GB1001665A - Triazine derivatives and process for their preparation - Google Patents
Triazine derivatives and process for their preparationInfo
- Publication number
- GB1001665A GB1001665A GB2118662A GB2118662A GB1001665A GB 1001665 A GB1001665 A GB 1001665A GB 2118662 A GB2118662 A GB 2118662A GB 2118662 A GB2118662 A GB 2118662A GB 1001665 A GB1001665 A GB 1001665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- ron
- mol
- mols
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B5/00—Preserving by using additives, e.g. anti-oxidants
- C11B5/0042—Preserving by using additives, e.g. anti-oxidants containing nitrogen
- C11B5/0064—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L1/00—Liquid carbonaceous fuels
- C10L1/10—Liquid carbonaceous fuels containing additives
- C10L1/14—Organic compounds
- C10L1/22—Organic compounds containing nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:1001665/C2/1> (wherein R is a lower alkyl, C3-7 cycloalkyl, hydroxy-lower alkyl, phenyl-lower alkyl, lower alkenyl or propargyl group, R1 is hydrogen or R, and X and Y are identical or different and are hydrogen or halogen atoms or lower alkyl, trihalomethyl, phenyl-lower alkyl, lower alkoxy, lower alkylmercapto, phenyl, lower alkoxyalkoxy, lower alkoxyalkyl, mercapto, hydroxy, phenoxy, phenylthio or amino groups, or mono-or di-substituted amino groups, viz.-NRR1, piperidino, lower alkyl-piperidino, piperazino, 4-R-piperazino, morpholino or pyrrolidino, or <FORM:1001665/C2/2> any phenyl radical optionally bearing halogen, trifluoromethyl, lower alkyl or lower alkoxy substituents, and the term "lower" denoting a maximum of 6 carbon atoms) and their pharmaceutically acceptable salts, and the preparation thereof by condensing a compound of the general formula <FORM:1001665/C2/3> (wherein Z is a halogen atom and Xa and Ya are Z or are X and Y) with an oxyamine of the general formula <FORM:1001665/C2/4> (wherein R11 is hydrogen or R), and, if necessary, converting Xa and/or Ya into X and/or Y by a displacement reaction and/or replacing R11, when hydrogen, by R, and, if desired, replacing R1, when hydrogen, by R, and in all cases, if desired, converting the product into a pharmaceutically acceptable salt thereof, or by the following alternative processes illustrated in examples: (a) using, in place of a compound of the general formula above, a corresponding compound containing one or more mercapto groups in place of one or more halogen atoms; (b) <FORM:1001665/C2/5> trimerizing a cyanamide RON(R1)CN by the action of a strong acid, or heating a pseudourea RON(R1)C(:NH)-O-alkyl with acid; (c) (when X = Y) condensing 2 mols of a nitrile XCN with 1 mol of a cyanamide RON(R1)CN, or 2 mols of an imidate RC(:NH)-O-alkyl with 1 mol of a pseudourea RON(R1)C(:NH)-O-alkyl; (d) (when X = Y = NH2) condensing 2 mols of biguanide with 1 mol of a carbamate RON(R1)-COO-alkyl, or 2 mols of dicyandiamide with 1 mol of a cyanamide RON(R1)CN; (e) (when Y = NH2) condensing 1 mol of an alkoxybiguanide RON(R1)C(: NH)NHC(: NH)NH2 with 1 mol of an ester X-COO-alkyl; (f) for 2,4 - bis - (N - methyl - N - methoxyamino)-s-triazine, condensing 2 mols of N-methyl-N-methoxy-O-methylpseudourea with 1 mol of formamidine. Pharmaceutical preparations comprise the compounds of the invention in pharmaceutically acceptable carriers. They possess a tranquillizing activity and may take the form of tablets, dragees, capsules, suppositories, drops, emulsions, suspensions, syrups, chocolate, candy and chewing gum.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11465761A | 1961-06-05 | 1961-06-05 | |
US19026762A | 1962-04-26 | 1962-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1001665A true GB1001665A (en) | 1965-08-18 |
Family
ID=26812430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2118662A Expired GB1001665A (en) | 1961-06-05 | 1962-06-01 | Triazine derivatives and process for their preparation |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE618563A (en) |
ES (1) | ES277976A1 (en) |
GB (1) | GB1001665A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9162992B2 (en) | 2010-11-29 | 2015-10-20 | Galleon Pharmaceuticals, Inc. | Compounds and compositions for treatment of breathing control disorders or diseases |
US9351972B2 (en) | 2010-11-29 | 2016-05-31 | Galleon Pharmaceuticals, Inc. | Compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1005030A (en) * | 1962-11-01 | 1965-09-22 | Shell Res Ltd | Novel alkylaminotriazine derivatives |
AU2016299092B2 (en) * | 2015-07-30 | 2020-08-20 | Centaurus Biopharma Co., Ltd. | 1, 3, 5-triazine derivative and method of using same |
-
1962
- 1962-06-01 GB GB2118662A patent/GB1001665A/en not_active Expired
- 1962-06-05 BE BE618563A patent/BE618563A/en unknown
- 1962-06-05 ES ES277976A patent/ES277976A1/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9162992B2 (en) | 2010-11-29 | 2015-10-20 | Galleon Pharmaceuticals, Inc. | Compounds and compositions for treatment of breathing control disorders or diseases |
US9351972B2 (en) | 2010-11-29 | 2016-05-31 | Galleon Pharmaceuticals, Inc. | Compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
Also Published As
Publication number | Publication date |
---|---|
ES277976A1 (en) | 1962-12-01 |
BE618563A (en) | 1962-12-14 |
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