JP2013544089A5 - - Google Patents
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- JP2013544089A5 JP2013544089A5 JP2013537286A JP2013537286A JP2013544089A5 JP 2013544089 A5 JP2013544089 A5 JP 2013544089A5 JP 2013537286 A JP2013537286 A JP 2013537286A JP 2013537286 A JP2013537286 A JP 2013537286A JP 2013544089 A5 JP2013544089 A5 JP 2013544089A5
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- krtap4
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- tfpi2
- mmp1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 22
- 201000008450 Intracranial aneurysm Diseases 0.000 claims 13
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 claims 12
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 claims 12
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 12
- 102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 claims 12
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims 10
- 102100031168 CCN family member 2 Human genes 0.000 claims 10
- 102100028228 COUP transcription factor 1 Human genes 0.000 claims 10
- 102100033902 Endothelin-1 Human genes 0.000 claims 10
- 102100038514 FERM domain-containing protein 3 Human genes 0.000 claims 10
- 102000049982 HMGA2 Human genes 0.000 claims 10
- 108700039143 HMGA2 Proteins 0.000 claims 10
- 101150073387 Hmga2 gene Proteins 0.000 claims 10
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 claims 10
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 10
- 101000860854 Homo sapiens COUP transcription factor 1 Proteins 0.000 claims 10
- 101000925493 Homo sapiens Endothelin-1 Proteins 0.000 claims 10
- 101001030545 Homo sapiens FERM domain-containing protein 3 Proteins 0.000 claims 10
- 101001007046 Homo sapiens Keratin-associated protein 4-7 Proteins 0.000 claims 10
- 101001007048 Homo sapiens Keratin-associated protein 4-9 Proteins 0.000 claims 10
- 101001128427 Homo sapiens Myeloma-overexpressed gene protein Proteins 0.000 claims 10
- 101000982003 Homo sapiens Myopalladin Proteins 0.000 claims 10
- 101001067187 Homo sapiens Plexin-A2 Proteins 0.000 claims 10
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 10
- 101000882233 Homo sapiens Protein FAM43A Proteins 0.000 claims 10
- 101000868747 Homo sapiens SPOC domain-containing protein 1 Proteins 0.000 claims 10
- 101000616718 Homo sapiens Sialate O-acetylesterase Proteins 0.000 claims 10
- 101000577874 Homo sapiens Stromelysin-2 Proteins 0.000 claims 10
- 101000866292 Homo sapiens Transcription factor E2F7 Proteins 0.000 claims 10
- 101000702691 Homo sapiens Zinc finger protein SNAI1 Proteins 0.000 claims 10
- 102100028332 Keratin-associated protein 4-7 Human genes 0.000 claims 10
- 102100028330 Keratin-associated protein 4-9 Human genes 0.000 claims 10
- 102100031791 Myeloma-overexpressed gene protein Human genes 0.000 claims 10
- 102100026786 Myopalladin Human genes 0.000 claims 10
- 102100034381 Plexin-A2 Human genes 0.000 claims 10
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 10
- 102100038924 Protein FAM43A Human genes 0.000 claims 10
- 108091006553 SLC30A3 Proteins 0.000 claims 10
- 102100032395 SPOC domain-containing protein 1 Human genes 0.000 claims 10
- 102100021837 Sialate O-acetylesterase Human genes 0.000 claims 10
- 102100028848 Stromelysin-2 Human genes 0.000 claims 10
- 102100031556 Transcription factor E2F7 Human genes 0.000 claims 10
- 102100030917 Zinc finger protein SNAI1 Human genes 0.000 claims 10
- 102100034988 Zinc transporter 3 Human genes 0.000 claims 10
- 101001007047 Homo sapiens Keratin-associated protein 4-8 Proteins 0.000 claims 9
- 101001128694 Homo sapiens Neuroendocrine convertase 1 Proteins 0.000 claims 9
- 101001108364 Homo sapiens Neuronal cell adhesion molecule Proteins 0.000 claims 9
- 102100028331 Keratin-associated protein 4-8 Human genes 0.000 claims 9
- 102100032132 Neuroendocrine convertase 1 Human genes 0.000 claims 9
- 102100021852 Neuronal cell adhesion molecule Human genes 0.000 claims 9
- 208000026292 Cystic Kidney disease Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 claims 7
- 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 claims 7
- 101001076680 Homo sapiens Insulin-induced gene 1 protein Proteins 0.000 claims 7
- 101000713288 Homo sapiens Solute carrier family 22 member 5 Proteins 0.000 claims 7
- 101000631826 Homo sapiens Stearoyl-CoA desaturase Proteins 0.000 claims 7
- 101000642613 Homo sapiens Sterol O-acyltransferase 2 Proteins 0.000 claims 7
- 102100025887 Insulin-induced gene 1 protein Human genes 0.000 claims 7
- 102100028897 Stearoyl-CoA desaturase Human genes 0.000 claims 7
- 102100039082 3 beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1 Human genes 0.000 claims 6
- 102100029824 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Human genes 0.000 claims 6
- 101000798762 Anguilla anguilla Troponin C, skeletal muscle Proteins 0.000 claims 6
- 102100023086 Anosmin-1 Human genes 0.000 claims 6
- 101000744065 Homo sapiens 3 beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1 Proteins 0.000 claims 6
- 101000794082 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Proteins 0.000 claims 6
- 101001050039 Homo sapiens Anosmin-1 Proteins 0.000 claims 6
- 101001099051 Homo sapiens GPI inositol-deacylase Proteins 0.000 claims 6
- 101000975502 Homo sapiens Keratin, type II cytoskeletal 7 Proteins 0.000 claims 6
- 101000604463 Homo sapiens Netrin-G1 Proteins 0.000 claims 6
- 101000604469 Homo sapiens Netrin-G2 Proteins 0.000 claims 6
- 101001095308 Homo sapiens Periostin Proteins 0.000 claims 6
- 101000585344 Homo sapiens Sulfotransferase 1E1 Proteins 0.000 claims 6
- 101000666340 Homo sapiens Tenascin Proteins 0.000 claims 6
- 101000777206 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 40 Proteins 0.000 claims 6
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 claims 6
- 102100038699 Netrin-G2 Human genes 0.000 claims 6
- 102100037765 Periostin Human genes 0.000 claims 6
- 102100029862 Sulfotransferase 1E1 Human genes 0.000 claims 6
- 102100038126 Tenascin Human genes 0.000 claims 6
- 102100031284 Ubiquitin carboxyl-terminal hydrolase 40 Human genes 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 208000030761 polycystic kidney disease Diseases 0.000 claims 6
- 230000002103 transcriptional effect Effects 0.000 claims 6
- 230000000069 prophylactic effect Effects 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 108700026244 Open Reading Frames Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000002924 silencing RNA Substances 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 101100517190 Arabidopsis thaliana NRPC1 gene Proteins 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- -1 NRPC Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 208000021138 brain aneurysm Diseases 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000003668 pericyte Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41075710P | 2010-11-05 | 2010-11-05 | |
| US61/410,757 | 2010-11-05 | ||
| US201161530269P | 2011-09-01 | 2011-09-01 | |
| US61/530,269 | 2011-09-01 | ||
| PCT/JP2011/006203 WO2012060109A1 (en) | 2010-11-05 | 2011-11-07 | Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544089A JP2013544089A (ja) | 2013-12-12 |
| JP2013544089A5 true JP2013544089A5 (enExample) | 2014-12-25 |
| JP6021021B2 JP6021021B2 (ja) | 2016-11-02 |
Family
ID=46024234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537286A Active JP6021021B2 (ja) | 2010-11-05 | 2011-11-07 | 多発性嚢胞腎の検査方法および治療剤のスクリーニング方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130225443A1 (enExample) |
| EP (1) | EP2635707B1 (enExample) |
| JP (1) | JP6021021B2 (enExample) |
| WO (1) | WO2012060109A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5308328B2 (ja) | 2006-04-04 | 2013-10-09 | シングレックス，インコーポレイテッド | トロポニンの分析のための高感度のシステムおよび方法 |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| EP2440936A4 (en) | 2009-06-08 | 2013-03-13 | Singulex Inc | GROUPS OF HIGHLY SENSITIVE BIOMARKERS |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| PH12021550850A1 (en) | 2015-03-27 | 2022-10-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
| CN104771630A (zh) * | 2015-04-07 | 2015-07-15 | 陆开云 | 一种治疗小儿疝气的药物 |
| JP6621195B2 (ja) * | 2015-07-17 | 2019-12-18 | 国立大学法人京都大学 | 多発性嚢胞腎の検査方法および治療剤のスクリーニング方法 |
| BR112018009879A2 (pt) | 2015-11-18 | 2018-11-13 | Genzyme Corp | biomarcador da doença renal policística e seus usos |
| JP7176766B2 (ja) * | 2017-11-17 | 2022-11-22 | 国立大学法人大阪大学 | Ｃｄ３１陽性ｃｄ４５陰性ｃｄ２００陽性の哺乳動物細胞からなる細胞集団、およびその利用 |
| KR102288447B1 (ko) * | 2018-12-28 | 2021-08-10 | 서울대학교산학협력단 | Ctgf 검출용 제제를 포함하는 다낭신의 진단용 조성물 및 이의 이용 |
| KR102859441B1 (ko) * | 2019-11-22 | 2025-09-12 | 서울대학교산학협력단 | Opn 검출용 제제를 포함하는, 다낭신의 진단용 조성물 및 이의 이용 |
| KR102885974B1 (ko) * | 2019-11-22 | 2025-11-13 | 서울대학교산학협력단 | Metrnl 검출용 제제를 포함하는 다낭신의 진단용 조성물 및 이의 이용 |
| WO2022018266A1 (en) * | 2020-07-23 | 2022-01-27 | Johann Wolfgang Goethe-Universität Frankfurt | Combinatorial inhibition of transcription factors for treatment of heart failure |
| CN112798789A (zh) * | 2020-12-08 | 2021-05-14 | 彭志勇 | 一种用于重症患者aki早期诊断的方法 |
| CN112877275B (zh) * | 2021-02-04 | 2023-03-31 | 中国农业科学院兰州兽医研究所 | Hdac2基因敲除的bhk-21细胞系及其构建方法和应用 |
| WO2023230339A1 (en) * | 2022-05-26 | 2023-11-30 | Yale University | Method of treating, ameliorating and/or preventing polycystic kidney disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US20020103360A1 (en) | 1998-09-01 | 2002-08-01 | Yang Pan | Novel protein related to melanoma-inhibiting protein and uses thereof |
| CA2697031C (en) | 2000-07-13 | 2017-10-31 | The Johns Hopkins University School Of Medicine | Detection and treatment of polycystic kidney disease |
| US6916619B2 (en) | 2001-10-12 | 2005-07-12 | Athena Diagnostics, Inc. | Compositions and methods for genetic analysis of polycystic kidney disease |
| CA2872385C (en) * | 2003-04-11 | 2019-01-15 | Athena Diagnostics, Inc. | Compositions and methods for genetic analysis of polycystic kidney disease |
| JP4892740B2 (ja) | 2005-02-03 | 2012-03-07 | 国立大学法人 岡山大学 | 胚性幹細胞の肝細胞への分化誘導方法および該方法により誘導される肝細胞 |
| JP2006239169A (ja) | 2005-03-03 | 2006-09-14 | Miyako Takagi | 胚性幹細胞から分化誘導した腸管様細胞塊における壁内神経系の形成方法 |
| JP5119430B2 (ja) | 2005-04-08 | 2013-01-16 | 国立大学法人名古屋大学 | 多発性嚢胞腎疾患関連遺伝子及びその利用 |
| US7709204B2 (en) * | 2005-04-29 | 2010-05-04 | Mayo Foundation For Medical Education And Research | Assessing brain aneurysms |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| JP6110048B2 (ja) | 2006-03-02 | 2017-04-05 | ヴィアサイト，インコーポレイテッド | 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 |
| JP2010075631A (ja) | 2008-09-29 | 2010-04-08 | Japan Science & Technology Agency | 未分化細胞から肝臓を分化誘導する方法 |
| EP2376626A4 (en) | 2008-12-13 | 2012-10-17 | Dna Microarray | MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS) |
-
2011
- 2011-11-07 JP JP2013537286A patent/JP6021021B2/ja active Active
- 2011-11-07 WO PCT/JP2011/006203 patent/WO2012060109A1/en not_active Ceased
- 2011-11-07 EP EP11837763.9A patent/EP2635707B1/en not_active Not-in-force
- 2011-11-07 US US13/883,735 patent/US20130225443A1/en not_active Abandoned
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