JP2013536419A5 - - Google Patents
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- Publication number
- JP2013536419A5 JP2013536419A5 JP2013524450A JP2013524450A JP2013536419A5 JP 2013536419 A5 JP2013536419 A5 JP 2013536419A5 JP 2013524450 A JP2013524450 A JP 2013524450A JP 2013524450 A JP2013524450 A JP 2013524450A JP 2013536419 A5 JP2013536419 A5 JP 2013536419A5
- Authority
- JP
- Japan
- Prior art keywords
- tmab
- monoclonal antibody
- antibody
- alternative
- agg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 239000007790 solid phase Substances 0.000 claims 5
- 229960002685 biotin Drugs 0.000 claims 4
- 235000020958 biotin Nutrition 0.000 claims 4
- 239000011616 biotin Substances 0.000 claims 4
- 229960004641 rituximab Drugs 0.000 claims 4
- 206010061623 Adverse drug reaction Diseases 0.000 claims 3
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 229960002964 adalimumab Drugs 0.000 claims 3
- 229960003115 certolizumab pegol Drugs 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 229960000598 infliximab Drugs 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- DDFYFBUWEBINLX-UHFFFAOYSA-M tetramethylammonium bromide Chemical compound [Br-].C[N+](C)(C)C DDFYFBUWEBINLX-UHFFFAOYSA-M 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10173408.5 | 2010-08-19 | ||
| EP10173408 | 2010-08-19 | ||
| PCT/EP2011/064178 WO2012022774A1 (en) | 2010-08-19 | 2011-08-17 | An assay for measurement of antibodies binding to a therapeutic monoclonal antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536419A JP2013536419A (ja) | 2013-09-19 |
| JP2013536419A5 true JP2013536419A5 (enExample) | 2014-04-24 |
| JP5805190B2 JP5805190B2 (ja) | 2015-11-04 |
Family
ID=42727619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524450A Active JP5805190B2 (ja) | 2010-08-19 | 2011-08-17 | 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9081016B2 (enExample) |
| EP (1) | EP2606362B1 (enExample) |
| JP (1) | JP5805190B2 (enExample) |
| CN (1) | CN103109190B (enExample) |
| CA (1) | CA2802278A1 (enExample) |
| ES (1) | ES2555864T3 (enExample) |
| WO (1) | WO2012022774A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104614535B (zh) * | 2015-02-10 | 2017-11-28 | 深圳市新产业生物医学工程股份有限公司 | 甲状腺微粒体抗体检测试剂盒及其制备方法和应用 |
| US11119096B2 (en) * | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| CN106093413A (zh) * | 2016-07-18 | 2016-11-09 | 本·沙朗 | 一种抗英夫利西抗体elisa检测试剂盒和检测方法 |
| WO2019055938A1 (en) * | 2017-09-15 | 2019-03-21 | Beckman Coulter, Inc. | FLOW-BASED DOSINGS FOR THERAPEUTIC AGENTS |
| JP2021519284A (ja) * | 2018-03-27 | 2021-08-10 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 治療薬による処置から利益を受けうる被験体を特定するためのサンドウィッチｅｌｉｓａ |
| CN114902052B (zh) * | 2020-01-02 | 2025-07-18 | 豪夫迈·罗氏有限公司 | Ada应答特异性化测定 |
| US12560598B2 (en) | 2020-03-11 | 2026-02-24 | Genesis Intelligence, Llc | Cartridge-based automated rapid test analyzer |
| WO2021224360A1 (en) * | 2020-05-08 | 2021-11-11 | F. Hoffmann-La Roche Ag | High ionic strength dissociation assay for high drug tolerant testing |
| CN117590002B (zh) * | 2023-11-23 | 2024-10-22 | 上海领检科技有限公司 | 一种TNFα抗药抗体的检测方法及检测试剂盒 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508132A (en) | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
| US5219730A (en) | 1982-09-28 | 1993-06-15 | New York University | Idiotype-anti-idiotype immunoassay |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4698302A (en) | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
| US4695393A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4628037A (en) | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| US4554088A (en) | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4828981A (en) | 1983-08-24 | 1989-05-09 | Synbiotics Corporation | Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents |
| EP0170302A1 (fr) | 1984-06-27 | 1986-02-05 | l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire | Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| JPH0823558B2 (ja) | 1984-11-27 | 1996-03-06 | オ−ジエニクス リミテツド | 検定装置 |
| EP0222146B1 (de) | 1985-10-16 | 1994-02-16 | Fresenius AG | Selektives Adsorbens zur Bindung von Immunkomplexen |
| WO1987002778A1 (en) | 1985-10-22 | 1987-05-07 | Cooper-Lipotech | Solid-phase liposome immunoassay system |
| US6316607B1 (en) | 1986-04-30 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent assays |
| US4965392A (en) | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| US5935779A (en) | 1988-11-03 | 1999-08-10 | Igen International Inc. | Methods for improved particle electrochemiluminescence assay |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| ZA898290B (en) | 1988-11-03 | 1991-06-26 | Igen Inc | Electrochemiluminescent assays |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| JPH04507285A (ja) | 1988-12-09 | 1992-12-17 | セントコー・インコーポレーテッド | 抗イディオトープ免疫検定法 |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5364930A (en) | 1990-10-16 | 1994-11-15 | Northwestern University | Synthetic C1q peptide fragments |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| ATE161964T1 (de) | 1991-10-15 | 1998-01-15 | Multilyte Ltd | Bindungstest unter benutzung eines markierten reagens |
| JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
| US5466416A (en) | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| US6241963B1 (en) | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| DE19806989A1 (de) | 1998-02-19 | 1999-08-26 | Roche Diagnostics Gmbh | Erzeugung räumlich scharf begrenzter Festphasen für Bindungsassays |
| IT1315254B1 (it) | 1999-11-05 | 2003-02-03 | Diesse Diagnostica Senese Spa | Metodo per la determinazione qualitativa e quantitativa di anticorpiumani di classe igc. |
| AU774575C (en) | 1999-11-16 | 2005-09-08 | Genentech Inc. | Elisa for VEGF |
| CA2543830A1 (en) | 2003-10-27 | 2005-05-19 | Monogram Biosciences, Inc. | Detecting human anti-therapeutic antibodies |
| DE102004052729A1 (de) * | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
| SI2645106T2 (sl) | 2005-04-04 | 2025-05-30 | Biogen Ma Inc. | Metode za ocenjevanje imunskega odziva na terapevtsko sredstvo |
| EP2389946A1 (en) * | 2006-03-23 | 2011-11-30 | Novartis AG | Anti-tumor cell antigen antibody therapeutics |
| CN101646449A (zh) * | 2006-10-10 | 2010-02-10 | 斯奎科公司 | 用于治疗和诊断癌症的组合物和方法 |
| US8501417B2 (en) * | 2007-06-26 | 2013-08-06 | Vanderbilt University | Immunological compositions as cancer biomarkers and/or therapeutics |
-
2011
- 2011-08-17 EP EP11746230.9A patent/EP2606362B1/en active Active
- 2011-08-17 CA CA2802278A patent/CA2802278A1/en not_active Abandoned
- 2011-08-17 JP JP2013524450A patent/JP5805190B2/ja active Active
- 2011-08-17 WO PCT/EP2011/064178 patent/WO2012022774A1/en not_active Ceased
- 2011-08-17 ES ES11746230.9T patent/ES2555864T3/es active Active
- 2011-08-17 CN CN201180042537.9A patent/CN103109190B/zh active Active
-
2013
- 2013-02-13 US US13/766,130 patent/US9081016B2/en active Active
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