JP2013538195A - Ｈｉｖ汚染の予防、ａｉｄｓを含むｈｉｖによって引き起こされる疾患及びｈｉｖに関連する疾患の予防及び治療のための医薬及び方法 - Google Patents
Ｈｉｖ汚染の予防、ａｉｄｓを含むｈｉｖによって引き起こされる疾患及びｈｉｖに関連する疾患の予防及び治療のための医薬及び方法 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/249—Interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010133045 | 2010-08-06 | ||
| RU2010133045/15A RU2535033C2 (ru) | 2010-08-06 | 2010-08-06 | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| PCT/RU2011/000523 WO2012018284A1 (ru) | 2010-08-06 | 2011-07-15 | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013538195A true JP2013538195A (ja) | 2013-10-10 |
| JP2013538195A5 JP2013538195A5 (enExample) | 2014-04-24 |
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| JP2013523123A Pending JP2013538195A (ja) | 2010-08-06 | 2011-07-15 | Ｈｉｖ汚染の予防、ａｉｄｓを含むｈｉｖによって引き起こされる疾患及びｈｉｖに関連する疾患の予防及び治療のための医薬及び方法 |
Country Status (14)
| Country | Link |
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| US (1) | US20130224219A1 (enExample) |
| EP (1) | EP2601967A4 (enExample) |
| JP (1) | JP2013538195A (enExample) |
| CN (1) | CN103209705A (enExample) |
| AU (1) | AU2011286486B9 (enExample) |
| CA (1) | CA2807540A1 (enExample) |
| DE (1) | DE112011102649T5 (enExample) |
| EA (1) | EA030411B1 (enExample) |
| ES (1) | ES2555557R1 (enExample) |
| GB (1) | GB2498276B (enExample) |
| NZ (1) | NZ606992A (enExample) |
| RU (1) | RU2535033C2 (enExample) |
| UA (1) | UA112747C2 (enExample) |
| WO (1) | WO2012018284A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| MX2013000543A (es) | 2010-07-15 | 2013-10-28 | Oleg Iliich Epshtein | Un metodo para aumentar el efecto de una forma activa potenciada de un anticuerpo. |
| FR2962652A1 (fr) | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees a des maladies neurodegeneratives |
| PH12013500144A1 (en) | 2010-07-21 | 2018-03-21 | Oleg Iliich Epshtein | A method of treating attention deficit hyperactivity disorder |
| WO2014116789A1 (en) * | 2013-01-25 | 2014-07-31 | Thymon, Llc | Immunogenic and prophylactic compositions, methods of making same, and method for treating and preventing tnf-mediated disease and hiv-1 infection |
| KR101759687B1 (ko) | 2013-01-25 | 2017-07-19 | 타이몬, 엘엘씨 | 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법 |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4236069A1 (de) * | 1992-10-26 | 1994-04-28 | Werner Dr Bergmann | Arzneimittel, insbesondere für orale Einnahme |
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
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|---|---|---|---|---|
| AU2275395A (en) * | 1994-03-31 | 1995-10-23 | Biomedical Explorations, Llc | Therapeutic homeopathic dilutions of growth factors and methods of their use |
| US20030228310A1 (en) * | 1996-12-23 | 2003-12-11 | Advanced Biotherapy, Inc. | Treatment of skin diseases |
| US6090388A (en) * | 1998-06-20 | 2000-07-18 | United Biomedical Inc. | Peptide composition for prevention and treatment of HIV infection and immune disorders |
| JP2000143537A (ja) * | 1998-11-13 | 2000-05-23 | Nippon Zoki Pharmaceut Co Ltd | 細胞接着分子発現抑制剤 |
| RU2192888C1 (ru) * | 2001-02-15 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома |
| RU2195317C1 (ru) * | 2001-04-18 | 2002-12-27 | Эпштейн Олег Ильич | Способ коррекции патологических иммунных реакций и лекарственное средство |
| RU2001134982A (ru) * | 2001-12-26 | 2004-02-20 | Олег Ильич Эпштейн | Способ коррекции иммунного ответа и лекарственное средство |
| RU2201255C1 (ru) * | 2001-12-26 | 2003-03-27 | Эпштейн Олег Ильич | Лекарственное средство и способ регуляции сосудистого тонуса |
| RU2205025C1 (ru) * | 2001-12-26 | 2003-05-27 | Гольдберг Евгений Данилович | Способ коррекции иммунного ответа и лекарственное средство |
| UA76640C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| AU2006281981A1 (en) * | 2005-08-15 | 2007-02-22 | Cephalon Australia Pty Ltd | Chimeric antibodies with new world primate regions |
| DE602007006429D1 (de) * | 2006-02-10 | 2010-06-24 | Zymogenetics Inc | Lösliches il-17rcx4 und verfahren zu dessen anwendung bei entzündungen |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| MX345039B (es) * | 2008-06-25 | 2017-01-16 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el tnfa. |
| CZ2013159A3 (cs) * | 2010-08-06 | 2013-06-12 | Iliich Epshtein@Oleg | Kombinovaná farmaceutická kompozice a zpusoby lécby a prevence infekcních chorob |
-
2010
- 2010-08-06 RU RU2010133045/15A patent/RU2535033C2/ru not_active IP Right Cessation
-
2011
- 2011-07-15 US US13/814,659 patent/US20130224219A1/en not_active Abandoned
- 2011-07-15 ES ES201390021A patent/ES2555557R1/es active Pending
- 2011-07-15 EP EP11814861.8A patent/EP2601967A4/en not_active Ceased
- 2011-07-15 UA UAA201300101A patent/UA112747C2/uk unknown
- 2011-07-15 WO PCT/RU2011/000523 patent/WO2012018284A1/ru not_active Ceased
- 2011-07-15 GB GB1303983.9A patent/GB2498276B/en not_active Expired - Fee Related
- 2011-07-15 CA CA2807540A patent/CA2807540A1/en not_active Abandoned
- 2011-07-15 JP JP2013523123A patent/JP2013538195A/ja active Pending
- 2011-07-15 EA EA201300136A patent/EA030411B1/ru not_active IP Right Cessation
- 2011-07-15 DE DE112011102649T patent/DE112011102649T5/de not_active Withdrawn
- 2011-07-15 NZ NZ606992A patent/NZ606992A/en not_active IP Right Cessation
- 2011-07-15 CN CN2011800403882A patent/CN103209705A/zh active Pending
- 2011-07-15 AU AU2011286486A patent/AU2011286486B9/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4236069A1 (de) * | 1992-10-26 | 1994-04-28 | Werner Dr Bergmann | Arzneimittel, insbesondere für orale Einnahme |
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
Non-Patent Citations (1)
| Title |
|---|
| JPN6015013122; 東方医学， ２００７， ｖｏｌ．２３， Ｎｏ．２， ｐ．２１-３３ * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2555557A2 (es) | 2016-01-04 |
| AU2011286486A2 (en) | 2013-05-02 |
| DE112011102649T5 (de) | 2013-06-20 |
| EA030411B1 (ru) | 2018-08-31 |
| EP2601967A4 (en) | 2014-05-07 |
| CN103209705A (zh) | 2013-07-17 |
| GB2498276A (en) | 2013-07-10 |
| NZ606992A (en) | 2016-03-31 |
| CA2807540A1 (en) | 2012-02-09 |
| RU2535033C2 (ru) | 2014-12-10 |
| WO2012018284A1 (ru) | 2012-02-09 |
| US20130224219A1 (en) | 2013-08-29 |
| EA201300136A1 (ru) | 2013-09-30 |
| GB201303983D0 (en) | 2013-04-17 |
| AU2011286486B2 (en) | 2017-02-02 |
| EP2601967A1 (en) | 2013-06-12 |
| GB2498276B (en) | 2018-05-23 |
| AU2011286486B9 (en) | 2017-02-23 |
| RU2010133045A (ru) | 2012-02-20 |
| AU2011286486A1 (en) | 2013-03-28 |
| UA112747C2 (uk) | 2016-10-25 |
| ES2555557R1 (es) | 2016-02-05 |
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