JP2013540821A5 - - Google Patents
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- Publication number
- JP2013540821A5 JP2013540821A5 JP2013536780A JP2013536780A JP2013540821A5 JP 2013540821 A5 JP2013540821 A5 JP 2013540821A5 JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013540821 A5 JP2013540821 A5 JP 2013540821A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- chitosan
- agents
- particles
- solid sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 20
- 206010039509 Scab Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920002527 Glycogen Polymers 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 229920002201 Oxidized cellulose Polymers 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 229940125687 antiparasitic agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000002599 biostatic effect Effects 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 125000000404 glutamine group Chemical class N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 229940096919 glycogen Drugs 0.000 claims 1
- 239000002874 hemostatic agent Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940066491 mucolytics Drugs 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229940107304 oxidized cellulose Drugs 0.000 claims 1
- 239000001254 oxidized starch Substances 0.000 claims 1
- 235000013808 oxidized starch Nutrition 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000005526 vasoconstrictor agent Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 239000000499 gel Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000007614 solvation Methods 0.000 description 2
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40739110P | 2010-10-27 | 2010-10-27 | |
| US61/407,391 | 2010-10-27 | ||
| PCT/US2011/057893 WO2012058312A1 (en) | 2010-10-27 | 2011-10-26 | Artificial scab for use in an airway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540821A JP2013540821A (ja) | 2013-11-07 |
| JP2013540821A5 true JP2013540821A5 (enExample) | 2016-03-03 |
| JP5937094B2 JP5937094B2 (ja) | 2016-06-22 |
Family
ID=45034163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536780A Active JP5937094B2 (ja) | 2010-10-27 | 2011-10-26 | 気道に使用する人口かさぶた |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9700648B2 (enExample) |
| EP (1) | EP2632502B1 (enExample) |
| JP (1) | JP5937094B2 (enExample) |
| AU (1) | AU2011319947B2 (enExample) |
| CA (1) | CA2814148C (enExample) |
| ES (1) | ES2543019T3 (enExample) |
| WO (1) | WO2012058312A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| US8668899B2 (en) | 2009-11-13 | 2014-03-11 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| US8920364B2 (en) | 2013-02-28 | 2014-12-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
| US8845578B2 (en) * | 2013-02-28 | 2014-09-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
| WO2014160136A1 (en) | 2013-03-13 | 2014-10-02 | University Of Maryland, Office Of Technology Commercialization | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| US10183132B2 (en) | 2014-09-11 | 2019-01-22 | Ethicon Llc | Methods and devices for co-delivery of liquid and powdered hemostats and sealants |
| CN104744723B (zh) * | 2015-03-10 | 2018-06-12 | 江苏卓见医疗用品有限公司 | 壳聚糖医用材料及其制备方法和用途 |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| US11571492B2 (en) | 2017-08-04 | 2023-02-07 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US12102729B2 (en) | 2017-08-04 | 2024-10-01 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US10835635B2 (en) | 2017-08-04 | 2020-11-17 | Hcs Innovation, Llc | Natural polymer based tissue adhesive with healing promoting properties |
| US10786596B2 (en) * | 2018-01-12 | 2020-09-29 | Boston Scientific Scimed, Inc. | Powder for achieving hemostasis |
| US12091471B2 (en) | 2018-11-19 | 2024-09-17 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
| US10517988B1 (en) | 2018-11-19 | 2019-12-31 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
| CN109498833B (zh) * | 2018-12-12 | 2021-05-28 | 济南格莱威医疗科技有限公司 | 一种医用可吸收多聚糖复合材料及其用途 |
| NL2022788B1 (en) * | 2019-03-22 | 2020-09-28 | No Ceuticals B V | Chitosan nitrate for use as a nitric oxide donor (NO donor) |
| EP4054440B1 (en) | 2019-11-04 | 2024-06-05 | Covidien LP | Manufacturing method of devices for treatment of intracranial aneurysms |
| US12364793B2 (en) | 2021-03-16 | 2025-07-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
| US20240350126A1 (en) | 2021-09-10 | 2024-10-24 | Guangzhou Bioseal Biotech Co., Ltd. | Combined hemostatic powder and liquid delivery devices for controlling bleeding and sealing tissue at surgical sites |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2772999A (en) * | 1952-06-06 | 1956-12-04 | Johnson & Johnson | Hemostatic surgical compositions and dressings |
| US4952618A (en) * | 1988-05-03 | 1990-08-28 | Minnesota Mining And Manufacturing Company | Hydrocolloid/adhesive composition |
| CZ288792B6 (cs) | 1993-12-23 | 2001-09-12 | Johnson & Johnson Medical, Inc. | Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby |
| CN1130205C (zh) * | 1994-07-01 | 2003-12-10 | 巴克斯特国际有限公司 | 生物化学平衡的腹膜透析溶液 |
| WO1998022114A1 (en) * | 1996-11-15 | 1998-05-28 | Dumex-Alpharma A/S | A method for promoting tissue repair |
| US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| WO2004087227A1 (en) | 2003-04-04 | 2004-10-14 | Tissuemed Limited | Tissue-adhesive formulations |
| US20060004314A1 (en) | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| ATA13842001A (de) | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
| DE10152407A1 (de) | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten |
| US6669695B2 (en) * | 2002-01-15 | 2003-12-30 | Giancarlo Luigi | Multifunctional electrosurgical instrument |
| JP4321007B2 (ja) * | 2002-04-25 | 2009-08-26 | 凸版印刷株式会社 | 多糖類複合体及びその製造方法 |
| US20040052850A1 (en) | 2002-09-13 | 2004-03-18 | Kemal Schankereli | Proteinaceous hemostatic tissue sealant |
| GB2393120A (en) * | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
| US7834065B2 (en) * | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| US20090062233A1 (en) * | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
| CA2722155C (en) * | 2008-04-24 | 2019-07-30 | Medtronic, Inc. | Cold ionizing radiation sterilization |
| CA2721938C (en) | 2008-04-24 | 2016-08-09 | Medtronic, Inc. | Chitosan-containing protective composition |
| CN102065849B (zh) | 2008-04-24 | 2015-04-29 | 麦德托尼克公司 | 基于壳聚糖和氧化多糖的保护性凝胶 |
-
2011
- 2011-10-26 CA CA2814148A patent/CA2814148C/en not_active Expired - Fee Related
- 2011-10-26 ES ES11787959.3T patent/ES2543019T3/es active Active
- 2011-10-26 WO PCT/US2011/057893 patent/WO2012058312A1/en not_active Ceased
- 2011-10-26 JP JP2013536780A patent/JP5937094B2/ja active Active
- 2011-10-26 EP EP11787959.3A patent/EP2632502B1/en active Active
- 2011-10-26 AU AU2011319947A patent/AU2011319947B2/en not_active Ceased
- 2011-10-26 US US13/282,332 patent/US9700648B2/en active Active
-
2017
- 2017-07-10 US US15/645,674 patent/US10279072B2/en active Active
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