JP2013540821A5 - - Google Patents
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- Publication number
- JP2013540821A5 JP2013540821A5 JP2013536780A JP2013536780A JP2013540821A5 JP 2013540821 A5 JP2013540821 A5 JP 2013540821A5 JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013540821 A5 JP2013540821 A5 JP 2013540821A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- chitosan
- agents
- particles
- solid sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 20
- 206010039509 Scab Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920002527 Glycogen Polymers 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 229920002201 Oxidized cellulose Polymers 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 229940125687 antiparasitic agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000002599 biostatic effect Effects 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 125000000404 glutamine group Chemical class N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 229940096919 glycogen Drugs 0.000 claims 1
- 239000002874 hemostatic agent Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940066491 mucolytics Drugs 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229940107304 oxidized cellulose Drugs 0.000 claims 1
- 239000001254 oxidized starch Substances 0.000 claims 1
- 235000013808 oxidized starch Nutrition 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000005526 vasoconstrictor agent Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 239000000499 gel Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000007614 solvation Methods 0.000 description 2
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40739110P | 2010-10-27 | 2010-10-27 | |
| US61/407,391 | 2010-10-27 | ||
| PCT/US2011/057893 WO2012058312A1 (en) | 2010-10-27 | 2011-10-26 | Artificial scab for use in an airway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540821A JP2013540821A (ja) | 2013-11-07 |
| JP2013540821A5 true JP2013540821A5 (enExample) | 2016-03-03 |
| JP5937094B2 JP5937094B2 (ja) | 2016-06-22 |
Family
ID=45034163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536780A Active JP5937094B2 (ja) | 2010-10-27 | 2011-10-26 | 気道に使用する人口かさぶた |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9700648B2 (enExample) |
| EP (1) | EP2632502B1 (enExample) |
| JP (1) | JP5937094B2 (enExample) |
| AU (1) | AU2011319947B2 (enExample) |
| CA (1) | CA2814148C (enExample) |
| ES (1) | ES2543019T3 (enExample) |
| WO (1) | WO2012058312A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| WO2011060390A2 (en) | 2009-11-13 | 2011-05-19 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| US8920364B2 (en) * | 2013-02-28 | 2014-12-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
| US8845578B2 (en) | 2013-02-28 | 2014-09-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
| CA2914610C (en) | 2013-03-13 | 2022-08-02 | University Of Maryland | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| US10183132B2 (en) | 2014-09-11 | 2019-01-22 | Ethicon Llc | Methods and devices for co-delivery of liquid and powdered hemostats and sealants |
| CN104744723B (zh) * | 2015-03-10 | 2018-06-12 | 江苏卓见医疗用品有限公司 | 壳聚糖医用材料及其制备方法和用途 |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| US12102729B2 (en) | 2017-08-04 | 2024-10-01 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US11571492B2 (en) | 2017-08-04 | 2023-02-07 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US10835635B2 (en) | 2017-08-04 | 2020-11-17 | Hcs Innovation, Llc | Natural polymer based tissue adhesive with healing promoting properties |
| CN121944198A (zh) | 2018-01-12 | 2026-05-01 | 波士顿科学国际有限公司 | 实现止血的粉末 |
| US10517988B1 (en) | 2018-11-19 | 2019-12-31 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
| WO2020106703A1 (en) | 2018-11-19 | 2020-05-28 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
| CN109498833B (zh) * | 2018-12-12 | 2021-05-28 | 济南格莱威医疗科技有限公司 | 一种医用可吸收多聚糖复合材料及其用途 |
| NL2022788B1 (en) * | 2019-03-22 | 2020-09-28 | No Ceuticals B V | Chitosan nitrate for use as a nitric oxide donor (NO donor) |
| CN114667103A (zh) | 2019-11-04 | 2022-06-24 | 柯惠有限合伙公司 | 用于治疗颅内动脉瘤的装置、系统和方法 |
| WO2022198208A1 (en) | 2021-03-16 | 2022-09-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
| CN118284367A (zh) | 2021-09-10 | 2024-07-02 | 广州倍绣生物技术有限公司 | 用于在手术部位控制出血并密封组织的组合式止血粉末和液体递送装置 |
| WO2026024703A1 (en) * | 2024-07-22 | 2026-01-29 | NovoMedTek LLC | Chemical composition for oral applications |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2772999A (en) * | 1952-06-06 | 1956-12-04 | Johnson & Johnson | Hemostatic surgical compositions and dressings |
| US4952618A (en) * | 1988-05-03 | 1990-08-28 | Minnesota Mining And Manufacturing Company | Hydrocolloid/adhesive composition |
| CZ288792B6 (cs) | 1993-12-23 | 2001-09-12 | Johnson & Johnson Medical, Inc. | Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby |
| CN1130205C (zh) * | 1994-07-01 | 2003-12-10 | 巴克斯特国际有限公司 | 生物化学平衡的腹膜透析溶液 |
| AU4941297A (en) * | 1996-11-15 | 1998-06-10 | Dumex-Alpharma A/S | A method for promoting tissue repair |
| US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| US20060004314A1 (en) | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| ATA13842001A (de) | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
| DE10152407A1 (de) | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten |
| US6669695B2 (en) * | 2002-01-15 | 2003-12-30 | Giancarlo Luigi | Multifunctional electrosurgical instrument |
| JP4321007B2 (ja) * | 2002-04-25 | 2009-08-26 | 凸版印刷株式会社 | 多糖類複合体及びその製造方法 |
| US20040052850A1 (en) | 2002-09-13 | 2004-03-18 | Kemal Schankereli | Proteinaceous hemostatic tissue sealant |
| GB2393120A (en) * | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
| MXPA05010692A (es) | 2003-04-04 | 2006-04-18 | Tissuemed Ltd | Formulaciones que se adhieren a tejido. |
| US7834065B2 (en) * | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| US20090062233A1 (en) * | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
| US8653319B2 (en) * | 2008-04-24 | 2014-02-18 | Medtronic, Inc. | Cold ionizing radiation sterilization |
| CA2721937C (en) | 2008-04-24 | 2016-07-12 | Medtronic, Inc. | Protective gel based on chitosan and oxidized polysaccharide |
| EP2296637B1 (en) | 2008-04-24 | 2014-04-02 | Medtronic, Inc | Chitosan-containing protective composition |
-
2011
- 2011-10-26 JP JP2013536780A patent/JP5937094B2/ja active Active
- 2011-10-26 CA CA2814148A patent/CA2814148C/en not_active Expired - Fee Related
- 2011-10-26 ES ES11787959.3T patent/ES2543019T3/es active Active
- 2011-10-26 EP EP11787959.3A patent/EP2632502B1/en active Active
- 2011-10-26 US US13/282,332 patent/US9700648B2/en active Active
- 2011-10-26 AU AU2011319947A patent/AU2011319947B2/en not_active Ceased
- 2011-10-26 WO PCT/US2011/057893 patent/WO2012058312A1/en not_active Ceased
-
2017
- 2017-07-10 US US15/645,674 patent/US10279072B2/en active Active
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