JP2013534424A - 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物 - Google Patents

二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物 Download PDF

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JP2013534424A
JP2013534424A JP2013518760A JP2013518760A JP2013534424A JP 2013534424 A JP2013534424 A JP 2013534424A JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013534424 A JP2013534424 A JP 2013534424A
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JP2013534424A5 (enExample
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ボブ， デール ブラウン，
ヘンリク， ティー ドゥーデック，
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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JP2013518760A 2010-07-06 2011-07-01 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物 Pending JP2013534424A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36175910P 2010-07-06 2010-07-06
US61/361,759 2010-07-06
PCT/US2011/042810 WO2012006241A2 (en) 2010-07-06 2011-07-01 Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna

Publications (2)

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JP2013534424A true JP2013534424A (ja) 2013-09-05
JP2013534424A5 JP2013534424A5 (enExample) 2014-08-14

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JP2013518760A Pending JP2013534424A (ja) 2010-07-06 2011-07-01 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物

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US (2) US8927515B2 (enExample)
EP (1) EP2591104A4 (enExample)
JP (1) JP2013534424A (enExample)
AU (1) AU2011276363A1 (enExample)
CA (1) CA2804210A1 (enExample)
WO (1) WO2012006241A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019526260A (ja) * 2016-09-01 2019-09-19 プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ 化学修飾された一本鎖ｒｎａ編集オリゴヌクレオチド
JP2022513662A (ja) * 2018-11-28 2022-02-09 バイオニア コーポレーション アンドロゲン受容体特異的配列を含む二本鎖オリゴヌクレオチド構造体、及びこれを含む脱毛予防及び発毛用組成物

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US20100048914A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009128936A2 (en) 2008-04-16 2009-10-22 The Johns Hopkins University Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
JP2016501533A (ja) * 2012-12-14 2016-01-21 ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 二本鎖ｒｎａによるｃｋａｐ５の特異的阻害に関する方法および組成物
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
ES2905257T3 (es) 2013-07-03 2022-04-07 Dicerna Pharmaceuticals Inc Métodos y composiciones para la inhibición específica de alfa-1 antitripsina mediante ARN bicatenario
WO2015023710A1 (en) 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
US10774387B2 (en) 2014-05-19 2020-09-15 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
CA2959336A1 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
DK3234134T3 (da) 2014-12-17 2020-07-27 Proqr Therapeutics Ii Bv Målrettet rna-redigering
CA2989384A1 (en) * 2015-07-30 2017-02-02 Bayer Cropscience Aktiengesellschaft Methods and compositions for the control of rust fungi by inhibiting expression of the hxt1 gene
MA45340A (fr) * 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques du récepteur des androgènes et leurs utilisations
WO2017220751A1 (en) 2016-06-22 2017-12-28 Proqr Therapeutics Ii B.V. Single-stranded rna-editing oligonucleotides
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
US11274300B2 (en) 2017-01-19 2022-03-15 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in RNA editing
KR102321426B1 (ko) * 2017-02-21 2021-11-05 올릭스 주식회사 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA
EP3755814B1 (en) * 2018-02-23 2025-04-09 Cornell University Assay for detection of androgen receptor variants
AU2019243946B2 (en) 2018-03-27 2025-03-06 Proqr Therapeutics Ii B.V. Nucleic acid molecules for pseudouridylation
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
WO2025160224A1 (en) * 2024-01-24 2025-07-31 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use
WO2025226946A1 (en) * 2024-04-24 2025-10-30 Cedric Francois Methods and compositions for the treatment of androgenic alopecia

Citations (3)

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US20050164970A1 (en) * 2003-12-22 2005-07-28 University Of Kansas Medical Center Method for treating prostate cancer using siRNA duplex for androgen receptor
JP2007215481A (ja) * 2006-02-16 2007-08-30 Ehime Univ アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ
US20080014584A1 (en) * 2006-06-01 2008-01-17 Mayo Foundation For Medical Education And Research Modulating androgen receptor activity

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US20050170371A1 (en) * 2001-05-18 2005-08-04 Sirna Therapeutics, Inc. RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
US20060257851A1 (en) * 2002-11-26 2006-11-16 Itzhak Bentwich Bioinformatically detectable group of novel viral regulatory genes and uses thereof
JP5243789B2 (ja) * 2004-03-15 2013-07-24 シティ・オブ・ホープ 二本鎖ｒｎａによる遺伝子発現の特異的阻害のための方法及び組成物
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA

Patent Citations (3)

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US20050164970A1 (en) * 2003-12-22 2005-07-28 University Of Kansas Medical Center Method for treating prostate cancer using siRNA duplex for androgen receptor
JP2007215481A (ja) * 2006-02-16 2007-08-30 Ehime Univ アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ
US20080014584A1 (en) * 2006-06-01 2008-01-17 Mayo Foundation For Medical Education And Research Modulating androgen receptor activity

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JPN6015029964; ＰＬＯＳ　ｏｎｅ，　２００７，　Ｉｓｓｕｅ　１０，　ｅ１００６ *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019526260A (ja) * 2016-09-01 2019-09-19 プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ 化学修飾された一本鎖ｒｎａ編集オリゴヌクレオチド
JP7244922B2 (ja) 2016-09-01 2023-03-23 プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ 化学修飾された一本鎖ｒｎａ編集オリゴヌクレオチド
JP2022513662A (ja) * 2018-11-28 2022-02-09 バイオニア コーポレーション アンドロゲン受容体特異的配列を含む二本鎖オリゴヌクレオチド構造体、及びこれを含む脱毛予防及び発毛用組成物
JP2023113845A (ja) * 2018-11-28 2023-08-16 バイオニア コーポレーション アンドロゲン受容体特異的配列を含む二本鎖オリゴヌクレオチド構造体、及びこれを含む脱毛予防及び発毛用組成物
JP7625033B2 (ja) 2018-11-28 2025-01-31 バイオニア コーポレーション アンドロゲン受容体特異的配列を含む二本鎖オリゴヌクレオチド構造体、及びこれを含む脱毛予防及び発毛用組成物

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US9732347B2 (en) 2017-08-15
CA2804210A1 (en) 2012-01-12
US8927515B2 (en) 2015-01-06
WO2012006241A2 (en) 2012-01-12
AU2011276363A1 (en) 2013-01-10
EP2591104A2 (en) 2013-05-15
US20130131149A1 (en) 2013-05-23
EP2591104A4 (en) 2014-09-03
US20150197756A1 (en) 2015-07-16
WO2012006241A3 (en) 2012-04-19

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