JP2013540821A - 気道に使用する人口かさぶた - Google Patents
気道に使用する人口かさぶた Download PDFInfo
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- JP2013540821A JP2013540821A JP2013536780A JP2013536780A JP2013540821A JP 2013540821 A JP2013540821 A JP 2013540821A JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013536780 A JP2013536780 A JP 2013536780A JP 2013540821 A JP2013540821 A JP 2013540821A
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Abstract
【選択図】図1
Description
[0001]本出願は、2010年10月27日に出願された米国特許仮出願第61/407391号「気道に使用する人口かさぶた(ARTIFICIAL SCAB FOR USE IN AN AIRWAY)」の優先権を主張するものである。この米国特許仮出願の開示内容を、ここで参照することによって本願明細書に援用する。
[0050]キトサングルタメート(エフエムシー・バイオポリマー・エーエス(FMC BioPolymer AS)のノバマトリックス(NovaMatrix)ユニット製のPROTASAN(登録商標)UP G 213)と酸化でんぷん(シグマ・アルドリッチ(Sigma-Aldrich)製のP9265ポリマージアルデヒド)との50:50の混合物から、粉末混合物を生成した。以下の表では「実行第1号」としたこの混合物について、ハムスターの頬袋モデルを使用して、その生体内粘膜接着性を評価した。ハムスターの頬袋のそれぞれにおいて2か所、紙やすりで皮をめくって、その露出した表面にテスト試料を塗布した。動物たちにはカラーをつけて試料が剥がれてしまわないようにして、塗布のあと1日、3日、5日、7日後に目視で検査を行い、滞留期間を評価した。また、粉末状混合物を湿らせたソーセージの皮の欠片にも塗布し、混合物が古くなっていくうちに気道を塞いでしまう危険性が発生するかどうかについて、医者団によって客観的に判断してもらった。同様の粘膜接着性と気道閉塞についての評価を、PCT出願公開番号:WO2009/132229A2に記載の通りに低温電子線ビーム(cold e-beam)で滅菌した酸化でんぷんとして、モノマー・ポリマー及びダジャック・ラボ社(Monomer-Polymer and Dajac Labs, Inc.)製のジアルデヒドスターチ(Dialdehyde Starch)9056を使用して生成した試料(実行第2号)において行った。その他7つの市販されている又は実験により生成可能なシーリング材(実行第3〜9号)を同様に評価した。以下の表にその結果を示す。
[0052]実施例1における実行第1号の粉末状混合物を、犬の扁桃摘出術モデルを使用して評価し、組織学的分析を通して、無治療対照と比較して刺激性がないものと判断された。第2の犬扁桃摘出術テストを行い、様々な電気焼灼器切除の設定を使用し、また、粉体の塗布直後に潅注工程を実行して、その止血作用を評価した。電気焼灼器の設定に関わらずすべての部位において粉末状混合物は問題なく接着し、止血効果を発揮することが分かった。塗布された粉末状混合物は潅注後であってもその場に留まり続けた。扁桃床の治癒についても検査したが、その結果は、電気焼灼器設定が低いほど、治癒効果が高いということを示した。
[0053]実施例1における実行第1号の粉末状混合物を、豚肝臓生検パンチ止血モデルにおいて評価した。当該混合物は、可撓性のある背部を有するキトサンをベースとした止血材料である、ヘムコム・メディカルテクノロジーズ社(HemCon Medical Technologies, Inc.)製のHemCom(登録商標)包帯が示す機能と同様の機能を示し、止血手段として認められるものであると評価された。
[0054]第3の犬扁桃摘出術テストを行い、治療の効能を評価した。塗布から10日後、実施例1の実行第2号の粉末状混合物によって治療した創傷部位は、無治療対照の部位と比較して約50%小さくなっていた。
[0001]本出願は、2010年10月27日に出願された米国特許仮出願第61/407391号「気道に使用する人口かさぶた(ARTIFICIAL SCAB FOR USE IN AN AIRWAY)」の優先権を主張するものである。この米国特許仮出願の開示内容を、ここで参照することによって本願明細書に援用する。
[0050]キトサングルタメート(エフエムシー・バイオポリマー・エーエス(FMC BioPolymer AS)のノバマトリックス(NovaMatrix)ユニット製のPROTASAN(登録商標)UP G 213)と酸化でんぷん(シグマ・アルドリッチ(Sigma-Aldrich)製のP9265ポリマージアルデヒド)との50:50の混合物から、粉末混合物を生成した。以下の表では「実行第1号」としたこの混合物について、ハムスターの頬袋モデルを使用して、その生体内粘膜接着性を評価した。ハムスターの頬袋のそれぞれにおいて2か所、紙やすりで皮をめくって、その露出した表面にテスト試料を塗布した。動物たちにはカラーをつけて試料が剥がれてしまわないようにして、塗布のあと1日、3日、5日、7日後に目視で検査を行い、滞留期間を評価した。また、粉末状混合物を湿らせたソーセージの皮の欠片にも塗布し、混合物が古くなっていくうちに気道を塞いでしまう危険性が発生するかどうかについて、医者団によって客観的に判断してもらった。同様の粘膜接着性と気道閉塞についての評価を、PCT出願公開番号:WO2009/132229A2に記載の通りに低温電子線ビーム(cold e-beam)で滅菌した酸化でんぷんとして、モノマー・ポリマー及びダジャック・ラボ社(Monomer-Polymer and Dajac Labs, Inc.)製のジアルデヒドスターチ(Dialdehyde Starch)9056を使用して生成した試料(実行第2号)において行った。その他7つの市販されている又は実験により生成可能なシーリング材(実行第3〜9号)を同様に評価した。以下の表にその結果を示す。
[0052]実施例1における実行第1号の粉末状混合物を、犬の扁桃摘出術モデルを使用して評価し、組織学的分析を通して、無治療対照と比較して刺激性がないものと判断された。第2の犬扁桃摘出術テストを行い、様々な電気焼灼器切除の設定を使用し、また、粉体の塗布直後に潅注工程を実行して、その止血作用を評価した。電気焼灼器の設定に関わらずすべての部位において粉末状混合物は問題なく接着し、止血効果を発揮することが分かった。塗布された粉末状混合物は潅注後であってもその場に留まり続けた。扁桃床の治癒についても検査したが、その結果は、電気焼灼器設定が低いほど、治癒効果が高いということを示した。
[0053]実施例1における実行第1号の粉末状混合物を、豚肝臓生検パンチ止血モデルにおいて評価した。当該混合物は、可撓性のある背部を有するキトサンをベースとした止血材料である、ヘムコム・メディカルテクノロジーズ社(HemCon Medical Technologies, Inc.)製のHemCom(登録商標)包帯が示す機能と同様の機能を示し、止血手段として認められるものであると評価された。
[0054]第3の犬扁桃摘出術テストを行い、治療の効能を評価した。塗布から10日後、実施例1の実行第2号の粉末状混合物によって治療した創傷部位は、無治療対照の部位と比較して約50%小さくなっていた。
Claims (20)
- 少なくとも部分的に溶媒和可能であるキトサン粒子と少なくとも部分的に溶媒和可能である酸化多糖粒子よりなる、実質的に乾燥した自由流動性の粉末状混合物を含む組成物であって、
前記粉末状混合物は、体液で湿潤した手術部位又は創傷部位に付着することによって不均一で非結合の固形シート状体を形成し、当該固形シート状体は前記手術部位又は創傷部位から剥がれた場合、より小さな欠片へと分解するようになっている、組成物。 - 請求項1記載の組成物において、
前記実質的に乾燥した自由流動性の粉末状混合物は、10wt%未満の水を含んでいる、組成物。 - 請求項1記載の組成物において、
前記実質的に乾燥した自由流動性の粉末状混合物は、5wt%未満の水を含んでいる、組成物。 - 請求項1記載の組成物において、
前記キトサンは、高分子量のキトサンを含む、組成物。 - 請求項1記載の組成物において、
前記キトサンは、塩を含む、組成物。 - 請求項1記載の組成物において、
前記キトサンは、グルタミン塩を含む、組成物。 - 請求項1記載の組成物において、
前記酸化多糖は、酸化セルロース、キチン、キトサン、コンドロイチン硫酸、デキストラン、グリコーゲン、及びヒアルロン酸のうちのいずれかを含む、組成物。 - 請求項1記載の組成物において、
前記酸化多糖は、酸化でんぷんを含む、組成物。 - 請求項1記載の組成物において、
約10〜約90wt%のキトサンと、約90〜10wt%の酸化多糖とを含む、組成物。 - 請求項1記載の組成物において、
約20〜約80wt%のキトサンと、約90〜10wt%の酸化多糖をと含む、組成物。 - 請求項1記載の組成物において、
約30〜約70wt%のキトサンと、約90〜10wt%の酸化多糖をと含む、組成物。 - 請求項1記載の組成物において、
さらに抗菌剤を含む、組成物。 - 請求項1記載の組成物において、
さらに、鎮痛薬、抗コリン作動薬、抗真菌剤、抗ヒスタミン剤、ステロイド性又は非ステロイド性抗炎症剤、抗寄生虫剤、抗ウイルス剤、生物静力学的組成物、化学療法剤又は抗腫瘍剤、サイトカイン、充血除去剤、追加の止血剤、免疫抑制剤、粘液溶解剤、核酸、ペプチド、タンパク質、ステロイド、血管収縮剤、ビタミン、及びこれらの組合せのうちのいずれかを含む、組成物。 - 手術部位又は創傷部位に付着する不均一で非結合の固形シート状体を含む人工かさぶたであって、
前記固形シート状体は、前記手術部位又は創傷部位から剥がれるとより小さな欠片へ分解するようになっているキトサン粒子及び多糖粒子からなる粒状混合物を含んでいる、人工かさぶた。 - 請求項14記載の人工かさぶたにおいて、
前記手術部位又は創傷部位は気道内にある、人工かさぶた。 - 請求項14記載の人工かさぶたにおいて、
1日よりも長い滞留期間を有する、人工かさぶた。 - 請求項14記載の人工かさぶたにおいて、
3日よりも長い滞留期間を有する、人工かさぶた。 - 請求項14記載の人工かさぶたにおいて、
2週間未満の滞留期間を有する、人工かさぶた。 - (a)少なくとも部分的に溶媒和可能であるキトサン粒子と少なくとも部分的に溶媒和可能である酸化多糖粒子よりなる、実質的に乾燥した自由流動性の粉末状混合物を、血液やその他の体液、又は水で湿潤した、気道中の手術部位又は創傷部位に塗布する工程と、
(b)前記組織又は構造に付着した不均一で非結合の固形シート状体であって、前記手術部位又は創傷部位から剥がれたときにより小さい欠片へと分解する、前記キトサン粒子及び前記多糖粒子からなる粒状混合物を含む固形シート状体からなる人工かさぶたを形成する工程と、
を含む、方法。 - 請求項19記載の方法において、
前記手術部位又は創傷部位から大量の塗布した粉末を取り除くことなしに、前記塗布した粉末状混合物に水を加える工程をさらに含む、方法。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021517829A (ja) * | 2018-01-12 | 2021-07-29 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 止血を達成するための粉末 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
CA2780898A1 (en) | 2009-11-13 | 2011-05-19 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
US8845578B2 (en) | 2013-02-28 | 2014-09-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
US8920364B2 (en) | 2013-02-28 | 2014-12-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
WO2014160136A1 (en) | 2013-03-13 | 2014-10-02 | University Of Maryland, Office Of Technology Commercialization | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
US10183132B2 (en) * | 2014-09-11 | 2019-01-22 | Ethicon Llc | Methods and devices for co-delivery of liquid and powdered hemostats and sealants |
CN104744723B (zh) * | 2015-03-10 | 2018-06-12 | 江苏卓见医疗用品有限公司 | 壳聚糖医用材料及其制备方法和用途 |
US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
US11571492B2 (en) | 2017-08-04 | 2023-02-07 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
US10835635B2 (en) | 2017-08-04 | 2020-11-17 | Hcs Innovation, Llc | Natural polymer based tissue adhesive with healing promoting properties |
US10517988B1 (en) | 2018-11-19 | 2019-12-31 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
CN109498833B (zh) * | 2018-12-12 | 2021-05-28 | 济南格莱威医疗科技有限公司 | 一种医用可吸收多聚糖复合材料及其用途 |
NL2022788B1 (en) * | 2019-03-22 | 2020-09-28 | No Ceuticals B V | Chitosan nitrate for use as a nitric oxide donor (NO donor) |
KR20240056585A (ko) | 2021-09-10 | 2024-04-30 | 광저우 바이오실 바이오테크 캄파니 리미티드 | 수술 부위에서 출혈을 제어하고 조직을 봉합하기 위한 조합형 지혈 분말 및 액체 전달 디바이스 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321398A (ja) * | 2002-04-25 | 2003-11-11 | Toppan Printing Co Ltd | 多糖類複合体及びその製造方法 |
JP2006514843A (ja) * | 2002-09-18 | 2006-05-18 | ジョンソン・アンド・ジョンソン・メディカル・リミテッド | キトサンと酸化セルロースとを含有する創傷包帯用組成物 |
WO2009132228A1 (en) * | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Chitosan-containing protective composition |
WO2009132225A2 (en) * | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Rehydratable polysaccharide particles and sponge |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2772999A (en) * | 1952-06-06 | 1956-12-04 | Johnson & Johnson | Hemostatic surgical compositions and dressings |
US4952618A (en) * | 1988-05-03 | 1990-08-28 | Minnesota Mining And Manufacturing Company | Hydrocolloid/adhesive composition |
CZ288792B6 (cs) * | 1993-12-23 | 2001-09-12 | Johnson & Johnson Medical, Inc. | Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby |
CN1130205C (zh) * | 1994-07-01 | 2003-12-10 | 巴克斯特国际有限公司 | 生物化学平衡的腹膜透析溶液 |
AU4941297A (en) * | 1996-11-15 | 1998-06-10 | Dumex-Alpharma A/S | A method for promoting tissue repair |
US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
US20060004314A1 (en) | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
ATA13842001A (de) | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
DE10152407A1 (de) | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten |
US6669695B2 (en) * | 2002-01-15 | 2003-12-30 | Giancarlo Luigi | Multifunctional electrosurgical instrument |
US20040052850A1 (en) | 2002-09-13 | 2004-03-18 | Kemal Schankereli | Proteinaceous hemostatic tissue sealant |
AU2004226578A1 (en) | 2003-04-04 | 2004-10-14 | Tissuemed Limited | Tissue-adhesive formulations |
US7834065B2 (en) * | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
US20090062233A1 (en) * | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
WO2009132227A1 (en) | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Protective gel based on chitosan and oxidized polysaccharide |
-
2011
- 2011-10-26 US US13/282,332 patent/US9700648B2/en active Active
- 2011-10-26 CA CA2814148A patent/CA2814148C/en not_active Expired - Fee Related
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321398A (ja) * | 2002-04-25 | 2003-11-11 | Toppan Printing Co Ltd | 多糖類複合体及びその製造方法 |
JP2006514843A (ja) * | 2002-09-18 | 2006-05-18 | ジョンソン・アンド・ジョンソン・メディカル・リミテッド | キトサンと酸化セルロースとを含有する創傷包帯用組成物 |
WO2009132228A1 (en) * | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Chitosan-containing protective composition |
WO2009132225A2 (en) * | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Rehydratable polysaccharide particles and sponge |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021517829A (ja) * | 2018-01-12 | 2021-07-29 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 止血を達成するための粉末 |
JP7317839B2 (ja) | 2018-01-12 | 2023-07-31 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 止血を達成するための粉末 |
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ES2543019T3 (es) | 2015-08-14 |
WO2012058312A1 (en) | 2012-05-03 |
CA2814148A1 (en) | 2012-05-03 |
US9700648B2 (en) | 2017-07-11 |
CA2814148C (en) | 2018-11-06 |
JP5937094B2 (ja) | 2016-06-22 |
US20120108509A1 (en) | 2012-05-03 |
EP2632502A1 (en) | 2013-09-04 |
AU2011319947A1 (en) | 2013-05-09 |
AU2011319947B2 (en) | 2015-01-22 |
EP2632502B1 (en) | 2015-05-06 |
US20170304487A1 (en) | 2017-10-26 |
US10279072B2 (en) | 2019-05-07 |
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