JP2013537632A - 絹ベースのバイオフォトニックセンサー - Google Patents
絹ベースのバイオフォトニックセンサー Download PDFInfo
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- JP2013537632A JP2013537632A JP2013523236A JP2013523236A JP2013537632A JP 2013537632 A JP2013537632 A JP 2013537632A JP 2013523236 A JP2013523236 A JP 2013523236A JP 2013523236 A JP2013523236 A JP 2013523236A JP 2013537632 A JP2013537632 A JP 2013537632A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4788—Diffraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Crystallography & Structural Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36940210P | 2010-07-30 | 2010-07-30 | |
| US61/369,402 | 2010-07-30 | ||
| PCT/US2011/046060 WO2012054121A2 (en) | 2010-07-30 | 2011-07-30 | Silk-based biophotonic sensors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537632A true JP2013537632A (ja) | 2013-10-03 |
| JP2013537632A5 JP2013537632A5 (https=) | 2014-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523236A Pending JP2013537632A (ja) | 2010-07-30 | 2011-07-30 | 絹ベースのバイオフォトニックセンサー |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130330710A1 (https=) |
| EP (1) | EP2598883A2 (https=) |
| JP (1) | JP2013537632A (https=) |
| WO (1) | WO2012054121A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020519874A (ja) * | 2017-05-10 | 2020-07-02 | エーテーハー チューリヒ | 表面増感ラマン分光の活用方法、目的用途、及びそのための装置 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130330711A1 (en) * | 2012-06-06 | 2013-12-12 | National Taiwan University | Sensor for detection of a target of interest |
| US20150368417A1 (en) | 2013-02-15 | 2015-12-24 | Tufts University | Silk-based nanoimprinting |
| WO2014197093A2 (en) | 2013-03-15 | 2014-12-11 | Tufts University | All water-based nanopatterning |
| US10464361B2 (en) | 2013-03-15 | 2019-11-05 | Tufts University | Silk water lithography |
| EP3004950A1 (en) * | 2013-06-04 | 2016-04-13 | Danmarks Tekniske Universitet | An optical device capable of providing a structural color, and a corresponding method of manufacturing such a device |
| CR20160468A (es) | 2014-03-07 | 2017-01-20 | Univ Tufts | Conservación de productos perecederos a base de biopolímeros |
| WO2015157691A1 (en) * | 2014-04-10 | 2015-10-15 | President And Fellows Of Harvard College | Colorimetric sensor with automated readout |
| US10348424B2 (en) * | 2015-03-04 | 2019-07-09 | Commscope Technologies Llc | Intermodulation byproduct cancellation in one or more nodes of a distributed antenna system |
| EP3076161A1 (en) | 2015-04-01 | 2016-10-05 | Danmarks Tekniske Universitet | A substrate and a method of using it |
| US20200054792A1 (en) | 2015-07-28 | 2020-02-20 | Trustees Of Tufts College | Polypeptide monoliths |
| CN108603839A (zh) | 2016-04-18 | 2018-09-28 | 惠普发展公司，有限责任合伙企业 | 散射辐射的多重光谱的同时检测 |
| AU2017374052B2 (en) * | 2016-12-08 | 2022-10-27 | Drinksavvy, Inc. | Surface plasmon resonance sensor comprising metal coated nanostructures and a molecularly imprinted polymer layer |
| CN110462127B (zh) | 2017-02-14 | 2021-03-26 | 耐克创新有限合伙公司 | 防味组合物、具有防味特性的结构、制备防味组合物和结构的方法 |
| WO2018187758A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Directed plasma nanosynthesis (dpns) methods, uses and systems |
| JP7349982B2 (ja) | 2017-09-29 | 2023-09-25 | ナイキ イノベイト シーブイ | 構造色を付与した物品および構造色を付与した物品の製造方法並びに使用方法 |
| WO2020263362A1 (en) | 2019-06-26 | 2020-12-30 | Nike Innovate C.V. | Structurally-colored articles and methods for making and using structurally-colored articles |
| CN114206149A (zh) | 2019-07-26 | 2022-03-18 | 耐克创新有限合伙公司 | 结构着色的物品以及用于制造和使用结构着色的物品的方法 |
| US11473968B2 (en) | 2019-08-06 | 2022-10-18 | Apple Inc. | Electronic devices with light sensor system having polarized light source and light detector to detect reflected light used to determine reflectivity of an object |
| US11986042B2 (en) | 2019-10-21 | 2024-05-21 | Nike, Inc. | Structurally-colored articles and methods for making and using structurally-colored articles |
| FI129618B (en) | 2019-11-05 | 2022-05-31 | Teknologian Tutkimuskeskus Vtt Oy | Breakdown or breakdown reflection of light received by a cellulosic film comprising a surface pattern |
| WO2021243231A2 (en) | 2020-05-29 | 2021-12-02 | Nike, Inc. | Structurally-colored articles and methods for making and using structurally-colored articles |
| US11889894B2 (en) | 2020-08-07 | 2024-02-06 | Nike, Inc. | Footwear article having concealing layer |
| US11129444B1 (en) | 2020-08-07 | 2021-09-28 | Nike, Inc. | Footwear article having repurposed material with concealing layer |
| US11241062B1 (en) | 2020-08-07 | 2022-02-08 | Nike, Inc. | Footwear article having repurposed material with structural-color concealing layer |
| CN116180331A (zh) * | 2023-03-06 | 2023-05-30 | 天津工业大学 | 基于结构转变的速显色和动态变色的结构色纤维膜及其制备方法和应用 |
| WO2025193717A1 (en) * | 2024-03-11 | 2025-09-18 | Trustees Of Tufts College | Sound mediated assembly of biopolymers |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005283556A (ja) * | 2004-03-05 | 2005-10-13 | Canon Inc | 標的物質認識素子、検出方法及び装置 |
| WO2009061823A1 (en) * | 2007-11-05 | 2009-05-14 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| JP2009150708A (ja) * | 2007-12-19 | 2009-07-09 | Canon Inc | 標的物質の検出方法及び検査キット |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060275911A1 (en) * | 2005-06-03 | 2006-12-07 | Shih-Yuan Wang | Method and apparatus for moleclular analysis using nanostructure-enhanced Raman spectroscopy |
| US8195021B2 (en) * | 2006-11-03 | 2012-06-05 | Tufts University/Trustees Of Tufts College | Biopolymer optical waveguide and method of manufacturing the same |
| WO2010088585A1 (en) * | 2009-01-30 | 2010-08-05 | Trustees Of Boston University | Chemical/biological sensor employing scattered chromatic components in nano-patterned aperiodic surfaces |
-
2011
- 2011-07-30 EP EP11834780.6A patent/EP2598883A2/en not_active Withdrawn
- 2011-07-30 JP JP2013523236A patent/JP2013537632A/ja active Pending
- 2011-07-30 WO PCT/US2011/046060 patent/WO2012054121A2/en not_active Ceased
- 2011-07-30 US US13/813,288 patent/US20130330710A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005283556A (ja) * | 2004-03-05 | 2005-10-13 | Canon Inc | 標的物質認識素子、検出方法及び装置 |
| WO2009061823A1 (en) * | 2007-11-05 | 2009-05-14 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| JP2011504421A (ja) * | 2007-11-05 | 2011-02-10 | トラスティーズ オブ タフツ カレッジ | ナノコンタクトインプリンティングによる絹フィブロインフォトニック構造の作製 |
| JP2009150708A (ja) * | 2007-12-19 | 2009-07-09 | Canon Inc | 標的物質の検出方法及び検査キット |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020519874A (ja) * | 2017-05-10 | 2020-07-02 | エーテーハー チューリヒ | 表面増感ラマン分光の活用方法、目的用途、及びそのための装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130330710A1 (en) | 2013-12-12 |
| WO2012054121A9 (en) | 2012-06-14 |
| WO2012054121A3 (en) | 2012-08-09 |
| WO2012054121A2 (en) | 2012-04-26 |
| EP2598883A2 (en) | 2013-06-05 |
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