2011-11-29 SG SG10201601507YA patent/SG10201601507YA/en unknown
- 2011-11-29 KR KR1020137016890A patent/KR20140049961A/ko not_active Ceased
- 2011-11-29 BR BR112013013429A patent/BR112013013429A2/pt not_active IP Right Cessation
- 2011-11-29 WO PCT/US2011/062386 patent/WO2012074999A1/en not_active Ceased
- 2011-11-29 JP JP2013542100A patent/JP5907986B2/ja active Active
- 2011-11-29 CA CA2819333A patent/CA2819333A1/en not_active Abandoned
- 2011-11-29 US US13/306,349 patent/US9351972B2/en active Active
- 2011-11-29 SG SG2013041439A patent/SG190921A1/en unknown
-
2013
- 2013-05-30 ZA ZA2013/03960A patent/ZA201303960B/en unknown
-
2016
- 2016-05-16 US US15/155,897 patent/US20160256463A1/en not_active Abandoned
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