JP2013540826A5 - - Google Patents
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- Publication number
- JP2013540826A5 JP2013540826A5 JP2013536904A JP2013536904A JP2013540826A5 JP 2013540826 A5 JP2013540826 A5 JP 2013540826A5 JP 2013536904 A JP2013536904 A JP 2013536904A JP 2013536904 A JP2013536904 A JP 2013536904A JP 2013540826 A5 JP2013540826 A5 JP 2013540826A5
- Authority
- JP
- Japan
- Prior art keywords
- formulated
- administration
- crofelemer
- daily
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001393 Crofelemer Polymers 0.000 claims description 65
- 229940047615 crofelemer Drugs 0.000 claims description 65
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 claims description 65
- 206010012735 Diarrhoea Diseases 0.000 claims description 20
- 238000011225 antiretroviral therapy Methods 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 208000034347 Faecal incontinence Diseases 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 208000004998 Abdominal Pain Diseases 0.000 claims description 4
- 230000002550 fecal effect Effects 0.000 claims description 3
- 208000031886 HIV Infections Diseases 0.000 claims description 2
- 208000037357 HIV infectious disease Diseases 0.000 claims description 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 2
- 206010000059 abdominal discomfort Diseases 0.000 claims description 2
- 208000023505 abnormal feces Diseases 0.000 claims description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 230000006866 deterioration Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 34
- 230000005713 exacerbation Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40862210P | 2010-10-31 | 2010-10-31 | |
| US61/408,622 | 2010-10-31 | ||
| US40933510P | 2010-11-02 | 2010-11-02 | |
| US61/409,335 | 2010-11-02 | ||
| US41624910P | 2010-11-22 | 2010-11-22 | |
| US61/416,249 | 2010-11-22 | ||
| US201161434379P | 2011-01-19 | 2011-01-19 | |
| US61/434,379 | 2011-01-19 | ||
| PCT/US2011/058549 WO2012058664A1 (en) | 2010-10-31 | 2011-10-31 | Methods and compositions for treating hiv-associated diarrhea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016151656A Division JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540826A JP2013540826A (ja) | 2013-11-07 |
| JP2013540826A5 true JP2013540826A5 (cg-RX-API-DMAC7.html) | 2014-12-18 |
| JP6063385B2 JP6063385B2 (ja) | 2017-01-18 |
Family
ID=45994461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536904A Active JP6063385B2 (ja) | 2010-10-31 | 2011-10-31 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
| JP2016151656A Active JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016151656A Active JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Country Status (20)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| EP2015639A4 (en) | 2006-05-01 | 2009-11-25 | Napo Pharmaceuticals Inc | METHOD FOR TREATING CONSTITUTIONAL PREDOMINANT IRRITATION SYNDROME |
| WO2007130893A2 (en) * | 2006-05-01 | 2007-11-15 | Napo Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer |
| HUE035393T2 (en) | 2010-10-31 | 2018-05-02 | Napo Pharmaceuticals Inc | Procedures and preparations for the treatment of HIV-related diarrhea |
| US20140163096A1 (en) * | 2012-12-07 | 2014-06-12 | Pam Golden | Methods and compositions for treating hiv-associated diarrhea |
| US11389424B2 (en) | 2017-03-09 | 2022-07-19 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating chemotherapy-induced diarrhea |
| JOP20190275A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج اضطراب إسهال خِلقي |
| JOP20190276A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| JOP20220339A1 (ar) * | 2020-06-19 | 2023-01-30 | Napo Pharmaceuticals Inc | طرق وتركيبات علاج الإسهال الناتج عن العلاج الكيميائي |
| WO2022115481A1 (en) * | 2020-11-24 | 2022-06-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating post-acute infection gastrointestinal disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211944A (en) | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| EP2255661A3 (en) | 1996-10-16 | 2010-12-22 | Napo Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer antidiarrheal compositions |
| WO2000047062A2 (en) | 1999-02-01 | 2000-08-17 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same |
| US20040071793A1 (en) | 2002-10-05 | 2004-04-15 | Bobrowski Paul J. | Oral rehydration methods and compositions |
| US20080025966A1 (en) * | 2004-01-30 | 2008-01-31 | Currie Mark G | Methods And Compositions For The Treatment Of Gastrointestinal disorders |
| EP1937655A1 (en) * | 2005-06-22 | 2008-07-02 | University of Massachusetts | Hiv-1 protease inhibitors, and methods of making and using them |
| JP2009524585A (ja) | 2005-12-15 | 2009-07-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ウイルス感染を処置するためのジアリールウレア |
| EP2015639A4 (en) * | 2006-05-01 | 2009-11-25 | Napo Pharmaceuticals Inc | METHOD FOR TREATING CONSTITUTIONAL PREDOMINANT IRRITATION SYNDROME |
| WO2007130893A2 (en) | 2006-05-01 | 2007-11-15 | Napo Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| US20100092479A1 (en) | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| PH12012500557A1 (en) | 2009-08-26 | 2012-10-22 | Glenmark Pharmaceuticals Ltd | Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations |
| CA2777214A1 (en) * | 2009-10-06 | 2011-04-14 | The Regents Of The University Of California | Methods of treating diseases with proanthocyanidin oligomers such as crofelemer |
| US20110087530A1 (en) | 2009-10-09 | 2011-04-14 | Visa U.S.A. Inc. | Systems and Methods to Provide Loyalty Programs |
| HUE035393T2 (en) | 2010-10-31 | 2018-05-02 | Napo Pharmaceuticals Inc | Procedures and preparations for the treatment of HIV-related diarrhea |
| BR112013018688B1 (pt) | 2011-01-27 | 2021-08-24 | Napo Pharmaceuticals, Inc | Método de produção de uma composição polimérica de proantocianidina |
| MX2014007635A (es) | 2011-12-22 | 2014-09-22 | Glenmark Pharmaceuticals Ltd | Composicion farmaceutica no enterica que comprende crofelemer. |
| US20140163096A1 (en) | 2012-12-07 | 2014-06-12 | Pam Golden | Methods and compositions for treating hiv-associated diarrhea |
-
2011
- 2011-10-31 HU HUE11837249A patent/HUE035393T2/en unknown
- 2011-10-31 DK DK11837249.9T patent/DK2632550T3/en active
- 2011-10-31 JP JP2013536904A patent/JP6063385B2/ja active Active
- 2011-10-31 PE PE2013000926A patent/PE20140036A1/es not_active Application Discontinuation
- 2011-10-31 PH PH1/2013/500857A patent/PH12013500857A1/en unknown
- 2011-10-31 WO PCT/US2011/058549 patent/WO2012058664A1/en not_active Ceased
- 2011-10-31 BR BR112013010774A patent/BR112013010774A2/pt not_active Application Discontinuation
- 2011-10-31 MX MX2013004873A patent/MX348184B/es active IP Right Grant
- 2011-10-31 PT PT118372499T patent/PT2632550T/pt unknown
- 2011-10-31 CA CA2816416A patent/CA2816416C/en active Active
- 2011-10-31 RU RU2013123794/15A patent/RU2597746C2/ru active
- 2011-10-31 CN CN201711077144.7A patent/CN107595836A/zh active Pending
- 2011-10-31 ES ES11837249.9T patent/ES2635435T3/es active Active
- 2011-10-31 AU AU2011320155A patent/AU2011320155B2/en active Active
- 2011-10-31 EP EP11837249.9A patent/EP2632550B1/en active Active
- 2011-10-31 US US13/285,397 patent/US8962680B2/en active Active
- 2011-10-31 PL PL11837249T patent/PL2632550T3/pl unknown
- 2011-10-31 CN CN2011800637391A patent/CN103370101A/zh active Pending
- 2011-11-11 US US13/294,307 patent/US20120107370A1/en not_active Abandoned
-
2013
- 2013-04-29 ZA ZA2013/03136A patent/ZA201303136B/en unknown
- 2013-05-31 EC ECSP13012650 patent/ECSP13012650A/es unknown
-
2014
- 2014-06-17 US US14/307,175 patent/US20140294903A1/en not_active Abandoned
-
2015
- 2015-01-15 US US14/597,740 patent/US9585868B2/en active Active
-
2016
- 2016-08-02 JP JP2016151656A patent/JP6310971B2/ja active Active
-
2018
- 2018-07-09 HK HK18108819.2A patent/HK1249036A1/zh unknown
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