JP2013538786A5 - - Google Patents
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- Publication number
- JP2013538786A5 JP2013538786A5 JP2013515601A JP2013515601A JP2013538786A5 JP 2013538786 A5 JP2013538786 A5 JP 2013538786A5 JP 2013515601 A JP2013515601 A JP 2013515601A JP 2013515601 A JP2013515601 A JP 2013515601A JP 2013538786 A5 JP2013538786 A5 JP 2013538786A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- aromatic heterocyclic
- substituted
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims description 62
- 125000003277 amino group Chemical group 0.000 claims description 53
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 49
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 31
- 125000005843 halogen group Chemical group 0.000 claims description 30
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 25
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 24
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 21
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 2
- NVCYESZQCJFSDL-NSHDSACASA-N (2r)-2-phenyl-2-(trifluoromethyl)-1,4-oxazepane Chemical compound C=1C=CC=CC=1[C@]1(C(F)(F)F)CNCCCO1 NVCYESZQCJFSDL-NSHDSACASA-N 0.000 claims 1
- AWMLZOAUCZXUQG-NXEZZACHSA-N (6r,7r)-6-hydroxy-7-phenyl-1,4-oxazepan-5-one Chemical compound O1CCNC(=O)[C@H](O)[C@H]1C1=CC=CC=C1 AWMLZOAUCZXUQG-NXEZZACHSA-N 0.000 claims 1
- BKYNHOGAASXLEV-UHFFFAOYSA-N 2-methyl-2-phenyl-1,4-oxazepane Chemical compound C=1C=CC=CC=1C1(C)CNCCCO1 BKYNHOGAASXLEV-UHFFFAOYSA-N 0.000 claims 1
- CFHMIFNNYVJLRQ-UHFFFAOYSA-N 6-methyl-6-phenyl-1,4-oxazepane Chemical compound C=1C=CC=CC=1C1(C)CNCCOC1 CFHMIFNNYVJLRQ-UHFFFAOYSA-N 0.000 claims 1
- JSXUKIZDGHZTQO-UHFFFAOYSA-N 7-hydroxy-7-(4-methoxyphenyl)-1,4-oxazepan-2-one Chemical compound C1=CC(OC)=CC=C1C1(O)OC(=O)CNCC1 JSXUKIZDGHZTQO-UHFFFAOYSA-N 0.000 claims 1
- OJUYHLMOHQANOU-UHFFFAOYSA-N 7-methyl-7-phenyl-1,4-oxazepane Chemical compound C=1C=CC=CC=1C1(C)CCNCCO1 OJUYHLMOHQANOU-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- -1 methylsulfonylamino, ethylsulfonylamino Chemical group 0.000 description 185
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 67
- 125000004043 oxo group Chemical group O=* 0.000 description 59
- 125000005049 dihydrooxadiazolyl group Chemical group O1N(NC=C1)* 0.000 description 48
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 47
- 125000000217 alkyl group Chemical group 0.000 description 29
- 125000001153 fluoro group Chemical group F* 0.000 description 25
- 229910052731 fluorine Inorganic materials 0.000 description 23
- 125000004122 cyclic group Chemical group 0.000 description 22
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 18
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 description 15
- 125000003545 alkoxy group Chemical group 0.000 description 15
- 229910052801 chlorine Inorganic materials 0.000 description 13
- 125000001309 chloro group Chemical group Cl* 0.000 description 13
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 12
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 10
- 125000003831 tetrazolyl group Chemical group 0.000 description 10
- 125000001425 triazolyl group Chemical group 0.000 description 10
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 description 9
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 8
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 8
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 8
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 8
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 7
- 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 6
- 125000003710 aryl alkyl group Chemical group 0.000 description 6
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 6
- 125000004104 aryloxy group Chemical group 0.000 description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 6
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 6
- 125000004076 pyridyl group Chemical group 0.000 description 6
- 125000005554 pyridyloxy group Chemical group 0.000 description 6
- 125000000335 thiazolyl group Chemical group 0.000 description 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 description 4
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 4
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 4
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 4
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 4
- 125000005058 dihydrotriazolyl group Chemical group N1(NNC=C1)* 0.000 description 4
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 4
- 125000001715 oxadiazolyl group Chemical group 0.000 description 4
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 3
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 2
- 125000001607 1,2,3-triazol-1-yl group Chemical group [*]N1N=NC([H])=C1[H] 0.000 description 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- KJTRXVXWSSPHRV-UHFFFAOYSA-N 4-benzoyl-5-methyl-2-phenyl-1h-pyrazol-3-one Chemical compound O=C1C(C(=O)C=2C=CC=CC=2)=C(C)NN1C1=CC=CC=C1 KJTRXVXWSSPHRV-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000001691 aryl alkyl amino group Chemical group 0.000 description 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 2
- 125000005110 aryl thio group Chemical group 0.000 description 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 2
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 2
- 125000000000 cycloalkoxy group Chemical group 0.000 description 2
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 description 2
- 125000000131 cyclopropyloxy group Chemical group C1(CC1)O* 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 125000000532 dioxanyl group Chemical group 0.000 description 2
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 description 2
- 125000000842 isoxazolyl group Chemical group 0.000 description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 description 2
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 description 2
- 125000002971 oxazolyl group Chemical group 0.000 description 2
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 2
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 2
- 125000004523 tetrazol-1-yl group Chemical group N1(N=NN=C1)* 0.000 description 2
- 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 description 2
- 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 description 2
- 125000000464 thioxo group Chemical group S=* 0.000 description 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 description 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 description 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 description 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 description 1
- 125000005129 aryl carbonyl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000002632 imidazolidinyl group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013515601A JP5873487B2 (ja) | 2010-10-07 | 2011-10-05 | １，４−オキサゼパン誘導体 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010227864 | 2010-10-07 | ||
| JP2010227864 | 2010-10-07 | ||
| JP2011175336 | 2011-08-10 | ||
| JP2011175336 | 2011-08-10 | ||
| JP2013515601A JP5873487B2 (ja) | 2010-10-07 | 2011-10-05 | １，４−オキサゼパン誘導体 |
| PCT/JP2011/073745 WO2012046882A1 (en) | 2010-10-07 | 2011-10-05 | 1,4-oxazepane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538786A JP2013538786A (ja) | 2013-10-17 |
| JP2013538786A5 true JP2013538786A5 (https=) | 2014-10-30 |
| JP5873487B2 JP5873487B2 (ja) | 2016-03-01 |
Family
ID=44906302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515601A Expired - Fee Related JP5873487B2 (ja) | 2010-10-07 | 2011-10-05 | １，４−オキサゼパン誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8722662B2 (https=) |
| EP (1) | EP2625170A1 (https=) |
| JP (1) | JP5873487B2 (https=) |
| KR (1) | KR20130116073A (https=) |
| CN (1) | CN103261176B (https=) |
| AR (1) | AR083313A1 (https=) |
| AU (1) | AU2011313150A1 (https=) |
| BR (1) | BR112013008420A2 (https=) |
| CA (1) | CA2813911A1 (https=) |
| CL (1) | CL2013000927A1 (https=) |
| CO (1) | CO6700872A2 (https=) |
| CR (1) | CR20130158A (https=) |
| DO (1) | DOP2013000074A (https=) |
| EA (1) | EA201390491A1 (https=) |
| EC (1) | ECSP13012593A (https=) |
| GE (1) | GEP20156295B (https=) |
| IL (1) | IL225189A0 (https=) |
| MX (1) | MX2013003749A (https=) |
| NZ (1) | NZ608499A (https=) |
| PE (1) | PE20140239A1 (https=) |
| PH (1) | PH12013500657A1 (https=) |
| SG (1) | SG188346A1 (https=) |
| TW (1) | TW201242956A (https=) |
| UY (1) | UY33650A (https=) |
| WO (1) | WO2012046882A1 (https=) |
| ZA (1) | ZA201302112B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2630677C2 (ru) * | 2011-12-21 | 2017-09-12 | Оно Фармасьютикал Ко., Лтд. | Соединения |
| CA2918814C (en) * | 2013-07-23 | 2021-10-12 | Bayer Pharma Aktiengesellschaft | Substituted oxopyridine derivatives and use thereof as factor xia/plasma |
| CN105693652B (zh) * | 2014-11-27 | 2019-01-08 | 常州合全药业有限公司 | 一种4-叔丁基-5-乙基-6-氧亚基-1,4-噁吖庚环-4,5-二甲酸基酯的合成方法 |
| MX385021B (es) | 2014-12-10 | 2025-03-14 | Ono Pharmaceutical Co | Derivado de dihidroindolizinona. |
| US10414723B2 (en) | 2015-05-08 | 2019-09-17 | Vertellus Holdings Llc | Processes for converting carboxamides to thiocarboxamides |
| WO2024251807A1 (en) * | 2023-06-08 | 2024-12-12 | Cybin Irl Limited | Companion animal treatments |
| IL325385A (en) * | 2023-06-27 | 2026-02-01 | Rycarma Therapeutics Inc | Agents for the treatment of ryanodine receptor-related disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3018222A (en) | 1956-08-28 | 1962-01-23 | Ravensberg G M B H | Central stimulant and appetite depressant composition |
| US4010166A (en) * | 1974-11-25 | 1977-03-01 | Ciba-Geigy Corporation | 1,4-Oxazepines |
| DE3242923A1 (de) * | 1982-11-20 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | 7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepine, ihre herstellung und verwendung |
| EP0815134B1 (en) | 1995-03-14 | 2002-06-05 | Praecis Pharmaceuticals Incorporated | Modulators of amyloid aggregation |
| JP2992677B2 (ja) | 1995-06-05 | 1999-12-20 | 武田薬品工業株式会社 | 骨形成促進医薬組成物 |
| JP3238414B2 (ja) | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| PT929574E (pt) | 1996-08-27 | 2005-11-30 | Praecis Pharm Inc | Moduladores da agregacao de peptidos beta-amiloides compreendendo d-aminoacidos |
| AU2001293372A1 (en) | 2000-04-18 | 2001-10-30 | Cytovia, Inc. | Substituted 1,4-thiazepine and analogs and their use as activators of caspases |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| GB0229743D0 (en) * | 2002-12-20 | 2003-01-29 | Arakis Ltd | Novel benzoxazocines |
| GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| WO2007049041A1 (en) | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| CN101443014A (zh) * | 2006-03-10 | 2009-05-27 | 阿斯利康(瑞典)有限公司 | 化合物 |
| BRPI0712429A2 (pt) | 2006-05-31 | 2014-03-11 | Hoffmann La Roche | Derivados de benzazepina como inibidores de re-captação de monoamina |
| JP2010510962A (ja) | 2006-11-24 | 2010-04-08 | 武田薬品工業株式会社 | 複素単環化合物およびその用途 |
| GB0721178D0 (en) | 2007-10-29 | 2007-12-05 | Glaxo Group Ltd | Chemical compounds |
| WO2009119528A1 (ja) | 2008-03-24 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2010016554A1 (ja) | 2008-08-07 | 2010-02-11 | 武田薬品工業株式会社 | 環状アミン化合物 |
-
2011
- 2011-10-05 EP EP11778987.5A patent/EP2625170A1/en not_active Withdrawn
- 2011-10-05 JP JP2013515601A patent/JP5873487B2/ja not_active Expired - Fee Related
- 2011-10-05 TW TW100136019A patent/TW201242956A/zh unknown
- 2011-10-05 MX MX2013003749A patent/MX2013003749A/es active IP Right Grant
- 2011-10-05 UY UY0001033650A patent/UY33650A/es unknown
- 2011-10-05 US US13/253,293 patent/US8722662B2/en not_active Expired - Fee Related
- 2011-10-05 WO PCT/JP2011/073745 patent/WO2012046882A1/en not_active Ceased
- 2011-10-05 KR KR1020137011425A patent/KR20130116073A/ko not_active Withdrawn
- 2011-10-05 EA EA201390491A patent/EA201390491A1/ru unknown
- 2011-10-05 US US13/877,810 patent/US20130267494A1/en not_active Abandoned
- 2011-10-05 SG SG2013015268A patent/SG188346A1/en unknown
- 2011-10-05 PH PH1/2013/500657A patent/PH12013500657A1/en unknown
- 2011-10-05 AR ARP110103695A patent/AR083313A1/es unknown
- 2011-10-05 GE GEAP201113078A patent/GEP20156295B/en unknown
- 2011-10-05 CN CN201180059036.1A patent/CN103261176B/zh not_active Expired - Fee Related
- 2011-10-05 PE PE2013000801A patent/PE20140239A1/es not_active Application Discontinuation
- 2011-10-05 CA CA2813911A patent/CA2813911A1/en not_active Abandoned
- 2011-10-05 NZ NZ60849911A patent/NZ608499A/en not_active IP Right Cessation
- 2011-10-05 BR BR112013008420A patent/BR112013008420A2/pt not_active IP Right Cessation
- 2011-10-05 AU AU2011313150A patent/AU2011313150A1/en not_active Abandoned
-
2013
- 2013-03-13 IL IL225189A patent/IL225189A0/en unknown
- 2013-03-20 ZA ZA2013/02112A patent/ZA201302112B/en unknown
- 2013-04-04 CR CR20130158A patent/CR20130158A/es not_active Application Discontinuation
- 2013-04-04 DO DO2013000074A patent/DOP2013000074A/es unknown
- 2013-04-05 CL CL2013000927A patent/CL2013000927A1/es unknown
- 2013-04-29 EC ECSP13012593 patent/ECSP13012593A/es unknown
- 2013-05-07 CO CO13114306A patent/CO6700872A2/es unknown
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